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The map label for this gene is mutA [H]

Identifier: 182679162

GI number: 182679162

Start: 2515753

End: 2517627

Strand: Reverse

Name: mutA [H]

Synonym: Bind_2200

Alternate gene names: 182679162

Gene position: 2517627-2515753 (Counterclockwise)

Preceding gene: 182679167

Following gene: 182679161

Centisome position: 60.37

GC content: 62.77

Gene sequence:

>1875_bases
ATGACGATTGTCGATCCGAAACAATCCGCGGCGGCGGGAGCAGCCTTGGAGAAGGAATGGCGCGCTCGGGTCGATAAGGT
GCTGAAGGGCGCTGATTTCGAAGCGAGGCTTATAGCCCATAGTTTCGATGCGCTGCCGATCGGCCCGCTTTATCCGGCGG
CCCATGTCGATGCTCCACGCGCGATTCGTGCACGGCATTCGTCCTGGAACATCGTGCAACGGATCGATCACGTCGAGCCT
GCCTCCGCCCATGCGACGGCCCTGACCGATCTCGCTCATGGCGCGGACGGTCTGGCTCTGGTCGGCGCCAAGGCGCCGAA
TGCCTATGGATTTGGCCTTAAGGATTTTACGGTTTCGACGCTCGAGCAAGTCTTGGGCTCACTGTTCGCTCCTGGGCTCT
CCTTGCGGATTGAAGCCGGCCCCGAGGGCTTGGCCGCAACGCGCGGGCTGCTTGACTTGGCCGCGCGCCAGGGCGTGAGT
CTGGCGCGTCTCGATCTTCATCTGGGTCTTGATCCTATCGGTGGCGCCGCTTTCCATGCCAAGGACGCCGCGGCTTTGGC
GGCACCCCTTGAGGCGGCTTTGGCTCTCTTGCCTGAGTTGGAGGCCGGGGCGTTTTCTGGCCGGGTGTTTCTGTGCGATG
GGCGCCCGGCTCATGCCGCCGGTGCGTCTGAGGCCCAGGAACTCGCCTTTGTCCTCGCTAATGGCGTCGCACTTCTGCGG
GCGATGGAGTCCAAGGGCCATGATCTCGAAAAAGCGAGGTCCTGGCTGGCCTTCGCCTTGGCCGCCGATGCCGATCTCAC
CTTGACGTTGGCGAAATTCAGGGCCCTGCGCCGGCTTTGGGCACGGGTGGAAGCGGCTTGCGGTCTTGGCCCGTCTACGC
TTGACCTGCATGGCGAGACGGCTTGGCGTATGATGACGCGGCGTGATCCGTTCAATAACGTTCTGCGCGCCACGACCGCA
ACCTTGGCGGCGGGCTGCGGCGGAGCGGATTCGATCTCCATTCTGCCCTTCACACAGCCGCTCGGCCTGCCGGACGATTT
CGCCCGGCGCATTGCGCGCAACACGCACTTGATCCTTTTGGAAGAGGCTCGGCTCGGCTGGGTCGATGATCCGGCTGCGG
GTTCGGGGGCTTTCGAGAATCTGACCGAAGCTTTGTGCTCAGCCGCCTGGAGCTTGTTCCGTGCCATCGAGGAGGAGGGT
GGTCTTGGTGCCGCCTTGGCCAAAGGGTCGGTTCAGGCTGCCATCGGCAAGACACGAAGCGAGCGGGGGCAGGCGGTTGC
GCGTCGTCGTCTGCCGATCATTGGCACCAGCGCTTTCCCGAACCCTGGGGAACTGCCAGTAGCGGTCCTCGCGCCGGTTT
CTGATCTCGATGGGGACCACGCTCAAGAGACATCGCTGTTGCCGGCCTCGAGAGTGTCGGCGCCGTTTGAGCGCTTATAT
GCCAAAGCCGATGAATTGACGGCGCAATTGGGCAAAAGGCCAGCCATTTTCCTTGCCAATTTCGGCTCGCGATCCGATTT
CTCACCGCGTGCTGCTTTCGCCCAGAATTTCTTCGCGGCGGCCGGTTTCGACGTTCTGGAAAATGAAGGTTTCGAGAGCG
AGGCGGCCTTGATCGCGGGATTTGCCGAAAGCGGCGCACTGGCGGCTTGTTTGTGTTCCTCGGATGTCCTGTATGCGGAA
CAGGCCGTTCCGCTGGCGGGCAAACTGGCTGAGGCCGGCTGCGCCCATCTTGTTCTGGCCGGCAAGCCGGGGCAGGCGGA
GGAAACCTATCGCAGCGCCGGGATTGAGGCGTTCATCTTTACCGGCTGCGACGGGCTGGCCTATCCGACCGCTCTCCTGA
AGGAAAAAGCATCTACTCTGGCGGAGGCGATCTAA

Upstream 100 bases:

>100_bases
TTGCGCGCCCTGGTTCCTTCTTTCGTCTAGCTCCCAAGAGCACAAGGTTGTGATCATATGTGCTCGCCAAGCATGATGAA
AAGAGGGCGGTGACAGGCAC

Downstream 100 bases:

>100_bases
TGAGCAGAATTCCCGATTTCGCCGCTCCGGACCAGGCGTCATGGGCCGATGTCCATGCTGCGACGCAGCCCGTGGGTACG
TCGCCACGGATGACGGCTGA

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM-beta [H]

Number of amino acids: Translated: 624; Mature: 623

Protein sequence:

>624_residues
MTIVDPKQSAAAGAALEKEWRARVDKVLKGADFEARLIAHSFDALPIGPLYPAAHVDAPRAIRARHSSWNIVQRIDHVEP
ASAHATALTDLAHGADGLALVGAKAPNAYGFGLKDFTVSTLEQVLGSLFAPGLSLRIEAGPEGLAATRGLLDLAARQGVS
LARLDLHLGLDPIGGAAFHAKDAAALAAPLEAALALLPELEAGAFSGRVFLCDGRPAHAAGASEAQELAFVLANGVALLR
AMESKGHDLEKARSWLAFALAADADLTLTLAKFRALRRLWARVEAACGLGPSTLDLHGETAWRMMTRRDPFNNVLRATTA
TLAAGCGGADSISILPFTQPLGLPDDFARRIARNTHLILLEEARLGWVDDPAAGSGAFENLTEALCSAAWSLFRAIEEEG
GLGAALAKGSVQAAIGKTRSERGQAVARRRLPIIGTSAFPNPGELPVAVLAPVSDLDGDHAQETSLLPASRVSAPFERLY
AKADELTAQLGKRPAIFLANFGSRSDFSPRAAFAQNFFAAAGFDVLENEGFESEAALIAGFAESGALAACLCSSDVLYAE
QAVPLAGKLAEAGCAHLVLAGKPGQAEETYRSAGIEAFIFTGCDGLAYPTALLKEKASTLAEAI

Sequences:

>Translated_624_residues
MTIVDPKQSAAAGAALEKEWRARVDKVLKGADFEARLIAHSFDALPIGPLYPAAHVDAPRAIRARHSSWNIVQRIDHVEP
ASAHATALTDLAHGADGLALVGAKAPNAYGFGLKDFTVSTLEQVLGSLFAPGLSLRIEAGPEGLAATRGLLDLAARQGVS
LARLDLHLGLDPIGGAAFHAKDAAALAAPLEAALALLPELEAGAFSGRVFLCDGRPAHAAGASEAQELAFVLANGVALLR
AMESKGHDLEKARSWLAFALAADADLTLTLAKFRALRRLWARVEAACGLGPSTLDLHGETAWRMMTRRDPFNNVLRATTA
TLAAGCGGADSISILPFTQPLGLPDDFARRIARNTHLILLEEARLGWVDDPAAGSGAFENLTEALCSAAWSLFRAIEEEG
GLGAALAKGSVQAAIGKTRSERGQAVARRRLPIIGTSAFPNPGELPVAVLAPVSDLDGDHAQETSLLPASRVSAPFERLY
AKADELTAQLGKRPAIFLANFGSRSDFSPRAAFAQNFFAAAGFDVLENEGFESEAALIAGFAESGALAACLCSSDVLYAE
QAVPLAGKLAEAGCAHLVLAGKPGQAEETYRSAGIEAFIFTGCDGLAYPTALLKEKASTLAEAI
>Mature_623_residues
TIVDPKQSAAAGAALEKEWRARVDKVLKGADFEARLIAHSFDALPIGPLYPAAHVDAPRAIRARHSSWNIVQRIDHVEPA
SAHATALTDLAHGADGLALVGAKAPNAYGFGLKDFTVSTLEQVLGSLFAPGLSLRIEAGPEGLAATRGLLDLAARQGVSL
ARLDLHLGLDPIGGAAFHAKDAAALAAPLEAALALLPELEAGAFSGRVFLCDGRPAHAAGASEAQELAFVLANGVALLRA
MESKGHDLEKARSWLAFALAADADLTLTLAKFRALRRLWARVEAACGLGPSTLDLHGETAWRMMTRRDPFNNVLRATTAT
LAAGCGGADSISILPFTQPLGLPDDFARRIARNTHLILLEEARLGWVDDPAAGSGAFENLTEALCSAAWSLFRAIEEEGG
LGAALAKGSVQAAIGKTRSERGQAVARRRLPIIGTSAFPNPGELPVAVLAPVSDLDGDHAQETSLLPASRVSAPFERLYA
KADELTAQLGKRPAIFLANFGSRSDFSPRAAFAQNFFAAAGFDVLENEGFESEAALIAGFAESGALAACLCSSDVLYAEQ
AVPLAGKLAEAGCAHLVLAGKPGQAEETYRSAGIEAFIFTGCDGLAYPTALLKEKASTLAEAI

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. This conversion most likely represents an important source of building blocks for polyketide antibiotic biosynthes

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methylmalonyl-CoA mutase family [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=280, Percent_Identity=31.0714285714286, Blast_Score=112, Evalue=1e-24,
Organism=Escherichia coli, GI1789284, Length=277, Percent_Identity=32.8519855595668, Blast_Score=135, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI25144500, Length=242, Percent_Identity=30.5785123966942, Blast_Score=118, Evalue=7e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR004608 [H]

Pfam domain/function: PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 65103; Mature: 64971

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIVDPKQSAAAGAALEKEWRARVDKVLKGADFEARLIAHSFDALPIGPLYPAAHVDAPR
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCH
AIRARHSSWNIVQRIDHVEPASAHATALTDLAHGADGLALVGAKAPNAYGFGLKDFTVST
HHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHH
LEQVLGSLFAPGLSLRIEAGPEGLAATRGLLDLAARQGVSLARLDLHLGLDPIGGAAFHA
HHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCC
KDAAALAAPLEAALALLPELEAGAFSGRVFLCDGRPAHAAGASEAQELAFVLANGVALLR
CHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHH
AMESKGHDLEKARSWLAFALAADADLTLTLAKFRALRRLWARVEAACGLGPSTLDLHGET
HHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCH
AWRMMTRRDPFNNVLRATTATLAAGCGGADSISILPFTQPLGLPDDFARRIARNTHLILL
HHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHCCCEEEEE
EEARLGWVDDPAAGSGAFENLTEALCSAAWSLFRAIEEEGGLGAALAKGSVQAAIGKTRS
ECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHCCCHHHHHHCCHH
ERGQAVARRRLPIIGTSAFPNPGELPVAVLAPVSDLDGDHAQETSLLPASRVSAPFERLY
HHHHHHHHHCCCEEECCCCCCCCCCCEEEEECCCCCCCCCCHHCCCCCHHHHCHHHHHHH
AKADELTAQLGKRPAIFLANFGSRSDFSPRAAFAQNFFAAAGFDVLENEGFESEAALIAG
HHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCHHHEEE
FAESGALAACLCSSDVLYAEQAVPLAGKLAEAGCAHLVLAGKPGQAEETYRSAGIEAFIF
CCCCCCEEEEHHCCCCEEHHHCCCCHHHHHHCCCEEEEEECCCCCHHHHHHHCCCEEEEE
TGCDGLAYPTALLKEKASTLAEAI
ECCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TIVDPKQSAAAGAALEKEWRARVDKVLKGADFEARLIAHSFDALPIGPLYPAAHVDAPR
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCH
AIRARHSSWNIVQRIDHVEPASAHATALTDLAHGADGLALVGAKAPNAYGFGLKDFTVST
HHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHH
LEQVLGSLFAPGLSLRIEAGPEGLAATRGLLDLAARQGVSLARLDLHLGLDPIGGAAFHA
HHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCC
KDAAALAAPLEAALALLPELEAGAFSGRVFLCDGRPAHAAGASEAQELAFVLANGVALLR
CHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHH
AMESKGHDLEKARSWLAFALAADADLTLTLAKFRALRRLWARVEAACGLGPSTLDLHGET
HHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCH
AWRMMTRRDPFNNVLRATTATLAAGCGGADSISILPFTQPLGLPDDFARRIARNTHLILL
HHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHCCCEEEEE
EEARLGWVDDPAAGSGAFENLTEALCSAAWSLFRAIEEEGGLGAALAKGSVQAAIGKTRS
ECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHCCCHHHHHHCCHH
ERGQAVARRRLPIIGTSAFPNPGELPVAVLAPVSDLDGDHAQETSLLPASRVSAPFERLY
HHHHHHHHHCCCEEECCCCCCCCCCCEEEEECCCCCCCCCCHHCCCCCHHHHCHHHHHHH
AKADELTAQLGKRPAIFLANFGSRSDFSPRAAFAQNFFAAAGFDVLENEGFESEAALIAG
HHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCHHHEEE
FAESGALAACLCSSDVLYAEQAVPLAGKLAEAGCAHLVLAGKPGQAEETYRSAGIEAFIF
CCCCCCEEEEHHCCCCEEHHHCCCCHHHHHHCCCEEEEEECCCCCHHHHHHHCCCEEEEE
TGCDGLAYPTALLKEKASTLAEAI
ECCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8099072 [H]