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The map label for this gene is kduD [C]

Identifier: 182679817

GI number: 182679817

Start: 3311134

End: 3311928

Strand: Reverse

Name: kduD [C]

Synonym: Bind_2906

Alternate gene names: 182679817

Gene position: 3311928-3311134 (Counterclockwise)

Preceding gene: 182679820

Following gene: 182679816

Centisome position: 79.42

GC content: 62.52

Gene sequence:

>795_bases
ATGCAGGAACAGGCGGCGCGAGAACAGACGGGACTTGAACCGTCGTCGCCAGCAGCGCTCGTGACGGGCGCCGCCAAGCG
GCTCGGACGGCGGATTGCCGAGCGTCTTGCGGCGGCGGGCTACCGGCTGGCTCTCCATTGCAGCGAGGCGTCGCGGCCGC
AGGCGGAGGAACTTGCTTCCGCCATCCGCCGGGACGGTGGAACGGCTGAGGTTTTTGCCTTTGATCTCGCCGATCTCACG
GCCGTTTCCGGGGCCATGAAGGCAATTGTCCAAAAACTCGGGCCGATGGCTCTCCTCGTCAATAATGCGGCGCTTTTCGA
GCGGGATGATGCGGCGCATTTCTCTCCCGCGCTCTGGGAGCGGCATTTCGCGGTTAATTTGCGCGCACCGATCATTCTGG
CCAGCGATTTCGTGGCGCAAGTGCCGCAAGACAATGAGGCGGTGATCGTCAATATTGTCGACCAGCGCGTCTGGCATCTG
TCGCCGCAATTCTTTTCCTATACTTTAAGCAAATCGGCCTTGTGGACAGCGACCTTGACCATGGCCCAGGCTTTCGCGCC
CCGCCGCATCCGCGTCAATGCGGTGGGCCCGGGCCCGGTGCTGCCCAATCACCAGCAGGGACTGGAGGGCTTTGAACAAG
AGGTGGCCGGCCTGCCGCTTGGGCGCGCCGTCACGCCAGACGAAATTGCCGAAGCGGTGCTTTATCTCGCGCAGGCGCGC
AATGTCACCGGACAGATGATTGCCGTCGATGCAGGTCAGCATATCGCCTGGCAAACGCCGGATATTATCGGTTGA

Upstream 100 bases:

>100_bases
GGTTTCTTGAGCGTCTGTGACGACCATATTGGCCGCCTTGCCTTCTTCTTCCGGGCTTGTGATATGGTCCGAGCGGGAGA
TGATCGAGGTGGGATAGGGT

Downstream 100 bases:

>100_bases
GAACGCCGCGCGAAAATCGGCTCAAGCGTTGCTGTTGACAGAAGGGGTGAAGGTTAGAAGATTATATCGGTCACCCACCT
CTTCGTTTAAAAAAGCATCG

Product: short-chain dehydrogenase/reductase SDR

Products: @DEHY06.txt*3-Dehydro-2- Deoxy-D-Gluconate!; NADH. [C]

Alternate protein names: ORFC [H]

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MQEQAAREQTGLEPSSPAALVTGAAKRLGRRIAERLAAAGYRLALHCSEASRPQAEELASAIRRDGGTAEVFAFDLADLT
AVSGAMKAIVQKLGPMALLVNNAALFERDDAAHFSPALWERHFAVNLRAPIILASDFVAQVPQDNEAVIVNIVDQRVWHL
SPQFFSYTLSKSALWTATLTMAQAFAPRRIRVNAVGPGPVLPNHQQGLEGFEQEVAGLPLGRAVTPDEIAEAVLYLAQAR
NVTGQMIAVDAGQHIAWQTPDIIG

Sequences:

>Translated_264_residues
MQEQAAREQTGLEPSSPAALVTGAAKRLGRRIAERLAAAGYRLALHCSEASRPQAEELASAIRRDGGTAEVFAFDLADLT
AVSGAMKAIVQKLGPMALLVNNAALFERDDAAHFSPALWERHFAVNLRAPIILASDFVAQVPQDNEAVIVNIVDQRVWHL
SPQFFSYTLSKSALWTATLTMAQAFAPRRIRVNAVGPGPVLPNHQQGLEGFEQEVAGLPLGRAVTPDEIAEAVLYLAQAR
NVTGQMIAVDAGQHIAWQTPDIIG
>Mature_264_residues
MQEQAAREQTGLEPSSPAALVTGAAKRLGRRIAERLAAAGYRLALHCSEASRPQAEELASAIRRDGGTAEVFAFDLADLT
AVSGAMKAIVQKLGPMALLVNNAALFERDDAAHFSPALWERHFAVNLRAPIILASDFVAQVPQDNEAVIVNIVDQRVWHL
SPQFFSYTLSKSALWTATLTMAQAFAPRRIRVNAVGPGPVLPNHQQGLEGFEQEVAGLPLGRAVTPDEIAEAVLYLAQAR
NVTGQMIAVDAGQHIAWQTPDIIG

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI7705925, Length=241, Percent_Identity=32.3651452282158, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI40254992, Length=234, Percent_Identity=26.4957264957265, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI32483357, Length=243, Percent_Identity=25.9259259259259, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1789208, Length=248, Percent_Identity=31.4516129032258, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI2367175, Length=245, Percent_Identity=29.7959183673469, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788459, Length=247, Percent_Identity=28.3400809716599, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1789378, Length=251, Percent_Identity=27.0916334661355, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1786812, Length=262, Percent_Identity=25.5725190839695, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787335, Length=241, Percent_Identity=25.3112033195021, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1790717, Length=243, Percent_Identity=25.1028806584362, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI2367365, Length=235, Percent_Identity=27.6595744680851, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI87082100, Length=255, Percent_Identity=25.4901960784314, Blast_Score=61, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI71994604, Length=254, Percent_Identity=29.9212598425197, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71994600, Length=259, Percent_Identity=27.7992277992278, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17531453, Length=266, Percent_Identity=26.3157894736842, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI193204405, Length=263, Percent_Identity=26.615969581749, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17561402, Length=252, Percent_Identity=28.1746031746032, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562910, Length=271, Percent_Identity=23.2472324723247, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI115534694, Length=242, Percent_Identity=28.5123966942149, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17562906, Length=260, Percent_Identity=26.1538461538462, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17560676, Length=243, Percent_Identity=24.2798353909465, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI25147288, Length=241, Percent_Identity=27.3858921161826, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17562908, Length=264, Percent_Identity=26.5151515151515, Blast_Score=64, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17555706, Length=246, Percent_Identity=28.0487804878049, Blast_Score=64, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17562990, Length=273, Percent_Identity=25.6410256410256, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI23397609, Length=254, Percent_Identity=30.7086614173228, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28571526, Length=249, Percent_Identity=28.1124497991968, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21357041, Length=247, Percent_Identity=27.9352226720648, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21355319, Length=249, Percent_Identity=25.3012048192771, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24644339, Length=261, Percent_Identity=26.4367816091954, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.125 [C]

Molecular weight: Translated: 28374; Mature: 28374

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEQAAREQTGLEPSSPAALVTGAAKRLGRRIAERLAAAGYRLALHCSEASRPQAEELAS
CCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHH
AIRRDGGTAEVFAFDLADLTAVSGAMKAIVQKLGPMALLVNNAALFERDDAAHFSPALWE
HHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHEECCCCCCCCHHHHH
RHFAVNLRAPIILASDFVAQVPQDNEAVIVNIVDQRVWHLSPQFFSYTLSKSALWTATLT
HEEEEECCCCEEEECHHHHHCCCCCCEEEEEEHHHHHHHCCHHHHHHHHCCCHHHHHHHH
MAQAFAPRRIRVNAVGPGPVLPNHQQGLEGFEQEVAGLPLGRAVTPDEIAEAVLYLAQAR
HHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHC
NVTGQMIAVDAGQHIAWQTPDIIG
CCCCEEEEEECCCEEEECCCCCCC
>Mature Secondary Structure
MQEQAAREQTGLEPSSPAALVTGAAKRLGRRIAERLAAAGYRLALHCSEASRPQAEELAS
CCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHH
AIRRDGGTAEVFAFDLADLTAVSGAMKAIVQKLGPMALLVNNAALFERDDAAHFSPALWE
HHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHEECCCCCCCCHHHHH
RHFAVNLRAPIILASDFVAQVPQDNEAVIVNIVDQRVWHLSPQFFSYTLSKSALWTATLT
HEEEEECCCCEEEECHHHHHCCCCCCEEEEEEHHHHHHHCCHHHHHHHHCCCHHHHHHHH
MAQAFAPRRIRVNAVGPGPVLPNHQQGLEGFEQEVAGLPLGRAVTPDEIAEAVLYLAQAR
HHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHC
NVTGQMIAVDAGQHIAWQTPDIIG
CCCCEEEEEECCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 15.4 {2-deoxygluconate}} [C]

Substrates: @DEOX03.txt*2-Deoxy-D-Gluconate!; NAD(+) [C]

Specific reaction: @DEOX03.txt*2-Deoxy-D-Gluconate! + NAD(+) = @DEHY06.txt*3-Dehydro-2- Deoxy-D-Gluconate! + NADH. [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8868443 [H]