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The map label for this gene is nuoN

Identifier: 182679339

GI number: 182679339

Start: 2725011

End: 2726444

Strand: Reverse

Name: nuoN

Synonym: Bind_2385

Alternate gene names: 182679339

Gene position: 2726444-2725011 (Counterclockwise)

Preceding gene: 182679340

Following gene: 182679338

Centisome position: 65.38

GC content: 58.09

Gene sequence:

>1434_bases
ATGACCCCGCTTCCCGTCGTTCTCGCGCATGCCCTTCCAGAACTCATCCTGGCGGGTGGTGTGTTGTTGCTCATTCTCAT
CGGCGCGATCCGGGGTAAGGACTCCGACGGGCCGATGACAGAACTGGCGGTCGGATTGCTCGGCATCGCCATCTTGACCC
TCGTCCTCGGCACCAAAACCCAGGCGGTTCTGTTCGATGGGTCCTTCATCGACGATGCGTTTGGGCGCTTCATGAAAGTG
CTGGTTCTGATCGGCTCGCTCGTCAGCCTGATCATGGGGCAGACCTATCTCGCGCGCGAGAAAATCGACAAATTCGAATT
TCCGATCCTCATTCTTCTGTCGACACTCGGCATGCTGATGTTGATTTCGGCCACCGGGCTCATCGCGCTCTATCTCGGCC
TCGAATTGATGTCGCTCGCGCTTTACGTCATCGCGGCTTTCCATCGCGATGACGTCAAGGCCTCCGAGGCTGGCCTCAAA
TATTTCGTGCTCGGCGCCTTGTCCTCGGGCATGCTCCTTTATGGTGCATCGCTGATCTATGGCTTCGCCGGCACTGTGAA
TTTCACGGGCATTGCGACGGCTCTGCATGGTGAGACCTCGCTCGGCGTCGTGTTTGGCCTCGTCTTCCTGACCGCGGGCC
TCGCCTTTAAAATGTCCACCGTGCCGTTCCATATGTGGACGCCGGATGTCTATGAAGGCGCTCCGACGCCGGTTACCGCC
TTTTTTGCCTCGGCTCCAAAATTGGCCGCCATCGCCATCACAATGCGGATCATGATCACCGCCTTTGCCGGTATCAAACC
GCAATGGCAGCAGATCATTGTCTTCATCTCGATCCTGTCGATGGCGCTCGGTTCCTTCGCCGCGATCGGCCAGACCAATA
TCAAGCGGCTGATGGCCTATTCGTCGATCGGCCATATGGGCTTCGCCTTGGTCGGTCTTGCAGCCGGCACCGAAACCGGA
ATTCAAGGCGTGCTGGCCTATATGGCGATCTATCTCGTCATGACGCTTGGGACTTTCGCCGCGATCCTTTCCATGCGGGT
CAATGGCGTTAATGTGGAACAGATCAGCGATCTCGCTGGCCTTGCGCGCACACGTGGGTCTATGGCCTTCTTCCTGGCGA
TCATGATGTTCTCGCTGGCCGGCATACCCCCGCTCGCGGGTTTCTTCGCCAAATGGTATGTCTTCAATGCGGCGATCCAG
GCGCATCTCTATCCGCTCGCTGTGATCGGCGTTTTGTGCAGCACGGTGGGCGCCTATTATTATCTGCGGATCGTCAAGGT
GATGTATTTCGACGATCCCGCCCCGGCTTTCGACAGGCCTACGCCGACTCTTGCGGCGGTTTTGATCGTGACCGGTCTCG
CCGTTCTGCTCTTGTGTGTCTATCCCGGCTCCTTCGTGGAAGCGACCACCGTGGCGGCAAGGTCGCTGTTTTGA

Upstream 100 bases:

>100_bases
CCCCTCCATGAAAAGGGGAGGGGTGGCGTCAATGAATTGGAATCGCGTTGGAATCGTCACGTCGCGATCCCGTGCCCAAA
TCGTGTAAAAGGCTTGATCG

Downstream 100 bases:

>100_bases
TCGTGACGCTCATGGCAGCAGAGTCCCTGTCTCCTATCCGAAGGACTGACTCTGCTGTTTGACTTGGATGAACAGGCCGT
CGCGCGTGCCTTTCGACTGG

Product: proton-translocating NADH-quinone oxidoreductase subunit N

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N

Number of amino acids: Translated: 477; Mature: 476

Protein sequence:

>477_residues
MTPLPVVLAHALPELILAGGVLLLILIGAIRGKDSDGPMTELAVGLLGIAILTLVLGTKTQAVLFDGSFIDDAFGRFMKV
LVLIGSLVSLIMGQTYLAREKIDKFEFPILILLSTLGMLMLISATGLIALYLGLELMSLALYVIAAFHRDDVKASEAGLK
YFVLGALSSGMLLYGASLIYGFAGTVNFTGIATALHGETSLGVVFGLVFLTAGLAFKMSTVPFHMWTPDVYEGAPTPVTA
FFASAPKLAAIAITMRIMITAFAGIKPQWQQIIVFISILSMALGSFAAIGQTNIKRLMAYSSIGHMGFALVGLAAGTETG
IQGVLAYMAIYLVMTLGTFAAILSMRVNGVNVEQISDLAGLARTRGSMAFFLAIMMFSLAGIPPLAGFFAKWYVFNAAIQ
AHLYPLAVIGVLCSTVGAYYYLRIVKVMYFDDPAPAFDRPTPTLAAVLIVTGLAVLLLCVYPGSFVEATTVAARSLF

Sequences:

>Translated_477_residues
MTPLPVVLAHALPELILAGGVLLLILIGAIRGKDSDGPMTELAVGLLGIAILTLVLGTKTQAVLFDGSFIDDAFGRFMKV
LVLIGSLVSLIMGQTYLAREKIDKFEFPILILLSTLGMLMLISATGLIALYLGLELMSLALYVIAAFHRDDVKASEAGLK
YFVLGALSSGMLLYGASLIYGFAGTVNFTGIATALHGETSLGVVFGLVFLTAGLAFKMSTVPFHMWTPDVYEGAPTPVTA
FFASAPKLAAIAITMRIMITAFAGIKPQWQQIIVFISILSMALGSFAAIGQTNIKRLMAYSSIGHMGFALVGLAAGTETG
IQGVLAYMAIYLVMTLGTFAAILSMRVNGVNVEQISDLAGLARTRGSMAFFLAIMMFSLAGIPPLAGFFAKWYVFNAAIQ
AHLYPLAVIGVLCSTVGAYYYLRIVKVMYFDDPAPAFDRPTPTLAAVLIVTGLAVLLLCVYPGSFVEATTVAARSLF
>Mature_476_residues
TPLPVVLAHALPELILAGGVLLLILIGAIRGKDSDGPMTELAVGLLGIAILTLVLGTKTQAVLFDGSFIDDAFGRFMKVL
VLIGSLVSLIMGQTYLAREKIDKFEFPILILLSTLGMLMLISATGLIALYLGLELMSLALYVIAAFHRDDVKASEAGLKY
FVLGALSSGMLLYGASLIYGFAGTVNFTGIATALHGETSLGVVFGLVFLTAGLAFKMSTVPFHMWTPDVYEGAPTPVTAF
FASAPKLAAIAITMRIMITAFAGIKPQWQQIIVFISILSMALGSFAAIGQTNIKRLMAYSSIGHMGFALVGLAAGTETGI
QGVLAYMAIYLVMTLGTFAAILSMRVNGVNVEQISDLAGLARTRGSMAFFLAIMMFSLAGIPPLAGFFAKWYVFNAAIQA
HLYPLAVIGVLCSTVGAYYYLRIVKVMYFDDPAPAFDRPTPTLAAVLIVTGLAVLLLCVYPGSFVEATTVAARSLF

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1007

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 2 (chain N)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family

Homologues:

Organism=Homo sapiens, GI251831108, Length=299, Percent_Identity=23.4113712374582, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI145693160, Length=414, Percent_Identity=36.231884057971, Blast_Score=233, Evalue=3e-62,
Organism=Escherichia coli, GI1788614, Length=325, Percent_Identity=25.8461538461538, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1788831, Length=351, Percent_Identity=25.0712250712251, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788613, Length=313, Percent_Identity=25.2396166134185, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788827, Length=331, Percent_Identity=24.1691842900302, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1788829, Length=362, Percent_Identity=24.8618784530387, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUON_BEII9 (B2IHV3)

Other databases:

- EMBL:   CP001016
- RefSeq:   YP_001833485.1
- GeneID:   6201143
- GenomeReviews:   CP001016_GR
- KEGG:   bid:Bind_2385
- HOGENOM:   HBG747830
- OMA:   AMWIESP
- ProtClustDB:   CLSK2405710
- GO:   GO:0006810
- HAMAP:   MF_00445
- InterPro:   IPR010096
- InterPro:   IPR001750
- TIGRFAMs:   TIGR01770

Pfam domain/function: PF00361 Oxidored_q1

EC number: =1.6.99.5

Molecular weight: Translated: 50570; Mature: 50439

Theoretical pI: Translated: 8.17; Mature: 8.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x17faf234)-; HASH(0x17c86388)-; HASH(0x184f34e8)-; HASH(0x16a49b08)-; HASH(0x17b8dd88)-; HASH(0x17c142b8)-; HASH(0x13c6c780)-; HASH(0x18188d4c)-; HASH(0x18035bf4)-; HASH(0x17825590)-; HASH(0x1733416c)-; HASH(0x184f6dc8)-; HASH(0x13be9244)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPLPVVLAHALPELILAGGVLLLILIGAIRGKDSDGPMTELAVGLLGIAILTLVLGTKT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
QAVLFDGSFIDDAFGRFMKVLVLIGSLVSLIMGQTYLAREKIDKFEFPILILLSTLGMLM
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHH
LISATGLIALYLGLELMSLALYVIAAFHRDDVKASEAGLKYFVLGALSSGMLLYGASLIY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHCCHHHHHHHHHH
GFAGTVNFTGIATALHGETSLGVVFGLVFLTAGLAFKMSTVPFHMWTPDVYEGAPTPVTA
HHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEECCCEECCCCHHCCCCCCCHHH
FFASAPKLAAIAITMRIMITAFAGIKPQWQQIIVFISILSMALGSFAAIGQTNIKRLMAY
HHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
SSIGHMGFALVGLAAGTETGIQGVLAYMAIYLVMTLGTFAAILSMRVNGVNVEQISDLAG
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
LARTRGSMAFFLAIMMFSLAGIPPLAGFFAKWYVFNAAIQAHLYPLAVIGVLCSTVGAYY
HHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLRIVKVMYFDDPAPAFDRPTPTLAAVLIVTGLAVLLLCVYPGSFVEATTVAARSLF
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCH
>Mature Secondary Structure 
TPLPVVLAHALPELILAGGVLLLILIGAIRGKDSDGPMTELAVGLLGIAILTLVLGTKT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
QAVLFDGSFIDDAFGRFMKVLVLIGSLVSLIMGQTYLAREKIDKFEFPILILLSTLGMLM
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHH
LISATGLIALYLGLELMSLALYVIAAFHRDDVKASEAGLKYFVLGALSSGMLLYGASLIY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHCCHHHHHHHHHH
GFAGTVNFTGIATALHGETSLGVVFGLVFLTAGLAFKMSTVPFHMWTPDVYEGAPTPVTA
HHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEECCCEECCCCHHCCCCCCCHHH
FFASAPKLAAIAITMRIMITAFAGIKPQWQQIIVFISILSMALGSFAAIGQTNIKRLMAY
HHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
SSIGHMGFALVGLAAGTETGIQGVLAYMAIYLVMTLGTFAAILSMRVNGVNVEQISDLAG
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
LARTRGSMAFFLAIMMFSLAGIPPLAGFFAKWYVFNAAIQAHLYPLAVIGVLCSTVGAYY
HHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLRIVKVMYFDDPAPAFDRPTPTLAAVLIVTGLAVLLLCVYPGSFVEATTVAARSLF
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA