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The map label for this gene is pmrA [H]

Identifier: 182679117

GI number: 182679117

Start: 2461352

End: 2462008

Strand: Direct

Name: pmrA [H]

Synonym: Bind_2154

Alternate gene names: 182679117

Gene position: 2461352-2462008 (Clockwise)

Preceding gene: 182679116

Following gene: 182679118

Centisome position: 59.02

GC content: 54.34

Gene sequence:

>657_bases
GTGAGAGTTCTCATCGTCGAAGACGAAGATGCGCTCGGTTCCGCAGTGCGGGATCAAGTGCGTCACGCGGGGCATGCGAC
AGATTGGTTCAAGACGTTGCAAAGCGCGCAGGCCGCCCTGGATACGACTGATTACGATCTCCTCCTCTTGGACCTTGGCC
TCCCTGATGGCAATGGCCTTGAGTTTCTGAAAGCAATTCGCAGAAGCAATAGCAAAATGGCAATTCTGGTCATGACCGCG
CATGATCAAATCAGCGATCGCATCGCCGGATTGTCGGAAGGTGCCGACGATTACATCGTCAAACCTTTCGACCTCGATGA
GCTGATCGCGCGCATCGATGCCGTCTATCGCCGTTATGCGCCGGTTGCCGAGGAGGGGATCAAGATCAATGACATTCATC
TCGATCTTCACGGACAACGCCTGACGAAAAGTGGCGTCGACGTGGAATTGACAGCCAAGGAATGGGCGATACTCGAACTT
CTGGCCCGCCGGCCCGGCATGATCATCTCCAAGGAACGCATCGAGGAAGCCCTCTATGGGTTTGGCGAGGAAATCGAAAG
TAACGCAATCGAAGTTTTCGTGAGCCGAATTCGAAAAAAAGTGGGACGCAATATCATCCGTACGGTGCGAGGCCGCGGTT
ATTGTCTCGCGAGGTAA

Upstream 100 bases:

>100_bases
GGCCTCTCGCCACAGTGGTGATCGGCGGACTGGTCTCGTCCACTTTGCTCACATTGCTCGTTTTACCTTCACTCTATACA
CGTTTCATGAGAAAAAATTC

Downstream 100 bases:

>100_bases
CAGGAATGAAGAGCTGGAGTCTCGCATCACGCATTGTCGCAAGCGTTCTCATCGTCATTTCCGGCTGCCTCGTCCTCCTC
GGTCTTTCCGTCGGTGCCTT

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MRVLIVEDEDALGSAVRDQVRHAGHATDWFKTLQSAQAALDTTDYDLLLLDLGLPDGNGLEFLKAIRRSNSKMAILVMTA
HDQISDRIAGLSEGADDYIVKPFDLDELIARIDAVYRRYAPVAEEGIKINDIHLDLHGQRLTKSGVDVELTAKEWAILEL
LARRPGMIISKERIEEALYGFGEEIESNAIEVFVSRIRKKVGRNIIRTVRGRGYCLAR

Sequences:

>Translated_218_residues
MRVLIVEDEDALGSAVRDQVRHAGHATDWFKTLQSAQAALDTTDYDLLLLDLGLPDGNGLEFLKAIRRSNSKMAILVMTA
HDQISDRIAGLSEGADDYIVKPFDLDELIARIDAVYRRYAPVAEEGIKINDIHLDLHGQRLTKSGVDVELTAKEWAILEL
LARRPGMIISKERIEEALYGFGEEIESNAIEVFVSRIRKKVGRNIIRTVRGRGYCLAR
>Mature_218_residues
MRVLIVEDEDALGSAVRDQVRHAGHATDWFKTLQSAQAALDTTDYDLLLLDLGLPDGNGLEFLKAIRRSNSKMAILVMTA
HDQISDRIAGLSEGADDYIVKPFDLDELIARIDAVYRRYAPVAEEGIKINDIHLDLHGQRLTKSGVDVELTAKEWAILEL
LARRPGMIISKERIEEALYGFGEEIESNAIEVFVSRIRKKVGRNIIRTVRGRGYCLAR

Specific function: Member of the two-component regulatory system pmrB/pmrA involved in regulation of virulence. Unphosphorylated pmrA represses extracellular enzyme genes. Phosphorylation of pmrA by pmrB relieves such repression, which leads to activation of extracellular e

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789402, Length=217, Percent_Identity=38.7096774193548, Blast_Score=163, Evalue=9e-42,
Organism=Escherichia coli, GI1790552, Length=216, Percent_Identity=39.3518518518519, Blast_Score=157, Evalue=4e-40,
Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=37.5565610859729, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1787375, Length=220, Percent_Identity=36.8181818181818, Blast_Score=144, Evalue=5e-36,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=33.1818181818182, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=30.4545454545455, Blast_Score=117, Evalue=6e-28,
Organism=Escherichia coli, GI1786911, Length=219, Percent_Identity=31.9634703196347, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1788394, Length=220, Percent_Identity=33.6363636363636, Blast_Score=107, Evalue=7e-25,
Organism=Escherichia coli, GI1787229, Length=223, Percent_Identity=30.0448430493274, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=30.8370044052863, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI2367329, Length=176, Percent_Identity=31.8181818181818, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1790860, Length=225, Percent_Identity=26.2222222222222, Blast_Score=91, Evalue=6e-20,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=29.3859649122807, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1790299, Length=173, Percent_Identity=25.4335260115607, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=31.7757009345794, Blast_Score=67, Evalue=8e-13,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24442; Mature: 24442

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLIVEDEDALGSAVRDQVRHAGHATDWFKTLQSAQAALDTTDYDLLLLDLGLPDGNGL
CEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCH
EFLKAIRRSNSKMAILVMTAHDQISDRIAGLSEGADDYIVKPFDLDELIARIDAVYRRYA
HHHHHHHCCCCCEEEEEEECCHHHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHHHC
PVAEEGIKINDIHLDLHGQRLTKSGVDVELTAKEWAILELLARRPGMIISKERIEEALYG
CHHHCCCEEEEEEEEECCCCHHCCCCCEEEEHHHHHHHHHHHHCCCCEECHHHHHHHHHC
FGEEIESNAIEVFVSRIRKKVGRNIIRTVRGRGYCLAR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECC
>Mature Secondary Structure
MRVLIVEDEDALGSAVRDQVRHAGHATDWFKTLQSAQAALDTTDYDLLLLDLGLPDGNGL
CEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCH
EFLKAIRRSNSKMAILVMTAHDQISDRIAGLSEGADDYIVKPFDLDELIARIDAVYRRYA
HHHHHHHCCCCCEEEEEEECCHHHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHHHC
PVAEEGIKINDIHLDLHGQRLTKSGVDVELTAKEWAILELLARRPGMIISKERIEEALYG
CHHHCCCEEEEEEEEECCCCHHCCCCCEEEEHHHHHHHHHHHHCCCCEECHHHHHHHHHC
FGEEIESNAIEVFVSRIRKKVGRNIIRTVRGRGYCLAR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14617142 [H]