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The map label for this gene is dld [H]

Identifier: 182680351

GI number: 182680351

Start: 3917752

End: 3919491

Strand: Reverse

Name: dld [H]

Synonym: Bind_3451

Alternate gene names: 182680351

Gene position: 3919491-3917752 (Counterclockwise)

Preceding gene: 182680355

Following gene: 182680347

Centisome position: 93.99

GC content: 56.72

Gene sequence:

>1740_bases
ATGACAACCACCCTCAACGAGCATCGGGCGGCGAGCGGCGTGCCGGATCAAGGCAATGAGATCTTGATCGCGACATTGAA
AGGCATTGTCGGAGACAGCCATGTTCTGACGAGCCCTGAAGCCACTTTGCGATTTCGCACTGGCTTTCGCTTCGGTCGTG
GCTCCGCGCTGGCGGTGGTGCAGCCGGGCAGCCTCGTCGAGCAATGGAAAGTGCTGCAGGCCTGTGCGGCAGCGGACAAG
ATCATCATCATGCAGGCCGCCAATACGGGGTTGACCGGCGGCTCGACCCCGGATGGCGATGATTATGATCGTGAGATCGT
CATCATCAGCACTTTGCGGATGGCCAAGGTCTATCTGATCGAGGAGGGGCGGCAGGTAGTCTGCCTGCCCGGCGCGACGC
TCTATCAGCTTGAACAGGTTTTACGGCCCCTCGGCCGCGAGCCGCATTCGGTCATTGGCTCTTCCTGTATTGGCGCTTCG
GTGTTTGGCGGTGTCTGCAACAATTCCGGCGGCGCCCTGATCCAGCGTGGACCAGCCTATACACAAATGACGCTCTATGC
CCGCATCGACGAAACGGGCAAGATCGAATTGATCAATCATCTTGGCATTCGTCTCGGCAATGATCCCGAGACGATCCTGA
AAAGGCTCGATGACGGCGATCTCAAAGATACGGATGTCGATCATGATCCGAGCCGTTTCGCCTCGGATCATGATTACATT
CATCATGTCCGTGATATCGAGGCGGATACGCCGGCGCGATTCAACGCCGACCCCAAACGATTGTTCGAAGCCTCGGGGAG
CGCCGGCAAGGTCATGCTGTTCGCGGTCCGGCTGGATACATTCGAGCGCGAGGAGAAAACAGCCGTTTTCTATATCGGGA
CCAATGATCCGGCGGAATTGACCGAGATTCGCCGGCATATTCTGGCGCAATTCAAAACCCTGCCGGTGTCGGGCGAATAT
ATGCATCGCGACGCCTTCGACATTGCCGAAACCTATGGCAAGGATACGTTTCTCGCGATCCGCGCGCTCGGCACGGATCG
ATTACCCAAACTTTTTGCCTGGAAAGCCAAGTTCGATGTGTTCGTGCAGAGATACAGGTTTCTGCCCCAAGATCTCAGCG
ACAAGATCATGCAGGCGGTGAGCCGTCTCTTTCCGAGCCATCTGCCCCCGCGGATGAAAGACTATCGCGACCGGTTCGAG
CATCATCTGATGCTAAAAATGGCCGGCCCCGGCATCGAGGAGGCGCGCACCTATCTGCGATCCATTTTCCCCTCGGCGAA
GGGACATTTCTTCGAATGTACGCCGGAGGAGGGCGTAAAGGCTTTTCTGCATCGTTTCGCGACCGCCGGTGCGGCGATCC
GTTATCGCGCGATCCATCGCCAGGAAGTGGAGGATATTGTCGCTCTCGACATAGCGTTACGCCGCAACGATCGCGACTGG
ATAGAAACCCTGCCGCCCGCCATTGACGCGCCAATCCTCCATAAACTCTATTACGGCCACTTCTTCTGTTACGTCTTCCA
CCAGGATTATATTGTGAAGAAGGGCCATGACACGCTGGCGCTCGAACACGAGATGTGGACGCTTCTCGATGAGCGCGGCG
CGCAATATCCAGCAGAGCATAATGTCGGGCATCTTTATCATGCCAAACCAGCCCTGGTCGGGCATTATAAAAACCTCGAC
CCCTGCAATACGTTCAATCCGGGCATTGGGCATACATCGAAACATGCCCATTGGCGGTGA

Upstream 100 bases:

>100_bases
CTAGCTTAAGGACAGCAGCTGAAGTACTATCCTTGGAAAAATCTCGGCGGCTTTCTCGTCGGGGCGAGCGACGAGACCGG
TCGCGATCAGGGAGATGATA

Downstream 100 bases:

>100_bases
TAGGCGGCGGGTTTGCAGGAAGCAACAGACCCAAAAGCGGAGACCGCGTTTGGGTTCAAACAATTAGTGCGGGACCCAGA
AACGGGGGGCATTGTTATCA

Product: D-lactate dehydrogenase

Products: NA

Alternate protein names: Respiratory D-lactate dehydrogenase [H]

Number of amino acids: Translated: 579; Mature: 578

Protein sequence:

>579_residues
MTTTLNEHRAASGVPDQGNEILIATLKGIVGDSHVLTSPEATLRFRTGFRFGRGSALAVVQPGSLVEQWKVLQACAAADK
IIIMQAANTGLTGGSTPDGDDYDREIVIISTLRMAKVYLIEEGRQVVCLPGATLYQLEQVLRPLGREPHSVIGSSCIGAS
VFGGVCNNSGGALIQRGPAYTQMTLYARIDETGKIELINHLGIRLGNDPETILKRLDDGDLKDTDVDHDPSRFASDHDYI
HHVRDIEADTPARFNADPKRLFEASGSAGKVMLFAVRLDTFEREEKTAVFYIGTNDPAELTEIRRHILAQFKTLPVSGEY
MHRDAFDIAETYGKDTFLAIRALGTDRLPKLFAWKAKFDVFVQRYRFLPQDLSDKIMQAVSRLFPSHLPPRMKDYRDRFE
HHLMLKMAGPGIEEARTYLRSIFPSAKGHFFECTPEEGVKAFLHRFATAGAAIRYRAIHRQEVEDIVALDIALRRNDRDW
IETLPPAIDAPILHKLYYGHFFCYVFHQDYIVKKGHDTLALEHEMWTLLDERGAQYPAEHNVGHLYHAKPALVGHYKNLD
PCNTFNPGIGHTSKHAHWR

Sequences:

>Translated_579_residues
MTTTLNEHRAASGVPDQGNEILIATLKGIVGDSHVLTSPEATLRFRTGFRFGRGSALAVVQPGSLVEQWKVLQACAAADK
IIIMQAANTGLTGGSTPDGDDYDREIVIISTLRMAKVYLIEEGRQVVCLPGATLYQLEQVLRPLGREPHSVIGSSCIGAS
VFGGVCNNSGGALIQRGPAYTQMTLYARIDETGKIELINHLGIRLGNDPETILKRLDDGDLKDTDVDHDPSRFASDHDYI
HHVRDIEADTPARFNADPKRLFEASGSAGKVMLFAVRLDTFEREEKTAVFYIGTNDPAELTEIRRHILAQFKTLPVSGEY
MHRDAFDIAETYGKDTFLAIRALGTDRLPKLFAWKAKFDVFVQRYRFLPQDLSDKIMQAVSRLFPSHLPPRMKDYRDRFE
HHLMLKMAGPGIEEARTYLRSIFPSAKGHFFECTPEEGVKAFLHRFATAGAAIRYRAIHRQEVEDIVALDIALRRNDRDW
IETLPPAIDAPILHKLYYGHFFCYVFHQDYIVKKGHDTLALEHEMWTLLDERGAQYPAEHNVGHLYHAKPALVGHYKNLD
PCNTFNPGIGHTSKHAHWR
>Mature_578_residues
TTTLNEHRAASGVPDQGNEILIATLKGIVGDSHVLTSPEATLRFRTGFRFGRGSALAVVQPGSLVEQWKVLQACAAADKI
IIMQAANTGLTGGSTPDGDDYDREIVIISTLRMAKVYLIEEGRQVVCLPGATLYQLEQVLRPLGREPHSVIGSSCIGASV
FGGVCNNSGGALIQRGPAYTQMTLYARIDETGKIELINHLGIRLGNDPETILKRLDDGDLKDTDVDHDPSRFASDHDYIH
HVRDIEADTPARFNADPKRLFEASGSAGKVMLFAVRLDTFEREEKTAVFYIGTNDPAELTEIRRHILAQFKTLPVSGEYM
HRDAFDIAETYGKDTFLAIRALGTDRLPKLFAWKAKFDVFVQRYRFLPQDLSDKIMQAVSRLFPSHLPPRMKDYRDRFEH
HLMLKMAGPGIEEARTYLRSIFPSAKGHFFECTPEEGVKAFLHRFATAGAAIRYRAIHRQEVEDIVALDIALRRNDRDWI
ETLPPAIDAPILHKLYYGHFFCYVFHQDYIVKKGHDTLALEHEMWTLLDERGAQYPAEHNVGHLYHAKPALVGHYKNLDP
CNTFNPGIGHTSKHAHWR

Specific function: First component of the membrane-bound D-lactate oxidase, which is believed to play an important role in the energization of the active transport of a variety of sugars and amino acids [H]

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Escherichia coli, GI1788454, Length=568, Percent_Identity=64.2605633802817, Blast_Score=761, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016172
- InterPro:   IPR016173
- InterPro:   IPR012256
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR015409
- InterPro:   IPR006094 [H]

Pfam domain/function: PF01565 FAD_binding_4; PF09330 Lact-deh-memb [H]

EC number: =1.1.1.28 [H]

Molecular weight: Translated: 65092; Mature: 64961

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00290 IG_MHC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTLNEHRAASGVPDQGNEILIATLKGIVGDSHVLTSPEATLRFRTGFRFGRGSALAVV
CCCCCCCHHCCCCCCCCCCEEEEEEEHHHCCCCCEECCCCCEEEEECCCEECCCCEEEEE
QPGSLVEQWKVLQACAAADKIIIMQAANTGLTGGSTPDGDDYDREIVIISTLRMAKVYLI
CCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEHHHHHHEEEE
EEGRQVVCLPGATLYQLEQVLRPLGREPHSVIGSSCIGASVFGGVCNNSGGALIQRGPAY
ECCCEEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCC
TQMTLYARIDETGKIELINHLGIRLGNDPETILKRLDDGDLKDTDVDHDPSRFASDHDYI
EEEEEEEEECCCCCEEEEEECCCEECCCHHHHHHHCCCCCCCCCCCCCCHHHHCCCHHHH
HHVRDIEADTPARFNADPKRLFEASGSAGKVMLFAVRLDTFEREEKTAVFYIGTNDPAEL
HHHHHCCCCCCCCCCCCHHHHHHCCCCCCEEEEEEEECCCCCCCCCEEEEEEECCCHHHH
TEIRRHILAQFKTLPVSGEYMHRDAFDIAETYGKDTFLAIRALGTDRLPKLFAWKAKFDV
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHH
FVQRYRFLPQDLSDKIMQAVSRLFPSHLPPRMKDYRDRFEHHLMLKMAGPGIEEARTYLR
HHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEEECCCCHHHHHHHHH
SIFPSAKGHFFECTPEEGVKAFLHRFATAGAAIRYRAIHRQEVEDIVALDIALRRNDRDW
HHCCCCCCCEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
IETLPPAIDAPILHKLYYGHFFCYVFHQDYIVKKGHDTLALEHEMWTLLDERGAQYPAEH
HHHCCCCCCHHHHHHHHHHHEEEEEEECCEEEECCCCCEEEHHHHHHHHHHCCCCCCCCC
NVGHLYHAKPALVGHYKNLDPCNTFNPGIGHTSKHAHWR
CCCCEEECCCHHEECCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TTTLNEHRAASGVPDQGNEILIATLKGIVGDSHVLTSPEATLRFRTGFRFGRGSALAVV
CCCCCCHHCCCCCCCCCCEEEEEEEHHHCCCCCEECCCCCEEEEECCCEECCCCEEEEE
QPGSLVEQWKVLQACAAADKIIIMQAANTGLTGGSTPDGDDYDREIVIISTLRMAKVYLI
CCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEHHHHHHEEEE
EEGRQVVCLPGATLYQLEQVLRPLGREPHSVIGSSCIGASVFGGVCNNSGGALIQRGPAY
ECCCEEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCC
TQMTLYARIDETGKIELINHLGIRLGNDPETILKRLDDGDLKDTDVDHDPSRFASDHDYI
EEEEEEEEECCCCCEEEEEECCCEECCCHHHHHHHCCCCCCCCCCCCCCHHHHCCCHHHH
HHVRDIEADTPARFNADPKRLFEASGSAGKVMLFAVRLDTFEREEKTAVFYIGTNDPAEL
HHHHHCCCCCCCCCCCCHHHHHHCCCCCCEEEEEEEECCCCCCCCCEEEEEEECCCHHHH
TEIRRHILAQFKTLPVSGEYMHRDAFDIAETYGKDTFLAIRALGTDRLPKLFAWKAKFDV
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHH
FVQRYRFLPQDLSDKIMQAVSRLFPSHLPPRMKDYRDRFEHHLMLKMAGPGIEEARTYLR
HHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEEECCCCHHHHHHHHH
SIFPSAKGHFFECTPEEGVKAFLHRFATAGAAIRYRAIHRQEVEDIVALDIALRRNDRDW
HHCCCCCCCEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
IETLPPAIDAPILHKLYYGHFFCYVFHQDYIVKKGHDTLALEHEMWTLLDERGAQYPAEH
HHHCCCCCCHHHHHHHHHHHEEEEEEECCEEEECCCCCEEEHHHHHHHHHHCCCCCCCCC
NVGHLYHAKPALVGHYKNLDPCNTFNPGIGHTSKHAHWR
CCCCEEECCCHHEECCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6386470; 3882663; 9278503; 10944213 [H]