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The map label for this gene is yvaG [H]

Identifier: 182678111

GI number: 182678111

Start: 1306106

End: 1306897

Strand: Direct

Name: yvaG [H]

Synonym: Bind_1126

Alternate gene names: 182678111

Gene position: 1306106-1306897 (Clockwise)

Preceding gene: 182678109

Following gene: 182678115

Centisome position: 31.32

GC content: 58.59

Gene sequence:

>792_bases
ATGAAAATCGATCTTTCCGGCAAAACGGCGCTCGTCACCGGCTCCACGGCGGGCATCGGATGGGCGGCGGCCAAGGGGCT
TGCGGAAAGCGGGGCGACGGTGATTGTCAACGGGCGCAAGGAAGCGACTGTGGCCGAGGCTGTCTCGACTTTGCGCAAGC
AAGTTCCCGATGCGCAGATCCAGCATTTTACCGGCGATCTTGGCACGGCGCAGGGCTGTGCGGCTTTGGTCGCAGCCATT
CCCGCCTGCGATATTCTCATCAATAATCTTGGTATTTATGGCCCGAAGGATTTCTTCGAGACGCCTGACGAGGACTGGGC
GCATTTCTTCGAGGTCAATGTCATGTCCGGCGTCAGGCTCTCGCGCGCCTATTTGCCGGGAATGGTTTCGCAGGGCTGGG
GACGGGTCGTTTTTGTGTCCTCGGAATCGGCAATCAATATTCCCACCGAGATGATTCACTACGGCTTTTCCAAAACCGCT
CAGCTTTCCATCGCGCGCGGTCTTGCCCAAAGGGTGGCGGGCAGTGGTGTTACCGTTAATTCCGTGCTGCCGGGGCCGAC
GCTTTCCGAAGGGCTTGCTGAAATGTTGCAGGATGAAGTGAAGACATCCGGCAAGTCTGTGGAGGCCGTGGCAGCCGATT
TCGTCATGGCCCATCGGCCGTCCTCGATTATCCGGCGGGCGGCCACGGTCGAGGAAGTCGCCAATATGATCGTCTATATT
TCATCGAAACAGGCTTCAGCAACCACAGGCGCCGCCTTGCGCGTCGATGGTGGTGTGATCAGCGCAATCTGA

Upstream 100 bases:

>100_bases
TTGAAGACCCCCGTCATATCTCCCCGTCAAAATGCTTTATCTTGACGCTCCCAAAAGAGATGCGGCTTCCATCCGCGCGA
TGGCAGTTTAAGGAGGTTCC

Downstream 100 bases:

>100_bases
GTCTTAAAAAGCGGATCGCCCTTGGCTGATCCGCTTTTACGAAAATAATTCAAGGCTGTTTGAAGATCGGCAGGCCGAAG
TAATTTTCATCGGCTCCGCC

Product: short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MKIDLSGKTALVTGSTAGIGWAAAKGLAESGATVIVNGRKEATVAEAVSTLRKQVPDAQIQHFTGDLGTAQGCAALVAAI
PACDILINNLGIYGPKDFFETPDEDWAHFFEVNVMSGVRLSRAYLPGMVSQGWGRVVFVSSESAINIPTEMIHYGFSKTA
QLSIARGLAQRVAGSGVTVNSVLPGPTLSEGLAEMLQDEVKTSGKSVEAVAADFVMAHRPSSIIRRAATVEEVANMIVYI
SSKQASATTGAALRVDGGVISAI

Sequences:

>Translated_263_residues
MKIDLSGKTALVTGSTAGIGWAAAKGLAESGATVIVNGRKEATVAEAVSTLRKQVPDAQIQHFTGDLGTAQGCAALVAAI
PACDILINNLGIYGPKDFFETPDEDWAHFFEVNVMSGVRLSRAYLPGMVSQGWGRVVFVSSESAINIPTEMIHYGFSKTA
QLSIARGLAQRVAGSGVTVNSVLPGPTLSEGLAEMLQDEVKTSGKSVEAVAADFVMAHRPSSIIRRAATVEEVANMIVYI
SSKQASATTGAALRVDGGVISAI
>Mature_263_residues
MKIDLSGKTALVTGSTAGIGWAAAKGLAESGATVIVNGRKEATVAEAVSTLRKQVPDAQIQHFTGDLGTAQGCAALVAAI
PACDILINNLGIYGPKDFFETPDEDWAHFFEVNVMSGVRLSRAYLPGMVSQGWGRVVFVSSESAINIPTEMIHYGFSKTA
QLSIARGLAQRVAGSGVTVNSVLPGPTLSEGLAEMLQDEVKTSGKSVEAVAADFVMAHRPSSIIRRAATVEEVANMIVYI
SSKQASATTGAALRVDGGVISAI

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=267, Percent_Identity=30.7116104868914, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI5031737, Length=259, Percent_Identity=30.1158301158301, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI126723750, Length=267, Percent_Identity=28.4644194756554, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI33667109, Length=187, Percent_Identity=34.7593582887701, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI126723191, Length=185, Percent_Identity=34.0540540540541, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI7705925, Length=264, Percent_Identity=26.1363636363636, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI66933014, Length=255, Percent_Identity=27.0588235294118, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI4504505, Length=213, Percent_Identity=28.169014084507, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI15277342, Length=267, Percent_Identity=25.0936329588015, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1787335, Length=257, Percent_Identity=28.7937743190661, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1787905, Length=263, Percent_Identity=29.6577946768061, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1790717, Length=274, Percent_Identity=27.3722627737226, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1786812, Length=259, Percent_Identity=32.046332046332, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI87082100, Length=277, Percent_Identity=27.7978339350181, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1789208, Length=264, Percent_Identity=25.7575757575758, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788459, Length=263, Percent_Identity=25.8555133079848, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI2367175, Length=258, Percent_Identity=31.0077519379845, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI2367365, Length=260, Percent_Identity=28.8461538461538, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787820, Length=180, Percent_Identity=28.8888888888889, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1789378, Length=263, Percent_Identity=27.7566539923954, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17560676, Length=266, Percent_Identity=30.0751879699248, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17561402, Length=262, Percent_Identity=28.2442748091603, Blast_Score=101, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI71994604, Length=257, Percent_Identity=32.295719844358, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI71994600, Length=258, Percent_Identity=31.0077519379845, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI193204405, Length=265, Percent_Identity=29.4339622641509, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17562910, Length=272, Percent_Identity=29.0441176470588, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17531453, Length=266, Percent_Identity=31.203007518797, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI115534694, Length=262, Percent_Identity=29.7709923664122, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17562904, Length=266, Percent_Identity=26.6917293233083, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17568967, Length=237, Percent_Identity=27.0042194092827, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562906, Length=266, Percent_Identity=30.4511278195489, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17560150, Length=272, Percent_Identity=26.4705882352941, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562908, Length=266, Percent_Identity=30.8270676691729, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17560332, Length=267, Percent_Identity=27.3408239700375, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI32565532, Length=217, Percent_Identity=27.6497695852535, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI25147288, Length=259, Percent_Identity=23.9382239382239, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI21355319, Length=259, Percent_Identity=29.3436293436293, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24643142, Length=258, Percent_Identity=30.2325581395349, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI23397609, Length=256, Percent_Identity=28.90625, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28571526, Length=263, Percent_Identity=28.5171102661597, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24644339, Length=260, Percent_Identity=28.8461538461538, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI18859837, Length=212, Percent_Identity=27.8301886792453, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24639444, Length=262, Percent_Identity=28.2442748091603, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21357041, Length=254, Percent_Identity=29.9212598425197, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI45553409, Length=199, Percent_Identity=29.6482412060301, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24647948, Length=199, Percent_Identity=29.6482412060301, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24647946, Length=199, Percent_Identity=29.6482412060301, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 27336; Mature: 27336

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIDLSGKTALVTGSTAGIGWAAAKGLAESGATVIVNGRKEATVAEAVSTLRKQVPDAQI
CEEECCCCEEEEECCCCCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCHHH
QHFTGDLGTAQGCAALVAAIPACDILINNLGIYGPKDFFETPDEDWAHFFEVNVMSGVRL
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCHHHHHEEEEEHHCCCHH
SRAYLPGMVSQGWGRVVFVSSESAINIPTEMIHYGFSKTAQLSIARGLAQRVAGSGVTVN
HHHHCCCHHCCCCCEEEEEECCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEE
SVLPGPTLSEGLAEMLQDEVKTSGKSVEAVAADFVMAHRPSSIIRRAATVEEVANMIVYI
CCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEEEE
SSKQASATTGAALRVDGGVISAI
ECCCCCCCCCCEEEECCCEEECC
>Mature Secondary Structure
MKIDLSGKTALVTGSTAGIGWAAAKGLAESGATVIVNGRKEATVAEAVSTLRKQVPDAQI
CEEECCCCEEEEECCCCCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCHHH
QHFTGDLGTAQGCAALVAAIPACDILINNLGIYGPKDFFETPDEDWAHFFEVNVMSGVRL
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCHHHHHEEEEEHHCCCHH
SRAYLPGMVSQGWGRVVFVSSESAINIPTEMIHYGFSKTAQLSIARGLAQRVAGSGVTVN
HHHHCCCHHCCCCCEEEEEECCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEE
SVLPGPTLSEGLAEMLQDEVKTSGKSVEAVAADFVMAHRPSSIIRRAATVEEVANMIVYI
CCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEEEE
SSKQASATTGAALRVDGGVISAI
ECCCCCCCCCCEEEECCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]