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The map label for this gene is serA [H]

Identifier: 182679741

GI number: 182679741

Start: 3223946

End: 3224941

Strand: Reverse

Name: serA [H]

Synonym: Bind_2829

Alternate gene names: 182679741

Gene position: 3224941-3223946 (Counterclockwise)

Preceding gene: 182679742

Following gene: 182679740

Centisome position: 77.33

GC content: 59.14

Gene sequence:

>996_bases
ATGACGCATATTCTTGTCGCCGGACGCATACATGAAGCAGGGCTCGACATCCTGCGCAATGCATCAGGTATCACGCTGGA
TTTAGTGGATGAAGTCTCGACGGAATCCTATGCTCCTCTGGTCGATCGGGCCGACGCGATCTTGATCCGCACGCAGCCCT
TGCCCGAGTCTGTCATCGACCGGGCGCAGAAACTGAAATTTGTGTCGCGGCATGGTGTCGGTTACGACGTCGTCGATGTG
GAGGCACTGACCCGGCGGAATATTCCGCTTGCCATTGTCGGTGACGTCAATTCACGCTCTGTCGCCGAACATGCCATGAT
GCTGATGCTGGCCGTTGCCAAGCGTGTCTGTGTCTATGATGCCGCGACGCGCGCAGGCAAATGGGGCATACGCAACGATC
TTTACGCGACGGACATTTCCGGTAAGACGTTGCTGCTTATCGGCTTTGGACGGATCGGCCGGCTCGTCGCGAGCATGGCG
CGCGGTTTTGATATGACCATCCTCGCCTATGATCCCTTTCTCGACGAGGCTGCAATCAAGGCGGCGGGGGCGATCCCAAC
GCGTGACCTTGAGGGAGCCTTGCGCAGTGCCGATTTCGTTTCTCTTCACATGCCGCCGCCTCGGAATGGGGCCTTGCTTG
GCGAAAGCGAGCTGGCCTCAATGAAACCCGGAGCCATTCTCATCAATACCGCGCGTGGCGGCGTCGTTGATGAGAAAGCG
CTGGCGAAAGCCTTGACCGACGGTCGGCTTGCTGGAGCCGGGCTCGATGTGTTCACGCAAGAGCCTCCGCCTGCCGATCA
TCCGCTGCTGCAAATGGATCGGGTCATCCTCACCCCCCATTCCGCCGTCATGACGCGCGAATGCGCGGCTCGCATGGCGG
TTTCGGCAAGCCGCAACATTCTTGATTATTTCGCGGGTCGGCTCGATCCTTCGCTCGTCGTCAATGGAGAGGTTCTTTCC
GCTCCAGCTCGCGAAAGCGTCTCTGTCGGAGGATAG

Upstream 100 bases:

>100_bases
CTTGCTGGCGCGGCGCAGGCATCGGTGGCGACGGCGCGTCAGCTCATCGGCCAATTGACCAGTGTGCCCGATCTTAAACA
GGCGGCGGGAGGATATTGAA

Downstream 100 bases:

>100_bases
GATTGCAATAATAATTGCAAAAGTTTTAGTTATAGAATATATGTTGAAAACACCAAGCGAGAGCCGCTGAAACGGCCAGG
CAGGGAGGTTATCCGGTGAC

Product: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MTHILVAGRIHEAGLDILRNASGITLDLVDEVSTESYAPLVDRADAILIRTQPLPESVIDRAQKLKFVSRHGVGYDVVDV
EALTRRNIPLAIVGDVNSRSVAEHAMMLMLAVAKRVCVYDAATRAGKWGIRNDLYATDISGKTLLLIGFGRIGRLVASMA
RGFDMTILAYDPFLDEAAIKAAGAIPTRDLEGALRSADFVSLHMPPPRNGALLGESELASMKPGAILINTARGGVVDEKA
LAKALTDGRLAGAGLDVFTQEPPPADHPLLQMDRVILTPHSAVMTRECAARMAVSASRNILDYFAGRLDPSLVVNGEVLS
APARESVSVGG

Sequences:

>Translated_331_residues
MTHILVAGRIHEAGLDILRNASGITLDLVDEVSTESYAPLVDRADAILIRTQPLPESVIDRAQKLKFVSRHGVGYDVVDV
EALTRRNIPLAIVGDVNSRSVAEHAMMLMLAVAKRVCVYDAATRAGKWGIRNDLYATDISGKTLLLIGFGRIGRLVASMA
RGFDMTILAYDPFLDEAAIKAAGAIPTRDLEGALRSADFVSLHMPPPRNGALLGESELASMKPGAILINTARGGVVDEKA
LAKALTDGRLAGAGLDVFTQEPPPADHPLLQMDRVILTPHSAVMTRECAARMAVSASRNILDYFAGRLDPSLVVNGEVLS
APARESVSVGG
>Mature_330_residues
THILVAGRIHEAGLDILRNASGITLDLVDEVSTESYAPLVDRADAILIRTQPLPESVIDRAQKLKFVSRHGVGYDVVDVE
ALTRRNIPLAIVGDVNSRSVAEHAMMLMLAVAKRVCVYDAATRAGKWGIRNDLYATDISGKTLLLIGFGRIGRLVASMAR
GFDMTILAYDPFLDEAAIKAAGAIPTRDLEGALRSADFVSLHMPPPRNGALLGESELASMKPGAILINTARGGVVDEKAL
AKALTDGRLAGAGLDVFTQEPPPADHPLLQMDRVILTPHSAVMTRECAARMAVSASRNILDYFAGRLDPSLVVNGEVLSA
PARESVSVGG

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=288, Percent_Identity=35.7638888888889, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI145580578, Length=332, Percent_Identity=33.1325301204819, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI4557499, Length=332, Percent_Identity=33.1325301204819, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI61743967, Length=329, Percent_Identity=31.9148936170213, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI4557497, Length=329, Percent_Identity=31.9148936170213, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI145580575, Length=332, Percent_Identity=33.1325301204819, Blast_Score=131, Evalue=8e-31,
Organism=Homo sapiens, GI6912396, Length=255, Percent_Identity=30.5882352941176, Blast_Score=108, Evalue=6e-24,
Organism=Escherichia coli, GI87082289, Length=285, Percent_Identity=37.1929824561403, Blast_Score=160, Evalue=8e-41,
Organism=Escherichia coli, GI1789279, Length=313, Percent_Identity=33.8658146964856, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1787645, Length=319, Percent_Identity=26.0188087774295, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI87081824, Length=260, Percent_Identity=26.9230769230769, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1788660, Length=255, Percent_Identity=29.0196078431373, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=315, Percent_Identity=33.3333333333333, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI25147481, Length=328, Percent_Identity=27.4390243902439, Blast_Score=104, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6324055, Length=261, Percent_Identity=31.0344827586207, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320925, Length=272, Percent_Identity=29.7794117647059, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6324964, Length=300, Percent_Identity=31.3333333333333, Blast_Score=109, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6322116, Length=274, Percent_Identity=29.5620437956204, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6324980, Length=193, Percent_Identity=30.5699481865285, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6325144, Length=182, Percent_Identity=28.021978021978, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI19921140, Length=304, Percent_Identity=33.2236842105263, Blast_Score=146, Evalue=1e-35,
Organism=Drosophila melanogaster, GI28571528, Length=305, Percent_Identity=33.4426229508197, Blast_Score=128, Evalue=6e-30,
Organism=Drosophila melanogaster, GI24646446, Length=327, Percent_Identity=31.4984709480122, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24646448, Length=327, Percent_Identity=31.4984709480122, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24646452, Length=327, Percent_Identity=31.4984709480122, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24646450, Length=327, Percent_Identity=31.4984709480122, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI62472511, Length=327, Percent_Identity=31.4984709480122, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI28574286, Length=252, Percent_Identity=32.5396825396825, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24585516, Length=263, Percent_Identity=28.8973384030418, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24585514, Length=261, Percent_Identity=31.4176245210728, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI28574282, Length=261, Percent_Identity=31.4176245210728, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI45552429, Length=260, Percent_Identity=31.5384615384615, Blast_Score=107, Evalue=9e-24,
Organism=Drosophila melanogaster, GI45551003, Length=260, Percent_Identity=31.5384615384615, Blast_Score=107, Evalue=9e-24,
Organism=Drosophila melanogaster, GI28574284, Length=260, Percent_Identity=31.5384615384615, Blast_Score=107, Evalue=9e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 35248; Mature: 35117

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHILVAGRIHEAGLDILRNASGITLDLVDEVSTESYAPLVDRADAILIRTQPLPESVID
CCEEEEECCCCHHHHHHHHCCCCCEEEEHHHCCCCCCCCHHCCCCEEEEECCCCCHHHHH
RAQKLKFVSRHGVGYDVVDVEALTRRNIPLAIVGDVNSRSVAEHAMMLMLAVAKRVCVYD
HHHHHHHHHHCCCCCEEEEHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
AATRAGKWGIRNDLYATDISGKTLLLIGFGRIGRLVASMARGFDMTILAYDPFLDEAAIK
HHHHCCCCCCCCCCEEECCCCCEEEEEECCHHHHHHHHHHCCCCEEEEEECCCHHHHHHH
AAGAIPTRDLEGALRSADFVSLHMPPPRNGALLGESELASMKPGAILINTARGGVVDEKA
HCCCCCCHHHHHHHCCCCEEEEECCCCCCCCEECCHHHHHCCCCEEEEECCCCCCCCHHH
LAKALTDGRLAGAGLDVFTQEPPPADHPLLQMDRVILTPHSAVMTRECAARMAVSASRNI
HHHHHCCCCCCCCCCEEEECCCCCCCCCHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHH
LDYFAGRLDPSLVVNGEVLSAPARESVSVGG
HHHHHHCCCCCEEECCCEECCCCCCCCCCCC
>Mature Secondary Structure 
THILVAGRIHEAGLDILRNASGITLDLVDEVSTESYAPLVDRADAILIRTQPLPESVID
CEEEEECCCCHHHHHHHHCCCCCEEEEHHHCCCCCCCCHHCCCCEEEEECCCCCHHHHH
RAQKLKFVSRHGVGYDVVDVEALTRRNIPLAIVGDVNSRSVAEHAMMLMLAVAKRVCVYD
HHHHHHHHHHCCCCCEEEEHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
AATRAGKWGIRNDLYATDISGKTLLLIGFGRIGRLVASMARGFDMTILAYDPFLDEAAIK
HHHHCCCCCCCCCCEEECCCCCEEEEEECCHHHHHHHHHHCCCCEEEEEECCCHHHHHHH
AAGAIPTRDLEGALRSADFVSLHMPPPRNGALLGESELASMKPGAILINTARGGVVDEKA
HCCCCCCHHHHHHHCCCCEEEEECCCCCCCCEECCHHHHHCCCCEEEEECCCCCCCCHHH
LAKALTDGRLAGAGLDVFTQEPPPADHPLLQMDRVILTPHSAVMTRECAARMAVSASRNI
HHHHHCCCCCCCCCCEEEECCCCCCCCCHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHH
LDYFAGRLDPSLVVNGEVLSAPARESVSVGG
HHHHHHCCCCCEEECCCEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]