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The map label for this gene is moeA [H]

Identifier: 182678401

GI number: 182678401

Start: 1630271

End: 1631551

Strand: Direct

Name: moeA [H]

Synonym: Bind_1418

Alternate gene names: 182678401

Gene position: 1630271-1631551 (Clockwise)

Preceding gene: 182678400

Following gene: 182678402

Centisome position: 39.09

GC content: 62.92

Gene sequence:

>1281_bases
ATGAACGCGGTTGCCCCGCACAAAAATGCAGGTCCTGTTAAAACGGACCAACCGAAACCGGCCCTGTCCGTCGCTGAGGC
GCGCCGGACGATTTTGACGAGCGTCGCCCTGCCGCGCGCCGTCGAAACCGTGGCCCTTGCCGAAGCGCATGGCCGCACAT
TGGCCGCGCCTCTTGCCGCCAAGCGCACGCAGCCGCCCTTCGCCGCTTCGGCGATGGATGGCTATGCGATCCGCGCTGAC
GATCTGCACAGTGCTCGCGCGCCGGTCAAACTCACGCTCATCGGTGAAAGCGCGGCGGGCCATGGTTTTGCCGGCACAGT
CGGGCCTATGGAGACCGTGCGGATCTTTACCGGTGCTCCGGTGCCGGAAGGCACCGATACGATCCTCATCCAGGAATTGG
TGACAATCGAGGATGGTTTGATCCTGCCGCAAAAGACACCGCCGCGTGGCCGCTACATTCGCGAGGCGGGTCTCGATTTT
CAGGAAGGGGAGATTCTGCTTCCGGAGGGGCGCCGCTTGAGCGCTGCCGATCTCGCTTTGGCGGCGGCGATGAACCACGC
TGTCGTGCCGGTGACGAAACAGCCGCGTGTTGGCATTCTCGCGACGGGCGATGAATTGGTGCGGCCGGGCGAGGCGCTCG
GACCCTCGCAGATCGTCTCTTCCAATTCCTACGCTATTGCGGCGCAGGTGCGTGCCGCCGGCGGTCTGCCCGTCGATCTT
GGCATTGCGGGGGATAATGCCATAGCGCTTGCGCAAGGCATTGCCGCGGCCCGCATGCTCAAGGTCGATGTGCTGGTGAT
CTCGGGCGGCGTGTCCGTCGGTGATTACGATCTCGTGCGCAAGGCTTTGTTGCAGGAAGGCATGGAATTGAGCTTCTGGC
GCATCGCCATGCGTCCCGGACGGCCGCTCATTCATGGCATGCTGGGAGATATGGCGATTTTGGGTCTGCCGGGTAATCCG
GTCGCCGCGCTCGTCTGCGGCCTGCTGTTTTTGACACCCCTTGTGCGTATTTTGGATGGAGAGGCTGGCGTGCTCGAAGC
CGATCCGAGCGAACCGGCGCTTCTTGCCGAGGCGCTTCCCGAAAACGATGCGCGCGAGGATTTCTTGCGGGCCACTTATG
TGCGGACAGACAATGGTCTGCCGTCCGTCACACCCTTTGCGGCGCAGGATTCCTCCTTGCTGCATGTGATGGCCGAGGCC
AATTGCCTGTTGATTCGACCACCTCATGCTCCGACCGCTTCGGCTGGCGACCCATGCCGGATCATCCGGCTTGATCGCTA
A

Upstream 100 bases:

>100_bases
ATGACATGCTGAAGGCCGTTGACCGTTTCATGCGCATTGAAGGAATAGGCCTCCTGGAAAAACAGGGAGGCAAATCAGGT
TCCTGGAAACGAGAAAAAGA

Downstream 100 bases:

>100_bases
AGCATCTTGCGGAACACAGGGCGAACAGATATAGTCTGTTCACTGTTTGTTTAAGGTTTGCGGGCAATTTGCGGGGGCAT
ATCCGCAAACAGGGTCCGCT

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MNAVAPHKNAGPVKTDQPKPALSVAEARRTILTSVALPRAVETVALAEAHGRTLAAPLAAKRTQPPFAASAMDGYAIRAD
DLHSARAPVKLTLIGESAAGHGFAGTVGPMETVRIFTGAPVPEGTDTILIQELVTIEDGLILPQKTPPRGRYIREAGLDF
QEGEILLPEGRRLSAADLALAAAMNHAVVPVTKQPRVGILATGDELVRPGEALGPSQIVSSNSYAIAAQVRAAGGLPVDL
GIAGDNAIALAQGIAAARMLKVDVLVISGGVSVGDYDLVRKALLQEGMELSFWRIAMRPGRPLIHGMLGDMAILGLPGNP
VAALVCGLLFLTPLVRILDGEAGVLEADPSEPALLAEALPENDAREDFLRATYVRTDNGLPSVTPFAAQDSSLLHVMAEA
NCLLIRPPHAPTASAGDPCRIIRLDR

Sequences:

>Translated_426_residues
MNAVAPHKNAGPVKTDQPKPALSVAEARRTILTSVALPRAVETVALAEAHGRTLAAPLAAKRTQPPFAASAMDGYAIRAD
DLHSARAPVKLTLIGESAAGHGFAGTVGPMETVRIFTGAPVPEGTDTILIQELVTIEDGLILPQKTPPRGRYIREAGLDF
QEGEILLPEGRRLSAADLALAAAMNHAVVPVTKQPRVGILATGDELVRPGEALGPSQIVSSNSYAIAAQVRAAGGLPVDL
GIAGDNAIALAQGIAAARMLKVDVLVISGGVSVGDYDLVRKALLQEGMELSFWRIAMRPGRPLIHGMLGDMAILGLPGNP
VAALVCGLLFLTPLVRILDGEAGVLEADPSEPALLAEALPENDAREDFLRATYVRTDNGLPSVTPFAAQDSSLLHVMAEA
NCLLIRPPHAPTASAGDPCRIIRLDR
>Mature_426_residues
MNAVAPHKNAGPVKTDQPKPALSVAEARRTILTSVALPRAVETVALAEAHGRTLAAPLAAKRTQPPFAASAMDGYAIRAD
DLHSARAPVKLTLIGESAAGHGFAGTVGPMETVRIFTGAPVPEGTDTILIQELVTIEDGLILPQKTPPRGRYIREAGLDF
QEGEILLPEGRRLSAADLALAAAMNHAVVPVTKQPRVGILATGDELVRPGEALGPSQIVSSNSYAIAAQVRAAGGLPVDL
GIAGDNAIALAQGIAAARMLKVDVLVISGGVSVGDYDLVRKALLQEGMELSFWRIAMRPGRPLIHGMLGDMAILGLPGNP
VAALVCGLLFLTPLVRILDGEAGVLEADPSEPALLAEALPENDAREDFLRATYVRTDNGLPSVTPFAAQDSSLLHVMAEA
NCLLIRPPHAPTASAGDPCRIIRLDR

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=411, Percent_Identity=33.5766423357664, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI66932975, Length=411, Percent_Identity=33.5766423357664, Blast_Score=171, Evalue=2e-42,
Organism=Escherichia coli, GI1787049, Length=385, Percent_Identity=34.8051948051948, Blast_Score=199, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI25147659, Length=413, Percent_Identity=29.0556900726392, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17562606, Length=357, Percent_Identity=25.7703081232493, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI17136978, Length=438, Percent_Identity=26.4840182648402, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24638841, Length=438, Percent_Identity=26.4840182648402, Blast_Score=118, Evalue=6e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44445; Mature: 44445

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAVAPHKNAGPVKTDQPKPALSVAEARRTILTSVALPRAVETVALAEAHGRTLAAPLAA
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHH
KRTQPPFAASAMDGYAIRADDLHSARAPVKLTLIGESAAGHGFAGTVGPMETVRIFTGAP
CCCCCCCCHHCCCCEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCEEEEEEECCC
VPEGTDTILIQELVTIEDGLILPQKTPPRGRYIREAGLDFQEGEILLPEGRRLSAADLAL
CCCCCCHHHHHHHHHHCCCEECCCCCCCCCCHHHHHCCCCCCCCEECCCCCCCCHHHHHH
AAAMNHAVVPVTKQPRVGILATGDELVRPGEALGPSQIVSSNSYAIAAQVRAAGGLPVDL
HHHHCCEEEEECCCCCEEEEECCHHHHCCCCCCCHHHHHCCCCEEEEEEEECCCCCEEEE
GIAGDNAIALAQGIAAARMLKVDVLVISGGVSVGDYDLVRKALLQEGMELSFWRIAMRPG
EECCCCHHHHHHHHHHHHEEEEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEEEECCC
RPLIHGMLGDMAILGLPGNPVAALVCGLLFLTPLVRILDGEAGVLEADPSEPALLAEALP
CHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHCC
ENDAREDFLRATYVRTDNGLPSVTPFAAQDSSLLHVMAEANCLLIRPPHAPTASAGDPCR
CCCHHHHHHHEEEEECCCCCCCCCCCCCCCCCEEEEEECCCEEEEECCCCCCCCCCCCEE
IIRLDR
EEEECC
>Mature Secondary Structure
MNAVAPHKNAGPVKTDQPKPALSVAEARRTILTSVALPRAVETVALAEAHGRTLAAPLAA
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHH
KRTQPPFAASAMDGYAIRADDLHSARAPVKLTLIGESAAGHGFAGTVGPMETVRIFTGAP
CCCCCCCCHHCCCCEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCEEEEEEECCC
VPEGTDTILIQELVTIEDGLILPQKTPPRGRYIREAGLDFQEGEILLPEGRRLSAADLAL
CCCCCCHHHHHHHHHHCCCEECCCCCCCCCCHHHHHCCCCCCCCEECCCCCCCCHHHHHH
AAAMNHAVVPVTKQPRVGILATGDELVRPGEALGPSQIVSSNSYAIAAQVRAAGGLPVDL
HHHHCCEEEEECCCCCEEEEECCHHHHCCCCCCCHHHHHCCCCEEEEEEEECCCCCEEEE
GIAGDNAIALAQGIAAARMLKVDVLVISGGVSVGDYDLVRKALLQEGMELSFWRIAMRPG
EECCCCHHHHHHHHHHHHEEEEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEEEECCC
RPLIHGMLGDMAILGLPGNPVAALVCGLLFLTPLVRILDGEAGVLEADPSEPALLAEALP
CHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHCC
ENDAREDFLRATYVRTDNGLPSVTPFAAQDSSLLHVMAEANCLLIRPPHAPTASAGDPCR
CCCHHHHHHHEEEEECCCCCCCCCCCCCCCCCEEEEEECCCEEEEECCCCCCCCCCCCEE
IIRLDR
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]