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The map label for this gene is nuoF1 [H]

Identifier: 182679348

GI number: 182679348

Start: 2735126

End: 2736436

Strand: Reverse

Name: nuoF1 [H]

Synonym: Bind_2394

Alternate gene names: 182679348

Gene position: 2736436-2735126 (Counterclockwise)

Preceding gene: 182679349

Following gene: 182679347

Centisome position: 65.62

GC content: 57.59

Gene sequence:

>1311_bases
ATGCTTGAGGACAAGGACCGCATCTTCACCAATCTTTACGGCTACGGCGATTGGGGTCTCAAGGGCGCCATGGCACGCGG
CGCCTGGGACAATACCAAAGGCTTGATTGATAAGGGCAAGGACTGGATTCTCAATGAGATGAAAGCTTCCGGCCTGCGTG
GGCGTGGGGGGGCCGGTTTCCCGACTGGCCTTAAATGGTCCTTCATGCCCAAGGCCGATCCGGCGCGTCCTTCCTATCTC
GTCGTCAATGCCGATGAATCCGAGCCGGGCACCTGCAAGGACAGGGAGATCATGCGCAATGATCCCCATCTTCTGATCGA
AGGATGTCTCATCGCTTCTTTCGCGATGGAGGCGCATGCCTGCTACATTTACATTCGCGGTGAATATATTTTCGAACGCG
AGAGGCTCGAGGCCGCCGTCGCCCAGGCCTATGAGGCCAAGCTGGTCGGCAAGAATAATATCCACGGCTGGCCTTTCGAT
ATTTACGTCCACCATGGTGCGGGCGCCTATATCTGCGGCGAAGAAACGGCTCTTCTCGAATCGCTCGAGGGCAAGAAGGG
CATGCCGCGCATGAAGCCGCCATTCCCCGCCAATATGGGCCTTTATGGCTGCCCGACGACAGTCAATAATGTGGAATCGA
TTGCTGTCGCGCCGACCATTCTGCGGCGTGGCGCGGCTTGGTTTTCGAGCTTTGGCGCCAAGAATAATGCCGGCACCAAG
CTCTTCTGTATTTCCGGCCATGTGAACAAGCGGTGCAATGTTGAGGAAGCCATGTCGATCCCGTTCCGGGAGTTGATCGA
CCGGCATTGCGGCGGTATTCGCGGCGGTTGGGATAATCTTCTGGCTGTCATTCCCGGTGGCTCTTCCGTGCCCTGTGTGC
CGGCGCATGAGATCATCGACGCGCCGATGGATTTCGATACATTGCGCGGGTTGAAATCCGGTCTTGGCACGGCGGCCGTC
ATCGTGATGGATAAATCCACGGATATTGTGCGTGCCATCGCGCGGCTCAGCCATTTCTATAAACACGAGAGCTGTGGCCA
ATGCACGCCCTGCCGCGAGGGGACGGGTTGGCTGTGGCGCGTGATGACCCGCATGGCGGAAGGCCGCGCACAAAAGCGTG
AGATTGACATGTTGCTGGATGTCACGACCCGGATTGAAGGTCATACGATCTGCGCCTTGGGAGATGCGGCCGCTTGGCCG
GTGCAAGGCCTGATCCGTCATTTCCGCTCGGAAATCGAAAAGAAGATCGATCAATATGCGGCTAATCCGCATAGCGAACC
GATCCGCGATTTCGGTGTCGCGGCTGAATAG

Upstream 100 bases:

>100_bases
TGACGACATTCTATGGCACCGATGGTCTCTCCGGGCCGCAATCTTTAAAAACGACTGCACCCGGCGACAAGCCGGCGCAG
AAATAAGAGAGGGATTGTCC

Downstream 100 bases:

>100_bases
GTGCGATGATCGTGGCGACGACGATGGCTTCTCCCACTGATAAAGGCGTTCCTATGGATAAAGACATGGGTGCCTTGGTG
AAAGAATCGCTGTATCGCCT

Product: NADH dehydrogenase I subunit F

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F 1; NDH-1 subunit F 1 [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MLEDKDRIFTNLYGYGDWGLKGAMARGAWDNTKGLIDKGKDWILNEMKASGLRGRGGAGFPTGLKWSFMPKADPARPSYL
VVNADESEPGTCKDREIMRNDPHLLIEGCLIASFAMEAHACYIYIRGEYIFERERLEAAVAQAYEAKLVGKNNIHGWPFD
IYVHHGAGAYICGEETALLESLEGKKGMPRMKPPFPANMGLYGCPTTVNNVESIAVAPTILRRGAAWFSSFGAKNNAGTK
LFCISGHVNKRCNVEEAMSIPFRELIDRHCGGIRGGWDNLLAVIPGGSSVPCVPAHEIIDAPMDFDTLRGLKSGLGTAAV
IVMDKSTDIVRAIARLSHFYKHESCGQCTPCREGTGWLWRVMTRMAEGRAQKREIDMLLDVTTRIEGHTICALGDAAAWP
VQGLIRHFRSEIEKKIDQYAANPHSEPIRDFGVAAE

Sequences:

>Translated_436_residues
MLEDKDRIFTNLYGYGDWGLKGAMARGAWDNTKGLIDKGKDWILNEMKASGLRGRGGAGFPTGLKWSFMPKADPARPSYL
VVNADESEPGTCKDREIMRNDPHLLIEGCLIASFAMEAHACYIYIRGEYIFERERLEAAVAQAYEAKLVGKNNIHGWPFD
IYVHHGAGAYICGEETALLESLEGKKGMPRMKPPFPANMGLYGCPTTVNNVESIAVAPTILRRGAAWFSSFGAKNNAGTK
LFCISGHVNKRCNVEEAMSIPFRELIDRHCGGIRGGWDNLLAVIPGGSSVPCVPAHEIIDAPMDFDTLRGLKSGLGTAAV
IVMDKSTDIVRAIARLSHFYKHESCGQCTPCREGTGWLWRVMTRMAEGRAQKREIDMLLDVTTRIEGHTICALGDAAAWP
VQGLIRHFRSEIEKKIDQYAANPHSEPIRDFGVAAE
>Mature_436_residues
MLEDKDRIFTNLYGYGDWGLKGAMARGAWDNTKGLIDKGKDWILNEMKASGLRGRGGAGFPTGLKWSFMPKADPARPSYL
VVNADESEPGTCKDREIMRNDPHLLIEGCLIASFAMEAHACYIYIRGEYIFERERLEAAVAQAYEAKLVGKNNIHGWPFD
IYVHHGAGAYICGEETALLESLEGKKGMPRMKPPFPANMGLYGCPTTVNNVESIAVAPTILRRGAAWFSSFGAKNNAGTK
LFCISGHVNKRCNVEEAMSIPFRELIDRHCGGIRGGWDNLLAVIPGGSSVPCVPAHEIIDAPMDFDTLRGLKSGLGTAAV
IVMDKSTDIVRAIARLSHFYKHESCGQCTPCREGTGWLWRVMTRMAEGRAQKREIDMLLDVTTRIEGHTICALGDAAAWP
VQGLIRHFRSEIEKKIDQYAANPHSEPIRDFGVAAE

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI260656005, Length=419, Percent_Identity=65.3937947494033, Blast_Score=580, Evalue=1e-166,
Organism=Homo sapiens, GI20149568, Length=419, Percent_Identity=65.3937947494033, Blast_Score=580, Evalue=1e-166,
Organism=Escherichia coli, GI1788620, Length=395, Percent_Identity=43.7974683544304, Blast_Score=319, Evalue=2e-88,
Organism=Caenorhabditis elegans, GI17531727, Length=419, Percent_Identity=67.0644391408115, Blast_Score=591, Evalue=1e-169,
Organism=Drosophila melanogaster, GI19920794, Length=420, Percent_Identity=67.6190476190476, Blast_Score=605, Evalue=1e-173,
Organism=Drosophila melanogaster, GI45550452, Length=426, Percent_Identity=63.3802816901408, Blast_Score=561, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24653819, Length=422, Percent_Identity=45.0236966824645, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24653817, Length=422, Percent_Identity=41.7061611374408, Blast_Score=333, Evalue=1e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 48035; Mature: 48035

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: PS00644 COMPLEX1_51K_1 ; PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEDKDRIFTNLYGYGDWGLKGAMARGAWDNTKGLIDKGKDWILNEMKASGLRGRGGAGF
CCCCHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCHHHCCHHHHHHHHHHCCCCCCCCCCC
PTGLKWSFMPKADPARPSYLVVNADESEPGTCKDREIMRNDPHLLIEGCLIASFAMEAHA
CCCCEEEECCCCCCCCCCEEEEECCCCCCCCCCCHHHHCCCCCEEEHHHHHHHHHHCCEE
CYIYIRGEYIFERERLEAAVAQAYEAKLVGKNNIHGWPFDIYVHHGAGAYICGEETALLE
EEEEEECCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEEECCHHHHHH
SLEGKKGMPRMKPPFPANMGLYGCPTTVNNVESIAVAPTILRRGAAWFSSFGAKNNAGTK
HHCCCCCCCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCE
LFCISGHVNKRCNVEEAMSIPFRELIDRHCGGIRGGWDNLLAVIPGGSSVPCVPAHEIID
EEEEECCCCCCCCHHHHHCCCHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCHHHHHC
APMDFDTLRGLKSGLGTAAVIVMDKSTDIVRAIARLSHFYKHESCGQCTPCREGTGWLWR
CCCCHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHH
VMTRMAEGRAQKREIDMLLDVTTRIEGHTICALGDAAAWPVQGLIRHFRSEIEKKIDQYA
HHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
ANPHSEPIRDFGVAAE
CCCCCCCHHHCCCCCC
>Mature Secondary Structure
MLEDKDRIFTNLYGYGDWGLKGAMARGAWDNTKGLIDKGKDWILNEMKASGLRGRGGAGF
CCCCHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCHHHCCHHHHHHHHHHCCCCCCCCCCC
PTGLKWSFMPKADPARPSYLVVNADESEPGTCKDREIMRNDPHLLIEGCLIASFAMEAHA
CCCCEEEECCCCCCCCCCEEEEECCCCCCCCCCCHHHHCCCCCEEEHHHHHHHHHHCCEE
CYIYIRGEYIFERERLEAAVAQAYEAKLVGKNNIHGWPFDIYVHHGAGAYICGEETALLE
EEEEEECCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEEECCHHHHHH
SLEGKKGMPRMKPPFPANMGLYGCPTTVNNVESIAVAPTILRRGAAWFSSFGAKNNAGTK
HHCCCCCCCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCE
LFCISGHVNKRCNVEEAMSIPFRELIDRHCGGIRGGWDNLLAVIPGGSSVPCVPAHEIID
EEEEECCCCCCCCHHHHHCCCHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCHHHHHC
APMDFDTLRGLKSGLGTAAVIVMDKSTDIVRAIARLSHFYKHESCGQCTPCREGTGWLWR
CCCCHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHH
VMTRMAEGRAQKREIDMLLDVTTRIEGHTICALGDAAAWPVQGLIRHFRSEIEKKIDQYA
HHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
ANPHSEPIRDFGVAAE
CCCCCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]