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The map label for this gene is rnhA [H]

Identifier: 182679289

GI number: 182679289

Start: 2670145

End: 2670606

Strand: Reverse

Name: rnhA [H]

Synonym: Bind_2333

Alternate gene names: 182679289

Gene position: 2670606-2670145 (Counterclockwise)

Preceding gene: 182679290

Following gene: 182679288

Centisome position: 64.04

GC content: 60.61

Gene sequence:

>462_bases
ATGAGCGGGCGTGTCACGATCTACACCGACGGCGCCTGTTCCGGTAATCCAGGGCCCGGCGGCTGGGGCGCCATTTTGAT
GTTTGGACAGCATGAAAAGGAACTGTCTGGCGGCGAGGCGCAAACGACAAATAATCGGATGGAACTGACCGCCGCGATTC
GCGCGCTTGAAGCCTTGACCCGCCCATGCGCGGTCGATCTCCATACGGATTCCAATTATCTGCGTGGCGGCGTCACCAGT
TGGATCAAGGGCTGGAAGAAGAATGGCTGGCGCACGGCCGATAAAAAGCCGGTCAAGAATGTCGAGCTTTGGCAGGAACT
CGATCAATTGGCCGCGAGCCATGAGATCGCGTGGCACTGGGTTAAGGGTCATGCCGGGCATCCGCTGAATGAACGCGCCG
ATGCGCTGGCCCGCCAGGGCATGGCGCCGTTTCGCGGCGGCGCTCGTATCCACCCTCATTGA

Upstream 100 bases:

>100_bases
CAAAGGGCGCCATGGTGAATCCCAAGGACCCGCTGGAATATATGGGCAAGCTGGCCTTTCACCAGACCGTGGGGACCGTG
CGCGAGCTGGGATTGTTGCG

Downstream 100 bases:

>100_bases
AGCGCGACCTGTCGCGGTTCAATGAGGGTGGATTGGATACGGTTTAAAAAAGTGACGTATCGAGAATCTATGATTCTCGA
TACTAGGCGGGAATCGGCGG

Product: ribonuclease H

Products: NA

Alternate protein names: RNase H [H]

Number of amino acids: Translated: 153; Mature: 152

Protein sequence:

>153_residues
MSGRVTIYTDGACSGNPGPGGWGAILMFGQHEKELSGGEAQTTNNRMELTAAIRALEALTRPCAVDLHTDSNYLRGGVTS
WIKGWKKNGWRTADKKPVKNVELWQELDQLAASHEIAWHWVKGHAGHPLNERADALARQGMAPFRGGARIHPH

Sequences:

>Translated_153_residues
MSGRVTIYTDGACSGNPGPGGWGAILMFGQHEKELSGGEAQTTNNRMELTAAIRALEALTRPCAVDLHTDSNYLRGGVTS
WIKGWKKNGWRTADKKPVKNVELWQELDQLAASHEIAWHWVKGHAGHPLNERADALARQGMAPFRGGARIHPH
>Mature_152_residues
SGRVTIYTDGACSGNPGPGGWGAILMFGQHEKELSGGEAQTTNNRMELTAAIRALEALTRPCAVDLHTDSNYLRGGVTSW
IKGWKKNGWRTADKKPVKNVELWQELDQLAASHEIAWHWVKGHAGHPLNERADALARQGMAPFRGGARIHPH

Specific function: Endonuclease that specifically degrades the RNA of RNA- DNA hybrids [H]

COG id: COG0328

COG function: function code L; Ribonuclease HI

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain [H]

Homologues:

Organism=Homo sapiens, GI21359816, Length=145, Percent_Identity=39.3103448275862, Blast_Score=87, Evalue=5e-18,
Organism=Escherichia coli, GI1786408, Length=138, Percent_Identity=64.4927536231884, Blast_Score=186, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI115532542, Length=144, Percent_Identity=37.5, Blast_Score=89, Evalue=9e-19,
Organism=Drosophila melanogaster, GI45552509, Length=153, Percent_Identity=36.6013071895425, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI17137476, Length=153, Percent_Identity=36.6013071895425, Blast_Score=97, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022892
- InterPro:   IPR012337
- InterPro:   IPR002156 [H]

Pfam domain/function: PF00075 RnaseH [H]

EC number: =3.1.26.4 [H]

Molecular weight: Translated: 16757; Mature: 16626

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGRVTIYTDGACSGNPGPGGWGAILMFGQHEKELSGGEAQTTNNRMELTAAIRALEALT
CCCCEEEEECCCCCCCCCCCCCEEEEEECCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHC
RPCAVDLHTDSNYLRGGVTSWIKGWKKNGWRTADKKPVKNVELWQELDQLAASHEIAWHW
CCCEEEEECCCCHHHCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEE
VKGHAGHPLNERADALARQGMAPFRGGARIHPH
ECCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SGRVTIYTDGACSGNPGPGGWGAILMFGQHEKELSGGEAQTTNNRMELTAAIRALEALT
CCCEEEEECCCCCCCCCCCCCEEEEEECCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHC
RPCAVDLHTDSNYLRGGVTSWIKGWKKNGWRTADKKPVKNVELWQELDQLAASHEIAWHW
CCCEEEEECCCCHHHCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEE
VKGHAGHPLNERADALARQGMAPFRGGARIHPH
ECCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA