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The map label for this gene is hom [H]

Identifier: 182678370

GI number: 182678370

Start: 1591052

End: 1592353

Strand: Direct

Name: hom [H]

Synonym: Bind_1387

Alternate gene names: 182678370

Gene position: 1591052-1592353 (Clockwise)

Preceding gene: 182678366

Following gene: 182678371

Centisome position: 38.15

GC content: 63.13

Gene sequence:

>1302_bases
ATGCAGCGACCTCTGCGTGTCGGCATCGCTGGTCTCGGGACTGTCGGCGCCGCCGTGATCAAGCTCCTCGACCGTCAAGC
CGAGGCCCTGGCAAGCCGTGTTGGCCGCGCTGTGATCGTCACAGGCGTCAGCGCCCGCGATAAAACCAAGGAGCGCGGGA
TCGACCTTTCCCGCTTTGTCTGGTTCGATGATCCAGTCGCGCTCGCCCGTTCGGAAGAGATCGATCTCTTCGTTGAACTC
ATCGGCGGCGCTGATGGCACCGCGCTCGCGGGCGCCGAACAGGCCTTGGCTTCGGGTAAACCGGTCGTCACAGCCAATAA
GGCGCTTCTCGCCCGTCATGGCATGCGACTCGCGACTTTGGCCGAGGAAATGAGCCTGGCGCTCGCCTTCGAGGCTTCCG
TCGCGGGCGGCATACCCATCGTCAAAACCCTGCGCGAGGGTCTCGCCGGGAATTCGATCGAGCGCGTCTATGGGATTTTG
AACGGCACCTGCAATTACATTCTGAGCCGCATGGAAACGGAAGGCCTGTCCTTCGAAGCCTGTCTCGCTGAGGCGCAAAA
GCTCGGCTATGCGGAGGCCGATCCGACTTTCGACATCGGTGGTTTCGACACGGCGCATAAGCTCGCCATTCTTGCGTCGC
TCGCTTTTGGCACGGCCGTGGACCCGGAGGGGATCAGTGTCGAGGGCATCGAATCGATCAGCCTCGCCGATCTCCAGGCC
GCTGACGAATTGGGCTATCGAGTCAAATTGCTGGGTGTCGCCCAGCGTTCTGCCGATGGTATCGAGCAGCGCGTGCATCC
GAGCATGGTGCCCAAAACCTCGGCCATCGCACAGGTCATGGGCGTGACCAACGCCGTGACGATCGATGCCGATGCCGTGC
ATGAATTGACTCTCGCCGGGCCGGGCGCGGGTGGCGAGGCCACGGCTTCGGCCATTGTCGCCGATATTGCTGATATCGCC
CGGGGTGTCCGATCCGCTCCCTTTGGTCTGCCGGTCGCGGCCTTGACCAGCTTGCCGCGGCCGCCCATGCGGCTGCATCA
GGGCGGTTATTATATCCGCCTTTCGGTGGAGGATCGTCCTGGCGCGGCCGCCGCCATTGCCAAGCGCATGGCGGAGCGGG
AGATTTCGCTGGAAAGCATTGTTCAGCGGCGCCGTCCCGGCACTATCGCGAGCGGAGCAGTGCCGGTGATCCTTGTGACC
TACGCGACGCATGAACAGACTGTGCGTGAGGCGCTCGATGCCGTCGTCGCGGATGGCTATCTCGCCGCAAAGCCGCAACT
CATTCGGATCGAACGGGAATGA

Upstream 100 bases:

>100_bases
GGCATGATCCAGCTTTCTTGATCGAACCTCGAAAATAGGGCACAAGACGCCACCGGATCGTTCCGAATCCCGATCGTTCG
TCTTGTGGAATTCCCCCTTC

Downstream 100 bases:

>100_bases
GACAATTCGCCTCGTTTTGCCGTTGTGTCATCTGGAAAAGGTAAGGGAATGCGTTAGGAGCGGCTGTTGCGGGATCTGCC
GCACGCCGAAGAAGACGTCC

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MQRPLRVGIAGLGTVGAAVIKLLDRQAEALASRVGRAVIVTGVSARDKTKERGIDLSRFVWFDDPVALARSEEIDLFVEL
IGGADGTALAGAEQALASGKPVVTANKALLARHGMRLATLAEEMSLALAFEASVAGGIPIVKTLREGLAGNSIERVYGIL
NGTCNYILSRMETEGLSFEACLAEAQKLGYAEADPTFDIGGFDTAHKLAILASLAFGTAVDPEGISVEGIESISLADLQA
ADELGYRVKLLGVAQRSADGIEQRVHPSMVPKTSAIAQVMGVTNAVTIDADAVHELTLAGPGAGGEATASAIVADIADIA
RGVRSAPFGLPVAALTSLPRPPMRLHQGGYYIRLSVEDRPGAAAAIAKRMAEREISLESIVQRRRPGTIASGAVPVILVT
YATHEQTVREALDAVVADGYLAAKPQLIRIERE

Sequences:

>Translated_433_residues
MQRPLRVGIAGLGTVGAAVIKLLDRQAEALASRVGRAVIVTGVSARDKTKERGIDLSRFVWFDDPVALARSEEIDLFVEL
IGGADGTALAGAEQALASGKPVVTANKALLARHGMRLATLAEEMSLALAFEASVAGGIPIVKTLREGLAGNSIERVYGIL
NGTCNYILSRMETEGLSFEACLAEAQKLGYAEADPTFDIGGFDTAHKLAILASLAFGTAVDPEGISVEGIESISLADLQA
ADELGYRVKLLGVAQRSADGIEQRVHPSMVPKTSAIAQVMGVTNAVTIDADAVHELTLAGPGAGGEATASAIVADIADIA
RGVRSAPFGLPVAALTSLPRPPMRLHQGGYYIRLSVEDRPGAAAAIAKRMAEREISLESIVQRRRPGTIASGAVPVILVT
YATHEQTVREALDAVVADGYLAAKPQLIRIERE
>Mature_433_residues
MQRPLRVGIAGLGTVGAAVIKLLDRQAEALASRVGRAVIVTGVSARDKTKERGIDLSRFVWFDDPVALARSEEIDLFVEL
IGGADGTALAGAEQALASGKPVVTANKALLARHGMRLATLAEEMSLALAFEASVAGGIPIVKTLREGLAGNSIERVYGIL
NGTCNYILSRMETEGLSFEACLAEAQKLGYAEADPTFDIGGFDTAHKLAILASLAFGTAVDPEGISVEGIESISLADLQA
ADELGYRVKLLGVAQRSADGIEQRVHPSMVPKTSAIAQVMGVTNAVTIDADAVHELTLAGPGAGGEATASAIVADIADIA
RGVRSAPFGLPVAALTSLPRPPMRLHQGGYYIRLSVEDRPGAAAAIAKRMAEREISLESIVQRRRPGTIASGAVPVILVT
YATHEQTVREALDAVVADGYLAAKPQLIRIERE

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790376, Length=356, Percent_Identity=26.685393258427, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1786183, Length=247, Percent_Identity=30.3643724696356, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6322599, Length=118, Percent_Identity=33.0508474576271, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 45269; Mature: 45269

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRPLRVGIAGLGTVGAAVIKLLDRQAEALASRVGRAVIVTGVSARDKTKERGIDLSRFV
CCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHCCCHHHEE
WFDDPVALARSEEIDLFVELIGGADGTALAGAEQALASGKPVVTANKALLARHGMRLATL
EECCCHHHCCCCCHHHHHHHHCCCCCCCCCCHHHHHHCCCCEEEECHHHHHHCCCHHHHH
AEEMSLALAFEASVAGGIPIVKTLREGLAGNSIERVYGILNGTCNYILSRMETEGLSFEA
HHHHHHHEEEECHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
CLAEAQKLGYAEADPTFDIGGFDTAHKLAILASLAFGTAVDPEGISVEGIESISLADLQA
HHHHHHHCCCCCCCCCEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHH
ADELGYRVKLLGVAQRSADGIEQRVHPSMVPKTSAIAQVMGVTNAVTIDADAVHELTLAG
HHHCCCEEEEEEEHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEECCHHHHEEEEEC
PGAGGEATASAIVADIADIARGVRSAPFGLPVAALTSLPRPPMRLHQGGYYIRLSVEDRP
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCHHHCCCCEEEEEEECCCC
GAAAAIAKRMAEREISLESIVQRRRPGTIASGAVPVILVTYATHEQTVREALDAVVADGY
CHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCE
LAAKPQLIRIERE
EECCCEEEEEECC
>Mature Secondary Structure
MQRPLRVGIAGLGTVGAAVIKLLDRQAEALASRVGRAVIVTGVSARDKTKERGIDLSRFV
CCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHCCCHHHEE
WFDDPVALARSEEIDLFVELIGGADGTALAGAEQALASGKPVVTANKALLARHGMRLATL
EECCCHHHCCCCCHHHHHHHHCCCCCCCCCCHHHHHHCCCCEEEECHHHHHHCCCHHHHH
AEEMSLALAFEASVAGGIPIVKTLREGLAGNSIERVYGILNGTCNYILSRMETEGLSFEA
HHHHHHHEEEECHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
CLAEAQKLGYAEADPTFDIGGFDTAHKLAILASLAFGTAVDPEGISVEGIESISLADLQA
HHHHHHHCCCCCCCCCEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHH
ADELGYRVKLLGVAQRSADGIEQRVHPSMVPKTSAIAQVMGVTNAVTIDADAVHELTLAG
HHHCCCEEEEEEEHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEECCHHHHEEEEEC
PGAGGEATASAIVADIADIARGVRSAPFGLPVAALTSLPRPPMRLHQGGYYIRLSVEDRP
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCHHHCCCCEEEEEEECCCC
GAAAAIAKRMAEREISLESIVQRRRPGTIASGAVPVILVTYATHEQTVREALDAVVADGY
CHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCE
LAAKPQLIRIERE
EECCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]