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The map label for this gene is hoxL [H]

Identifier: 182678136

GI number: 182678136

Start: 1334411

End: 1336228

Strand: Direct

Name: hoxL [H]

Synonym: Bind_1151

Alternate gene names: 182678136

Gene position: 1334411-1336228 (Clockwise)

Preceding gene: 182678135

Following gene: 182678137

Centisome position: 32.0

GC content: 56.27

Gene sequence:

>1818_bases
ATGAATGTGCAGACGCCGAACGGGTTTACCCTGGACAATTCCGGCAGGCGCATTGTCGTCGATCCCTTGACCCGCATCGA
AGGCCATATGCGGTGCGAGGTCAATGTGGATGCGGATAATATCATCCGCAATGCCGTTTCGACTGGTACGATGTGGCGCG
GCCTGGAAGTCATTTTGAAGGGCCGCGATCCGCGTGATGCCTGGGCTTTCGTGGAGCGGATCTGTGGCGTGTGCACCGGT
TGCCATGCCTTGGCTTCCGTCCGCGCCGTCGAGGATGCGCTGGATATCCGTATTCCCTATAATGCATTCCTGATCCGCCA
GATCATGTCCAAAGTTTTGGCCTGGCATGATCATGTCGTGCATTTCTACCATTTGCATGCGCTCGACTGGGTTAATCCCG
TCAATGCCTTGAAGGCTGATCCGCGCGCGACTTCGGCATTGCAACAGGCGGTTTCGCCCAATCATCCGCTTTCCTCGCCC
GGTTATTTCCGCGACGTGCAGAACCGGCTGAAGAAATTCGTCGAAAGCGGGCAACTCGGCATTTTCAAGAATGGCTATTG
GGACAGCAAGGCCTATCTCTTGCCGCCCGAAGCTGATCTGATGGCCGTGACCCATTATCTGGAAGCGCTCGATTTCCAGA
AGGAAATCGTCAAGATCCATACGATCTTCGGGGGCAAGAATCCGCATCCGAACTATCTCGTCGGCGGTGTGCCTTGCGCT
ATCAATATGGAAGGCGATATGGCGGCCGGTGCGCCGCTGAACATGGAACGCTTGAATTTCGTCAAACAGAAGATTGATGA
AGCTTTCGAATTTTCCAAGAATGTGTATGTGCCGGATGTCATCGCCATCGCCAGTTTCTACAAGGGCTGGCTCTATGGCG
GCGGCCTCTCTGCGACCAATGTTCTGGATTATGGTGATTATCCGACTTCGCAGGAGGATAAATCCACTGACCGTCTGCCT
GGTGGCGTGATCCTCGGCGGCAATTGGGATGAAATCCATCCGGTTGATGCGCGTGATCCAGAGCAGGTGCAGGAATTTGT
CACCCATAGCTGGTACACTTACGGCGGTGGCCGCGAAAATGTCGGCTTGCATCCCTGGGATGGTGTGACGGACTCTCATT
TCGAACTTGGTGCTGGCACCAAGGGCACTCGCACCAACATTCAGGAAATCGACGAAAACGCGAAATATTCCTGGGTCAAA
TCACCTCGCTGGCGTGGCAATGCCTGTGAAGTCGGCCCGCTTTCGCGTTACATTATCGCCTACGCCAAGAATGTTCCCTA
TGTGAAGGCGCAGGTCGATGACGCGTTGAGCCAGTTCAACCATCTGGCTGGCACCAATCTGACCGCGCGTCAGGCGTTGC
CGACTACAATCGGCCGCACGCTCGCCCGCGCGCTCGAGGCGCATTATTGCGCGCAAATGATGATCGACGATTATGATGCG
CTGATCGCCAATATCCGCAATGGCGATCTTGCGACCGCCAATGTCGCCAAATGGGACCCTTCAACCTGGCCGAAGGAAGC
CAAGGGCGTTGGCCTCGTAGCGGCACCGCGCGGTGGGCTGGGGCATTGGATCAAGATCCGCGATGGCCGGATCGAGAATT
ATCAATGCGTCGTGCCTTCCACCTGGAACAGTGGGCCGCGTGATGCCAAGGGCAATATTGGTGCTTTCGAAGCGTCGCTG
CTTGGCACTCCGATGGTCAATCCGGAACAGCCCGTGGAAATCCTGCGGACGCTGCATTCCTTTGACCCTTGCATGGCTTG
TGCGACCCATGTGATGGCGCCGGACGGCGAAGAACTCGCCCGTGTCACAATCCGCTGA

Upstream 100 bases:

>100_bases
GTATCGGCTTGACCGCCGCCGCCGCCGTCGGCACGGGTCTCGCGGTCCATGCAGCCATCAGCGCCTTGCAGCGCGCGCGT
TACAAAGGGGATGACGTTTA

Downstream 100 bases:

>100_bases
GGAAATCACGATGGCTGCATTAAAACCGGCGCGCATTCTCCATGATGACGATCTCGCCGGCACCAATCTGGAAGGATTGA
AGGCGGCGCCTTTGCGGGCG

Product: nickel-dependent hydrogenase large subunit

Products: NA

Alternate protein names: Hydrogenlyase; Membrane-bound hydrogenase large subunit [H]

Number of amino acids: Translated: 605; Mature: 605

Protein sequence:

>605_residues
MNVQTPNGFTLDNSGRRIVVDPLTRIEGHMRCEVNVDADNIIRNAVSTGTMWRGLEVILKGRDPRDAWAFVERICGVCTG
CHALASVRAVEDALDIRIPYNAFLIRQIMSKVLAWHDHVVHFYHLHALDWVNPVNALKADPRATSALQQAVSPNHPLSSP
GYFRDVQNRLKKFVESGQLGIFKNGYWDSKAYLLPPEADLMAVTHYLEALDFQKEIVKIHTIFGGKNPHPNYLVGGVPCA
INMEGDMAAGAPLNMERLNFVKQKIDEAFEFSKNVYVPDVIAIASFYKGWLYGGGLSATNVLDYGDYPTSQEDKSTDRLP
GGVILGGNWDEIHPVDARDPEQVQEFVTHSWYTYGGGRENVGLHPWDGVTDSHFELGAGTKGTRTNIQEIDENAKYSWVK
SPRWRGNACEVGPLSRYIIAYAKNVPYVKAQVDDALSQFNHLAGTNLTARQALPTTIGRTLARALEAHYCAQMMIDDYDA
LIANIRNGDLATANVAKWDPSTWPKEAKGVGLVAAPRGGLGHWIKIRDGRIENYQCVVPSTWNSGPRDAKGNIGAFEASL
LGTPMVNPEQPVEILRTLHSFDPCMACATHVMAPDGEELARVTIR

Sequences:

>Translated_605_residues
MNVQTPNGFTLDNSGRRIVVDPLTRIEGHMRCEVNVDADNIIRNAVSTGTMWRGLEVILKGRDPRDAWAFVERICGVCTG
CHALASVRAVEDALDIRIPYNAFLIRQIMSKVLAWHDHVVHFYHLHALDWVNPVNALKADPRATSALQQAVSPNHPLSSP
GYFRDVQNRLKKFVESGQLGIFKNGYWDSKAYLLPPEADLMAVTHYLEALDFQKEIVKIHTIFGGKNPHPNYLVGGVPCA
INMEGDMAAGAPLNMERLNFVKQKIDEAFEFSKNVYVPDVIAIASFYKGWLYGGGLSATNVLDYGDYPTSQEDKSTDRLP
GGVILGGNWDEIHPVDARDPEQVQEFVTHSWYTYGGGRENVGLHPWDGVTDSHFELGAGTKGTRTNIQEIDENAKYSWVK
SPRWRGNACEVGPLSRYIIAYAKNVPYVKAQVDDALSQFNHLAGTNLTARQALPTTIGRTLARALEAHYCAQMMIDDYDA
LIANIRNGDLATANVAKWDPSTWPKEAKGVGLVAAPRGGLGHWIKIRDGRIENYQCVVPSTWNSGPRDAKGNIGAFEASL
LGTPMVNPEQPVEILRTLHSFDPCMACATHVMAPDGEELARVTIR
>Mature_605_residues
MNVQTPNGFTLDNSGRRIVVDPLTRIEGHMRCEVNVDADNIIRNAVSTGTMWRGLEVILKGRDPRDAWAFVERICGVCTG
CHALASVRAVEDALDIRIPYNAFLIRQIMSKVLAWHDHVVHFYHLHALDWVNPVNALKADPRATSALQQAVSPNHPLSSP
GYFRDVQNRLKKFVESGQLGIFKNGYWDSKAYLLPPEADLMAVTHYLEALDFQKEIVKIHTIFGGKNPHPNYLVGGVPCA
INMEGDMAAGAPLNMERLNFVKQKIDEAFEFSKNVYVPDVIAIASFYKGWLYGGGLSATNVLDYGDYPTSQEDKSTDRLP
GGVILGGNWDEIHPVDARDPEQVQEFVTHSWYTYGGGRENVGLHPWDGVTDSHFELGAGTKGTRTNIQEIDENAKYSWVK
SPRWRGNACEVGPLSRYIIAYAKNVPYVKAQVDDALSQFNHLAGTNLTARQALPTTIGRTLARALEAHYCAQMMIDDYDA
LIANIRNGDLATANVAKWDPSTWPKEAKGVGLVAAPRGGLGHWIKIRDGRIENYQCVVPSTWNSGPRDAKGNIGAFEASL
LGTPMVNPEQPVEILRTLHSFDPCMACATHVMAPDGEELARVTIR

Specific function: This enzyme recycles the H(2) produced by nitrogenase to increase the production of ATP and to protect nitrogenase against inhibition or damage by O(2) under carbon- or phosphate-limited conditions [H]

COG id: COG0374

COG function: function code C; Ni,Fe-hydrogenase I large subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family [H]

Homologues:

Organism=Escherichia coli, GI1787207, Length=601, Percent_Identity=57.7371048252912, Blast_Score=715, Evalue=0.0,
Organism=Escherichia coli, GI1789368, Length=594, Percent_Identity=43.2659932659933, Blast_Score=476, Evalue=1e-135,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001501
- InterPro:   IPR018194 [H]

Pfam domain/function: PF00374 NiFeSe_Hases [H]

EC number: =1.12.99.6 [H]

Molecular weight: Translated: 66970; Mature: 66970

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00507 NI_HGENASE_L_1 ; PS00508 NI_HGENASE_L_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVQTPNGFTLDNSGRRIVVDPLTRIEGHMRCEVNVDADNIIRNAVSTGTMWRGLEVILK
CCCCCCCCEEECCCCCEEEECCHHHCCCCEEEEEECCHHHHHHHHHHCCHHHHCHHHEEE
GRDPRDAWAFVERICGVCTGCHALASVRAVEDALDIRIPYNAFLIRQIMSKVLAWHDHVV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHHHH
HFYHLHALDWVNPVNALKADPRATSALQQAVSPNHPLSSPGYFRDVQNRLKKFVESGQLG
HHHHHHHHHHCCHHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCEE
IFKNGYWDSKAYLLPPEADLMAVTHYLEALDFQKEIVKIHTIFGGKNPHPNYLVGGVPCA
EEECCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCEEECCCCEE
INMEGDMAAGAPLNMERLNFVKQKIDEAFEFSKNVYVPDVIAIASFYKGWLYGGGLSATN
EECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
VLDYGDYPTSQEDKSTDRLPGGVILGGNWDEIHPVDARDPEQVQEFVTHSWYTYGGGREN
EEECCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHCCEEECCCCCC
VGLHPWDGVTDSHFELGAGTKGTRTNIQEIDENAKYSWVKSPRWRGNACEVGPLSRYIIA
CCCCCCCCCCCCCEEECCCCCCCCCHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHH
YAKNVPYVKAQVDDALSQFNHLAGTNLTARQALPTTIGRTLARALEAHYCAQMMIDDYDA
HHCCCCEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIANIRNGDLATANVAKWDPSTWPKEAKGVGLVAAPRGGLGHWIKIRDGRIENYQCVVPS
HHHHCCCCCEEECEECCCCCCCCCCHHCCCEEEECCCCCCCCEEEEECCCCCCEEEEECC
TWNSGPRDAKGNIGAFEASLLGTPMVNPEQPVEILRTLHSFDPCMACATHVMAPDGEELA
CCCCCCCCCCCCCCEEHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHH
RVTIR
EEECC
>Mature Secondary Structure
MNVQTPNGFTLDNSGRRIVVDPLTRIEGHMRCEVNVDADNIIRNAVSTGTMWRGLEVILK
CCCCCCCCEEECCCCCEEEECCHHHCCCCEEEEEECCHHHHHHHHHHCCHHHHCHHHEEE
GRDPRDAWAFVERICGVCTGCHALASVRAVEDALDIRIPYNAFLIRQIMSKVLAWHDHVV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHHHH
HFYHLHALDWVNPVNALKADPRATSALQQAVSPNHPLSSPGYFRDVQNRLKKFVESGQLG
HHHHHHHHHHCCHHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCEE
IFKNGYWDSKAYLLPPEADLMAVTHYLEALDFQKEIVKIHTIFGGKNPHPNYLVGGVPCA
EEECCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCEEECCCCEE
INMEGDMAAGAPLNMERLNFVKQKIDEAFEFSKNVYVPDVIAIASFYKGWLYGGGLSATN
EECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
VLDYGDYPTSQEDKSTDRLPGGVILGGNWDEIHPVDARDPEQVQEFVTHSWYTYGGGREN
EEECCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHCCEEECCCCCC
VGLHPWDGVTDSHFELGAGTKGTRTNIQEIDENAKYSWVKSPRWRGNACEVGPLSRYIIA
CCCCCCCCCCCCCEEECCCCCCCCCHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHH
YAKNVPYVKAQVDDALSQFNHLAGTNLTARQALPTTIGRTLARALEAHYCAQMMIDDYDA
HHCCCCEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIANIRNGDLATANVAKWDPSTWPKEAKGVGLVAAPRGGLGHWIKIRDGRIENYQCVVPS
HHHHCCCCCEEECEECCCCCCCCCCHHCCCEEEECCCCCCCCEEEEECCCCCCEEEEECC
TWNSGPRDAKGNIGAFEASLLGTPMVNPEQPVEILRTLHSFDPCMACATHVMAPDGEELA
CCCCCCCCCCCCCCEEHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHH
RVTIR
EEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9324252 [H]