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The map label for this gene is nqo13 [H]

Identifier: 182679340

GI number: 182679340

Start: 2726557

End: 2728080

Strand: Reverse

Name: nqo13 [H]

Synonym: Bind_2386

Alternate gene names: 182679340

Gene position: 2728080-2726557 (Counterclockwise)

Preceding gene: 182679341

Following gene: 182679339

Centisome position: 65.42

GC content: 57.41

Gene sequence:

>1524_bases
ATGTTCGGCTTCGGTATTCTTTCAGCCCTCATTTTCCTGCCCCTCGTCGGCGCGCTCTTCATCGCGTTGCTGCCGGGAGA
CAGTGAAGCCAGCCGTTCCAGCGCGCGCTGGGCCGCCTTGATCACGACCCTGATCACCTTTGCGTTATCGGTCTATGCCT
ATACGCAATTCGATCCGGCCTCCTCGGCCTTCCAGCTCATTGAGGAAAAGAGCTGGTTCGGGCTCGGGCTCGTTTACAAG
CTCGGTGTCGATGGCATGTCGATCCCGTTCCTGGTGCTGACAGCCTTCCTCATGCCTTTCTGTATCCTTGCGTCGTGGGA
ATCGATCCAGACCCGCGTCAAGGAATATATGGTGGCCTTCCTGATCCTGGAGAGCCTGCTGCTCGGCGTCTTCACCGCGC
TCGACACCATTCTCTTCTATCTCTTCTTCGAAGGCAGCCTCATTCCGATGTTCCTCATCATCGGCATATGGGGTGGACCG
CGCCGCATCTATGCGAGCTTTAAATTCTTCCTCTATACGCTCGTCGGCTCGCTTCTGATGCTGCTCGCCGTCATGGCCAT
GTATGGGATCGCCGGGACGACCGATATTACGGTCCTTCTGAAGACAGCGTTTCCGGCCTCCATGCAGAAATGGCTGTGGC
TTGCCTTTTTTGCCTCCTTTGCCGTCAAAATGCCGATGTGGCCGGTCCATACCTGGTTGCCGGACGCTCACGTCGAGGCG
CCGACGGCGGGGTCGGTCATTCTGGCCGGCATTCTCCTGAAGATGGGTGGTTACGGTTTCATCCGCTTCTCCCTGCCCAT
GTTCCCTGAGGCCTCGGCTTATTTCGCGCCGCTCGTGTTCGCCTTGTCGGTGATCGCCATCATCTATACGTCGCTGGTCG
CGCTCGTTCAGAATGATATCAAGAAGCTGATCGCTTATTCGTCCGTGGCTCATATGGGCTTCGTGACCATGGGGCTGTTC
TCCATGACGGAGCAGGGCGTGCAGGGCGCCATCTTCCAGATGGTGTCGCATGGCATTGTCGCCAGCGCTTTGTTCTTGTG
CGTCGGCGTTGTCTATGACCGGCTGCATACACGTGACATCGCGGCCTATGGCGGTATTGTCGAGCGCATGCCGCGCTATG
GCACGGCCTTCATGATCTTCACCATGGCCAATGTCGGTCTGCCGGGCACGTCCGGGTTCATCGGTGAGTTCCTCACCATG
ATCGGCACTTTCCAGATCAACAGCACCGTTGTTCTCTTTGCGGCGACAGGCGTCATTTTCTCGGCGGCCTATGCGCTTTA
TCTCTACCGCAGGGTCCTTTTCGGGGCCTTGGAAAAAGCGAACTTGAAGACGCTGCTCGATCTTTCGGGACGCGAAATCG
CTCTTCTCGCGCCCCTGATCGTTTTGACACTTTATTATGGGGTGCATCCCGCTCCCATTCTCGATGGTTGTGCGGCGTCG
GTTGAAGCTCTTATCCGGGGTTATGACGCGGCACTTTCCCTTGCGCATACGGCATCGCTTGTTTCTCCCGTTGCCATCCC
CTGA

Upstream 100 bases:

>100_bases
TCGTGAAATTGCAGACCGGTTACATCTACCATTACGCATTCGCCATGCTCATCGGTGTCGCCGCGATCGTCACCTTCTAT
GTCGTCGGAGGTGTGCACTA

Downstream 100 bases:

>100_bases
TCCATCGGTCACCCCCTCCATGAAAAGGGGAGGGGTGGCGTCAATGAATTGGAATCGCGTTGGAATCGTCACGTCGCGAT
CCCGTGCCCAAATCGTGTAA

Product: proton-translocating NADH-quinone oxidoreductase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I, chain 13; NDH-1, chain 13 [H]

Number of amino acids: Translated: 507; Mature: 507

Protein sequence:

>507_residues
MFGFGILSALIFLPLVGALFIALLPGDSEASRSSARWAALITTLITFALSVYAYTQFDPASSAFQLIEEKSWFGLGLVYK
LGVDGMSIPFLVLTAFLMPFCILASWESIQTRVKEYMVAFLILESLLLGVFTALDTILFYLFFEGSLIPMFLIIGIWGGP
RRIYASFKFFLYTLVGSLLMLLAVMAMYGIAGTTDITVLLKTAFPASMQKWLWLAFFASFAVKMPMWPVHTWLPDAHVEA
PTAGSVILAGILLKMGGYGFIRFSLPMFPEASAYFAPLVFALSVIAIIYTSLVALVQNDIKKLIAYSSVAHMGFVTMGLF
SMTEQGVQGAIFQMVSHGIVASALFLCVGVVYDRLHTRDIAAYGGIVERMPRYGTAFMIFTMANVGLPGTSGFIGEFLTM
IGTFQINSTVVLFAATGVIFSAAYALYLYRRVLFGALEKANLKTLLDLSGREIALLAPLIVLTLYYGVHPAPILDGCAAS
VEALIRGYDAALSLAHTASLVSPVAIP

Sequences:

>Translated_507_residues
MFGFGILSALIFLPLVGALFIALLPGDSEASRSSARWAALITTLITFALSVYAYTQFDPASSAFQLIEEKSWFGLGLVYK
LGVDGMSIPFLVLTAFLMPFCILASWESIQTRVKEYMVAFLILESLLLGVFTALDTILFYLFFEGSLIPMFLIIGIWGGP
RRIYASFKFFLYTLVGSLLMLLAVMAMYGIAGTTDITVLLKTAFPASMQKWLWLAFFASFAVKMPMWPVHTWLPDAHVEA
PTAGSVILAGILLKMGGYGFIRFSLPMFPEASAYFAPLVFALSVIAIIYTSLVALVQNDIKKLIAYSSVAHMGFVTMGLF
SMTEQGVQGAIFQMVSHGIVASALFLCVGVVYDRLHTRDIAAYGGIVERMPRYGTAFMIFTMANVGLPGTSGFIGEFLTM
IGTFQINSTVVLFAATGVIFSAAYALYLYRRVLFGALEKANLKTLLDLSGREIALLAPLIVLTLYYGVHPAPILDGCAAS
VEALIRGYDAALSLAHTASLVSPVAIP
>Mature_507_residues
MFGFGILSALIFLPLVGALFIALLPGDSEASRSSARWAALITTLITFALSVYAYTQFDPASSAFQLIEEKSWFGLGLVYK
LGVDGMSIPFLVLTAFLMPFCILASWESIQTRVKEYMVAFLILESLLLGVFTALDTILFYLFFEGSLIPMFLIIGIWGGP
RRIYASFKFFLYTLVGSLLMLLAVMAMYGIAGTTDITVLLKTAFPASMQKWLWLAFFASFAVKMPMWPVHTWLPDAHVEA
PTAGSVILAGILLKMGGYGFIRFSLPMFPEASAYFAPLVFALSVIAIIYTSLVALVQNDIKKLIAYSSVAHMGFVTMGLF
SMTEQGVQGAIFQMVSHGIVASALFLCVGVVYDRLHTRDIAAYGGIVERMPRYGTAFMIFTMANVGLPGTSGFIGEFLTM
IGTFQINSTVVLFAATGVIFSAAYALYLYRRVLFGALEKANLKTLLDLSGREIALLAPLIVLTLYYGVHPAPILDGCAAS
VEALIRGYDAALSLAHTASLVSPVAIP

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=363, Percent_Identity=36.0881542699724, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI251831117, Length=235, Percent_Identity=27.6595744680851, Blast_Score=87, Evalue=5e-17,
Organism=Escherichia coli, GI1788613, Length=495, Percent_Identity=38.5858585858586, Blast_Score=318, Evalue=4e-88,
Organism=Escherichia coli, GI1788827, Length=305, Percent_Identity=27.8688524590164, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1788831, Length=301, Percent_Identity=26.2458471760797, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1788614, Length=532, Percent_Identity=25, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1788829, Length=412, Percent_Identity=25.4854368932039, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI2367154, Length=252, Percent_Identity=26.1904761904762, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI145693160, Length=421, Percent_Identity=26.1282660332542, Blast_Score=73, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- InterPro:   IPR000260 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01059 Oxidored_q5_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 55078; Mature: 55078

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGFGILSALIFLPLVGALFIALLPGDSEASRSSARWAALITTLITFALSVYAYTQFDPA
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
SSAFQLIEEKSWFGLGLVYKLGVDGMSIPFLVLTAFLMPFCILASWESIQTRVKEYMVAF
HHHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LILESLLLGVFTALDTILFYLFFEGSLIPMFLIIGIWGGPRRIYASFKFFLYTLVGSLLM
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
LLAVMAMYGIAGTTDITVLLKTAFPASMQKWLWLAFFASFAVKMPMWPVHTWLPDAHVEA
HHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCC
PTAGSVILAGILLKMGGYGFIRFSLPMFPEASAYFAPLVFALSVIAIIYTSLVALVQNDI
CCCHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKLIAYSSVAHMGFVTMGLFSMTEQGVQGAIFQMVSHGIVASALFLCVGVVYDRLHTRDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAYGGIVERMPRYGTAFMIFTMANVGLPGTSGFIGEFLTMIGTFQINSTVVLFAATGVIF
HHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHEEECCEEEEHHHHHHHH
SAAYALYLYRRVLFGALEKANLKTLLDLSGREIALLAPLIVLTLYYGVHPAPILDGCAAS
HHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
VEALIRGYDAALSLAHTASLVSPVAIP
HHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MFGFGILSALIFLPLVGALFIALLPGDSEASRSSARWAALITTLITFALSVYAYTQFDPA
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
SSAFQLIEEKSWFGLGLVYKLGVDGMSIPFLVLTAFLMPFCILASWESIQTRVKEYMVAF
HHHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LILESLLLGVFTALDTILFYLFFEGSLIPMFLIIGIWGGPRRIYASFKFFLYTLVGSLLM
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
LLAVMAMYGIAGTTDITVLLKTAFPASMQKWLWLAFFASFAVKMPMWPVHTWLPDAHVEA
HHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCC
PTAGSVILAGILLKMGGYGFIRFSLPMFPEASAYFAPLVFALSVIAIIYTSLVALVQNDI
CCCHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKLIAYSSVAHMGFVTMGLFSMTEQGVQGAIFQMVSHGIVASALFLCVGVVYDRLHTRDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAYGGIVERMPRYGTAFMIFTMANVGLPGTSGFIGEFLTMIGTFQINSTVVLFAATGVIF
HHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHEEECCEEEEHHHHHHHH
SAAYALYLYRRVLFGALEKANLKTLLDLSGREIALLAPLIVLTLYYGVHPAPILDGCAAS
HHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
VEALIRGYDAALSLAHTASLVSPVAIP
HHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8422400 [H]