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The map label for this gene is glmS [H]

Identifier: 182678772

GI number: 182678772

Start: 2042593

End: 2044428

Strand: Reverse

Name: glmS [H]

Synonym: Bind_1801

Alternate gene names: 182678772

Gene position: 2044428-2042593 (Counterclockwise)

Preceding gene: 182678773

Following gene: 182678771

Centisome position: 49.03

GC content: 58.44

Gene sequence:

>1836_bases
ATGTGCGGCATCGTCGGTATCCTTGGCCAGGGTCCTGTTGCTCCGTCCCTGGTTGAGGCGCTGAAGCGGCTTGAATATCG
CGGTTACGATTCGGCCGGCATAGCGACGCTCGAGAATGGCAGGCTCGAACGGCTGCGGGCCGAGGGCAAGCTCAAGAATC
TGGCACAAAAGCTCGCCTCGCATCCACTTTCTGGCACCAGCGGCATTGGCCATACGCGCTGGGCGACCCATGGCAAGCCG
ACCGAGAATAATGCGCATCCCCATGCCAGCGATAAAGTCGCGTTGGTGCATAATGGCATTATCGAGAATTTTCGCGAGCT
GCGCGCGGAGCTCAAGGCGAAGGGCCATGTTTTTTCGACGGATACGGATTCTGAAGTCGTCGCGCATCTCGTCAGTGAAG
CCATGCGAGAAGGGCTGAAGCCTGTCGATGCGGTCGCTGCGAGCCTGCCGCGTCTCAGAGGGGCTTTCGCGCTCGCCTTT
CTGTTCGAGGATGAACCTGATCTTCTGATCGGTGCGCGGCGAGGTTCGCCGCTCGCGGTCGGTTTTGGGACGGAGGAAGA
GCCAGGGATCTATCTCGGCTCCGATGCCCTGGCGCTCGCGCCCTTCACCGATACTATTACCTACCTCGAAGATGGCGACA
GCGTTGTCCTGACCCGTTCCAGAGCGACCTTTTTCGACGCGGGTAACCAGATCGTGGAGCGTCGCAAAATCAAGACGCAG
GCCGGAGCCTTTCTCATCGACAAGGGCAATTATCGGCATTTCATGGCCAAGGAGATCCACGAACAGCCGGAAGTCGTCGG
CCTCGCCCTGGGGCACTATCTCGATTTCTCCGCGGGCCGTGTCGCCCTACCGTTTGCGTTGCCGGTTAATCCTGCCTCGA
TCGACCGCTTGACGATTTGCGGTTGCGGCACGGCCTATATGGCTGGGCTGGTCGCGAAATATTGGTTCGAGCGCTTTGCG
GGGATTGAGGTCAATGTCGAATTGGCCTCGGAATTTCGCTATGCCGAACCTCCTTTGAAGGCGGATGGCCTTACACTTTT
CATTTCGCAATCGGGCGAGACGGCGGATGTCCTGGCTTCCCTCCGTTATGCCAAGGCGCGTGGGCAAAAAACAATGGGCG
TCGTGAATGTGGAAACATCCACGCTTGCGCGCGAATGTGACCTCGCCGTACCCATTCGCGCCGGCACCGAGATCGGGGTT
GCTTCGACCAAGGCTTTTACCTGTCAGCTTGCTGTGCTCGCCAGTCTCGCACTCGCTTTTGGGCGAGAGCGACAGGCCAT
TAGTGATGAGACAGAGGCAAGGCTTGTCGGTGAACTGATGGCGGTACCAGGGCTCATGGCCGAGGCTTTGCGCAAAGACT
CCCTGGTCGAGCAGATCGCTCGTGATCTCAGCCATGCGCATGATGTGCTCTATCTCGGGCGTGGCACGGCCTATCCTTTG
GCGCTCGAAGGCGCGCTCAAGCTCAAAGAACTTTCTTATATTCACGCGGAAGGCTATGCGGCCGGCGAATTGAAACATGG
TCCAATCGCTTTGATCGATGAAACAATGCCGGTGATTGTTATCGCTCCGCCGAGCCCGGTGCTTGAAAAGACGATTTCCA
ACATGGAGGAAGTCGCGGCGCGTGGCGGCAAGCTCATCCTGATCGGAGAAGCCGGGCTTGCGCGGGATGTCGCCGATGAA
GTCAAGCGCTCGCTCGTTCTGTCGCCAATGGCACCAGACTTTGCTGCCATGGTCTATGCCATACCCGTCCAATTGCTTGC
CTATCATACGGCGGTGGTCATGGGGAAGGATGCCGACCAGCCTCGCAATCTCGCCAAGAGTGTCACTGTCGAATAA

Upstream 100 bases:

>100_bases
TTACCGCTCTTGCTGTTTGTTAGTCCTTCCCGGATCTGTTGCCCGTTTCAATTTCCCTTTGGAGGATGGATTCCTTTGAA
GGCCAAGCAGGATTTTCTTC

Downstream 100 bases:

>100_bases
TGCTGGAAGGCGTAAAGAGAAGCGATTGATATCAGGCTGTCATTGTCCTTCTCAAAGGATTGTCGTCATTCGAAAGAGTC
CAATGATCCTCCTTTATGAG

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 611; Mature: 611

Protein sequence:

>611_residues
MCGIVGILGQGPVAPSLVEALKRLEYRGYDSAGIATLENGRLERLRAEGKLKNLAQKLASHPLSGTSGIGHTRWATHGKP
TENNAHPHASDKVALVHNGIIENFRELRAELKAKGHVFSTDTDSEVVAHLVSEAMREGLKPVDAVAASLPRLRGAFALAF
LFEDEPDLLIGARRGSPLAVGFGTEEEPGIYLGSDALALAPFTDTITYLEDGDSVVLTRSRATFFDAGNQIVERRKIKTQ
AGAFLIDKGNYRHFMAKEIHEQPEVVGLALGHYLDFSAGRVALPFALPVNPASIDRLTICGCGTAYMAGLVAKYWFERFA
GIEVNVELASEFRYAEPPLKADGLTLFISQSGETADVLASLRYAKARGQKTMGVVNVETSTLARECDLAVPIRAGTEIGV
ASTKAFTCQLAVLASLALAFGRERQAISDETEARLVGELMAVPGLMAEALRKDSLVEQIARDLSHAHDVLYLGRGTAYPL
ALEGALKLKELSYIHAEGYAAGELKHGPIALIDETMPVIVIAPPSPVLEKTISNMEEVAARGGKLILIGEAGLARDVADE
VKRSLVLSPMAPDFAAMVYAIPVQLLAYHTAVVMGKDADQPRNLAKSVTVE

Sequences:

>Translated_611_residues
MCGIVGILGQGPVAPSLVEALKRLEYRGYDSAGIATLENGRLERLRAEGKLKNLAQKLASHPLSGTSGIGHTRWATHGKP
TENNAHPHASDKVALVHNGIIENFRELRAELKAKGHVFSTDTDSEVVAHLVSEAMREGLKPVDAVAASLPRLRGAFALAF
LFEDEPDLLIGARRGSPLAVGFGTEEEPGIYLGSDALALAPFTDTITYLEDGDSVVLTRSRATFFDAGNQIVERRKIKTQ
AGAFLIDKGNYRHFMAKEIHEQPEVVGLALGHYLDFSAGRVALPFALPVNPASIDRLTICGCGTAYMAGLVAKYWFERFA
GIEVNVELASEFRYAEPPLKADGLTLFISQSGETADVLASLRYAKARGQKTMGVVNVETSTLARECDLAVPIRAGTEIGV
ASTKAFTCQLAVLASLALAFGRERQAISDETEARLVGELMAVPGLMAEALRKDSLVEQIARDLSHAHDVLYLGRGTAYPL
ALEGALKLKELSYIHAEGYAAGELKHGPIALIDETMPVIVIAPPSPVLEKTISNMEEVAARGGKLILIGEAGLARDVADE
VKRSLVLSPMAPDFAAMVYAIPVQLLAYHTAVVMGKDADQPRNLAKSVTVE
>Mature_611_residues
MCGIVGILGQGPVAPSLVEALKRLEYRGYDSAGIATLENGRLERLRAEGKLKNLAQKLASHPLSGTSGIGHTRWATHGKP
TENNAHPHASDKVALVHNGIIENFRELRAELKAKGHVFSTDTDSEVVAHLVSEAMREGLKPVDAVAASLPRLRGAFALAF
LFEDEPDLLIGARRGSPLAVGFGTEEEPGIYLGSDALALAPFTDTITYLEDGDSVVLTRSRATFFDAGNQIVERRKIKTQ
AGAFLIDKGNYRHFMAKEIHEQPEVVGLALGHYLDFSAGRVALPFALPVNPASIDRLTICGCGTAYMAGLVAKYWFERFA
GIEVNVELASEFRYAEPPLKADGLTLFISQSGETADVLASLRYAKARGQKTMGVVNVETSTLARECDLAVPIRAGTEIGV
ASTKAFTCQLAVLASLALAFGRERQAISDETEARLVGELMAVPGLMAEALRKDSLVEQIARDLSHAHDVLYLGRGTAYPL
ALEGALKLKELSYIHAEGYAAGELKHGPIALIDETMPVIVIAPPSPVLEKTISNMEEVAARGGKLILIGEAGLARDVADE
VKRSLVLSPMAPDFAAMVYAIPVQLLAYHTAVVMGKDADQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=690, Percent_Identity=35.9420289855072, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI4826742, Length=692, Percent_Identity=35.2601156069364, Blast_Score=379, Evalue=1e-105,
Organism=Escherichia coli, GI1790167, Length=619, Percent_Identity=48.7883683360258, Blast_Score=556, Evalue=1e-159,
Organism=Escherichia coli, GI1788651, Length=169, Percent_Identity=34.9112426035503, Blast_Score=89, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17539970, Length=439, Percent_Identity=37.8132118451025, Blast_Score=263, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI17532899, Length=431, Percent_Identity=37.3549883990719, Blast_Score=262, Evalue=4e-70,
Organism=Caenorhabditis elegans, GI17532897, Length=431, Percent_Identity=37.3549883990719, Blast_Score=261, Evalue=6e-70,
Organism=Saccharomyces cerevisiae, GI6322745, Length=484, Percent_Identity=37.1900826446281, Blast_Score=260, Evalue=4e-70,
Organism=Saccharomyces cerevisiae, GI6323731, Length=436, Percent_Identity=30.045871559633, Blast_Score=169, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6323730, Length=207, Percent_Identity=36.231884057971, Blast_Score=122, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6323958, Length=140, Percent_Identity=32.1428571428571, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21357745, Length=685, Percent_Identity=37.0802919708029, Blast_Score=390, Evalue=1e-108,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 65487; Mature: 65487

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGILGQGPVAPSLVEALKRLEYRGYDSAGIATLENGRLERLRAEGKLKNLAQKLAS
CCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHC
HPLSGTSGIGHTRWATHGKPTENNAHPHASDKVALVHNGIIENFRELRAELKAKGHVFST
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCEECC
DTDSEVVAHLVSEAMREGLKPVDAVAASLPRLRGAFALAFLFEDEPDLLIGARRGSPLAV
CCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEEEEEECCCCCEEEEECCCCEEEE
GFGTEEEPGIYLGSDALALAPFTDTITYLEDGDSVVLTRSRATFFDAGNQIVERRKIKTQ
ECCCCCCCCEEECCCCEEECCCCCEEEEEECCCEEEEEECCCHHHHCCHHHHHHHHHHHH
AGAFLIDKGNYRHFMAKEIHEQPEVVGLALGHYLDFSAGRVALPFALPVNPASIDRLTIC
CCEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCEEEEE
GCGTAYMAGLVAKYWFERFAGIEVNVELASEFRYAEPPLKADGLTLFISQSGETADVLAS
CCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCEEEEEECCCCHHHHHHH
LRYAKARGQKTMGVVNVETSTLARECDLAVPIRAGTEIGVASTKAFTCQLAVLASLALAF
HHHHHHCCCCCEEEEEECHHHHHHHCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHH
GRERQAISDETEARLVGELMAVPGLMAEALRKDSLVEQIARDLSHAHDVLYLGRGTAYPL
CCCHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCE
ALEGALKLKELSYIHAEGYAAGELKHGPIALIDETMPVIVIAPPSPVLEKTISNMEEVAA
EECCCHHHHHHHEEECCCCCCCCCCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHH
RGGKLILIGEAGLARDVADEVKRSLVLSPMAPDFAAMVYAIPVQLLAYHTAVVMGKDADQ
CCCCEEEEECCCCHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCC
PRNLAKSVTVE
HHHHHHHCCCC
>Mature Secondary Structure
MCGIVGILGQGPVAPSLVEALKRLEYRGYDSAGIATLENGRLERLRAEGKLKNLAQKLAS
CCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHC
HPLSGTSGIGHTRWATHGKPTENNAHPHASDKVALVHNGIIENFRELRAELKAKGHVFST
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCEECC
DTDSEVVAHLVSEAMREGLKPVDAVAASLPRLRGAFALAFLFEDEPDLLIGARRGSPLAV
CCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEEEEEECCCCCEEEEECCCCEEEE
GFGTEEEPGIYLGSDALALAPFTDTITYLEDGDSVVLTRSRATFFDAGNQIVERRKIKTQ
ECCCCCCCCEEECCCCEEECCCCCEEEEEECCCEEEEEECCCHHHHCCHHHHHHHHHHHH
AGAFLIDKGNYRHFMAKEIHEQPEVVGLALGHYLDFSAGRVALPFALPVNPASIDRLTIC
CCEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCEEEEE
GCGTAYMAGLVAKYWFERFAGIEVNVELASEFRYAEPPLKADGLTLFISQSGETADVLAS
CCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCEEEEEECCCCHHHHHHH
LRYAKARGQKTMGVVNVETSTLARECDLAVPIRAGTEIGVASTKAFTCQLAVLASLALAF
HHHHHHCCCCCEEEEEECHHHHHHHCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHH
GRERQAISDETEARLVGELMAVPGLMAEALRKDSLVEQIARDLSHAHDVLYLGRGTAYPL
CCCHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCE
ALEGALKLKELSYIHAEGYAAGELKHGPIALIDETMPVIVIAPPSPVLEKTISNMEEVAA
EECCCHHHHHHHEEECCCCCCCCCCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHH
RGGKLILIGEAGLARDVADEVKRSLVLSPMAPDFAAMVYAIPVQLLAYHTAVVMGKDADQ
CCCCEEEEECCCCHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCC
PRNLAKSVTVE
HHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]