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The map label for this gene is yhcW [H]

Identifier: 182677927

GI number: 182677927

Start: 1071872

End: 1072579

Strand: Direct

Name: yhcW [H]

Synonym: Bind_0935

Alternate gene names: 182677927

Gene position: 1071872-1072579 (Clockwise)

Preceding gene: 182677926

Following gene: 182677928

Centisome position: 25.7

GC content: 57.63

Gene sequence:

>708_bases
ATGACAGCTTCTGAACAAACCTGGGTTGCGCCGCAATCCGTGATTTTCGATATGGATGGGCTCCTGATCGATAGTGAGAG
CCTTGCGATGAAGGCGCTCAATAAGGCGGGCGAGGAGATGGGCTATGATACGCCGTTTTCCTTTTGCCAAGCGATGATCG
GCGTGCCGATTGATCGCTGCCGCAGCCTTGTCGCCGAACGGTTTGGTGAGGATTTCCCGCTCGATCTCTATTTCGCAACT
TCCGACAAGCATTTCACATCACTGGTCGAAGCCGGCCACTTGCAATTGAAGGCAGGTGTCGAAAATCTTCTCGGCGCACT
TGAGGAGCAAGGCATCAGCAAGGCGGTCGCGACCTCCTCGAGCCGTCGCAAGGCTGATCATCATCTCGAACTCATTGGCA
TTCGCGAGCGGTTCAGCGCCATTATCACGCGCGATGATGTCCAGCGCGGTAAGCCTGATCCGGATCCCTTCCTTCGCGCG
GCCGAGGCCCTGCAAACGCCACCCGAACGCTGCCTGGTCCTGGAAGATTCCCACAATGGTGTCAGGGCCGCCCATGCGGC
AGGAATGCGGGTGATCATGGTGCCGGATCTTTTGGGTCCGACCGATGAAATGCTCGAAAAGGTCTTCATGGTCGCCGACG
ATCTGAATGTCGTCGCCGAACTCATCCGTTCGAGCGTGCCCGAGACCGCGCCCGCAACCAAGCAGTAA

Upstream 100 bases:

>100_bases
ATCAGATTGATCCCAAAAGTGGGAGCCACTTTTGGGTCTGATGCTCTAGAGGGTCGCGTGCCGCGATCCCGACAGATGGA
ATTTTTGCCAAGGCAGGTCA

Downstream 100 bases:

>100_bases
TCCCTTCGGTCAGTAAGAAGGCCGTCGCGCGCTGGGAGCTTTTCTTGTTGGGCGGGCTACCATCATGATTTCCTCGTCGT
GCATTGGAAAGACTGTCCTT

Product: HAD family hydrolase

Products: Beta-D-Glucose 6- Phosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 235; Mature: 234

Protein sequence:

>235_residues
MTASEQTWVAPQSVIFDMDGLLIDSESLAMKALNKAGEEMGYDTPFSFCQAMIGVPIDRCRSLVAERFGEDFPLDLYFAT
SDKHFTSLVEAGHLQLKAGVENLLGALEEQGISKAVATSSSRRKADHHLELIGIRERFSAIITRDDVQRGKPDPDPFLRA
AEALQTPPERCLVLEDSHNGVRAAHAAGMRVIMVPDLLGPTDEMLEKVFMVADDLNVVAELIRSSVPETAPATKQ

Sequences:

>Translated_235_residues
MTASEQTWVAPQSVIFDMDGLLIDSESLAMKALNKAGEEMGYDTPFSFCQAMIGVPIDRCRSLVAERFGEDFPLDLYFAT
SDKHFTSLVEAGHLQLKAGVENLLGALEEQGISKAVATSSSRRKADHHLELIGIRERFSAIITRDDVQRGKPDPDPFLRA
AEALQTPPERCLVLEDSHNGVRAAHAAGMRVIMVPDLLGPTDEMLEKVFMVADDLNVVAELIRSSVPETAPATKQ
>Mature_234_residues
TASEQTWVAPQSVIFDMDGLLIDSESLAMKALNKAGEEMGYDTPFSFCQAMIGVPIDRCRSLVAERFGEDFPLDLYFATS
DKHFTSLVEAGHLQLKAGVENLLGALEEQGISKAVATSSSRRKADHHLELIGIRERFSAIITRDDVQRGKPDPDPFLRAA
EALQTPPERCLVLEDSHNGVRAAHAAGMRVIMVPDLLGPTDEMLEKVFMVADDLNVVAELIRSSVPETAPATKQ

Specific function: Reversible Transformation Of Glucose 6-Phosphate And Beta-Glucose 1-Phosphate (By Similarity). [C]

COG id: COG0637

COG function: function code R; Predicted phosphatase/phosphohexomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family [H]

Homologues:

Organism=Homo sapiens, GI197382691, Length=209, Percent_Identity=37.799043062201, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI296011030, Length=197, Percent_Identity=36.0406091370558, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI207113149, Length=109, Percent_Identity=48.6238532110092, Blast_Score=86, Evalue=4e-17,
Organism=Escherichia coli, GI1787576, Length=206, Percent_Identity=28.1553398058252, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1788021, Length=199, Percent_Identity=31.6582914572864, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI1789046, Length=186, Percent_Identity=31.1827956989247, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1789787, Length=198, Percent_Identity=29.7979797979798, Blast_Score=68, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17554716, Length=194, Percent_Identity=31.4432989690722, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17137324, Length=188, Percent_Identity=34.0425531914894, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI45550911, Length=203, Percent_Identity=31.5270935960591, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI116008157, Length=193, Percent_Identity=32.1243523316062, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI20129151, Length=201, Percent_Identity=30.8457711442786, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24580849, Length=179, Percent_Identity=29.0502793296089, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006439
- InterPro:   IPR006402
- InterPro:   IPR005833 [H]

Pfam domain/function: PF00702 Hydrolase [H]

EC number: 5.4.2.6 [C]

Molecular weight: Translated: 25723; Mature: 25591

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASEQTWVAPQSVIFDMDGLLIDSESLAMKALNKAGEEMGYDTPFSFCQAMIGVPIDRC
CCCCCCCCCCHHHHHEECCCEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHH
RSLVAERFGEDFPLDLYFATSDKHFTSLVEAGHLQLKAGVENLLGALEEQGISKAVATSS
HHHHHHHCCCCCCEEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
SRRKADHHLELIGIRERFSAIITRDDVQRGKPDPDPFLRAAEALQTPPERCLVLEDSHNG
HHHHHHHHHHHEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHEEEEECCCCC
VRAAHAAGMRVIMVPDLLGPTDEMLEKVFMVADDLNVVAELIRSSVPETAPATKQ
HHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
TASEQTWVAPQSVIFDMDGLLIDSESLAMKALNKAGEEMGYDTPFSFCQAMIGVPIDRC
CCCCCCCCCHHHHHEECCCEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHH
RSLVAERFGEDFPLDLYFATSDKHFTSLVEAGHLQLKAGVENLLGALEEQGISKAVATSS
HHHHHHHCCCCCCEEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
SRRKADHHLELIGIRERFSAIITRDDVQRGKPDPDPFLRAAEALQTPPERCLVLEDSHNG
HHHHHHHHHHHEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHEEEEECCCCC
VRAAHAAGMRVIMVPDLLGPTDEMLEKVFMVADDLNVVAELIRSSVPETAPATKQ
HHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Beta-D-Glucose 1-Phosphate [C]

Specific reaction: Beta-D-Glucose 1-Phosphate = Beta-D-Glucose 6- Phosphate. [C]

General reaction: Group transfer (intramolecular phosphate group isomerization [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969498; 9384377 [H]