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The map label for this gene is glmU [H]

Identifier: 182678773

GI number: 182678773

Start: 2044580

End: 2045938

Strand: Reverse

Name: glmU [H]

Synonym: Bind_1802

Alternate gene names: 182678773

Gene position: 2045938-2044580 (Counterclockwise)

Preceding gene: 182678774

Following gene: 182678772

Centisome position: 49.06

GC content: 60.26

Gene sequence:

>1359_bases
TTGACCGAGCAAACCGCCAAATCGGGGCGCCGCTGTCTTGCCGTCGTCTTGGCCGCGGGACTCGGATCGCGGATGAAATC
GGCACAGCCGAAAGTCCTGCATGCCCTGGCTGGACGCTCCATGCTGGCGCATGTGCTCGCGACCCTGCGGGAAGCCGATG
TCAGCGACATTGTCGTGGTCGTTGGACCGGATCAGGAAGGCGTCGCTCAGGAAGCCGCCGCGATGATCCCTCATGCCACG
ATCGCCATTCAGGCCGAACGTCTCGGCACGGCGCATGCCGTCCTGGCGGCGCGTAAAAGCCTGGAGAAAGGATTCGATGA
TCTGCTGGTCGTCTTTGCTGACACGCCCTTGGTGAGCGCGGAAACCTTCATCGCCATGCGCGCGGTGCTGGCTGAGACAA
AAGCCGCAGCCCTGGTGCTCGGGTTTGAGGCGGCCGATCCGACAGGCTATGGCCGTCTCATTCTCGAACAAGGTCAATTG
ATTGCCATTCGGGAGGAACGCGATGCCGATCCATCGGAACGCGCGCTCACTTTATGCAATGGCGGTCTGATGGCGCTTGC
GGGGGAGCAGGCTTTGGGCCTCTTGGATCGAATCGGCAAGGCTAATGCGCAGGGGGAATATTATCTCACGGATATCGTGG
CCCTGGCGCGCGATACCGGGCAAGAGGCTGAGGTCCTGATCGTGCCCGAGGATGAAGTGATGGGCGTCAACGACAGGGTT
CAACTGGCGCGGGCCGAAAGCCTTTTGCAGGACCGTTTGCGTGAGAAAGCCATGCGCGCAGGAGCGACGCTCATCGATCC
GGCCAGCATCTTCCTGAGTTTCGATACGCAACTCGACCGTGATGTCATCGTCGAGCCGCATGTGGTTTTCGGTCCGGGTG
TCACCATTGGCGAGGGCGCGCGCATCAGGGCTTTCTCGCATCTTGAGGAAGCGAGGGTCGGGGCAGGGGCTATCATCGGA
CCCTTCGCGCGGCTGCGGCCAGGCGCGGATTTGGCCGAGGCCGTTCACATCGGCAATTTCGTGGAGATCAAGGCCACCAA
GGTCGGGGCAGGGGCCAAGATCAACCATCTTTCCTATATAGGGGATGCGAGTATCGGCGCGAAAACCAATATTGGAGCTG
GCACGATTACTTGTAATTACGATGGTTTCGGTAAATTCAAGACTGAGATCGGGGCTGGAGCCTTCATAGGCTCCCAGACT
GCGCTGGTCGCGCCCGTCAAGGTGGGCGACGGCGCCTATGTCGGGACGGGCTCGGTCATTACCCATGATGTCCCGGAAGA
TGCACTCGCCATTGCGCGGGAAAGGCAGATCGACAAGCCCGGTTGGGCTAAGGCCTTTCGTGAGAAATATAGAAAATGA

Upstream 100 bases:

>100_bases
ATGGCCTTATGCTAGCCGTGCTGTGTTTTAATCGGGAAGCAAATGCGGCGCTCTGGATCTTTGACCGAATTGAAGGCTCG
ATGCTTCAGGAGAGAGTAAT

Downstream 100 bases:

>100_bases
CATAACTCTCGTGCAAGTCTCGTCTGATCTGTTGGGCTTGCGGTGACGGTTTTACCGCTCTTGCTGTTTGTTAGTCCTTC
CCGGATCTGTTGCCCGTTTC

Product: UDP-N-acetylglucosamine pyrophosphorylase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MTEQTAKSGRRCLAVVLAAGLGSRMKSAQPKVLHALAGRSMLAHVLATLREADVSDIVVVVGPDQEGVAQEAAAMIPHAT
IAIQAERLGTAHAVLAARKSLEKGFDDLLVVFADTPLVSAETFIAMRAVLAETKAAALVLGFEAADPTGYGRLILEQGQL
IAIREERDADPSERALTLCNGGLMALAGEQALGLLDRIGKANAQGEYYLTDIVALARDTGQEAEVLIVPEDEVMGVNDRV
QLARAESLLQDRLREKAMRAGATLIDPASIFLSFDTQLDRDVIVEPHVVFGPGVTIGEGARIRAFSHLEEARVGAGAIIG
PFARLRPGADLAEAVHIGNFVEIKATKVGAGAKINHLSYIGDASIGAKTNIGAGTITCNYDGFGKFKTEIGAGAFIGSQT
ALVAPVKVGDGAYVGTGSVITHDVPEDALAIARERQIDKPGWAKAFREKYRK

Sequences:

>Translated_452_residues
MTEQTAKSGRRCLAVVLAAGLGSRMKSAQPKVLHALAGRSMLAHVLATLREADVSDIVVVVGPDQEGVAQEAAAMIPHAT
IAIQAERLGTAHAVLAARKSLEKGFDDLLVVFADTPLVSAETFIAMRAVLAETKAAALVLGFEAADPTGYGRLILEQGQL
IAIREERDADPSERALTLCNGGLMALAGEQALGLLDRIGKANAQGEYYLTDIVALARDTGQEAEVLIVPEDEVMGVNDRV
QLARAESLLQDRLREKAMRAGATLIDPASIFLSFDTQLDRDVIVEPHVVFGPGVTIGEGARIRAFSHLEEARVGAGAIIG
PFARLRPGADLAEAVHIGNFVEIKATKVGAGAKINHLSYIGDASIGAKTNIGAGTITCNYDGFGKFKTEIGAGAFIGSQT
ALVAPVKVGDGAYVGTGSVITHDVPEDALAIARERQIDKPGWAKAFREKYRK
>Mature_451_residues
TEQTAKSGRRCLAVVLAAGLGSRMKSAQPKVLHALAGRSMLAHVLATLREADVSDIVVVVGPDQEGVAQEAAAMIPHATI
AIQAERLGTAHAVLAARKSLEKGFDDLLVVFADTPLVSAETFIAMRAVLAETKAAALVLGFEAADPTGYGRLILEQGQLI
AIREERDADPSERALTLCNGGLMALAGEQALGLLDRIGKANAQGEYYLTDIVALARDTGQEAEVLIVPEDEVMGVNDRVQ
LARAESLLQDRLREKAMRAGATLIDPASIFLSFDTQLDRDVIVEPHVVFGPGVTIGEGARIRAFSHLEEARVGAGAIIGP
FARLRPGADLAEAVHIGNFVEIKATKVGAGAKINHLSYIGDASIGAKTNIGAGTITCNYDGFGKFKTEIGAGAFIGSQTA
LVAPVKVGDGAYVGTGSVITHDVPEDALAIARERQIDKPGWAKAFREKYRK

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1790168, Length=454, Percent_Identity=42.2907488986784, Blast_Score=330, Evalue=2e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 47598; Mature: 47467

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQTAKSGRRCLAVVLAAGLGSRMKSAQPKVLHALAGRSMLAHVLATLREADVSDIVVV
CCCCCHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
VGPDQEGVAQEAAAMIPHATIAIQAERLGTAHAVLAARKSLEKGFDDLLVVFADTPLVSA
ECCCCCCHHHHHHHHCCCEEEEEEHHHCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCH
ETFIAMRAVLAETKAAALVLGFEAADPTGYGRLILEQGQLIAIREERDADPSERALTLCN
HHHHHHHHHHHHHCCEEEEEEEECCCCCCCCEEEEECCCEEEEECCCCCCHHHHEEEEEC
GGLMALAGEQALGLLDRIGKANAQGEYYLTDIVALARDTGQEAEVLIVPEDEVMGVNDRV
CCEEEECCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCHHEECCCHHH
QLARAESLLQDRLREKAMRAGATLIDPASIFLSFDTQLDRDVIVEPHVVFGPGVTIGEGA
HHHHHHHHHHHHHHHHHHHCCCCEECCEEEEEEECCCCCCCEEECCEEEECCCEEECCCC
RIRAFSHLEEARVGAGAIIGPFARLRPGADLAEAVHIGNFVEIKATKVGAGAKINHLSYI
EEEHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHHCCCEEEEEEEEECCCCEECCEEEE
GDASIGAKTNIGAGTITCNYDGFGKFKTEIGAGAFIGSQTALVAPVKVGDGAYVGTGSVI
CCCCCCCCCCCCCEEEEECCCCCCCCHHHCCCCEEECCCCEEEEEEEECCCCEECCCCEE
THDVPEDALAIARERQIDKPGWAKAFREKYRK
ECCCCHHHHHHHHHHCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
TEQTAKSGRRCLAVVLAAGLGSRMKSAQPKVLHALAGRSMLAHVLATLREADVSDIVVV
CCCCHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
VGPDQEGVAQEAAAMIPHATIAIQAERLGTAHAVLAARKSLEKGFDDLLVVFADTPLVSA
ECCCCCCHHHHHHHHCCCEEEEEEHHHCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCH
ETFIAMRAVLAETKAAALVLGFEAADPTGYGRLILEQGQLIAIREERDADPSERALTLCN
HHHHHHHHHHHHHCCEEEEEEEECCCCCCCCEEEEECCCEEEEECCCCCCHHHHEEEEEC
GGLMALAGEQALGLLDRIGKANAQGEYYLTDIVALARDTGQEAEVLIVPEDEVMGVNDRV
CCEEEECCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCHHEECCCHHH
QLARAESLLQDRLREKAMRAGATLIDPASIFLSFDTQLDRDVIVEPHVVFGPGVTIGEGA
HHHHHHHHHHHHHHHHHHHCCCCEECCEEEEEEECCCCCCCEEECCEEEECCCEEECCCC
RIRAFSHLEEARVGAGAIIGPFARLRPGADLAEAVHIGNFVEIKATKVGAGAKINHLSYI
EEEHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHHCCCEEEEEEEEECCCCEECCEEEE
GDASIGAKTNIGAGTITCNYDGFGKFKTEIGAGAFIGSQTALVAPVKVGDGAYVGTGSVI
CCCCCCCCCCCCCEEEEECCCCCCCCHHHCCCCEEECCCCEEEEEEEECCCCEECCCCEE
THDVPEDALAIARERQIDKPGWAKAFREKYRK
ECCCCHHHHHHHHHHCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA