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The map label for this gene is hisI [H]

Identifier: 182678554

GI number: 182678554

Start: 1781250

End: 1781708

Strand: Direct

Name: hisI [H]

Synonym: Bind_1579

Alternate gene names: 182678554

Gene position: 1781250-1781708 (Clockwise)

Preceding gene: 182678551

Following gene: 182678562

Centisome position: 42.71

GC content: 57.95

Gene sequence:

>459_bases
ATGACAATGCCGGCGGCGGTTTTCCCCAGCGCAGACAGCAAGGCGGACCTTGAGGAAGGGACGAGGTTCACGCCGCGTTT
CGACAAGGATGGTCTGATCACCTGTGTGACATTGGACGTGCGTGACGGCCAGATCCTGATGCTCGCCCATATGAATGCCG
AATCGCTCCGGCTCACGCTGGAAACGGGAGAGGCCTATTATTGGTCACGCTCACGGCAAAAATTGTGGCGCAAGGGTGAG
ACCTCTGGTCAGATTCAGAAGGTTAAGGCGATTCACACCGATTGTGACCAGGACGCGCTGCTTCTCAGCGTCGAGCCCGG
CGGCGATGGCGGAGCTTGTCATACGGGGCGGAGAAGTTGTTTCTATCGCCGCGTCATCGCGGGTGAGAAAGGAACCGGGC
TAGTTTTCGAGGAGGAGACCACAGCCGATGTTTCAGCAAAAGAGCATCCCGCTCACTGA

Upstream 100 bases:

>100_bases
CCTTGACCTTACACTGTTTCCGACACGCCCATTTTGCTCTATCTTTTAAGCTGGATTATAAAATCCAGTAAAATCAATCA
TTCGTAGTGACAGGCTCAAG

Downstream 100 bases:

>100_bases
CCGGCCTGTATCAGTCCAAGGTGCGACGAAACGGGCATGAAGCCGTTGAAAAATTCGCTTGGACATTGAATTGAAAAAAG
TGGGCAAACGTGTCCAGGCT

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH [H]

Number of amino acids: Translated: 152; Mature: 151

Protein sequence:

>152_residues
MTMPAAVFPSADSKADLEEGTRFTPRFDKDGLITCVTLDVRDGQILMLAHMNAESLRLTLETGEAYYWSRSRQKLWRKGE
TSGQIQKVKAIHTDCDQDALLLSVEPGGDGGACHTGRRSCFYRRVIAGEKGTGLVFEEETTADVSAKEHPAH

Sequences:

>Translated_152_residues
MTMPAAVFPSADSKADLEEGTRFTPRFDKDGLITCVTLDVRDGQILMLAHMNAESLRLTLETGEAYYWSRSRQKLWRKGE
TSGQIQKVKAIHTDCDQDALLLSVEPGGDGGACHTGRRSCFYRRVIAGEKGTGLVFEEETTADVSAKEHPAH
>Mature_151_residues
TMPAAVFPSADSKADLEEGTRFTPRFDKDGLITCVTLDVRDGQILMLAHMNAESLRLTLETGEAYYWSRSRQKLWRKGET
SGQIQKVKAIHTDCDQDALLLSVEPGGDGGACHTGRRSCFYRRVIAGEKGTGLVFEEETTADVSAKEHPAH

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=92, Percent_Identity=45.6521739130435, Blast_Score=89, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319819, Length=111, Percent_Identity=41.4414414414414, Blast_Score=70, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH [H]

EC number: =3.5.4.19 [H]

Molecular weight: Translated: 16760; Mature: 16629

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMPAAVFPSADSKADLEEGTRFTPRFDKDGLITCVTLDVRDGQILMLAHMNAESLRLTL
CCCCCCCCCCCCCCCCCCCCCEECCCCCCCCEEEEEEEEECCCCEEEEEECCCCCEEEEE
ETGEAYYWSRSRQKLWRKGETSGQIQKVKAIHTDCDQDALLLSVEPGGDGGACHTGRRSC
ECCCEEEEEHHHHHHHHCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCHHH
FYRRVIAGEKGTGLVFEEETTADVSAKEHPAH
HHHHHHCCCCCCCEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
TMPAAVFPSADSKADLEEGTRFTPRFDKDGLITCVTLDVRDGQILMLAHMNAESLRLTL
CCCCCCCCCCCCCCCCCCCCEECCCCCCCCEEEEEEEEECCCCEEEEEECCCCCEEEEE
ETGEAYYWSRSRQKLWRKGETSGQIQKVKAIHTDCDQDALLLSVEPGGDGGACHTGRRSC
ECCCEEEEEHHHHHHHHCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCHHH
FYRRVIAGEKGTGLVFEEETTADVSAKEHPAH
HHHHHHCCCCCCCEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA