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The map label for this gene is dapA [H]

Identifier: 182678837

GI number: 182678837

Start: 2130219

End: 2131112

Strand: Reverse

Name: dapA [H]

Synonym: Bind_1870

Alternate gene names: 182678837

Gene position: 2131112-2130219 (Counterclockwise)

Preceding gene: 182678840

Following gene: 182678836

Centisome position: 51.1

GC content: 58.28

Gene sequence:

>894_bases
ATGGGAATGAAGGCAGCTTTCAAGGGCTCGATCACGGCGCTCGTGACCCCGTTTCGTGCCGGTAAGGTGGACGAACAGGC
CTTTCGCGCTTTCGTCGATTGGCAGATTTTGAGCGGCACGCATGGCCTTGTACCGGTCGGCACGACGGGTGAAAGCCCGA
CCCTGACGCATGAGGAGCATCGTCAGGTTGTTTCCGCCTGTATCAGCGAGGCAAAGGGCCGCGTGCCGGTCATCGCCGGA
GCCGGTTCAAACAACACGGAAGAGGCTATCGAACTCGCGCGTTTCGCGGAAAAAGCGGGTGCGGATGGCTTGCTGATCGT
GACGCCTTATTACAACAAGCCGTCTCAGGAAGGACTCTACCGGCATTTCAAGGCGGTGAATGATGCGGTGGGTATTCCGA
TCATCATCTATAATATTCCCCCGCGCTCCGTGGTCGACATGTCGATTGAGACGATGCAGCGTCTGTTCGAATTGAAGAAT
ATCGCGGGCGTCAAGGATGCGACCGGCAATCTCGCGCGCACGGCTTTGCAGCGTCAGGCCCTGGGACCGGATTTCATCCA
ATTGTCAGGTGAAGACATGACGGCGCTGGCGGTCAATGCGCTGGGTGGTCATGGCTGCATTTCCGTGACGTCGAATGTCG
CCCCGCGCCAATGTGCGGATATGCAACAGGCCAGCCTCGATGGCGATTTCGCCAAGGCTTTGCAAGTGCATGATGCCCTT
TCGCATTTGCATGCGGCACTGTTTGTCGAACCCAATCCCGCCGGCCCCAAATATGCGCTGAGTCTGCTTGGCAAGATCGA
GGACGAGATCAGGCTGCCCCTCGTCTCCGCCTCGGTCAATGCCCAGGCCGTGATCCGCGCTGCCATGGTGCATGCCGGTC
TCATTACAGAATAA

Upstream 100 bases:

>100_bases
GCGTCCAGCCGAATCGCCCGAACGGCGAAGCACCGGATTTTAAGCAAGATCTGGTCAAGGTTCCTCATCAGGCGAAGACA
CACGTGAAGGCACAAGGGCC

Downstream 100 bases:

>100_bases
GTGTGCTTGAGTGGCCGCAAAGAAACCAAGCGCGTTCAAGATCGCCGCGGAAAACCGCAAGGCGCGCTATAATTATGAAA
TTGGCGAGACTTTCGAGGCG

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MGMKAAFKGSITALVTPFRAGKVDEQAFRAFVDWQILSGTHGLVPVGTTGESPTLTHEEHRQVVSACISEAKGRVPVIAG
AGSNNTEEAIELARFAEKAGADGLLIVTPYYNKPSQEGLYRHFKAVNDAVGIPIIIYNIPPRSVVDMSIETMQRLFELKN
IAGVKDATGNLARTALQRQALGPDFIQLSGEDMTALAVNALGGHGCISVTSNVAPRQCADMQQASLDGDFAKALQVHDAL
SHLHAALFVEPNPAGPKYALSLLGKIEDEIRLPLVSASVNAQAVIRAAMVHAGLITE

Sequences:

>Translated_297_residues
MGMKAAFKGSITALVTPFRAGKVDEQAFRAFVDWQILSGTHGLVPVGTTGESPTLTHEEHRQVVSACISEAKGRVPVIAG
AGSNNTEEAIELARFAEKAGADGLLIVTPYYNKPSQEGLYRHFKAVNDAVGIPIIIYNIPPRSVVDMSIETMQRLFELKN
IAGVKDATGNLARTALQRQALGPDFIQLSGEDMTALAVNALGGHGCISVTSNVAPRQCADMQQASLDGDFAKALQVHDAL
SHLHAALFVEPNPAGPKYALSLLGKIEDEIRLPLVSASVNAQAVIRAAMVHAGLITE
>Mature_296_residues
GMKAAFKGSITALVTPFRAGKVDEQAFRAFVDWQILSGTHGLVPVGTTGESPTLTHEEHRQVVSACISEAKGRVPVIAGA
GSNNTEEAIELARFAEKAGADGLLIVTPYYNKPSQEGLYRHFKAVNDAVGIPIIIYNIPPRSVVDMSIETMQRLFELKNI
AGVKDATGNLARTALQRQALGPDFIQLSGEDMTALAVNALGGHGCISVTSNVAPRQCADMQQASLDGDFAKALQVHDALS
HLHAALFVEPNPAGPKYALSLLGKIEDEIRLPLVSASVNAQAVIRAAMVHAGLITE

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=306, Percent_Identity=26.4705882352941, Blast_Score=98, Evalue=7e-21,
Organism=Homo sapiens, GI13540533, Length=242, Percent_Identity=26.8595041322314, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1788823, Length=291, Percent_Identity=47.4226804123711, Blast_Score=266, Evalue=1e-72,
Organism=Escherichia coli, GI1786463, Length=245, Percent_Identity=35.5102040816327, Blast_Score=140, Evalue=9e-35,
Organism=Escherichia coli, GI87082415, Length=296, Percent_Identity=30.7432432432432, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1789620, Length=237, Percent_Identity=30.379746835443, Blast_Score=108, Evalue=6e-25,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 31513; Mature: 31382

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00665 DHDPS_1 ; PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGMKAAFKGSITALVTPFRAGKVDEQAFRAFVDWQILSGTHGLVPVGTTGESPTLTHEEH
CCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHCEEEECCCCCEEEECCCCCCCCCCHHHH
RQVVSACISEAKGRVPVIAGAGSNNTEEAIELARFAEKAGADGLLIVTPYYNKPSQEGLY
HHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHH
RHFKAVNDAVGIPIIIYNIPPRSVVDMSIETMQRLFELKNIAGVKDATGNLARTALQRQA
HHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHC
LGPDFIQLSGEDMTALAVNALGGHGCISVTSNVAPRQCADMQQASLDGDFAKALQVHDAL
CCCCEEEECCCCEEEEEEECCCCCCEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHH
SHLHAALFVEPNPAGPKYALSLLGKIEDEIRLPLVSASVNAQAVIRAAMVHAGLITE
HHHHEEEEECCCCCCHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
GMKAAFKGSITALVTPFRAGKVDEQAFRAFVDWQILSGTHGLVPVGTTGESPTLTHEEH
CCCCCCCCCEEEEECCCCCCCCCHHHHHHHHCEEEECCCCCEEEECCCCCCCCCCHHHH
RQVVSACISEAKGRVPVIAGAGSNNTEEAIELARFAEKAGADGLLIVTPYYNKPSQEGLY
HHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHH
RHFKAVNDAVGIPIIIYNIPPRSVVDMSIETMQRLFELKNIAGVKDATGNLARTALQRQA
HHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHC
LGPDFIQLSGEDMTALAVNALGGHGCISVTSNVAPRQCADMQQASLDGDFAKALQVHDAL
CCCCEEEECCCCEEEEEEECCCCCCEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHH
SHLHAALFVEPNPAGPKYALSLLGKIEDEIRLPLVSASVNAQAVIRAAMVHAGLITE
HHHHEEEEECCCCCCHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA