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The map label for this gene is thyA [H]

Identifier: 182678521

GI number: 182678521

Start: 1747828

End: 1748856

Strand: Reverse

Name: thyA [H]

Synonym: Bind_1545

Alternate gene names: 182678521

Gene position: 1748856-1747828 (Counterclockwise)

Preceding gene: 182678525

Following gene: 182678520

Centisome position: 41.94

GC content: 57.34

Gene sequence:

>1029_bases
GTGGAAATCGAAAAAGAATGTCTCGATGCAATCCTTTATAACCTCTACTGGTCAATAAAGGAACATGGGCGGACCAATGC
AGGTAGTCGCGGAAACACGGTCGAGCTGCTCGGGGTTGCCCTCCGAATCCTCAAGCCGAGGGCGAGAATTAGTCGTTCGG
AGAATCGCGGAAAACCGTTCAGCGCCATCGGCGAGTTGCTTTGGTACCTATCCGGTTTGGACACCTTGGCCTTCATCGAG
CCCTATGTCAGCGCATATCGGGACGATGCAGTAGCTGGCGTGATTCAGGGTGCTTATGGGCCGCGCCTTCGTGCGATGCG
GGATGGCATCGACCAGTTTGCCAGTATCGAGACGCTTCTGAGGCAGAAGCCAAATTCCCGACGAGCGGTGATCCAGCTCT
TCAACGCCGAGGACATCGCGACCGAACACAAGGAGATCCCTTGCACGACGACGTTGCAGTTCCATCTTCGCGACGGGCTG
CTGCACATGTCGGTGACCATGCGCTCCAACGACGCTTACTGGGGTCTGCCGCACGACGTGTTCTGCTTCACCATGATTCA
GGAGATGATGGCGCGCCGGCTGGGCGTCGAGCTCGGCGAATACTATCACTATGTCGGCAGCATGCACGTCTATGAGAAGC
ATCTCAACCATCTGGACAATTATCTCGTCGAGGGCTTCCAGCGCACCGCAGAGATGCCCCCGATGCCTGCGGGCGACCCA
TTTCAGCTCGTCGATCACCTTCTGTCGATCGAGGGCCGTCTCCGGCGGGGCGATGATCTCAATGCCGGGTCCGAGATATC
TGATCCATATTGGGCGGATATCGTTCGGTTAATGCAGGTCTTCTGGGCACGGGAATTTGCCCATGACCATCCGGCGAGGC
TGATGGAGCTACGGGCACAACTCGAAACGTCGTTCTACAAGCCGTATGTGGACGGAAGGCTGCATCTGGAAGCTCGTGTG
CCTATAAGGCATGGCGATCCCGCAACCACCAAGGAAGGGGAAAGCCATGTGGCCGTCGAGGCACGCTGA

Upstream 100 bases:

>100_bases
GCCGCTTCGCTATCCAGGCTAGTTGACACCAACAACTATAGCAGCAAAGGTTAGCCCTGAAGAATGCGGCCGGGGGCGCC
GTATTCATTGGCGACGCCAC

Downstream 100 bases:

>100_bases
ACACCAGCGGATCGCAACCGAGCTGGCGAACGCCAGGGCGGCCCTCGGGCTTCAGGGGCTCCCCGACCAAGCGACCATTG
ACACGCTCGCTATGCAGTTC

Product: thymidylate synthase

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MEIEKECLDAILYNLYWSIKEHGRTNAGSRGNTVELLGVALRILKPRARISRSENRGKPFSAIGELLWYLSGLDTLAFIE
PYVSAYRDDAVAGVIQGAYGPRLRAMRDGIDQFASIETLLRQKPNSRRAVIQLFNAEDIATEHKEIPCTTTLQFHLRDGL
LHMSVTMRSNDAYWGLPHDVFCFTMIQEMMARRLGVELGEYYHYVGSMHVYEKHLNHLDNYLVEGFQRTAEMPPMPAGDP
FQLVDHLLSIEGRLRRGDDLNAGSEISDPYWADIVRLMQVFWAREFAHDHPARLMELRAQLETSFYKPYVDGRLHLEARV
PIRHGDPATTKEGESHVAVEAR

Sequences:

>Translated_342_residues
MEIEKECLDAILYNLYWSIKEHGRTNAGSRGNTVELLGVALRILKPRARISRSENRGKPFSAIGELLWYLSGLDTLAFIE
PYVSAYRDDAVAGVIQGAYGPRLRAMRDGIDQFASIETLLRQKPNSRRAVIQLFNAEDIATEHKEIPCTTTLQFHLRDGL
LHMSVTMRSNDAYWGLPHDVFCFTMIQEMMARRLGVELGEYYHYVGSMHVYEKHLNHLDNYLVEGFQRTAEMPPMPAGDP
FQLVDHLLSIEGRLRRGDDLNAGSEISDPYWADIVRLMQVFWAREFAHDHPARLMELRAQLETSFYKPYVDGRLHLEARV
PIRHGDPATTKEGESHVAVEAR
>Mature_342_residues
MEIEKECLDAILYNLYWSIKEHGRTNAGSRGNTVELLGVALRILKPRARISRSENRGKPFSAIGELLWYLSGLDTLAFIE
PYVSAYRDDAVAGVIQGAYGPRLRAMRDGIDQFASIETLLRQKPNSRRAVIQLFNAEDIATEHKEIPCTTTLQFHLRDGL
LHMSVTMRSNDAYWGLPHDVFCFTMIQEMMARRLGVELGEYYHYVGSMHVYEKHLNHLDNYLVEGFQRTAEMPPMPAGDP
FQLVDHLLSIEGRLRRGDDLNAGSEISDPYWADIVRLMQVFWAREFAHDHPARLMELRAQLETSFYKPYVDGRLHLEARV
PIRHGDPATTKEGESHVAVEAR

Specific function: Provides the sole de novo source of dTMP for DNA biosynthesis [H]

COG id: COG0207

COG function: function code F; Thymidylate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate synthase family. Bacterial- type thyA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789191, Length=204, Percent_Identity=27.9411764705882, Blast_Score=83, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71993377, Length=110, Percent_Identity=30, Blast_Score=71, Evalue=9e-13,

Paralogues:

None

Copy number: 391 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000398
- InterPro:   IPR020940 [H]

Pfam domain/function: PF00303 Thymidylat_synt [H]

EC number: =2.1.1.45 [H]

Molecular weight: Translated: 39141; Mature: 39141

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIEKECLDAILYNLYWSIKEHGRTNAGSRGNTVELLGVALRILKPRARISRSENRGKPF
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCHHHHCCCCCCCCCH
SAIGELLWYLSGLDTLAFIEPYVSAYRDDAVAGVIQGAYGPRLRAMRDGIDQFASIETLL
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
RQKPNSRRAVIQLFNAEDIATEHKEIPCTTTLQFHLRDGLLHMSVTMRSNDAYWGLPHDV
HCCCCCCCHHHEECCCHHHHHHCCCCCCCCEEEHHHHCCEEEEEEEEECCCCCCCCCHHH
FCFTMIQEMMARRLGVELGEYYHYVGSMHVYEKHLNHLDNYLVEGFQRTAEMPPMPAGDP
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
FQLVDHLLSIEGRLRRGDDLNAGSEISDPYWADIVRLMQVFWAREFAHDHPARLMELRAQ
HHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LETSFYKPYVDGRLHLEARVPIRHGDPATTKEGESHVAVEAR
HHHHHCCCCCCCEEEEEEECCEECCCCCCCCCCCCCEEEECC
>Mature Secondary Structure
MEIEKECLDAILYNLYWSIKEHGRTNAGSRGNTVELLGVALRILKPRARISRSENRGKPF
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCHHHHCCCCCCCCCH
SAIGELLWYLSGLDTLAFIEPYVSAYRDDAVAGVIQGAYGPRLRAMRDGIDQFASIETLL
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
RQKPNSRRAVIQLFNAEDIATEHKEIPCTTTLQFHLRDGLLHMSVTMRSNDAYWGLPHDV
HCCCCCCCHHHEECCCHHHHHHCCCCCCCCEEEHHHHCCEEEEEEEEECCCCCCCCCHHH
FCFTMIQEMMARRLGVELGEYYHYVGSMHVYEKHLNHLDNYLVEGFQRTAEMPPMPAGDP
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
FQLVDHLLSIEGRLRRGDDLNAGSEISDPYWADIVRLMQVFWAREFAHDHPARLMELRAQ
HHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LETSFYKPYVDGRLHLEARVPIRHGDPATTKEGESHVAVEAR
HHHHHCCCCCCCEEEEEEECCEECCCCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA