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The map label for this gene is mutL

Identifier: 182677997

GI number: 182677997

Start: 1160705

End: 1162618

Strand: Direct

Name: mutL

Synonym: Bind_1011

Alternate gene names: 182677997

Gene position: 1160705-1162618 (Clockwise)

Preceding gene: 182677996

Following gene: 182677998

Centisome position: 27.83

GC content: 61.29

Gene sequence:

>1914_bases
TTGACGATCCGCCGTCTCGATCCCGTCCTCATCGATCGCATCGCCGCCGGCGAGGTCATCGAGCGGCCCGCCGCGGCGGT
GAAGGAACTCGTCGAAAATGCGCTCGACGCGCAGGCGAGCGAGATTGATGTCGTGCTTGAAGGCGGCGGCAAGACGCTCA
TCCGCGTCACCGATAATGGCTGCGGCATGAGCGCCGAGGATCTGGAACTCTCCGTCGAGCGCCATGCCACGTCCAAATTG
CCGGATGGCGATCTCTTCGCCATTGCGACGCTCGGGTTTCGTGGCGAGGCTTTGCCCTCGATCGGTTCCGTTTCGGTTCT
GTCGCTGACGAGCCGCATGGAAACGGCCACGCATGGTGTCGCGCTCAGCGTCGAACATGGACGCAAACAGACGGTCATTC
CCTGCGGCCAGCCACGTGGCACGCGGATCGAGGTCCGTGAACTGTTTCGCACGACGCCGGCAAGGCTCAAATTTTTGAAA
GGTGATCGCGCCGAGGCGCGCGCTGCCGCCGATGCCGTGCAGCGCCTGGCCATGGCGCATCCGACCCGGCGTTTTACCTT
CACGAGCACGGATACAGCGGGCTTTGATTATCTGCCTTGTGCCGAGGGACCAGAAGGCCTGCTCGCGCGTATCGGCGCCG
TGCTGGGCAAGGATTTCGAGGCCAATGCTTTGCCGGTCGAGGCGGAACGCGAAGGGATTATCCTCGAAGGGTTCATCGGC
CTGCCAACCTGGCATCGTGCCAATGGGCTAGCGCAATATCTTTTCGTCAATGGCCGGCCGGTGCGCGACAAATTGCTCAC
CGGCGCTGTGCGCGCGGCCTATATGGATTATCTGCCAGCCGGGCGTTATCCCGCCTTGGCTCTGTTTCTGCGGTGTGATC
CGCAAGAGGTCGATGTCAATGTGCATCCGGCCAAGGCGGAAGTTCGTTTCCGCGATCAGGGTCTTGTGCGCGGTCTCCTT
GTTGGCGCCTTGAAACAGACATTGCAGCAAGCCATGCATCGGGCGACGCCTGATGGTGGCAGAGTGGCGCTCGGCCTTCT
TGCGATGCATTCGGCGGGGCAGGGGCAGCGGCCCGTATCATCCGCGTCCATGCCATCCGCGTCAAGGCAAGCGCCGACCA
TGCCGCCCAGGGATTGGATCAAGGAAGGCGTTCAGGATTGGGATTGGCGGCAATCCCCCGCGCGACCGCAAAATCCGCCC
CAAAATCCGCCCCCTGGCGATCGTATCGAAATGTCAGGCTCGCTGCCTTTGGGTTTTGCCGAAACACCGGCTGGTCTGAA
CGGGGATAGCGGGAAAGAGCTCAGCGAGGCGGCTTCTGAGACGCCGCATGATGAGCCACTTGGATTTGCGCGGGCGCAAT
TGCATGAGACCTATATTGTCGCGCAAACGCGCGATGGTTTCGTGCTGGTCGATCAGCATGCGGCGCATGAACGTCTTGTC
TATGAACGTTTGAAACAGGCGCGCGCGGCGCAAACGGTCGAGCGCCAGATCCTTCTCCTGCCGACCATTGTCGAATTGCC
TGAGGCTGATGTCGAACGGCTGGTCGACGCGGCCTCGATGCTGGCCGATTTTGGCCTCGTGGTTGAAAGCTTCGGTCCCG
GCGCGCTAGCCGTGCGGGAAATTCCGATCGTTTTGAAGGATGGCTCGGTTCCGGCCTTGATCCATGATCTCGCGAACCAG
TTGCAAGAAGACGACAAAGCCTTGATCCCGCTCGAACGCAAACTCGATCATGTGCTGGCGACCTTTGCCTGCCATCATTC
CGTGCGTGCCGGCCGTCGTCTCGGTATCGAGGAGATGAATGCGCTCCTGCGCGAGATGGAACGCACGCCGGGCTCCGGCC
AATGCAATCACGGGCGCCCGACCTATATCGAATTGAAGCTCGGTGACATCGAGAGATTATTCGGGCGTGGATGA

Upstream 100 bases:

>100_bases
GCAAACGTTTGTTTGGCGATGGCCATCTGCTTGTCGCCATCGCCGGACGGCCTGAAAATCTGTAAAAGCTCATGCGGTAA
AATCTTCAAGCGATTAACCT

Downstream 100 bases:

>100_bases
GCGAAGCGACGAGATCTCATAAGTGTCGGATCGATGAAAATGAACCAAATCGTGCATCTCGATGTCTTTACCCATGTTCG
TCTGATCACAGGCTTTATCA

Product: DNA mismatch repair protein MutL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 637; Mature: 636

Protein sequence:

>637_residues
MTIRRLDPVLIDRIAAGEVIERPAAAVKELVENALDAQASEIDVVLEGGGKTLIRVTDNGCGMSAEDLELSVERHATSKL
PDGDLFAIATLGFRGEALPSIGSVSVLSLTSRMETATHGVALSVEHGRKQTVIPCGQPRGTRIEVRELFRTTPARLKFLK
GDRAEARAAADAVQRLAMAHPTRRFTFTSTDTAGFDYLPCAEGPEGLLARIGAVLGKDFEANALPVEAEREGIILEGFIG
LPTWHRANGLAQYLFVNGRPVRDKLLTGAVRAAYMDYLPAGRYPALALFLRCDPQEVDVNVHPAKAEVRFRDQGLVRGLL
VGALKQTLQQAMHRATPDGGRVALGLLAMHSAGQGQRPVSSASMPSASRQAPTMPPRDWIKEGVQDWDWRQSPARPQNPP
QNPPPGDRIEMSGSLPLGFAETPAGLNGDSGKELSEAASETPHDEPLGFARAQLHETYIVAQTRDGFVLVDQHAAHERLV
YERLKQARAAQTVERQILLLPTIVELPEADVERLVDAASMLADFGLVVESFGPGALAVREIPIVLKDGSVPALIHDLANQ
LQEDDKALIPLERKLDHVLATFACHHSVRAGRRLGIEEMNALLREMERTPGSGQCNHGRPTYIELKLGDIERLFGRG

Sequences:

>Translated_637_residues
MTIRRLDPVLIDRIAAGEVIERPAAAVKELVENALDAQASEIDVVLEGGGKTLIRVTDNGCGMSAEDLELSVERHATSKL
PDGDLFAIATLGFRGEALPSIGSVSVLSLTSRMETATHGVALSVEHGRKQTVIPCGQPRGTRIEVRELFRTTPARLKFLK
GDRAEARAAADAVQRLAMAHPTRRFTFTSTDTAGFDYLPCAEGPEGLLARIGAVLGKDFEANALPVEAEREGIILEGFIG
LPTWHRANGLAQYLFVNGRPVRDKLLTGAVRAAYMDYLPAGRYPALALFLRCDPQEVDVNVHPAKAEVRFRDQGLVRGLL
VGALKQTLQQAMHRATPDGGRVALGLLAMHSAGQGQRPVSSASMPSASRQAPTMPPRDWIKEGVQDWDWRQSPARPQNPP
QNPPPGDRIEMSGSLPLGFAETPAGLNGDSGKELSEAASETPHDEPLGFARAQLHETYIVAQTRDGFVLVDQHAAHERLV
YERLKQARAAQTVERQILLLPTIVELPEADVERLVDAASMLADFGLVVESFGPGALAVREIPIVLKDGSVPALIHDLANQ
LQEDDKALIPLERKLDHVLATFACHHSVRAGRRLGIEEMNALLREMERTPGSGQCNHGRPTYIELKLGDIERLFGRG
>Mature_636_residues
TIRRLDPVLIDRIAAGEVIERPAAAVKELVENALDAQASEIDVVLEGGGKTLIRVTDNGCGMSAEDLELSVERHATSKLP
DGDLFAIATLGFRGEALPSIGSVSVLSLTSRMETATHGVALSVEHGRKQTVIPCGQPRGTRIEVRELFRTTPARLKFLKG
DRAEARAAADAVQRLAMAHPTRRFTFTSTDTAGFDYLPCAEGPEGLLARIGAVLGKDFEANALPVEAEREGIILEGFIGL
PTWHRANGLAQYLFVNGRPVRDKLLTGAVRAAYMDYLPAGRYPALALFLRCDPQEVDVNVHPAKAEVRFRDQGLVRGLLV
GALKQTLQQAMHRATPDGGRVALGLLAMHSAGQGQRPVSSASMPSASRQAPTMPPRDWIKEGVQDWDWRQSPARPQNPPQ
NPPPGDRIEMSGSLPLGFAETPAGLNGDSGKELSEAASETPHDEPLGFARAQLHETYIVAQTRDGFVLVDQHAAHERLVY
ERLKQARAAQTVERQILLLPTIVELPEADVERLVDAASMLADFGLVVESFGPGALAVREIPIVLKDGSVPALIHDLANQL
QEDDKALIPLERKLDHVLATFACHHSVRAGRRLGIEEMNALLREMERTPGSGQCNHGRPTYIELKLGDIERLFGRG

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=312, Percent_Identity=36.5384615384615, Blast_Score=183, Evalue=4e-46,
Organism=Homo sapiens, GI4505913, Length=346, Percent_Identity=29.7687861271676, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI310128478, Length=346, Percent_Identity=29.7687861271676, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI4505911, Length=329, Percent_Identity=27.0516717325228, Blast_Score=115, Evalue=2e-25,
Organism=Homo sapiens, GI189458898, Length=326, Percent_Identity=26.9938650306748, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI310128480, Length=303, Percent_Identity=27.7227722772277, Blast_Score=107, Evalue=4e-23,
Organism=Homo sapiens, GI189458896, Length=322, Percent_Identity=25.776397515528, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI263191589, Length=218, Percent_Identity=28.8990825688073, Blast_Score=81, Evalue=3e-15,
Organism=Escherichia coli, GI1790612, Length=585, Percent_Identity=35.2136752136752, Blast_Score=253, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI71991825, Length=323, Percent_Identity=33.7461300309598, Blast_Score=146, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17562796, Length=410, Percent_Identity=24.6341463414634, Blast_Score=119, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6323819, Length=319, Percent_Identity=33.8557993730408, Blast_Score=170, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6324247, Length=363, Percent_Identity=25.6198347107438, Blast_Score=103, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6325093, Length=753, Percent_Identity=24.3027888446215, Blast_Score=97, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6323063, Length=362, Percent_Identity=25.414364640884, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17136968, Length=338, Percent_Identity=35.7988165680473, Blast_Score=179, Evalue=6e-45,
Organism=Drosophila melanogaster, GI17136970, Length=350, Percent_Identity=26.5714285714286, Blast_Score=111, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_BEII9 (B2II71)

Other databases:

- EMBL:   CP001016
- RefSeq:   YP_001832143.1
- GeneID:   6199443
- GenomeReviews:   CP001016_GR
- KEGG:   bid:Bind_1011
- HOGENOM:   HBG520262
- OMA:   HERIRRR
- ProtClustDB:   CLSK2405364
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 69145; Mature: 69014

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIRRLDPVLIDRIAAGEVIERPAAAVKELVENALDAQASEIDVVLEGGGKTLIRVTDNG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEEEEECCC
CGMSAEDLELSVERHATSKLPDGDLFAIATLGFRGEALPSIGSVSVLSLTSRMETATHGV
CCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCE
ALSVEHGRKQTVIPCGQPRGTRIEVRELFRTTPARLKFLKGDRAEARAAADAVQRLAMAH
EEEECCCCCCEEEECCCCCCCCHHHHHHHCCCHHHHEECCCCHHHHHHHHHHHHHHHHHC
PTRRFTFTSTDTAGFDYLPCAEGPEGLLARIGAVLGKDFEANALPVEAEREGIILEGFIG
CCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCC
LPTWHRANGLAQYLFVNGRPVRDKLLTGAVRAAYMDYLPAGRYPALALFLRCDPQEVDVN
CCCCHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCEE
VHPAKAEVRFRDQGLVRGLLVGALKQTLQQAMHRATPDGGRVALGLLAMHSAGQGQRPVS
ECCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCC
SASMPSASRQAPTMPPRDWIKEGVQDWDWRQSPARPQNPPQNPPPGDRIEMSGSLPLGFA
CCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCC
ETPAGLNGDSGKELSEAASETPHDEPLGFARAQLHETYIVAQTRDGFVLVDQHAAHERLV
CCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHCEEEEEECCCCEEEEECCHHHHHHH
YERLKQARAAQTVERQILLLPTIVELPEADVERLVDAASMLADFGLVVESFGPGALAVRE
HHHHHHHHHHHHHHHHHEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
IPIVLKDGSVPALIHDLANQLQEDDKALIPLERKLDHVLATFACHHSVRAGRRLGIEEMN
EEEEEECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
ALLREMERTPGSGQCNHGRPTYIELKLGDIERLFGRG
HHHHHHHCCCCCCCCCCCCCEEEEEEECCHHHHHCCC
>Mature Secondary Structure 
TIRRLDPVLIDRIAAGEVIERPAAAVKELVENALDAQASEIDVVLEGGGKTLIRVTDNG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEEEEECCC
CGMSAEDLELSVERHATSKLPDGDLFAIATLGFRGEALPSIGSVSVLSLTSRMETATHGV
CCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCE
ALSVEHGRKQTVIPCGQPRGTRIEVRELFRTTPARLKFLKGDRAEARAAADAVQRLAMAH
EEEECCCCCCEEEECCCCCCCCHHHHHHHCCCHHHHEECCCCHHHHHHHHHHHHHHHHHC
PTRRFTFTSTDTAGFDYLPCAEGPEGLLARIGAVLGKDFEANALPVEAEREGIILEGFIG
CCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCC
LPTWHRANGLAQYLFVNGRPVRDKLLTGAVRAAYMDYLPAGRYPALALFLRCDPQEVDVN
CCCCHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCEE
VHPAKAEVRFRDQGLVRGLLVGALKQTLQQAMHRATPDGGRVALGLLAMHSAGQGQRPVS
ECCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCC
SASMPSASRQAPTMPPRDWIKEGVQDWDWRQSPARPQNPPQNPPPGDRIEMSGSLPLGFA
CCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCC
ETPAGLNGDSGKELSEAASETPHDEPLGFARAQLHETYIVAQTRDGFVLVDQHAAHERLV
CCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHCEEEEEECCCCEEEEECCHHHHHHH
YERLKQARAAQTVERQILLLPTIVELPEADVERLVDAASMLADFGLVVESFGPGALAVRE
HHHHHHHHHHHHHHHHHEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
IPIVLKDGSVPALIHDLANQLQEDDKALIPLERKLDHVLATFACHHSVRAGRRLGIEEMN
EEEEEECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
ALLREMERTPGSGQCNHGRPTYIELKLGDIERLFGRG
HHHHHHHCCCCCCCCCCCCCEEEEEEECCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA