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The map label for this gene is fadA [H]

Identifier: 182678729

GI number: 182678729

Start: 1988965

End: 1990101

Strand: Reverse

Name: fadA [H]

Synonym: Bind_1756

Alternate gene names: 182678729

Gene position: 1990101-1988965 (Counterclockwise)

Preceding gene: 182678730

Following gene: 182678728

Centisome position: 47.72

GC content: 59.19

Gene sequence:

>1137_bases
ATGACTAAAGTTGTCATTGCCGGATACATTCGTTCGCCGTTCACCCTCGCCAAGAAAGGCGAACTGGCGACCGTCCGCCC
GGATGATCTTGCGGCCCAGGTGGTCAAGGGGCTCATTAAGAAAACGGGTATCCCGGCGGAGGATATCGAGGACTTGCTGC
TTGGGTGCGCCTTTCCGGAGGGGGAGCAGGGCTTCAATGTCGCGCGGCTCGTGAGCTTCCTTGCGGGGCTACCTCTTTCG
GTCGGTGCGTCAACCGTCAACCGCTTCTGCGGCTCCTCCATGACCACCGTGCATATGGCTGCCGGCGCAATTCAAATGAA
TGCGGGCAATGCCTTCATCGCGGCCGGTGTCGAGAGCATGTCCCGTGTGCCGATGATGGGGTTCAATCCTTTGCCCAATC
CGGAGCTCGCGGCGACCATGCCCGGCGCCTATATGGGCATGGGTGATACGGCTGAAAATGTCGCTGCTAAATGGACGATT
TCCCGCAAGGAGCAGGAAGAGTTCGCGCTGCGGTCGCATCAGCGCGCCACGGCGGCGCAGAAAGAGGGCCGGTTGACCGG
TGAAATCATCCCAATCACCGGCCGCAAAGGCACGATCACGACGGATGGCTGCATCCGCCCCGACACAACGCTTGAAGGGC
TGGCGGAGTTGAAACCTGCCTTCAGTGCAAACGGTGTCGTTACAGCCGGTACATCCTCGCCTTTAACCGACGGGGCCGCT
GCAGTACTGGTGTGCAGTGAAGATTACGCTAAGCACCATCATCTCGATGTGCTCGCTTCGGTCAAAGCCATCGCGGTCTC
TGGTTGCAGCCCGGAAATCATGGGCATCGGGCCTGTGGCGGCTTCGCGCAAGGCTCTAGCTCGTGCCGGACTCGAAGCCG
GTCAGATCGATATCGTCGAACTGAACGAAGCCTTCGCCTCTCAATCGATTGCCTGTATGCGCGAGCTGAACCTTTCACCG
GATCGAGTGAATATCGACGGCGGCGCCATTGCTCTTGGTCATCCGTTAGGAGCCACCGGCGCGCGTATCGTCGGTAAGGC
CGCTTCTTTGTTGAAGCGTGAAAAAGGCAAATATGCGCTTGCGACGCAATGTATTGGCGGCGGTCAAGGCATCGCGACAG
TTCTGGAGGCTTTCTGA

Upstream 100 bases:

>100_bases
CATCGAGGAGGAGCGAATTAAGATGTCAGTTCCGGTACACGATCGCGCCCTGTCCTGAAGCTTAAGCTTTCTCGGCAGAG
GCCTTATTTGGAGAATATTT

Downstream 100 bases:

>100_bases
TGACGGACATCAAAAAAGTTGCCGTCATCGGCGCAGGCGTCATGGGGGCGAGCATTGCCGCCCATGTCGCGAATGCGGGC
GTGCCTGTGGTTCTGCTCGA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 378; Mature: 377

Protein sequence:

>378_residues
MTKVVIAGYIRSPFTLAKKGELATVRPDDLAAQVVKGLIKKTGIPAEDIEDLLLGCAFPEGEQGFNVARLVSFLAGLPLS
VGASTVNRFCGSSMTTVHMAAGAIQMNAGNAFIAAGVESMSRVPMMGFNPLPNPELAATMPGAYMGMGDTAENVAAKWTI
SRKEQEEFALRSHQRATAAQKEGRLTGEIIPITGRKGTITTDGCIRPDTTLEGLAELKPAFSANGVVTAGTSSPLTDGAA
AVLVCSEDYAKHHHLDVLASVKAIAVSGCSPEIMGIGPVAASRKALARAGLEAGQIDIVELNEAFASQSIACMRELNLSP
DRVNIDGGAIALGHPLGATGARIVGKAASLLKREKGKYALATQCIGGGQGIATVLEAF

Sequences:

>Translated_378_residues
MTKVVIAGYIRSPFTLAKKGELATVRPDDLAAQVVKGLIKKTGIPAEDIEDLLLGCAFPEGEQGFNVARLVSFLAGLPLS
VGASTVNRFCGSSMTTVHMAAGAIQMNAGNAFIAAGVESMSRVPMMGFNPLPNPELAATMPGAYMGMGDTAENVAAKWTI
SRKEQEEFALRSHQRATAAQKEGRLTGEIIPITGRKGTITTDGCIRPDTTLEGLAELKPAFSANGVVTAGTSSPLTDGAA
AVLVCSEDYAKHHHLDVLASVKAIAVSGCSPEIMGIGPVAASRKALARAGLEAGQIDIVELNEAFASQSIACMRELNLSP
DRVNIDGGAIALGHPLGATGARIVGKAASLLKREKGKYALATQCIGGGQGIATVLEAF
>Mature_377_residues
TKVVIAGYIRSPFTLAKKGELATVRPDDLAAQVVKGLIKKTGIPAEDIEDLLLGCAFPEGEQGFNVARLVSFLAGLPLSV
GASTVNRFCGSSMTTVHMAAGAIQMNAGNAFIAAGVESMSRVPMMGFNPLPNPELAATMPGAYMGMGDTAENVAAKWTIS
RKEQEEFALRSHQRATAAQKEGRLTGEIIPITGRKGTITTDGCIRPDTTLEGLAELKPAFSANGVVTAGTSSPLTDGAAA
VLVCSEDYAKHHHLDVLASVKAIAVSGCSPEIMGIGPVAASRKALARAGLEAGQIDIVELNEAFASQSIACMRELNLSPD
RVNIDGGAIALGHPLGATGARIVGKAASLLKREKGKYALATQCIGGGQGIATVLEAF

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=387, Percent_Identity=41.343669250646, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI167614485, Length=390, Percent_Identity=37.9487179487179, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI148539872, Length=375, Percent_Identity=38.1333333333333, Blast_Score=232, Evalue=4e-61,
Organism=Homo sapiens, GI4557237, Length=393, Percent_Identity=33.587786259542, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI4504327, Length=424, Percent_Identity=34.6698113207547, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI194353979, Length=374, Percent_Identity=29.9465240641711, Blast_Score=140, Evalue=1e-33,
Organism=Escherichia coli, GI1787663, Length=402, Percent_Identity=45.771144278607, Blast_Score=300, Evalue=9e-83,
Organism=Escherichia coli, GI48994986, Length=389, Percent_Identity=46.0154241645244, Blast_Score=298, Evalue=3e-82,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=40.8163265306122, Blast_Score=268, Evalue=6e-73,
Organism=Escherichia coli, GI1788554, Length=395, Percent_Identity=38.2278481012658, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI1788683, Length=429, Percent_Identity=31.9347319347319, Blast_Score=169, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI133906874, Length=396, Percent_Identity=39.6464646464646, Blast_Score=258, Evalue=5e-69,
Organism=Caenorhabditis elegans, GI17551802, Length=432, Percent_Identity=33.5648148148148, Blast_Score=204, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI17535921, Length=389, Percent_Identity=33.1619537275064, Blast_Score=184, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI25147385, Length=385, Percent_Identity=29.8701298701299, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17535917, Length=374, Percent_Identity=25.1336898395722, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6322031, Length=383, Percent_Identity=37.3368146214099, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6325229, Length=396, Percent_Identity=34.0909090909091, Blast_Score=189, Evalue=5e-49,
Organism=Drosophila melanogaster, GI24655093, Length=393, Percent_Identity=37.9134860050891, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI17648125, Length=352, Percent_Identity=40.0568181818182, Blast_Score=241, Evalue=6e-64,
Organism=Drosophila melanogaster, GI24640423, Length=391, Percent_Identity=31.9693094629156, Blast_Score=178, Evalue=6e-45,
Organism=Drosophila melanogaster, GI17137578, Length=424, Percent_Identity=31.1320754716981, Blast_Score=167, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 39026; Mature: 38895

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKVVIAGYIRSPFTLAKKGELATVRPDDLAAQVVKGLIKKTGIPAEDIEDLLLGCAFPE
CCEEEEEECCCCCEEECCCCCEEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCC
GEQGFNVARLVSFLAGLPLSVGASTVNRFCGSSMTTVHMAAGAIQMNAGNAFIAAGVESM
CCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCEEEEECCEEEECCCCEEEEECHHHH
SRVPMMGFNPLPNPELAATMPGAYMGMGDTAENVAAKWTISRKEQEEFALRSHQRATAAQ
HCCCCCCCCCCCCCCCEEECCCHHCCCCCCHHHHEEEEEECCHHHHHHHHHHHHHHHHHH
KEGRLTGEIIPITGRKGTITTDGCIRPDTTLEGLAELKPAFSANGVVTAGTSSPLTDGAA
HCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCEEEECCCCCCCCCCE
AVLVCSEDYAKHHHLDVLASVKAIAVSGCSPEIMGIGPVAASRKALARAGLEAGQIDIVE
EEEEECHHHHHHHHHHHHHHHHHHEECCCCCCEEECCCHHHHHHHHHHCCCCCCCEEEEE
LNEAFASQSIACMRELNLSPDRVNIDGGAIALGHPLGATGARIVGKAASLLKREKGKYAL
CCHHHHHHHHHHHHHCCCCCCEEEECCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCEEE
ATQCIGGGQGIATVLEAF
EEECCCCCCHHHHHHHCC
>Mature Secondary Structure 
TKVVIAGYIRSPFTLAKKGELATVRPDDLAAQVVKGLIKKTGIPAEDIEDLLLGCAFPE
CEEEEEECCCCCEEECCCCCEEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCC
GEQGFNVARLVSFLAGLPLSVGASTVNRFCGSSMTTVHMAAGAIQMNAGNAFIAAGVESM
CCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCEEEEECCEEEECCCCEEEEECHHHH
SRVPMMGFNPLPNPELAATMPGAYMGMGDTAENVAAKWTISRKEQEEFALRSHQRATAAQ
HCCCCCCCCCCCCCCCEEECCCHHCCCCCCHHHHEEEEEECCHHHHHHHHHHHHHHHHHH
KEGRLTGEIIPITGRKGTITTDGCIRPDTTLEGLAELKPAFSANGVVTAGTSSPLTDGAA
HCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCEEEECCCCCCCCCCE
AVLVCSEDYAKHHHLDVLASVKAIAVSGCSPEIMGIGPVAASRKALARAGLEAGQIDIVE
EEEEECHHHHHHHHHHHHHHHHHHEECCCCCCEEECCCHHHHHHHHHHCCCCCCCEEEEE
LNEAFASQSIACMRELNLSPDRVNIDGGAIALGHPLGATGARIVGKAASLLKREKGKYAL
CCHHHHHHHHHHHHHCCCCCCEEEECCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCEEE
ATQCIGGGQGIATVLEAF
EEECCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]