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The map label for this gene is clpA [C]

Identifier: 182678641

GI number: 182678641

Start: 1885504

End: 1887993

Strand: Reverse

Name: clpA [C]

Synonym: Bind_1667

Alternate gene names: 182678641

Gene position: 1887993-1885504 (Counterclockwise)

Preceding gene: 182678642

Following gene: 182678637

Centisome position: 45.27

GC content: 58.96

Gene sequence:

>2490_bases
ATGCCGTCCTTCTCCCGCAATTTGGAACAATCGCTTCATCGGGCTCTCGCGATCGCCAACGAGCGTCACCATGAATATGC
GACTCTTGAGCATCTCCTGCTCAGCTTGACCGATGATGCCGATGCCGCGGCTGTGCTGCGCGCCTGCTCCGTCGACCTCG
ACCTTCTGAAAAAGAACCTGCGCGATTACATCGACCAAGAACTCGATAATCTCGTGAGTGATGGCCGCGAGGATGCCAAG
CCAACGGCGGGCTTCCAGCGTGTGATCCAGCGCGCGGTCATTCATGTCCAGTCCTCCGGGCGTGAGGAAGTCACGGGCGC
CAATGTGCTGGTCGCGATCTTCGCCGAGCGCGAAAGCCATGCCGCCTATTTCCTGCAAGAGCAGGATATGACCCGCTATG
ATGCGGTGAATTACATCAGCCATGGCATTGCCAAACGGCCTGGTCTCTCCGATTCCTCCAAGGCTCCGCGTGGTGCCGAA
GAAGAGGGCGAGAACCGCGAGGGCAAGGATGGCAAGGAAGGCGAGGGCAAGAAAAAGGAAGGCGCTCTCGACGCTTATTG
CATCAACCTCAACAAAAAGGCGAAGGATGGCCGCATCGATCCTTTGATCGGTCGCGAGGCAGAGGTGCAGCGCACCATCC
AGGTCCTGTGCCGCCGTCACAAGAACAATCCCTTGCTGGTCGGTGATCCCGGCGTTGGCAAGACGGCGATCGCCGAGGGT
CTCGCCCGCAAGATCGTCAAGGGCGAGGTTCCGGAAGTCCTGGCCGAGGCCACGGTCTTTGCGCTCGACATGGGCACCTT
GCTCGCTGGCACCCGCTATCGTGGCGATTTCGAGGAACGCCTCAAGCAGGTGATGAAGGAAATCGAGACGCATAAAAAGG
CGATACTCTTCATCGATGAAATTCATACGGTGATCGGCGCGGGGGCGACCTCGGGCGGTGCGATGGACGCCTCGAATTTG
CTCAAGCCTGCCTTGGCTCAAGGTTCGCTGCGCTGCATCGGTTCGACGACCTATAAGGAATATCGTCAATATTTCGAAAA
GGACCGGGCTCTCGTCCGGCGCTTCCAGAAAATTGACGTCAACGAGCCTTCTGTTCCGGATGCCATCGAGATCATCAAGG
GCCTGAAGCCCTATTTCGAGGAATTCCACAAGATTCGCTATACGACGGAAGCCGTTAAGGCCGCTGTCGAGCTTTCGGCC
CGGTATATCCATGACCGCAAGCTGCCCGACAAAGCGATCGACGTGATCGACGAGACGGGTGCCAGCCAGATGCTCTTGCC
GGAAGGCAAGCGCAAGAAGACGATCGGCATCAAGGAAATCGAGGCGACCATTGCGACAATGGCGCGGATTCCTCCCAAAA
CCGTCTCGAAGGACGATGCCGAGGTGCTCGAGCATCTGACCGAAACGCTGGAACGCGTGGTCTATGGCCAGAACAGCGCG
ATCGAAGCCCTGACGGCAGCGATCAAACTGGCTCGTGCCGGCCTGCGCGATGGTGAGAAGCCGATCGGCTCCTATCTCTT
CTCGGGCCCGACGGGCGTCGGTAAGACGGAGGTCGCTCGCCAGCTCGCCACAAGCCTCGGCGTCGAACTCGTCCGCTTCG
ACATGTCGGAATATATGGAACGGCATACCGTGTCCCGCCTCATCGGCGCGCCTCCCGGCTATGTCGGCTTCGATCAGGGC
GGTCTCCTGACCGATTCGATCGATCAGCATCCCCATTGCGTGCTGCTGCTCGACGAAATCGAGAAGGCGCATCCAGACCT
CTACAATATCCTTTTGCAGGTCATGGATCACGGCAAGCTGACCGACCATAGCGGCAAGCAGGTCGATTTCCGCAATGTCA
TCTTGATCATGACAACCAATGCCGGCGCCGCCGACATGCAGCGTGCGGCCTATGGCTTCACGCAGAACAAGCGGGAAGGT
GAGGATCTCGAGGCGATCAACCGTCTGTTCGCCCCGGAATTCCGCAACCGTCTCGATGCGATCGTGACCTTCGGCCATCT
GCCGCCGGAAGTGATCGTCAAGGTGGTCGACAAGTTCATCATGCAGCTCGAGGCACAGCTCGCCGATCGCAATGTCACGA
TCGAGCTGACCGACGAGGCCCGCAATTGGCTTGTCGAACATGGCTATGATCAGCAGATGGGCGCCAGGCCCATGGCGCGG
GTCATTCAGCAGACGATCAAGACTCCCTTGGCTGATGAAGTCTTGTTCGGCCGGCTGAAAAATGGTGGTACGGTCAAGGT
CATGGTCACCACGGACGAGAATGGAGCCAAAAAGCTTGGCTTCCTTTATCCTGAGGGGCCGGTGCTGCCGCGTCCCGACA
AGGAAATCGTCGAGGCGAGCAAGAAGCGCGTTCGGGCCGAACCGGAAGTGCGTCGCGCCAAAGCCCGCAAGAAGACCGAG
GACGCAGGCTCGGATGATGAGCTCAACAAAATCGATCCGTCCGAGGGAGATGAATCGGAGACGGTGAGCAGCGGCGAGCC
CAAGAACTGA

Upstream 100 bases:

>100_bases
GAAGTTGCCGAGACGAAAGTAACGCAGGTGATGGATTACGCGCGCAAGCACCAGCATCCCCTGCAGTGCATCATGGAAAA
GAAATGAGAGGTTGGAGCCT

Downstream 100 bases:

>100_bases
GTCTCATGAAAGCGCGCGGGCTTCCTTAAGGGGAGCTCGCGGACAAACAAAGCCGGCGCTTGCTCAGGCAAGCGCCGGCT
TTGTATTTTTAGGCATCCAT

Product: ATP-dependent Clp protease, ATP-binding subunit clpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 829; Mature: 828

Protein sequence:

>829_residues
MPSFSRNLEQSLHRALAIANERHHEYATLEHLLLSLTDDADAAAVLRACSVDLDLLKKNLRDYIDQELDNLVSDGREDAK
PTAGFQRVIQRAVIHVQSSGREEVTGANVLVAIFAERESHAAYFLQEQDMTRYDAVNYISHGIAKRPGLSDSSKAPRGAE
EEGENREGKDGKEGEGKKKEGALDAYCINLNKKAKDGRIDPLIGREAEVQRTIQVLCRRHKNNPLLVGDPGVGKTAIAEG
LARKIVKGEVPEVLAEATVFALDMGTLLAGTRYRGDFEERLKQVMKEIETHKKAILFIDEIHTVIGAGATSGGAMDASNL
LKPALAQGSLRCIGSTTYKEYRQYFEKDRALVRRFQKIDVNEPSVPDAIEIIKGLKPYFEEFHKIRYTTEAVKAAVELSA
RYIHDRKLPDKAIDVIDETGASQMLLPEGKRKKTIGIKEIEATIATMARIPPKTVSKDDAEVLEHLTETLERVVYGQNSA
IEALTAAIKLARAGLRDGEKPIGSYLFSGPTGVGKTEVARQLATSLGVELVRFDMSEYMERHTVSRLIGAPPGYVGFDQG
GLLTDSIDQHPHCVLLLDEIEKAHPDLYNILLQVMDHGKLTDHSGKQVDFRNVILIMTTNAGAADMQRAAYGFTQNKREG
EDLEAINRLFAPEFRNRLDAIVTFGHLPPEVIVKVVDKFIMQLEAQLADRNVTIELTDEARNWLVEHGYDQQMGARPMAR
VIQQTIKTPLADEVLFGRLKNGGTVKVMVTTDENGAKKLGFLYPEGPVLPRPDKEIVEASKKRVRAEPEVRRAKARKKTE
DAGSDDELNKIDPSEGDESETVSSGEPKN

Sequences:

>Translated_829_residues
MPSFSRNLEQSLHRALAIANERHHEYATLEHLLLSLTDDADAAAVLRACSVDLDLLKKNLRDYIDQELDNLVSDGREDAK
PTAGFQRVIQRAVIHVQSSGREEVTGANVLVAIFAERESHAAYFLQEQDMTRYDAVNYISHGIAKRPGLSDSSKAPRGAE
EEGENREGKDGKEGEGKKKEGALDAYCINLNKKAKDGRIDPLIGREAEVQRTIQVLCRRHKNNPLLVGDPGVGKTAIAEG
LARKIVKGEVPEVLAEATVFALDMGTLLAGTRYRGDFEERLKQVMKEIETHKKAILFIDEIHTVIGAGATSGGAMDASNL
LKPALAQGSLRCIGSTTYKEYRQYFEKDRALVRRFQKIDVNEPSVPDAIEIIKGLKPYFEEFHKIRYTTEAVKAAVELSA
RYIHDRKLPDKAIDVIDETGASQMLLPEGKRKKTIGIKEIEATIATMARIPPKTVSKDDAEVLEHLTETLERVVYGQNSA
IEALTAAIKLARAGLRDGEKPIGSYLFSGPTGVGKTEVARQLATSLGVELVRFDMSEYMERHTVSRLIGAPPGYVGFDQG
GLLTDSIDQHPHCVLLLDEIEKAHPDLYNILLQVMDHGKLTDHSGKQVDFRNVILIMTTNAGAADMQRAAYGFTQNKREG
EDLEAINRLFAPEFRNRLDAIVTFGHLPPEVIVKVVDKFIMQLEAQLADRNVTIELTDEARNWLVEHGYDQQMGARPMAR
VIQQTIKTPLADEVLFGRLKNGGTVKVMVTTDENGAKKLGFLYPEGPVLPRPDKEIVEASKKRVRAEPEVRRAKARKKTE
DAGSDDELNKIDPSEGDESETVSSGEPKN
>Mature_828_residues
PSFSRNLEQSLHRALAIANERHHEYATLEHLLLSLTDDADAAAVLRACSVDLDLLKKNLRDYIDQELDNLVSDGREDAKP
TAGFQRVIQRAVIHVQSSGREEVTGANVLVAIFAERESHAAYFLQEQDMTRYDAVNYISHGIAKRPGLSDSSKAPRGAEE
EGENREGKDGKEGEGKKKEGALDAYCINLNKKAKDGRIDPLIGREAEVQRTIQVLCRRHKNNPLLVGDPGVGKTAIAEGL
ARKIVKGEVPEVLAEATVFALDMGTLLAGTRYRGDFEERLKQVMKEIETHKKAILFIDEIHTVIGAGATSGGAMDASNLL
KPALAQGSLRCIGSTTYKEYRQYFEKDRALVRRFQKIDVNEPSVPDAIEIIKGLKPYFEEFHKIRYTTEAVKAAVELSAR
YIHDRKLPDKAIDVIDETGASQMLLPEGKRKKTIGIKEIEATIATMARIPPKTVSKDDAEVLEHLTETLERVVYGQNSAI
EALTAAIKLARAGLRDGEKPIGSYLFSGPTGVGKTEVARQLATSLGVELVRFDMSEYMERHTVSRLIGAPPGYVGFDQGG
LLTDSIDQHPHCVLLLDEIEKAHPDLYNILLQVMDHGKLTDHSGKQVDFRNVILIMTTNAGAADMQRAAYGFTQNKREGE
DLEAINRLFAPEFRNRLDAIVTFGHLPPEVIVKVVDKFIMQLEAQLADRNVTIELTDEARNWLVEHGYDQQMGARPMARV
IQQTIKTPLADEVLFGRLKNGGTVKVMVTTDENGAKKLGFLYPEGPVLPRPDKEIVEASKKRVRAEPEVRRAKARKKTED
AGSDDELNKIDPSEGDESETVSSGEPKN

Specific function: ATP-Dependent Specificity Component Of The Clpp Protease. It Directs The Protease To Specific Substrates. The Primary Function Of The Clpa-Clpp Complex Appears To Be The Degradation Of Unfolded Or Abnormal Proteins. [C]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=343, Percent_Identity=32.9446064139942, Blast_Score=165, Evalue=2e-40,
Organism=Escherichia coli, GI1787109, Length=759, Percent_Identity=57.8392621870883, Blast_Score=903, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=242, Percent_Identity=59.504132231405, Blast_Score=293, Evalue=3e-80,
Organism=Saccharomyces cerevisiae, GI6320464, Length=318, Percent_Identity=44.9685534591195, Blast_Score=285, Evalue=2e-77,
Organism=Saccharomyces cerevisiae, GI6323002, Length=366, Percent_Identity=39.344262295082, Blast_Score=248, Evalue=3e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 91814; Mature: 91682

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSFSRNLEQSLHRALAIANERHHEYATLEHLLLSLTDDADAAAVLRACSVDLDLLKKNL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHH
RDYIDQELDNLVSDGREDAKPTAGFQRVIQRAVIHVQSSGREEVTGANVLVAIFAERESH
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCC
AAYFLQEQDMTRYDAVNYISHGIAKRPGLSDSSKAPRGAEEEGENREGKDGKEGEGKKKE
CEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GALDAYCINLNKKAKDGRIDPLIGREAEVQRTIQVLCRRHKNNPLLVGDPGVGKTAIAEG
CCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHH
LARKIVKGEVPEVLAEATVFALDMGTLLAGTRYRGDFEERLKQVMKEIETHKKAILFIDE
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IHTVIGAGATSGGAMDASNLLKPALAQGSLRCIGSTTYKEYRQYFEKDRALVRRFQKIDV
HHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCC
NEPSVPDAIEIIKGLKPYFEEFHKIRYTTEAVKAAVELSARYIHDRKLPDKAIDVIDETG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
ASQMLLPEGKRKKTIGIKEIEATIATMARIPPKTVSKDDAEVLEHLTETLERVVYGQNSA
CCCEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHH
IEALTAAIKLARAGLRDGEKPIGSYLFSGPTGVGKTEVARQLATSLGVELVRFDMSEYME
HHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RHTVSRLIGAPPGYVGFDQGGLLTDSIDQHPHCVLLLDEIEKAHPDLYNILLQVMDHGKL
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHCCHHHHHHHHHHHCCCC
TDHSGKQVDFRNVILIMTTNAGAADMQRAAYGFTQNKREGEDLEAINRLFAPEFRNRLDA
CCCCCCEEECCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHCHHHHHHHHH
IVTFGHLPPEVIVKVVDKFIMQLEAQLADRNVTIELTDEARNWLVEHGYDQQMGARPMAR
HHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHCCCCHHCCCCHHHH
VIQQTIKTPLADEVLFGRLKNGGTVKVMVTTDENGAKKLGFLYPEGPVLPRPDKEIVEAS
HHHHHHCCCHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCEECCCCCCCCCCCHHHHHHH
KKRVRAEPEVRRAKARKKTEDAGSDDELNKIDPSEGDESETVSSGEPKN
HHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PSFSRNLEQSLHRALAIANERHHEYATLEHLLLSLTDDADAAAVLRACSVDLDLLKKNL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHH
RDYIDQELDNLVSDGREDAKPTAGFQRVIQRAVIHVQSSGREEVTGANVLVAIFAERESH
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCC
AAYFLQEQDMTRYDAVNYISHGIAKRPGLSDSSKAPRGAEEEGENREGKDGKEGEGKKKE
CEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GALDAYCINLNKKAKDGRIDPLIGREAEVQRTIQVLCRRHKNNPLLVGDPGVGKTAIAEG
CCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHH
LARKIVKGEVPEVLAEATVFALDMGTLLAGTRYRGDFEERLKQVMKEIETHKKAILFIDE
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IHTVIGAGATSGGAMDASNLLKPALAQGSLRCIGSTTYKEYRQYFEKDRALVRRFQKIDV
HHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCC
NEPSVPDAIEIIKGLKPYFEEFHKIRYTTEAVKAAVELSARYIHDRKLPDKAIDVIDETG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
ASQMLLPEGKRKKTIGIKEIEATIATMARIPPKTVSKDDAEVLEHLTETLERVVYGQNSA
CCCEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHH
IEALTAAIKLARAGLRDGEKPIGSYLFSGPTGVGKTEVARQLATSLGVELVRFDMSEYME
HHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RHTVSRLIGAPPGYVGFDQGGLLTDSIDQHPHCVLLLDEIEKAHPDLYNILLQVMDHGKL
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHCCHHHHHHHHHHHCCCC
TDHSGKQVDFRNVILIMTTNAGAADMQRAAYGFTQNKREGEDLEAINRLFAPEFRNRLDA
CCCCCCEEECCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHCHHHHHHHHH
IVTFGHLPPEVIVKVVDKFIMQLEAQLADRNVTIELTDEARNWLVEHGYDQQMGARPMAR
HHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHCCCCHHCCCCHHHH
VIQQTIKTPLADEVLFGRLKNGGTVKVMVTTDENGAKKLGFLYPEGPVLPRPDKEIVEAS
HHHHHHCCCHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCEECCCCCCCCCCCHHHHHHH
KKRVRAEPEVRRAKARKKTEDAGSDDELNKIDPSEGDESETVSSGEPKN
HHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6209404 [H]