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The map label for this gene is fadN [H]

Identifier: 182678728

GI number: 182678728

Start: 1986644

End: 1988965

Strand: Reverse

Name: fadN [H]

Synonym: Bind_1755

Alternate gene names: 182678728

Gene position: 1988965-1986644 (Counterclockwise)

Preceding gene: 182678729

Following gene: 182678727

Centisome position: 47.7

GC content: 56.8

Gene sequence:

>2322_bases
ATGACGGACATCAAAAAAGTTGCCGTCATCGGCGCAGGCGTCATGGGGGCGAGCATTGCCGCCCATGTCGCGAATGCGGG
CGTGCCTGTGGTTCTGCTCGACATTGTCGCCAAAGACAATCCCAACCGCAGCGCGATTGCCGAAGGCGCTCTGACCAAGC
TCCTGAAGGCCGATCCGGCACCGTTCATGAGCAAGGCCGCCGCGAAATTCGTGACCACTGGCAATATCGGGGACAATCTC
GATCTGCTGGCCGATTGCGATTGGATCATCGAGGCCGTGGTCGAGCGTTTGGATATCAAGCAAAACCTCTACGCGGCGGT
CGAAGCCATACGCAAGCCAGGCAGTATTGTCTCTTCAAATACTTCGACGATTCCGCTCAAGGCGCTTGTCAAAGGTATGC
CCGCGCGTTTCTCGAAAGATTTTATCATCACGCACTTCTTCAATCCGCCACGTTACATGCGGCTTCTTGAAGTGGTCGGT
GGCGAGAATTCGCGGGCTGACGCTATAGAAACCGTCACACGGTTTGCCGATGTCATGCTCGGCAAAAGCGTGATCTTTTG
CAAGGATCGGCCAGGCTTCATCGCTAATCGTCTGGGTGTGTTCTGGTTGCAAACCGCCGTCGTCGAGGCGTTGGATCTTG
CTCTTGATATCGAAGAGGTCGATGCGATCATCGGTAAGCCGATGGGCATTCCGAAAACCGGTGTTTTCGGTCTCATCGAC
CTCGTCGGTTTGGATCTGATGCCCCATATCAACGCCAGCCTATCAGCGGCGCTGCCGAAAGATGATCCATTTCACGTAGT
CAACCAGCCGATGCCCTTGGTCGAAAAGCTGATTGCCGAGGGCTATACGGGCCGCAAGGGCAAGGGTGGCTTCTATCGGA
TCAACCGTGAGCAGGGTAAGCAAAAGGAAGCTCTCGACCTCAAGACTGGCACCTTTCGGCCGGTTCGTAAGCCCGTCGTG
GAGGCGATTGAACAAGGCGGCAGCAAGCTTGATCGTCTGCTTGCGCATGAGAGCGTACATGGACGTTATGCATGGCAGGT
TCTCAGCCGCACGCTGGCCTATGCGGCTGCCTTGGTCGGTGATGCGACCGATGACGTGGCGGCGATCGATGAGGCGATGC
GGCTCGGCTACAATTGGAAATATGGTCCCTTTCAACTGATCGATCAGATCGGCGTCGAGGCGCTGGTCACGGGTCTCAAC
GCCAGCAAATTTCCGATCCCGGCTATTTTGCGGATCGCCGAAGGCAGGCCATTCTATCGCGTTGAGGATGGCCGCCGTCA
GGTCCTGGGTCTCGATGGCACCTATCATGATCTCCTGCGGCCTGAAGGCGTGATCATGTTGGAAGACATCAAATTGAAAT
CCAAGCCAGTTCTCAAGAACAGCTCGGCGGCCTTGTGGGATATCGGCGATGGTGTCGCCTGTTTCGAGTTCACGAGCAAG
ATGAATGCGCTCGACCCCGATATCATCGATCTCCTCATGCGTTCGATCCACTTGGTCGCGAAGGATTTCAAGGCGCTGGT
GATCTACAACGAGGGCAGCAACTTTTCCGTCGGTGCCAATCTTGGTCTCGCGCTATTCGCCGCCAATATCGCGGCCTGGA
AGGATATCGAGAACCTCATCCTGCAGGGACAGACGGCTTACGGCATGTTGAAATATGCGCCGTTTCCGGTTGTTGGCGCG
CCGGCCGGCATGGCGCTGGGTGGCGGCTGCGAAATTCTTCTGCATTGCGATGCGATTCAAGCCCATGCGGAAACCTATAC
CGGCCTTGTTGAGGTTGGTGTCGGTCTGATCCCAGGCTGGGGTGGCAACAAGGAGATGCTGCAGCGCTGGTTCACATTAG
GCCGCCTGCCGAAAGGCCCAATGCCCGCGATCAGCAAGGTCTTCGAGATCATCAGCACGGCGACCGTTTCCAAATCGGCG
GCCGAGGCCAAGGAGCTTTTGTTCCTGAGGCCGACCGATGCGATCACGATGAATCGCTACCGTCTGCTGGCCGATGCCAA
GGCTAAGGCCCTTGCTCTTGTGCCCGATTACAAACCGCCGGAGTCGGTCACTTTTAACCTGCCAGGACCTTCGGCCGCAA
CGGCCCTGAAGATGGCCGTCGACAGCTTTTTCCGCCTTGGTAAGGCGACAGCCTATGACGTCGTTGTGTCCAGTGCATTG
GCCGATGTCTTGTCGGGTGGTGACACGGACATCACCGTGCCGACGGATGAAAAGACGCTTCTCACGTTCGAACGCGAGGC
TTTCAGCAAGCTTGCTCGGCAGCCCGGTACATTGGCGCGTATTGAACACATGCTGACGACTGGAAAGCCCTTACGGAATT
AA

Upstream 100 bases:

>100_bases
AGGCCGCTTCTTTGTTGAAGCGTGAAAAAGGCAAATATGCGCTTGCGACGCAATGTATTGGCGGCGGTCAAGGCATCGCG
ACAGTTCTGGAGGCTTTCTG

Downstream 100 bases:

>100_bases
CAGGCGCATACAATAATTGTTCAGGAAAAAGCATCATGGCCAGCTACAAGGCTCCATTGCGCGATATGCGCTTTGTCATT
TTCGAACTCATGGATTGCGG

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 773; Mature: 772

Protein sequence:

>773_residues
MTDIKKVAVIGAGVMGASIAAHVANAGVPVVLLDIVAKDNPNRSAIAEGALTKLLKADPAPFMSKAAAKFVTTGNIGDNL
DLLADCDWIIEAVVERLDIKQNLYAAVEAIRKPGSIVSSNTSTIPLKALVKGMPARFSKDFIITHFFNPPRYMRLLEVVG
GENSRADAIETVTRFADVMLGKSVIFCKDRPGFIANRLGVFWLQTAVVEALDLALDIEEVDAIIGKPMGIPKTGVFGLID
LVGLDLMPHINASLSAALPKDDPFHVVNQPMPLVEKLIAEGYTGRKGKGGFYRINREQGKQKEALDLKTGTFRPVRKPVV
EAIEQGGSKLDRLLAHESVHGRYAWQVLSRTLAYAAALVGDATDDVAAIDEAMRLGYNWKYGPFQLIDQIGVEALVTGLN
ASKFPIPAILRIAEGRPFYRVEDGRRQVLGLDGTYHDLLRPEGVIMLEDIKLKSKPVLKNSSAALWDIGDGVACFEFTSK
MNALDPDIIDLLMRSIHLVAKDFKALVIYNEGSNFSVGANLGLALFAANIAAWKDIENLILQGQTAYGMLKYAPFPVVGA
PAGMALGGGCEILLHCDAIQAHAETYTGLVEVGVGLIPGWGGNKEMLQRWFTLGRLPKGPMPAISKVFEIISTATVSKSA
AEAKELLFLRPTDAITMNRYRLLADAKAKALALVPDYKPPESVTFNLPGPSAATALKMAVDSFFRLGKATAYDVVVSSAL
ADVLSGGDTDITVPTDEKTLLTFEREAFSKLARQPGTLARIEHMLTTGKPLRN

Sequences:

>Translated_773_residues
MTDIKKVAVIGAGVMGASIAAHVANAGVPVVLLDIVAKDNPNRSAIAEGALTKLLKADPAPFMSKAAAKFVTTGNIGDNL
DLLADCDWIIEAVVERLDIKQNLYAAVEAIRKPGSIVSSNTSTIPLKALVKGMPARFSKDFIITHFFNPPRYMRLLEVVG
GENSRADAIETVTRFADVMLGKSVIFCKDRPGFIANRLGVFWLQTAVVEALDLALDIEEVDAIIGKPMGIPKTGVFGLID
LVGLDLMPHINASLSAALPKDDPFHVVNQPMPLVEKLIAEGYTGRKGKGGFYRINREQGKQKEALDLKTGTFRPVRKPVV
EAIEQGGSKLDRLLAHESVHGRYAWQVLSRTLAYAAALVGDATDDVAAIDEAMRLGYNWKYGPFQLIDQIGVEALVTGLN
ASKFPIPAILRIAEGRPFYRVEDGRRQVLGLDGTYHDLLRPEGVIMLEDIKLKSKPVLKNSSAALWDIGDGVACFEFTSK
MNALDPDIIDLLMRSIHLVAKDFKALVIYNEGSNFSVGANLGLALFAANIAAWKDIENLILQGQTAYGMLKYAPFPVVGA
PAGMALGGGCEILLHCDAIQAHAETYTGLVEVGVGLIPGWGGNKEMLQRWFTLGRLPKGPMPAISKVFEIISTATVSKSA
AEAKELLFLRPTDAITMNRYRLLADAKAKALALVPDYKPPESVTFNLPGPSAATALKMAVDSFFRLGKATAYDVVVSSAL
ADVLSGGDTDITVPTDEKTLLTFEREAFSKLARQPGTLARIEHMLTTGKPLRN
>Mature_772_residues
TDIKKVAVIGAGVMGASIAAHVANAGVPVVLLDIVAKDNPNRSAIAEGALTKLLKADPAPFMSKAAAKFVTTGNIGDNLD
LLADCDWIIEAVVERLDIKQNLYAAVEAIRKPGSIVSSNTSTIPLKALVKGMPARFSKDFIITHFFNPPRYMRLLEVVGG
ENSRADAIETVTRFADVMLGKSVIFCKDRPGFIANRLGVFWLQTAVVEALDLALDIEEVDAIIGKPMGIPKTGVFGLIDL
VGLDLMPHINASLSAALPKDDPFHVVNQPMPLVEKLIAEGYTGRKGKGGFYRINREQGKQKEALDLKTGTFRPVRKPVVE
AIEQGGSKLDRLLAHESVHGRYAWQVLSRTLAYAAALVGDATDDVAAIDEAMRLGYNWKYGPFQLIDQIGVEALVTGLNA
SKFPIPAILRIAEGRPFYRVEDGRRQVLGLDGTYHDLLRPEGVIMLEDIKLKSKPVLKNSSAALWDIGDGVACFEFTSKM
NALDPDIIDLLMRSIHLVAKDFKALVIYNEGSNFSVGANLGLALFAANIAAWKDIENLILQGQTAYGMLKYAPFPVVGAP
AGMALGGGCEILLHCDAIQAHAETYTGLVEVGVGLIPGWGGNKEMLQRWFTLGRLPKGPMPAISKVFEIISTATVSKSAA
EAKELLFLRPTDAITMNRYRLLADAKAKALALVPDYKPPESVTFNLPGPSAATALKMAVDSFFRLGKATAYDVVVSSALA
DVLSGGDTDITVPTDEKTLLTFEREAFSKLARQPGTLARIEHMLTTGKPLRN

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=299, Percent_Identity=33.4448160535117, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI296179427, Length=316, Percent_Identity=32.2784810126582, Blast_Score=119, Evalue=9e-27,
Organism=Homo sapiens, GI20127408, Length=307, Percent_Identity=29.3159609120521, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI261878539, Length=250, Percent_Identity=28.8, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI68989263, Length=248, Percent_Identity=28.2258064516129, Blast_Score=86, Evalue=1e-16,
Organism=Escherichia coli, GI1787661, Length=351, Percent_Identity=29.3447293447293, Blast_Score=113, Evalue=5e-26,
Organism=Escherichia coli, GI1790281, Length=305, Percent_Identity=31.1475409836066, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI1788682, Length=224, Percent_Identity=31.25, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17553560, Length=306, Percent_Identity=33.3333333333333, Blast_Score=146, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17549919, Length=309, Percent_Identity=34.3042071197411, Blast_Score=138, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17558304, Length=411, Percent_Identity=26.7639902676399, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17563036, Length=295, Percent_Identity=29.8305084745763, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17508953, Length=304, Percent_Identity=28.9473684210526, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17508951, Length=304, Percent_Identity=28.9473684210526, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI25144276, Length=304, Percent_Identity=28.9473684210526, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71985923, Length=310, Percent_Identity=26.1290322580645, Blast_Score=88, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71985930, Length=312, Percent_Identity=25, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24583077, Length=410, Percent_Identity=26.8292682926829, Blast_Score=95, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24583079, Length=410, Percent_Identity=26.8292682926829, Blast_Score=95, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19921000, Length=410, Percent_Identity=26.8292682926829, Blast_Score=95, Evalue=2e-19,
Organism=Drosophila melanogaster, GI45549573, Length=253, Percent_Identity=26.8774703557312, Blast_Score=87, Evalue=5e-17,
Organism=Drosophila melanogaster, GI20129993, Length=251, Percent_Identity=23.9043824701195, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR001753
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N; PF00378 ECH [H]

EC number: =1.1.1.35 [H]

Molecular weight: Translated: 83367; Mature: 83236

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDIKKVAVIGAGVMGASIAAHVANAGVPVVLLDIVAKDNPNRSAIAEGALTKLLKADPA
CCCHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEEHHCCCCCHHHHHHHHHHHHHHCCCC
PFMSKAAAKFVTTGNIGDNLDLLADCDWIIEAVVERLDIKQNLYAAVEAIRKPGSIVSSN
HHHHHHHHHHEEECCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCC
TSTIPLKALVKGMPARFSKDFIITHFFNPPRYMRLLEVVGGENSRADAIETVTRFADVML
CCCCCHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
GKSVIFCKDRPGFIANRLGVFWLQTAVVEALDLALDIEEVDAIIGKPMGIPKTGVFGLID
CCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
LVGLDLMPHINASLSAALPKDDPFHVVNQPMPLVEKLIAEGYTGRKGKGGFYRINREQGK
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEHHCCC
QKEALDLKTGTFRPVRKPVVEAIEQGGSKLDRLLAHESVHGRYAWQVLSRTLAYAAALVG
CHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHC
DATDDVAAIDEAMRLGYNWKYGPFQLIDQIGVEALVTGLNASKFPIPAILRIAEGRPFYR
CCCCHHHHHHHHHHCCCCCCCCHHHHHHHHCHHHHHHCCCCCCCCHHHHHEECCCCCEEE
VEDGRRQVLGLDGTYHDLLRPEGVIMLEDIKLKSKPVLKNSSAALWDIGDGVACFEFTSK
ECCCCEEEEECCCCHHHHCCCCCEEEEECCCCCCCCCCCCCCCEEEECCCCEEHHHHHHH
MNALDPDIIDLLMRSIHLVAKDFKALVIYNEGSNFSVGANLGLALFAANIAAWKDIENLI
CCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCEEECCCCHHHHHHHHHHHHHHHHHHH
LQGQTAYGMLKYAPFPVVGAPAGMALGGGCEILLHCDAIQAHAETYTGLVEVGVGLIPGW
HCCCHHHCEEEECCCCCCCCCCCCEECCCCEEEEEECHHHHHHHHHHHHHHHCCCCCCCC
GGNKEMLQRWFTLGRLPKGPMPAISKVFEIISTATVSKSAAEAKELLFLRPTDAITMNRY
CCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEHHHH
RLLADAKAKALALVPDYKPPESVTFNLPGPSAATALKMAVDSFFRLGKATAYDVVVSSAL
HEEECCCCCEEEECCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
ADVLSGGDTDITVPTDEKTLLTFEREAFSKLARQPGTLARIEHMLTTGKPLRN
HHHHCCCCCEEEECCCCCEEEEECHHHHHHHHHCCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TDIKKVAVIGAGVMGASIAAHVANAGVPVVLLDIVAKDNPNRSAIAEGALTKLLKADPA
CCHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEEHHCCCCCHHHHHHHHHHHHHHCCCC
PFMSKAAAKFVTTGNIGDNLDLLADCDWIIEAVVERLDIKQNLYAAVEAIRKPGSIVSSN
HHHHHHHHHHEEECCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCC
TSTIPLKALVKGMPARFSKDFIITHFFNPPRYMRLLEVVGGENSRADAIETVTRFADVML
CCCCCHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
GKSVIFCKDRPGFIANRLGVFWLQTAVVEALDLALDIEEVDAIIGKPMGIPKTGVFGLID
CCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
LVGLDLMPHINASLSAALPKDDPFHVVNQPMPLVEKLIAEGYTGRKGKGGFYRINREQGK
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEHHCCC
QKEALDLKTGTFRPVRKPVVEAIEQGGSKLDRLLAHESVHGRYAWQVLSRTLAYAAALVG
CHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHC
DATDDVAAIDEAMRLGYNWKYGPFQLIDQIGVEALVTGLNASKFPIPAILRIAEGRPFYR
CCCCHHHHHHHHHHCCCCCCCCHHHHHHHHCHHHHHHCCCCCCCCHHHHHEECCCCCEEE
VEDGRRQVLGLDGTYHDLLRPEGVIMLEDIKLKSKPVLKNSSAALWDIGDGVACFEFTSK
ECCCCEEEEECCCCHHHHCCCCCEEEEECCCCCCCCCCCCCCCEEEECCCCEEHHHHHHH
MNALDPDIIDLLMRSIHLVAKDFKALVIYNEGSNFSVGANLGLALFAANIAAWKDIENLI
CCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCEEECCCCHHHHHHHHHHHHHHHHHHH
LQGQTAYGMLKYAPFPVVGAPAGMALGGGCEILLHCDAIQAHAETYTGLVEVGVGLIPGW
HCCCHHHCEEEECCCCCCCCCCCCEECCCCEEEEEECHHHHHHHHHHHHHHHCCCCCCCC
GGNKEMLQRWFTLGRLPKGPMPAISKVFEIISTATVSKSAAEAKELLFLRPTDAITMNRY
CCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEHHHH
RLLADAKAKALALVPDYKPPESVTFNLPGPSAATALKMAVDSFFRLGKATAYDVVVSSAL
HEEECCCCCEEEECCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
ADVLSGGDTDITVPTDEKTLLTFEREAFSKLARQPGTLARIEHMLTTGKPLRN
HHHHCCCCCEEEECCCCCEEEEECHHHHHHHHHCCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]