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The map label for this gene is nqo2 [H]

Identifier: 182679349

GI number: 182679349

Start: 2736451

End: 2737119

Strand: Reverse

Name: nqo2 [H]

Synonym: Bind_2395

Alternate gene names: 182679349

Gene position: 2737119-2736451 (Counterclockwise)

Preceding gene: 182679350

Following gene: 182679348

Centisome position: 65.64

GC content: 56.65

Gene sequence:

>669_bases
ATGAGTAACCGCCGCTTGGCCGAAATCCAGCCAGACTCTTTTGCCTTCACGCCGGAAAGCGAGGCGATTTGCAAGGTGAT
CCTTGCCAAATATCCGGAAGACCGTCAGGCTTCCGCCGTGATCTCGCTTTTGTGGCAGGCTCAGAAACAGCATGATTATT
GGCTGCCGCGGCCGGCGATAGAAAAAGTCGCCGACATGCTGCACATGCCTTATATTCGTGTGCTCGAAGTCGCGACCTTC
TATACGATGTTCAACCTCGAACCGGTTGGACGCTATTACATCCAATTCTGTGGTACGACGCCTTGCCTGATCGCCGGTTC
TGATGACATCAAGGCCGTGCTTGAGAAACGCGTCGGCCCGGAGGGGCAGGTGACGAGCGACGGTCTCTTCTCCTGGAAGG
AAGTCGAATGTCTCGGGGCTTGCTGCAATGCCCCCATGGTGCAGATCAATGATGATTATTACGAAGATCTGACGCCCGAG
AATTTCGCGACCTTGCTCGATGATCTGGCGGCGGGCCGGCCCGTGCGGATCGGTTCGCAGATCGGGCGGACGTCGTCGGA
AATGCATGGTGGCCTGACCGCCTTGACGACATTCTATGGCACCGATGGTCTCTCCGGGCCGCAATCTTTAAAAACGACTG
CACCCGGCGACAAGCCGGCGCAGAAATAA

Upstream 100 bases:

>100_bases
GCCGATGTCAGCGCCATTTTGGGTTCGCTCGACATCGTGTTCGGCGAGGTCGATCGATGAGCTTTGCGGCCCGTAAGACA
ATTTTCCAAGAGGTGCACGC

Downstream 100 bases:

>100_bases
GAGAGGGATTGTCCATGCTTGAGGACAAGGACCGCATCTTCACCAATCTTTACGGCTACGGCGATTGGGGTCTCAAGGGC
GCCATGGCACGCGGCGCCTG

Product: NADH-quinone oxidoreductase subunit E

Products: NA

Alternate protein names: NADH dehydrogenase I, chain 2; NDH-1, chain 2 [H]

Number of amino acids: Translated: 222; Mature: 221

Protein sequence:

>222_residues
MSNRRLAEIQPDSFAFTPESEAICKVILAKYPEDRQASAVISLLWQAQKQHDYWLPRPAIEKVADMLHMPYIRVLEVATF
YTMFNLEPVGRYYIQFCGTTPCLIAGSDDIKAVLEKRVGPEGQVTSDGLFSWKEVECLGACCNAPMVQINDDYYEDLTPE
NFATLLDDLAAGRPVRIGSQIGRTSSEMHGGLTALTTFYGTDGLSGPQSLKTTAPGDKPAQK

Sequences:

>Translated_222_residues
MSNRRLAEIQPDSFAFTPESEAICKVILAKYPEDRQASAVISLLWQAQKQHDYWLPRPAIEKVADMLHMPYIRVLEVATF
YTMFNLEPVGRYYIQFCGTTPCLIAGSDDIKAVLEKRVGPEGQVTSDGLFSWKEVECLGACCNAPMVQINDDYYEDLTPE
NFATLLDDLAAGRPVRIGSQIGRTSSEMHGGLTALTTFYGTDGLSGPQSLKTTAPGDKPAQK
>Mature_221_residues
SNRRLAEIQPDSFAFTPESEAICKVILAKYPEDRQASAVISLLWQAQKQHDYWLPRPAIEKVADMLHMPYIRVLEVATFY
TMFNLEPVGRYYIQFCGTTPCLIAGSDDIKAVLEKRVGPEGQVTSDGLFSWKEVECLGACCNAPMVQINDDYYEDLTPEN
FATLLDDLAAGRPVRIGSQIGRTSSEMHGGLTALTTFYGTDGLSGPQSLKTTAPGDKPAQK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1905

COG function: function code C; NADH:ubiquinone oxidoreductase 24 kD subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 24 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI222080062, Length=196, Percent_Identity=50.5102040816327, Blast_Score=193, Evalue=1e-49,
Organism=Escherichia coli, GI1788621, Length=162, Percent_Identity=39.5061728395062, Blast_Score=96, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17561328, Length=184, Percent_Identity=52.1739130434783, Blast_Score=199, Evalue=6e-52,
Organism=Drosophila melanogaster, GI18859877, Length=184, Percent_Identity=50, Blast_Score=173, Evalue=7e-44,
Organism=Drosophila melanogaster, GI21355353, Length=184, Percent_Identity=39.1304347826087, Blast_Score=132, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002023
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01257 Complex1_24kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 24533; Mature: 24402

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS01099 COMPLEX1_24K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNRRLAEIQPDSFAFTPESEAICKVILAKYPEDRQASAVISLLWQAQKQHDYWLPRPAI
CCCCCCEEECCCCEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHH
EKVADMLHMPYIRVLEVATFYTMFNLEPVGRYYIQFCGTTPCLIAGSDDIKAVLEKRVGP
HHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEECCHHHHHHHHHHCCC
EGQVTSDGLFSWKEVECLGACCNAPMVQINDDYYEDLTPENFATLLDDLAAGRPVRIGSQ
CCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCHHHCCCHHHHHHHHHHHHCCCCEEECHH
IGRTSSEMHGGLTALTTFYGTDGLSGPQSLKTTAPGDKPAQK
HCCCHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SNRRLAEIQPDSFAFTPESEAICKVILAKYPEDRQASAVISLLWQAQKQHDYWLPRPAI
CCCCCEEECCCCEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHH
EKVADMLHMPYIRVLEVATFYTMFNLEPVGRYYIQFCGTTPCLIAGSDDIKAVLEKRVGP
HHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEECCHHHHHHHHHHCCC
EGQVTSDGLFSWKEVECLGACCNAPMVQINDDYYEDLTPENFATLLDDLAAGRPVRIGSQ
CCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCHHHCCCHHHHHHHHHHHHCCCCEEECHH
IGRTSSEMHGGLTALTTFYGTDGLSGPQSLKTTAPGDKPAQK
HCCCHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1909571 [H]