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The map label for this gene is pdhA [H]

Identifier: 182678481

GI number: 182678481

Start: 1704815

End: 1705852

Strand: Direct

Name: pdhA [H]

Synonym: Bind_1505

Alternate gene names: 182678481

Gene position: 1704815-1705852 (Clockwise)

Preceding gene: 182678480

Following gene: 182678482

Centisome position: 40.88

GC content: 60.02

Gene sequence:

>1038_bases
ATGGCCGCAGCCCCCCCGACCAGCCGCGCCAAACCCACTGCTGGTAAACCGAGATCCGCTTCCAATACGCCGGAATTCAC
GCCCGAAGAGGAGCGTTACGCTTATCGCTCCATGCTGCTCATGCGGCGTTTCGAGGAAAAGGCCGGCCAGATGTATGGCA
TGGGCCTGATCGGCGGTTTCTGCCATCTCTACATCGGGCAAGAAGCCGTGGTGACCGGCATCATGATGGCCGCCAAGGAA
GGTGATCAAACCATCACCTCCTATCGCGACCATGCCCATATGCTTGCCTGTGGCCTTGATCCCAAGGGGGTTCTGGCGGA
ACTGACGGGACGCCGGCATGGCCTTTCAAAAGGCAAGGGCGGCTCCATGCATATGTTCTCGCGCGAGAAACATTTCTACG
GCGGCCACGGCATCGTCGGTGCCCAGGTACCGCTCGGGACGGGGCTCGCCTTCGCCAATTGGTATCGTGGCAACGATAAT
GTGTCCTTCGTCTATTTCGGTGACGGCGCGGCCAACCAGGGCCAGGTCTACGAGAGCTTCAACATGGCCGAGCTGTGGAA
GCTGCCTGTCGTCTATGTCATCGAAAACAACCGTTATGCCATGGGCACGTCGGTGACGCGGTCCTCGGCCCTGACCGATT
TTTCCAAACGCGGCCAGTCCTTCAATATTCCGGGCGAGCAGGTCGATGGCATGGATGTGCGGGCTGTCCGCGCGGCGACT
GAACATGCGGTCGAATGGTGCCGTGGCGGCAATGGGCCGATCATCCTCGAGATGCAGACCTATCGCTATCGCGGCCATTC
CATGTCCGATCCCGCGAAATACCGCAGCAAGGAAGAAGTCCAGAAGATGCGCGAGGAGCATGACCCGATCGAACAGGTCA
AGGCTCGGCTGCTGGGCGGCAATCTCGCCACCGAGGATGAACTGAAAGCCATCGATGCCGAAGTGCGTGCAATCGTCGCC
GAGGCGGCTGATTTCGCGACGCAGGACCCCGAGCCCGATGTGTCTGAATTGTGGACTGATATTCTGGTCGAGGGCTGA

Upstream 100 bases:

>100_bases
GGCTTGGCGGGACTCGATTTCGCCAAGGGCTGAAGTATTCTTTTCTCAGTCCACAGCCTTTCGAGGCATGTTCCTTTCGC
TGCATCAACGAGGCTCGATT

Downstream 100 bases:

>100_bases
GCTCTGCCTGTCTCGATAGAAGTGTCCTTGCCGTTGATGCCTCGCGCGGCCATGAGTGCCCTGCCGCAAGAGGTTTGCTT
CTTTCAGATCTTCGTGGGTC

Product: pyruvate dehydrogenase E1 component subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MAAAPPTSRAKPTAGKPRSASNTPEFTPEEERYAYRSMLLMRRFEEKAGQMYGMGLIGGFCHLYIGQEAVVTGIMMAAKE
GDQTITSYRDHAHMLACGLDPKGVLAELTGRRHGLSKGKGGSMHMFSREKHFYGGHGIVGAQVPLGTGLAFANWYRGNDN
VSFVYFGDGAANQGQVYESFNMAELWKLPVVYVIENNRYAMGTSVTRSSALTDFSKRGQSFNIPGEQVDGMDVRAVRAAT
EHAVEWCRGGNGPIILEMQTYRYRGHSMSDPAKYRSKEEVQKMREEHDPIEQVKARLLGGNLATEDELKAIDAEVRAIVA
EAADFATQDPEPDVSELWTDILVEG

Sequences:

>Translated_345_residues
MAAAPPTSRAKPTAGKPRSASNTPEFTPEEERYAYRSMLLMRRFEEKAGQMYGMGLIGGFCHLYIGQEAVVTGIMMAAKE
GDQTITSYRDHAHMLACGLDPKGVLAELTGRRHGLSKGKGGSMHMFSREKHFYGGHGIVGAQVPLGTGLAFANWYRGNDN
VSFVYFGDGAANQGQVYESFNMAELWKLPVVYVIENNRYAMGTSVTRSSALTDFSKRGQSFNIPGEQVDGMDVRAVRAAT
EHAVEWCRGGNGPIILEMQTYRYRGHSMSDPAKYRSKEEVQKMREEHDPIEQVKARLLGGNLATEDELKAIDAEVRAIVA
EAADFATQDPEPDVSELWTDILVEG
>Mature_344_residues
AAAPPTSRAKPTAGKPRSASNTPEFTPEEERYAYRSMLLMRRFEEKAGQMYGMGLIGGFCHLYIGQEAVVTGIMMAAKEG
DQTITSYRDHAHMLACGLDPKGVLAELTGRRHGLSKGKGGSMHMFSREKHFYGGHGIVGAQVPLGTGLAFANWYRGNDNV
SFVYFGDGAANQGQVYESFNMAELWKLPVVYVIENNRYAMGTSVTRSSALTDFSKRGQSFNIPGEQVDGMDVRAVRAATE
HAVEWCRGGNGPIILEMQTYRYRGHSMSDPAKYRSKEEVQKMREEHDPIEQVKARLLGGNLATEDELKAIDAEVRAIVAE
AADFATQDPEPDVSELWTDILVEG

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=316, Percent_Identity=54.4303797468354, Blast_Score=342, Evalue=3e-94,
Organism=Homo sapiens, GI4505685, Length=316, Percent_Identity=54.1139240506329, Blast_Score=327, Evalue=1e-89,
Organism=Homo sapiens, GI291084742, Length=316, Percent_Identity=54.1139240506329, Blast_Score=326, Evalue=2e-89,
Organism=Homo sapiens, GI291084744, Length=323, Percent_Identity=52.9411764705882, Blast_Score=319, Evalue=2e-87,
Organism=Homo sapiens, GI291084757, Length=316, Percent_Identity=48.4177215189873, Blast_Score=272, Evalue=3e-73,
Organism=Homo sapiens, GI11386135, Length=340, Percent_Identity=28.2352941176471, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI258645172, Length=340, Percent_Identity=28.8235294117647, Blast_Score=128, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17536047, Length=308, Percent_Identity=53.5714285714286, Blast_Score=315, Evalue=3e-86,
Organism=Caenorhabditis elegans, GI32564172, Length=308, Percent_Identity=53.5714285714286, Blast_Score=314, Evalue=3e-86,
Organism=Caenorhabditis elegans, GI86563357, Length=343, Percent_Identity=26.530612244898, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI86563355, Length=343, Percent_Identity=26.530612244898, Blast_Score=115, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6321026, Length=314, Percent_Identity=51.9108280254777, Blast_Score=326, Evalue=4e-90,
Organism=Drosophila melanogaster, GI24639744, Length=318, Percent_Identity=50.9433962264151, Blast_Score=320, Evalue=7e-88,
Organism=Drosophila melanogaster, GI28571106, Length=318, Percent_Identity=50.9433962264151, Blast_Score=320, Evalue=7e-88,
Organism=Drosophila melanogaster, GI24639740, Length=318, Percent_Identity=50.9433962264151, Blast_Score=320, Evalue=8e-88,
Organism=Drosophila melanogaster, GI24639746, Length=305, Percent_Identity=52.4590163934426, Blast_Score=316, Evalue=1e-86,
Organism=Drosophila melanogaster, GI24639748, Length=318, Percent_Identity=52.8301886792453, Blast_Score=314, Evalue=7e-86,
Organism=Drosophila melanogaster, GI21355903, Length=345, Percent_Identity=25.5072463768116, Blast_Score=101, Evalue=7e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 38015; Mature: 37884

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAAPPTSRAKPTAGKPRSASNTPEFTPEEERYAYRSMLLMRRFEEKAGQMYGMGLIGGF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEECHHHHHHH
CHLYIGQEAVVTGIMMAAKEGDQTITSYRDHAHMLACGLDPKGVLAELTGRRHGLSKGKG
HHHHCCHHHHHHHHHHHHCCCCHHHHHHHHCCEEEEECCCCCHHHHHHHCCCCCCCCCCC
GSMHMFSREKHFYGGHGIVGAQVPLGTGLAFANWYRGNDNVSFVYFGDGAANQGQVYESF
CCEEEEECCCCEECCCCEEECCCCCCCCCEEHEEEECCCCEEEEEECCCCCCCCCHHHCC
NMAELWKLPVVYVIENNRYAMGTSVTRSSALTDFSKRGQSFNIPGEQVDGMDVRAVRAAT
CHHHHHCCCEEEEEECCEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHH
EHAVEWCRGGNGPIILEMQTYRYRGHSMSDPAKYRSKEEVQKMREEHDPIEQVKARLLGG
HHHHHHHHCCCCCEEEEEEEEEECCCCCCCHHHHCCHHHHHHHHHHCCHHHHHHHHHHCC
NLATEDELKAIDAEVRAIVAEAADFATQDPEPDVSELWTDILVEG
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
AAAPPTSRAKPTAGKPRSASNTPEFTPEEERYAYRSMLLMRRFEEKAGQMYGMGLIGGF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEECHHHHHHH
CHLYIGQEAVVTGIMMAAKEGDQTITSYRDHAHMLACGLDPKGVLAELTGRRHGLSKGKG
HHHHCCHHHHHHHHHHHHCCCCHHHHHHHHCCEEEEECCCCCHHHHHHHCCCCCCCCCCC
GSMHMFSREKHFYGGHGIVGAQVPLGTGLAFANWYRGNDNVSFVYFGDGAANQGQVYESF
CCEEEEECCCCEECCCCEEECCCCCCCCCEEHEEEECCCCEEEEEECCCCCCCCCHHHCC
NMAELWKLPVVYVIENNRYAMGTSVTRSSALTDFSKRGQSFNIPGEQVDGMDVRAVRAAT
CHHHHHCCCEEEEEECCEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHH
EHAVEWCRGGNGPIILEMQTYRYRGHSMSDPAKYRSKEEVQKMREEHDPIEQVKARLLGG
HHHHHHHHCCCCCEEEEEEEEEECCCCCCCHHHHCCHHHHHHHHHHCCHHHHHHHHHHCC
NLATEDELKAIDAEVRAIVAEAADFATQDPEPDVSELWTDILVEG
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10796014; 11481430 [H]