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The map label for this gene is adk

Identifier: 182678358

GI number: 182678358

Start: 1580262

End: 1580843

Strand: Direct

Name: adk

Synonym: Bind_1375

Alternate gene names: 182678358

Gene position: 1580262-1580843 (Clockwise)

Preceding gene: 182678357

Following gene: 182678361

Centisome position: 37.89

GC content: 56.7

Gene sequence:

>582_bases
ATGAGGCTTATTCTTTTGGGACCGCCTGGCGCTGGCAAGGGGACTCAATCGGAGCGTTTGCGGGAACAATGCAAAATCCC
GCAGCTTTCGACAGGTGATATGCTGCGCGCAGCCGTGAAAGCCGGCACGCCGATCGGTCTGAAGGCCAAGGCCGTGATGG
ACGCGGGTGGTCTGGTGTCCGACGATATTGTGGTCGGCATTGTTGCGGATCGGATCGAAGAACCTGATGCGCGCAACGGA
TTCATTCTCGATGGCTTCCCGCGGACGGTCAAACAAGCGGAAGCCCTGACCACTATGCTCCACGAGAAGAAGATGGATCT
CGACGCGGTCATCGAGCTTGTCGTTGATGAAAACGCGCTTCTGGCCCGGATCGAAAAGCGCGCCAAGGAAACTTTGGCGG
CGGGCGGCACCGTGCGGGCGGATGATAATCCAGCCGCTTTCAAAACGCGTATTGATACTTATCGTGAGCAGACCGCTCCG
GTTTCGGCCTATTATGCCAGCCAGGGCGTCCTGAAAACAGTGGATGGGATGGCCGATATTGATACGGTGACGGCTGCGAT
CGATAAAATTCTCAAAGCCTAA

Upstream 100 bases:

>100_bases
TCAGTGTCACCATGGATACAGTGGCCCAGATTCATGGACATCTGCAGGCCCATCAGTATGAGGGTTTGATCAAGAAGGCA
AAATTGCGGGGGAAACGGAA

Downstream 100 bases:

>100_bases
AGCAAAACAGAGTGTCCGACGCGGCGGTTTCGATCAACGAAACCGCCTTTATTTTGCGTTGGATAGGAAACGTCCTAAAT
ATAATACATGAGGTCGGCAT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 193; Mature: 193

Protein sequence:

>193_residues
MRLILLGPPGAGKGTQSERLREQCKIPQLSTGDMLRAAVKAGTPIGLKAKAVMDAGGLVSDDIVVGIVADRIEEPDARNG
FILDGFPRTVKQAEALTTMLHEKKMDLDAVIELVVDENALLARIEKRAKETLAAGGTVRADDNPAAFKTRIDTYREQTAP
VSAYYASQGVLKTVDGMADIDTVTAAIDKILKA

Sequences:

>Translated_193_residues
MRLILLGPPGAGKGTQSERLREQCKIPQLSTGDMLRAAVKAGTPIGLKAKAVMDAGGLVSDDIVVGIVADRIEEPDARNG
FILDGFPRTVKQAEALTTMLHEKKMDLDAVIELVVDENALLARIEKRAKETLAAGGTVRADDNPAAFKTRIDTYREQTAP
VSAYYASQGVLKTVDGMADIDTVTAAIDKILKA
>Mature_193_residues
MRLILLGPPGAGKGTQSERLREQCKIPQLSTGDMLRAAVKAGTPIGLKAKAVMDAGGLVSDDIVVGIVADRIEEPDARNG
FILDGFPRTVKQAEALTTMLHEKKMDLDAVIELVVDENALLARIEKRAKETLAAGGTVRADDNPAAFKTRIDTYREQTAP
VSAYYASQGVLKTVDGMADIDTVTAAIDKILKA

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=208, Percent_Identity=42.7884615384615, Blast_Score=161, Evalue=3e-40,
Organism=Homo sapiens, GI4502013, Length=208, Percent_Identity=42.7884615384615, Blast_Score=161, Evalue=3e-40,
Organism=Homo sapiens, GI19923437, Length=199, Percent_Identity=33.6683417085427, Blast_Score=107, Evalue=8e-24,
Organism=Homo sapiens, GI4502011, Length=188, Percent_Identity=31.9148936170213, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI310110345, Length=199, Percent_Identity=31.1557788944724, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI53832003, Length=199, Percent_Identity=31.1557788944724, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI8051579, Length=199, Percent_Identity=31.1557788944724, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI53832001, Length=199, Percent_Identity=31.1557788944724, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI7706497, Length=194, Percent_Identity=27.8350515463918, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI28144897, Length=195, Percent_Identity=28.2051282051282, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI28144899, Length=195, Percent_Identity=28.2051282051282, Blast_Score=80, Evalue=1e-15,
Organism=Escherichia coli, GI1786680, Length=219, Percent_Identity=41.0958904109589, Blast_Score=148, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17552384, Length=213, Percent_Identity=36.6197183098592, Blast_Score=142, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI17567503, Length=187, Percent_Identity=33.1550802139037, Blast_Score=110, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17533833, Length=192, Percent_Identity=28.6458333333333, Blast_Score=96, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17550688, Length=192, Percent_Identity=27.0833333333333, Blast_Score=83, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6320432, Length=209, Percent_Identity=43.5406698564593, Blast_Score=159, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6321018, Length=199, Percent_Identity=34.1708542713568, Blast_Score=107, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6322828, Length=170, Percent_Identity=31.7647058823529, Blast_Score=87, Evalue=2e-18,
Organism=Drosophila melanogaster, GI22026816, Length=211, Percent_Identity=42.654028436019, Blast_Score=167, Evalue=4e-42,
Organism=Drosophila melanogaster, GI17737899, Length=199, Percent_Identity=34.1708542713568, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24645822, Length=199, Percent_Identity=34.1708542713568, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24663208, Length=195, Percent_Identity=32.3076923076923, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17647141, Length=195, Percent_Identity=32.3076923076923, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI221459597, Length=192, Percent_Identity=27.6041666666667, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21356893, Length=192, Percent_Identity=27.6041666666667, Blast_Score=89, Evalue=2e-18,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_BEII9 (B2IK83)

Other databases:

- EMBL:   CP001016
- RefSeq:   YP_001832504.1
- GeneID:   6200570
- GenomeReviews:   CP001016_GR
- KEGG:   bid:Bind_1375
- HOGENOM:   HBG630208
- OMA:   CGEGYHD
- ProtClustDB:   PRK00279
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 20588; Mature: 20588

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLILLGPPGAGKGTQSERLREQCKIPQLSTGDMLRAAVKAGTPIGLKAKAVMDAGGLVS
CEEEEECCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCHHHHHCCCCCCC
DDIVVGIVADRIEEPDARNGFILDGFPRTVKQAEALTTMLHEKKMDLDAVIELVVDENAL
CCCEEEHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHH
LARIEKRAKETLAAGGTVRADDNPAAFKTRIDTYREQTAPVSAYYASQGVLKTVDGMADI
HHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHCCHHHH
DTVTAAIDKILKA
HHHHHHHHHHHCC
>Mature Secondary Structure
MRLILLGPPGAGKGTQSERLREQCKIPQLSTGDMLRAAVKAGTPIGLKAKAVMDAGGLVS
CEEEEECCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCHHHHHCCCCCCC
DDIVVGIVADRIEEPDARNGFILDGFPRTVKQAEALTTMLHEKKMDLDAVIELVVDENAL
CCCEEEHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHH
LARIEKRAKETLAAGGTVRADDNPAAFKTRIDTYREQTAPVSAYYASQGVLKTVDGMADI
HHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHCCHHHH
DTVTAAIDKILKA
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA