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The map label for this gene is zraS [H]

Identifier: 182678849

GI number: 182678849

Start: 2145871

End: 2147829

Strand: Direct

Name: zraS [H]

Synonym: Bind_1882

Alternate gene names: 182678849

Gene position: 2145871-2147829 (Clockwise)

Preceding gene: 182678848

Following gene: 182678850

Centisome position: 51.46

GC content: 58.19

Gene sequence:

>1959_bases
ATGACGACCTTCTCTCTTTGCCTGACGCAACAGCATGACCTTGCCCTGACGGCTCTCGCCGTCCTGTTTTGCTGTCTCAT
GGCCTTCGCCTCGATCAACCTTTTCAGGCTTGCGTCTGAAATGGAGCAAGCACAGACACCGGCCTGGCTGTTTGCGACGG
CCTTGATCCTGACTTGCGGAGTCTGGACGACACATTTCGTAGCCTGCCTCGCTTACCAGCCAGGCCTGCCCATCTCCTAT
AATGCCGAGACCTTTCCTGTCTCGCTTCTGGCCAGCATGACAACGGCCTGGGTCGGTTTCACGCTGGCGCAACGGCGGCA
TTTCCGTCTCGGCGGCGCCATCATCGGCGTGTCGATCGCCATGATGCATTACATCAGCATGGCCTCTGTGAAATTTCAGG
CCGAAAAAAGCTGGGATCTCCGATTTGTGGCTCTGTCGGTCCTTGTCGGCATGACAGCGGCCGGAGGCTCCATGGCCGTG
TTCAAGGATGGGCGTAATCTGCGTCGCTGTCTCATGGCCTCCTTGCTCATAGTTCTGGCGATCTGCGGCACGCATTTCCT
CGGCATGGCGGCACTCACGCTCAAGGCCGTTCCGGGCATTCTCGTCGCCGATGGACAAGCCCAGTCTGCCCTGCTCGCCA
CGGCGCTCGCCGTCATGATGATCCTCATTGGCCTTGGTCTCCTCGGCTCGCTGACCGAACGTCGGTTGCGCACACAGGCT
CTTGAGGAAACCAGAAAACTGCGCCGCAGCCAGGACCATTTGGAGCGCGCGCAAAAGATCACCCAGACCGGCAGCGTCGA
GCGGGATCTGCGAACCGGCGAGATCGAACTCTCCTCTGAAATCTACCGGATCTTCAGCCTCGACCCCAACCAGCCTTCTG
CGGCGTCGCAGTCTCTCGCTCGCTTTTTTCATCCGGACGATCATCACGGATGCCAATTTGCGATGCGGACGCCGCAATTA
TCCAGTGCTTTCACGGATGAGCATCTGCGTCTCGTCACGCCAGAGGGGGCGATCCGCTGGCTGCGCCATGAGGCTGAATT
CATCTACGATGAAGCTGGAACACCCATTCGCTGGATCGCCACTTATACGGATGTCACGCGCATCCATGAAGCCGAGGACC
GGCAGAGAATTTTGCGGGAGGAATTGCGTGCCGCCAAGGAAATCGCCGAGGCCGCGACGCAAGCGGTGCTGAGCCTTAAC
GACAAACTCGAACATCGCGTCATGGAACGCACCGCCGAACTTGTTCAGGCTCAAGAAGATCTCTTGAAGAAAGAGCGCCT
GTCAACGATCGGCCAACTCACGGCCACCGTCGCGCATGAATTGCGCAATCCGCTGGGCGCCATCAAGAATACCGTCTTTA
CCCTCAAGGAACTCTCTGGCGCCAAAAATCTTAAACTCGACCGGCCGATCGCACGCATGGAACGCAGCGTCGACCGTTGC
AACAGCATCATCACCCACCTGCTCGAATATTCGCGGGTCAGTGCCCTGAAATATGAGTGCCGTGATTTCGATCAATGGCT
CGTGGATGTCCTCGATGAACTTGCCGTGCCACCGACCATCACGGTCGAACGGGTCCTTGCCGCCAGGGATCGGAATTGCG
CTTTCGATCCAGAGAGATTGCGTCAGGTCATCGTCAATCTGGTCGAAAACGCCATCCATGCTTTGAACGACGTAGGAGCG
GAAAGACCTGAGAAGCGCCTCCGTCTCAGCACGCGGCAAAACGCTGGGACGATCGAACTCACCATAGCCGACACGGGGCC
CGGCATTGCCGCCGAAAACCTCACCCGTGTCTTCGATCCCCTCTTCAGCACGAAAAGCTTCGGCACTGGGCTCGGCCTCC
CCGCCGTCAAGCAGATCGTCGAGCAACATGGCGGCACAATCACTTTGGCCAGCACTCTTGGCCAAGGGACTGAAGTAACC
GTTGTTATCCCACATGAAAGACAGGAATTGGCCGCATGA

Upstream 100 bases:

>100_bases
ATGAATTGCCACTGACTCTCTTTGCCGCTTTTTGTCCATGACTTGCGATGGCGCCTTGGCTGTTAAAGACTCTTAACCAA
CCCGGTCGCTCAATGAACCC

Downstream 100 bases:

>100_bases
GAAAACATATTTTCATCGTTGACGACGATCTCGATCATGCCGAGAGCCTTGCCGAAATTCTCGAATTGCAGGGCCATGAC
GTCGAACTCGCGCAATCAGG

Product: multi-sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 652; Mature: 651

Protein sequence:

>652_residues
MTTFSLCLTQQHDLALTALAVLFCCLMAFASINLFRLASEMEQAQTPAWLFATALILTCGVWTTHFVACLAYQPGLPISY
NAETFPVSLLASMTTAWVGFTLAQRRHFRLGGAIIGVSIAMMHYISMASVKFQAEKSWDLRFVALSVLVGMTAAGGSMAV
FKDGRNLRRCLMASLLIVLAICGTHFLGMAALTLKAVPGILVADGQAQSALLATALAVMMILIGLGLLGSLTERRLRTQA
LEETRKLRRSQDHLERAQKITQTGSVERDLRTGEIELSSEIYRIFSLDPNQPSAASQSLARFFHPDDHHGCQFAMRTPQL
SSAFTDEHLRLVTPEGAIRWLRHEAEFIYDEAGTPIRWIATYTDVTRIHEAEDRQRILREELRAAKEIAEAATQAVLSLN
DKLEHRVMERTAELVQAQEDLLKKERLSTIGQLTATVAHELRNPLGAIKNTVFTLKELSGAKNLKLDRPIARMERSVDRC
NSIITHLLEYSRVSALKYECRDFDQWLVDVLDELAVPPTITVERVLAARDRNCAFDPERLRQVIVNLVENAIHALNDVGA
ERPEKRLRLSTRQNAGTIELTIADTGPGIAAENLTRVFDPLFSTKSFGTGLGLPAVKQIVEQHGGTITLASTLGQGTEVT
VVIPHERQELAA

Sequences:

>Translated_652_residues
MTTFSLCLTQQHDLALTALAVLFCCLMAFASINLFRLASEMEQAQTPAWLFATALILTCGVWTTHFVACLAYQPGLPISY
NAETFPVSLLASMTTAWVGFTLAQRRHFRLGGAIIGVSIAMMHYISMASVKFQAEKSWDLRFVALSVLVGMTAAGGSMAV
FKDGRNLRRCLMASLLIVLAICGTHFLGMAALTLKAVPGILVADGQAQSALLATALAVMMILIGLGLLGSLTERRLRTQA
LEETRKLRRSQDHLERAQKITQTGSVERDLRTGEIELSSEIYRIFSLDPNQPSAASQSLARFFHPDDHHGCQFAMRTPQL
SSAFTDEHLRLVTPEGAIRWLRHEAEFIYDEAGTPIRWIATYTDVTRIHEAEDRQRILREELRAAKEIAEAATQAVLSLN
DKLEHRVMERTAELVQAQEDLLKKERLSTIGQLTATVAHELRNPLGAIKNTVFTLKELSGAKNLKLDRPIARMERSVDRC
NSIITHLLEYSRVSALKYECRDFDQWLVDVLDELAVPPTITVERVLAARDRNCAFDPERLRQVIVNLVENAIHALNDVGA
ERPEKRLRLSTRQNAGTIELTIADTGPGIAAENLTRVFDPLFSTKSFGTGLGLPAVKQIVEQHGGTITLASTLGQGTEVT
VVIPHERQELAA
>Mature_651_residues
TTFSLCLTQQHDLALTALAVLFCCLMAFASINLFRLASEMEQAQTPAWLFATALILTCGVWTTHFVACLAYQPGLPISYN
AETFPVSLLASMTTAWVGFTLAQRRHFRLGGAIIGVSIAMMHYISMASVKFQAEKSWDLRFVALSVLVGMTAAGGSMAVF
KDGRNLRRCLMASLLIVLAICGTHFLGMAALTLKAVPGILVADGQAQSALLATALAVMMILIGLGLLGSLTERRLRTQAL
EETRKLRRSQDHLERAQKITQTGSVERDLRTGEIELSSEIYRIFSLDPNQPSAASQSLARFFHPDDHHGCQFAMRTPQLS
SAFTDEHLRLVTPEGAIRWLRHEAEFIYDEAGTPIRWIATYTDVTRIHEAEDRQRILREELRAAKEIAEAATQAVLSLND
KLEHRVMERTAELVQAQEDLLKKERLSTIGQLTATVAHELRNPLGAIKNTVFTLKELSGAKNLKLDRPIARMERSVDRCN
SIITHLLEYSRVSALKYECRDFDQWLVDVLDELAVPPTITVERVLAARDRNCAFDPERLRQVIVNLVENAIHALNDVGAE
RPEKRLRLSTRQNAGTIELTIADTGPGIAAENLTRVFDPLFSTKSFGTGLGLPAVKQIVEQHGGTITLASTLGQGTEVTV
VIPHERQELAA

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=232, Percent_Identity=34.051724137931, Blast_Score=131, Evalue=2e-31,
Organism=Escherichia coli, GI1788549, Length=241, Percent_Identity=31.5352697095436, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI145693157, Length=257, Percent_Identity=31.1284046692607, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1789149, Length=313, Percent_Identity=28.7539936102236, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1790300, Length=238, Percent_Identity=28.1512605042017, Blast_Score=76, Evalue=8e-15,
Organism=Escherichia coli, GI1788393, Length=231, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1786600, Length=343, Percent_Identity=26.530612244898, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1787894, Length=224, Percent_Identity=29.9107142857143, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1790346, Length=277, Percent_Identity=25.6317689530686, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1789808, Length=219, Percent_Identity=25.5707762557078, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 72127; Mature: 71996

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS50924 MHYT ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTFSLCLTQQHDLALTALAVLFCCLMAFASINLFRLASEMEQAQTPAWLFATALILTCG
CCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
VWTTHFVACLAYQPGLPISYNAETFPVSLLASMTTAWVGFTLAQRRHFRLGGAIIGVSIA
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
MMHYISMASVKFQAEKSWDLRFVALSVLVGMTAAGGSMAVFKDGRNLRRCLMASLLIVLA
HHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHH
ICGTHFLGMAALTLKAVPGILVADGQAQSALLATALAVMMILIGLGLLGSLTERRLRTQA
HHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEETRKLRRSQDHLERAQKITQTGSVERDLRTGEIELSSEIYRIFSLDPNQPSAASQSLA
HHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCEEHHHHHHHHEECCCCCCCHHHHHHH
RFFHPDDHHGCQFAMRTPQLSSAFTDEHLRLVTPEGAIRWLRHEAEFIYDEAGTPIRWIA
HHCCCCCCCCCEEEECCCCHHHHHCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCEEEEE
TYTDVTRIHEAEDRQRILREELRAAKEIAEAATQAVLSLNDKLEHRVMERTAELVQAQED
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLKKERLSTIGQLTATVAHELRNPLGAIKNTVFTLKELSGAKNLKLDRPIARMERSVDRC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
NSIITHLLEYSRVSALKYECRDFDQWLVDVLDELAVPPTITVERVLAARDRNCAFDPERL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHH
RQVIVNLVENAIHALNDVGAERPEKRLRLSTRQNAGTIELTIADTGPGIAAENLTRVFDP
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHH
LFSTKSFGTGLGLPAVKQIVEQHGGTITLASTLGQGTEVTVVIPHERQELAA
HHCCCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCHHHHCC
>Mature Secondary Structure 
TTFSLCLTQQHDLALTALAVLFCCLMAFASINLFRLASEMEQAQTPAWLFATALILTCG
CCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
VWTTHFVACLAYQPGLPISYNAETFPVSLLASMTTAWVGFTLAQRRHFRLGGAIIGVSIA
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
MMHYISMASVKFQAEKSWDLRFVALSVLVGMTAAGGSMAVFKDGRNLRRCLMASLLIVLA
HHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHH
ICGTHFLGMAALTLKAVPGILVADGQAQSALLATALAVMMILIGLGLLGSLTERRLRTQA
HHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEETRKLRRSQDHLERAQKITQTGSVERDLRTGEIELSSEIYRIFSLDPNQPSAASQSLA
HHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCEEHHHHHHHHEECCCCCCCHHHHHHH
RFFHPDDHHGCQFAMRTPQLSSAFTDEHLRLVTPEGAIRWLRHEAEFIYDEAGTPIRWIA
HHCCCCCCCCCEEEECCCCHHHHHCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCEEEEE
TYTDVTRIHEAEDRQRILREELRAAKEIAEAATQAVLSLNDKLEHRVMERTAELVQAQED
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLKKERLSTIGQLTATVAHELRNPLGAIKNTVFTLKELSGAKNLKLDRPIARMERSVDRC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
NSIITHLLEYSRVSALKYECRDFDQWLVDVLDELAVPPTITVERVLAARDRNCAFDPERL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHH
RQVIVNLVENAIHALNDVGAERPEKRLRLSTRQNAGTIELTIADTGPGIAAENLTRVFDP
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHH
LFSTKSFGTGLGLPAVKQIVEQHGGTITLASTLGQGTEVTVVIPHERQELAA
HHCCCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11243806 [H]