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The map label for this gene is mazG [H]

Identifier: 182678503

GI number: 182678503

Start: 1728847

End: 1729755

Strand: Reverse

Name: mazG [H]

Synonym: Bind_1527

Alternate gene names: 182678503

Gene position: 1729755-1728847 (Counterclockwise)

Preceding gene: 182678504

Following gene: 182678492

Centisome position: 41.48

GC content: 57.43

Gene sequence:

>909_bases
GTGCCATGCGGTCCCTCCATTCTCAAAAGAATCAAAAACTCCCGCCTCAAATCTGCGCCGCCGCAGTCCGGTCCTCCCGT
GCCCATGCAACCTTCCCGGGATATTCGGCATCTCCTTGAGATCATGAATGCCTTGCGCTCACCCGAAACGGGATGTGCCT
GGGATCGCCAGCAGACCTATGCCACCATCGCGCCTTATACGATCGAGGAAGCCTATGAAGTGGCTGATGCGATCACCCGC
GAGGATCGTGCCGATCTTCGCGACGAATTAGGAGACCTCCTCTTTCAGGTCGTCTTCCATAGCCGTCTTGCCGAAGAAGA
AGGCGCTTTCGATTTTGGCGGTGTCGTCGAGGCCATCACCGCCAAAATGATCCGCCGTCATCCGCATGTGTTCGGAGCGG
AGCGGGAAAACTCGCCAGAAGCCATCAAAGCCCAATGGCAGAAGATCAAGGCTGAGGAACAAGCCGAGAAACAGGCCAGA
CAGGGCCTGGAAGCAAGCCGCCCCAAAAGCCTGCTCGACGATGTGCCCCTGCCCCTGCCCGGCCTGACCCGCTCGGTCAA
ACTGCAGAACAAGGCGGCACATGTTGGCTTTGATTGGGCGGATGCGCGCCTCGTTCTCGCCAAGGTGCGCGAGGAAACAC
GGGAAATAGAAGAAGCGATCGCCAGCGGGCAGGCTGAGGAGATCCATGCCGAAATTGGCGATCTTCTTTTCACCATCGCC
AATCTCGCACGTCATCTCAATGTCGATCCAGAAGCGGCGATCCGTTCGACGAATGCAAAATTCGAGCGCCGTTTCGCTTT
CATCGAAACGGCGCTGAGAGAGCAAGGCAAAACGCTGGAAGAGGCGAACCTGGCCGAAATGGATGCCCTATGGCAACAGG
CCAAGGAAAGCGAGAAATCAGGCGGTTAA

Upstream 100 bases:

>100_bases
CGCCGAGGGCCAGGCCGTGACCATGCGTGTCGTCGATACGCCCAAGGGACGTGAAGCCCTGTCGATCTCCCTCGACTAAA
AAGCATCATAATGGAGGGCC

Downstream 100 bases:

>100_bases
ACCTTCCCGCTCGACCAGCATCGCGCCAAAGCGCCGCTTGATCGGCTCAGCTCGTTCCGGCGCCACCCTCACTGAGACAT
GGATGGTGCCATCCTCATCA

Product: MazG family protein

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MPCGPSILKRIKNSRLKSAPPQSGPPVPMQPSRDIRHLLEIMNALRSPETGCAWDRQQTYATIAPYTIEEAYEVADAITR
EDRADLRDELGDLLFQVVFHSRLAEEEGAFDFGGVVEAITAKMIRRHPHVFGAERENSPEAIKAQWQKIKAEEQAEKQAR
QGLEASRPKSLLDDVPLPLPGLTRSVKLQNKAAHVGFDWADARLVLAKVREETREIEEAIASGQAEEIHAEIGDLLFTIA
NLARHLNVDPEAAIRSTNAKFERRFAFIETALREQGKTLEEANLAEMDALWQQAKESEKSGG

Sequences:

>Translated_302_residues
MPCGPSILKRIKNSRLKSAPPQSGPPVPMQPSRDIRHLLEIMNALRSPETGCAWDRQQTYATIAPYTIEEAYEVADAITR
EDRADLRDELGDLLFQVVFHSRLAEEEGAFDFGGVVEAITAKMIRRHPHVFGAERENSPEAIKAQWQKIKAEEQAEKQAR
QGLEASRPKSLLDDVPLPLPGLTRSVKLQNKAAHVGFDWADARLVLAKVREETREIEEAIASGQAEEIHAEIGDLLFTIA
NLARHLNVDPEAAIRSTNAKFERRFAFIETALREQGKTLEEANLAEMDALWQQAKESEKSGG
>Mature_301_residues
PCGPSILKRIKNSRLKSAPPQSGPPVPMQPSRDIRHLLEIMNALRSPETGCAWDRQQTYATIAPYTIEEAYEVADAITRE
DRADLRDELGDLLFQVVFHSRLAEEEGAFDFGGVVEAITAKMIRRHPHVFGAERENSPEAIKAQWQKIKAEEQAEKQARQ
GLEASRPKSLLDDVPLPLPGLTRSVKLQNKAAHVGFDWADARLVLAKVREETREIEEAIASGQAEEIHAEIGDLLFTIAN
LARHLNVDPEAAIRSTNAKFERRFAFIETALREQGKTLEEANLAEMDALWQQAKESEKSGG

Specific function: Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazEF toxin- antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp p

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=267, Percent_Identity=49.063670411985, Blast_Score=243, Evalue=2e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518
- InterPro:   IPR011551 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 33733; Mature: 33602

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPCGPSILKRIKNSRLKSAPPQSGPPVPMQPSRDIRHLLEIMNALRSPETGCAWDRQQTY
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCH
ATIAPYTIEEAYEVADAITREDRADLRDELGDLLFQVVFHSRLAEEEGAFDFGGVVEAIT
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
AKMIRRHPHVFGAERENSPEAIKAQWQKIKAEEQAEKQARQGLEASRPKSLLDDVPLPLP
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCC
GLTRSVKLQNKAAHVGFDWADARLVLAKVREETREIEEAIASGQAEEIHAEIGDLLFTIA
CCCHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
NLARHLNVDPEAAIRSTNAKFERRFAFIETALREQGKTLEEANLAEMDALWQQAKESEKS
HHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCC
GG
CC
>Mature Secondary Structure 
PCGPSILKRIKNSRLKSAPPQSGPPVPMQPSRDIRHLLEIMNALRSPETGCAWDRQQTY
CCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCH
ATIAPYTIEEAYEVADAITREDRADLRDELGDLLFQVVFHSRLAEEEGAFDFGGVVEAIT
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
AKMIRRHPHVFGAERENSPEAIKAQWQKIKAEEQAEKQARQGLEASRPKSLLDDVPLPLP
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCC
GLTRSVKLQNKAAHVGFDWADARLVLAKVREETREIEEAIASGQAEEIHAEIGDLLFTIA
CCCHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
NLARHLNVDPEAAIRSTNAKFERRFAFIETALREQGKTLEEANLAEMDALWQQAKESEKS
HHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCC
GG
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]