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The map label for this gene is ribBA [H]

Identifier: 182677933

GI number: 182677933

Start: 1082654

End: 1083958

Strand: Direct

Name: ribBA [H]

Synonym: Bind_0944

Alternate gene names: 182677933

Gene position: 1082654-1083958 (Clockwise)

Preceding gene: 182677930

Following gene: 182677934

Centisome position: 25.96

GC content: 60.15

Gene sequence:

>1305_bases
ATGAAACTCGGTGAGTGGCTAGAGCGCAATCATCTCACGCGATCGGATTTCGCCCGGAAGATCGGCCTTTCCAAGGGTTC
GATTTCACAAATGTGCAATCAGCACAAGGCTTGGCCCTCCCGTGAAACCGCCGAACTGATCGTGCGCGCGACCGAAGGCG
CCGTCACGCCCAATGATTTCCTGTCCAACGCCCTTCTCGAATCCCGCGCAAGCAAGGAGCGCTTCCCAATGCCCCATTCG
GTCGCCCAGGCCATCGAGGCCATCGCCAAGGGCGAACTCGTCATCGTCACCGACGATGACGATCGCGAAAACGAAGGCGA
TCTCATCTGTGCTGCCTCGCTCTGCACGCCGGAGAAAATGGCCTTCATCATCCGCCATTGCTGCGGCATCGTCTGCGCGC
CGCTCACGCTCGAGGAAGCGCGCCGTTTACATCTTTCCCCCATGGTCGCGGCCAATGATGCCCCCCATGGCACAGCCTTT
ACCGTCTCGGTCGATGGCAAACATGGGCTGACCACCGGCATTTCAGCAGAGCAGCGCTCCAATACCGTCCGGGCCTTAGC
CAACGGTAATATGGGGGCCAGCGATTTCGTGCGGCCGGGCCATATTTTTCCGCTGATCGCCCGCGAGGGTGGTGTCTTGA
TGCGCTCCGGCCATACCGAGGCGGCGGTCGATCTCTGCCGTCTCGCCGGGCTTCCGCCGGTTGGCGTGATCTGCGAATTG
ACCAATGACGATGGCACCGTCATGGTCGGCGCGCAGATCAATGCTTTTGCCAAGGACCATGGGCTAAAGCGGATTTCGGT
GGCCGATCTCATCGCTTATCGCCAGGCGCGTGAAAAGCTTGTCGAGCGGGTGGCGAGTTTCAGCGTGGAAGGGCCTTGCG
GACCGCTCACCGGTTATGCCTATCGCACACCCTATGACAGCGTTCAGCATTTCGCCTTCGTCGAGGGCGAGATCGGCGAT
GGCCGGGCCATGCCGACCCGCTTGCACCGCGTTGATATCGTTGCCGACGTCATTACCGGCGGCGAGACGATCCGCAAAAC
CTTTGCAAAATTCAAGACGGAAGGGCGTGGCGTCTTCATTTATCTGCGGGACGGAACGGCCGGTGTGCCGGCGCAGATCA
CCGGCCAGGACAAAATGGATTCGGAAGCTTTGCGGACCAAGGAATGGCGCGAGGTCGGACTCGGAGCGCAGATTTTGCGT
GATCTCGGCGTCAGCTCGATCAAGCTCTGCACCTCTGCCGCAATGACCTATGTCGGCCTCTCCGGCTTTGGCATAGAAAT
CGTTTCGACCGAAGGCTTGAGCTGA

Upstream 100 bases:

>100_bases
AAGAAAACCCGCATCAGAAGTTTAGTAAAAATGAACATTTGGCTGGCTGCCGTGGTTTGTTTTAGTTTGACTAAACCCAT
GGGCGTACTAGAATGGCTTT

Downstream 100 bases:

>100_bases
CAACGAGCTTTTTCGGAGCGTAAAGCGTGGATGACGTCCGTCAGACAAGCGGTGTTGGGCTTGCCGCGCTTTTGCTCTTC
TGGCCTGTGGTGCTTGTCGC

Product: XRE family transcriptional regulator

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MKLGEWLERNHLTRSDFARKIGLSKGSISQMCNQHKAWPSRETAELIVRATEGAVTPNDFLSNALLESRASKERFPMPHS
VAQAIEAIAKGELVIVTDDDDRENEGDLICAASLCTPEKMAFIIRHCCGIVCAPLTLEEARRLHLSPMVAANDAPHGTAF
TVSVDGKHGLTTGISAEQRSNTVRALANGNMGASDFVRPGHIFPLIAREGGVLMRSGHTEAAVDLCRLAGLPPVGVICEL
TNDDGTVMVGAQINAFAKDHGLKRISVADLIAYRQAREKLVERVASFSVEGPCGPLTGYAYRTPYDSVQHFAFVEGEIGD
GRAMPTRLHRVDIVADVITGGETIRKTFAKFKTEGRGVFIYLRDGTAGVPAQITGQDKMDSEALRTKEWREVGLGAQILR
DLGVSSIKLCTSAAMTYVGLSGFGIEIVSTEGLS

Sequences:

>Translated_434_residues
MKLGEWLERNHLTRSDFARKIGLSKGSISQMCNQHKAWPSRETAELIVRATEGAVTPNDFLSNALLESRASKERFPMPHS
VAQAIEAIAKGELVIVTDDDDRENEGDLICAASLCTPEKMAFIIRHCCGIVCAPLTLEEARRLHLSPMVAANDAPHGTAF
TVSVDGKHGLTTGISAEQRSNTVRALANGNMGASDFVRPGHIFPLIAREGGVLMRSGHTEAAVDLCRLAGLPPVGVICEL
TNDDGTVMVGAQINAFAKDHGLKRISVADLIAYRQAREKLVERVASFSVEGPCGPLTGYAYRTPYDSVQHFAFVEGEIGD
GRAMPTRLHRVDIVADVITGGETIRKTFAKFKTEGRGVFIYLRDGTAGVPAQITGQDKMDSEALRTKEWREVGLGAQILR
DLGVSSIKLCTSAAMTYVGLSGFGIEIVSTEGLS
>Mature_434_residues
MKLGEWLERNHLTRSDFARKIGLSKGSISQMCNQHKAWPSRETAELIVRATEGAVTPNDFLSNALLESRASKERFPMPHS
VAQAIEAIAKGELVIVTDDDDRENEGDLICAASLCTPEKMAFIIRHCCGIVCAPLTLEEARRLHLSPMVAANDAPHGTAF
TVSVDGKHGLTTGISAEQRSNTVRALANGNMGASDFVRPGHIFPLIAREGGVLMRSGHTEAAVDLCRLAGLPPVGVICEL
TNDDGTVMVGAQINAFAKDHGLKRISVADLIAYRQAREKLVERVASFSVEGPCGPLTGYAYRTPYDSVQHFAFVEGEIGD
GRAMPTRLHRVDIVADVITGGETIRKTFAKFKTEGRGVFIYLRDGTAGVPAQITGQDKMDSEALRTKEWREVGLGAQILR
DLGVSSIKLCTSAAMTYVGLSGFGIEIVSTEGLS

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=199, Percent_Identity=49.2462311557789, Blast_Score=194, Evalue=8e-51,
Organism=Saccharomyces cerevisiae, GI6320695, Length=202, Percent_Identity=51.4851485148515, Blast_Score=191, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 46762; Mature: 46762

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLGEWLERNHLTRSDFARKIGLSKGSISQMCNQHKAWPSRETAELIVRATEGAVTPNDF
CCHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHEEEECCCCCCHHHH
LSNALLESRASKERFPMPHSVAQAIEAIAKGELVIVTDDDDRENEGDLICAASLCTPEKM
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECCCCHHHH
AFIIRHCCGIVCAPLTLEEARRLHLSPMVAANDAPHGTAFTVSVDGKHGLTTGISAEQRS
HHHHHHHHHHHCCCCCHHHHHHHCCCCEEECCCCCCCCEEEEEECCCCCCCCCCCCHHHC
NTVRALANGNMGASDFVRPGHIFPLIAREGGVLMRSGHTEAAVDLCRLAGLPPVGVICEL
CCEEEEECCCCCHHHCCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHCCCCCCCEEEEE
TNDDGTVMVGAQINAFAKDHGLKRISVADLIAYRQAREKLVERVASFSVEGPCGPLTGYA
ECCCCEEEECCEEEHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCE
YRTPYDSVQHFAFVEGEIGDGRAMPTRLHRVDIVADVITGGETIRKTFAKFKTEGRGVFI
EECCHHHHHHEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEE
YLRDGTAGVPAQITGQDKMDSEALRTKEWREVGLGAQILRDLGVSSIKLCTSAAMTYVGL
EEECCCCCCCEEECCCCCCCHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHCC
SGFGIEIVSTEGLS
CCCCEEEEECCCCC
>Mature Secondary Structure
MKLGEWLERNHLTRSDFARKIGLSKGSISQMCNQHKAWPSRETAELIVRATEGAVTPNDF
CCHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHEEEECCCCCCHHHH
LSNALLESRASKERFPMPHSVAQAIEAIAKGELVIVTDDDDRENEGDLICAASLCTPEKM
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECCCCHHHH
AFIIRHCCGIVCAPLTLEEARRLHLSPMVAANDAPHGTAFTVSVDGKHGLTTGISAEQRS
HHHHHHHHHHHCCCCCHHHHHHHCCCCEEECCCCCCCCEEEEEECCCCCCCCCCCCHHHC
NTVRALANGNMGASDFVRPGHIFPLIAREGGVLMRSGHTEAAVDLCRLAGLPPVGVICEL
CCEEEEECCCCCHHHCCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHCCCCCCCEEEEE
TNDDGTVMVGAQINAFAKDHGLKRISVADLIAYRQAREKLVERVASFSVEGPCGPLTGYA
ECCCCEEEECCEEEHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCE
YRTPYDSVQHFAFVEGEIGDGRAMPTRLHRVDIVADVITGGETIRKTFAKFKTEGRGVFI
EECCHHHHHHEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEE
YLRDGTAGVPAQITGQDKMDSEALRTKEWREVGLGAQILRDLGVSSIKLCTSAAMTYVGL
EEECCCCCCCEEECCCCCCCHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHCC
SGFGIEIVSTEGLS
CCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA