Click here to switch to the map view.

The map label for this gene is mdmC [H]

Identifier: 182678651

GI number: 182678651

Start: 1896083

End: 1896751

Strand: Direct

Name: mdmC [H]

Synonym: Bind_1677

Alternate gene names: 182678651

Gene position: 1896083-1896751 (Clockwise)

Preceding gene: 182678644

Following gene: 182678654

Centisome position: 45.47

GC content: 58.0

Gene sequence:

>669_bases
ATGAGCCAGGATCAATGGACCGCGGTCGATCATTATATCAGCGATCTTTTCATTCCTCCGGACGCTGCCTTGGAAGCGGC
TCTGACACGCAGCGCAGCAGCCGGCTTGCCCTCGATCAATGTCGCTCCCAATCAGGGCAAGCTTCTTCATATGCTGGCGA
GATTGATCGGGGCCCGCGCCATTCTCGAAATCGGGACGCTCGGCGCCTATAGCACAATCTGGCTTGCGCGGGCGCTCCCA
ACGGACGGTTTCCTGATTACACTTGAAGCCAAGCCGGAGCATGCCAAAATCGCCCAAGAGAACCTCAGGCAAGCGGGCCT
CACGTCTCAAGTCGAAGTGCGCCTTGGGCCTGCGATCGAGACCCTGCCCCAGATCGCGGCGGAAAACAAAGGGCCCTTTG
ATCTCGTCTTCATCGATGCCGACAAACAGGGCACGCCCGAATATTTTCGATGGGCCCTCGACCTTTCACGCAAGGGGAGT
CTCATCATCGTCGATAATGTCGTTCGCGGCGGAAAAGTCATCGATGCCACGAGCACAGATCCCAATGTGCAGGGGATCCA
GCGCTTCCACCAATGGGTCGCAGCCGAACCTCGTGTCAGTGCCACGGCTTTGCAGACCGTGGGGTCCAAGGGCTATGACG
GTCTCACCTTCATCGAGGTTATCAACTAG

Upstream 100 bases:

>100_bases
AGACCATAAGCTGGCAAGATCCTCTCTTTTCTCATTCCGGGGCCCATTTGGGGGTCGCATGAGGACGCGAAGGGCTTCGA
AGCGATAGCGAGAGGATGGA

Downstream 100 bases:

>100_bases
CCAACACCCGACGCGGGCACCTTCTGTGATAAGAATTGTCAGCAAAAACAAAGTGATAGAGAGTATTTTCTGATTCCGAT
GAAACAGAAAATACTCCGGG

Product: O-methyltransferase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 222; Mature: 221

Protein sequence:

>222_residues
MSQDQWTAVDHYISDLFIPPDAALEAALTRSAAAGLPSINVAPNQGKLLHMLARLIGARAILEIGTLGAYSTIWLARALP
TDGFLITLEAKPEHAKIAQENLRQAGLTSQVEVRLGPAIETLPQIAAENKGPFDLVFIDADKQGTPEYFRWALDLSRKGS
LIIVDNVVRGGKVIDATSTDPNVQGIQRFHQWVAAEPRVSATALQTVGSKGYDGLTFIEVIN

Sequences:

>Translated_222_residues
MSQDQWTAVDHYISDLFIPPDAALEAALTRSAAAGLPSINVAPNQGKLLHMLARLIGARAILEIGTLGAYSTIWLARALP
TDGFLITLEAKPEHAKIAQENLRQAGLTSQVEVRLGPAIETLPQIAAENKGPFDLVFIDADKQGTPEYFRWALDLSRKGS
LIIVDNVVRGGKVIDATSTDPNVQGIQRFHQWVAAEPRVSATALQTVGSKGYDGLTFIEVIN
>Mature_221_residues
SQDQWTAVDHYISDLFIPPDAALEAALTRSAAAGLPSINVAPNQGKLLHMLARLIGARAILEIGTLGAYSTIWLARALPT
DGFLITLEAKPEHAKIAQENLRQAGLTSQVEVRLGPAIETLPQIAAENKGPFDLVFIDADKQGTPEYFRWALDLSRKGSL
IIVDNVVRGGKVIDATSTDPNVQGIQRFHQWVAAEPRVSATALQTVGSKGYDGLTFIEVIN

Specific function: 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics [H]

COG id: COG4122

COG function: function code R; Predicted O-methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Type 3 family [H]

Homologues:

Organism=Homo sapiens, GI31542747, Length=175, Percent_Identity=34.8571428571429, Blast_Score=88, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17565612, Length=195, Percent_Identity=29.2307692307692, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI25148771, Length=197, Percent_Identity=28.4263959390863, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI72001127, Length=166, Percent_Identity=30.7228915662651, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI72001028, Length=192, Percent_Identity=27.6041666666667, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002935 [H]

Pfam domain/function: PF01596 Methyltransf_3 [H]

EC number: NA

Molecular weight: Translated: 23964; Mature: 23832

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQDQWTAVDHYISDLFIPPDAALEAALTRSAAAGLPSINVAPNQGKLLHMLARLIGARA
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
ILEIGTLGAYSTIWLARALPTDGFLITLEAKPEHAKIAQENLRQAGLTSQVEVRLGPAIE
HHHHHCCCHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCEEEEEECCHHH
TLPQIAAENKGPFDLVFIDADKQGTPEYFRWALDLSRKGSLIIVDNVVRGGKVIDATSTD
HHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCEEEECCCCC
PNVQGIQRFHQWVAAEPRVSATALQTVGSKGYDGLTFIEVIN
CCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCEEEEEEEC
>Mature Secondary Structure 
SQDQWTAVDHYISDLFIPPDAALEAALTRSAAAGLPSINVAPNQGKLLHMLARLIGARA
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
ILEIGTLGAYSTIWLARALPTDGFLITLEAKPEHAKIAQENLRQAGLTSQVEVRLGPAIE
HHHHHCCCHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCEEEEEECCHHH
TLPQIAAENKGPFDLVFIDADKQGTPEYFRWALDLSRKGSLIIVDNVVRGGKVIDATSTD
HHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCEEEECCCCC
PNVQGIQRFHQWVAAEPRVSATALQTVGSKGYDGLTFIEVIN
CCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629172 [H]