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The map label for this gene is gor [H]

Identifier: 182677874

GI number: 182677874

Start: 1003260

End: 1004672

Strand: Direct

Name: gor [H]

Synonym: Bind_0881

Alternate gene names: 182677874

Gene position: 1003260-1004672 (Clockwise)

Preceding gene: 182677873

Following gene: 182677876

Centisome position: 24.06

GC content: 58.17

Gene sequence:

>1413_bases
ATGACCGATTACGATGTGGATCTTTTCGTTATCGGGGCGGGCTCCGGCGGCGTGCGCGCCGCGCGCATTGCCGCGGGTTA
TGGCGCGCGCGTGTTGATCGCGGAGGAGTTTCGGGTCGGCGGCACTTGCGTCATTCGCGGCTGCGTGCCGAAAAAACTCA
TGGTCTATGCAAGCCGTTTCGTCGATCATTTCGAGGATGCGGCGGGGTTCGGCTGGGACGTTCCGCAGCCCAGCTTTCAT
TGGTCGAAACTGGTCGCGGCGAAGGAAAAGGAAATCTCCCGTCTTTCGGCGATTTATCGGACCAATCTCGACAAAGCGGG
TGTCACGATCCTCGATTCACGCGCTGAAATCGAAGATGCGCATACTGTTTTGCTGAAAGCCGACGAACGGCGGGTGACGG
CGGGAATGATTCTGGTGGCGACGGGTGGCACGCCGGTCTTGGAACCGGATGTGCCGGGCCGGGATCTGGCTATTACCTCG
AATGAGATTTTCGATCTGCCGGAGATGCCGAAACGCCTGCTGATCGTTGGCGGAGGCTATATTGCCGTCGAATTCGCGAG
CATTTTCGCGCGTCTTGGCAGCAAGGTCACGCTCGTGCAACGCGGTGATAATGTCCTGCGCGGCTTTGATGAAGATATGC
GTAATGGCGTGCGCGACGCTCTGATCCATGCCGGTGTCGATGTGAAATCTGGCTTTTTGCCGACGGCCATCGAGAAACGC
GGTGATGCTTTGCATGTTTCCTTGACCAAGGGAACGCATATCGAAGTGGATCAGGTCCTCACCGCGACAGGGCGCAGGCC
GCATACACTCGGCCTTGGCCTGGAAAAGGCGGGTGTCATCGTGGATGATATCGGCGCGATCAAGGTCGATGCTTATTCCA
AGACCAATGTGGATTCGATCTATGCGGTGGGTGACGTCACCAATCGCCTGGCCTTGACGCCGGTGGCGATCCGCGAGGGC
CATGCCTTTGCTGACACGGTTTTTGGCCATAAGTCGACTGCCGTTAATCATACCAATGTCGCGACGGCTGTGTTCACGAC
GCCGGAACTGGGCACGATCGGATTGAGCGAAATGGAAGCGCGCGCAATTTACGATTGCGTCGATGTCTATCTGGCGAGCT
TCCGACCGTTGAAAGCCACTTTGTCAGGGCGGCAGGAAAAGACCGTGATGAAAATCCTGGTCGATGGACAGACCGATAAA
GTTCTGGGTGTCCATATCCTTGGTGAGGATGCTGGTGAAATGGCCCAGATTCTCGGGATCGCCATTACGGTGGGCGCGAC
CAAGGCTGATTTCGACGCGACCATGGCCGTGCATCCGACGTCTGCCGAGGAACTCGTGACCATGCGCGTGCGCACGGCCC
GTTATGAACGCGCGCCCCAAGGACTTGATGAGGCGCCGGGCGCCGCAGATTGA

Upstream 100 bases:

>100_bases
TTCCAATGGAACCATGTTTGGCGCTCTAGATCTTTGAAAAATGCATTTTCTCGATGCGAAGCGACATGCTTCGCCTGAAA
ATGCTCTGGGAGCGGATTTC

Downstream 100 bases:

>100_bases
AGCTTGGACGATGCTCTCCCCGCGTTGATCTGACTGCCGAAGCTCAGAGATGCGGGGCATGTACAACTATCTCCCTCTAG
CAAACTGCCGCGATAGTCTA

Product: glutathione-disulfide reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MTDYDVDLFVIGAGSGGVRAARIAAGYGARVLIAEEFRVGGTCVIRGCVPKKLMVYASRFVDHFEDAAGFGWDVPQPSFH
WSKLVAAKEKEISRLSAIYRTNLDKAGVTILDSRAEIEDAHTVLLKADERRVTAGMILVATGGTPVLEPDVPGRDLAITS
NEIFDLPEMPKRLLIVGGGYIAVEFASIFARLGSKVTLVQRGDNVLRGFDEDMRNGVRDALIHAGVDVKSGFLPTAIEKR
GDALHVSLTKGTHIEVDQVLTATGRRPHTLGLGLEKAGVIVDDIGAIKVDAYSKTNVDSIYAVGDVTNRLALTPVAIREG
HAFADTVFGHKSTAVNHTNVATAVFTTPELGTIGLSEMEARAIYDCVDVYLASFRPLKATLSGRQEKTVMKILVDGQTDK
VLGVHILGEDAGEMAQILGIAITVGATKADFDATMAVHPTSAEELVTMRVRTARYERAPQGLDEAPGAAD

Sequences:

>Translated_470_residues
MTDYDVDLFVIGAGSGGVRAARIAAGYGARVLIAEEFRVGGTCVIRGCVPKKLMVYASRFVDHFEDAAGFGWDVPQPSFH
WSKLVAAKEKEISRLSAIYRTNLDKAGVTILDSRAEIEDAHTVLLKADERRVTAGMILVATGGTPVLEPDVPGRDLAITS
NEIFDLPEMPKRLLIVGGGYIAVEFASIFARLGSKVTLVQRGDNVLRGFDEDMRNGVRDALIHAGVDVKSGFLPTAIEKR
GDALHVSLTKGTHIEVDQVLTATGRRPHTLGLGLEKAGVIVDDIGAIKVDAYSKTNVDSIYAVGDVTNRLALTPVAIREG
HAFADTVFGHKSTAVNHTNVATAVFTTPELGTIGLSEMEARAIYDCVDVYLASFRPLKATLSGRQEKTVMKILVDGQTDK
VLGVHILGEDAGEMAQILGIAITVGATKADFDATMAVHPTSAEELVTMRVRTARYERAPQGLDEAPGAAD
>Mature_469_residues
TDYDVDLFVIGAGSGGVRAARIAAGYGARVLIAEEFRVGGTCVIRGCVPKKLMVYASRFVDHFEDAAGFGWDVPQPSFHW
SKLVAAKEKEISRLSAIYRTNLDKAGVTILDSRAEIEDAHTVLLKADERRVTAGMILVATGGTPVLEPDVPGRDLAITSN
EIFDLPEMPKRLLIVGGGYIAVEFASIFARLGSKVTLVQRGDNVLRGFDEDMRNGVRDALIHAGVDVKSGFLPTAIEKRG
DALHVSLTKGTHIEVDQVLTATGRRPHTLGLGLEKAGVIVDDIGAIKVDAYSKTNVDSIYAVGDVTNRLALTPVAIREGH
AFADTVFGHKSTAVNHTNVATAVFTTPELGTIGLSEMEARAIYDCVDVYLASFRPLKATLSGRQEKTVMKILVDGQTDKV
LGVHILGEDAGEMAQILGIAITVGATKADFDATMAVHPTSAEELVTMRVRTARYERAPQGLDEAPGAAD

Specific function: Maintains High Levels Of Reduced Glutathione In The Cytosol. [C]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=457, Percent_Identity=41.3566739606127, Blast_Score=313, Evalue=3e-85,
Organism=Homo sapiens, GI22035672, Length=431, Percent_Identity=36.8909512761021, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI291045266, Length=475, Percent_Identity=35.5789473684211, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI148277065, Length=476, Percent_Identity=33.6134453781513, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI33519430, Length=476, Percent_Identity=33.6134453781513, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI33519428, Length=476, Percent_Identity=33.6134453781513, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI33519426, Length=476, Percent_Identity=33.6134453781513, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI148277071, Length=476, Percent_Identity=33.6134453781513, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI291045268, Length=473, Percent_Identity=32.9809725158562, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI91199540, Length=456, Percent_Identity=29.3859649122807, Blast_Score=155, Evalue=6e-38,
Organism=Escherichia coli, GI1789915, Length=431, Percent_Identity=37.8190255220418, Blast_Score=282, Evalue=4e-77,
Organism=Escherichia coli, GI1786307, Length=457, Percent_Identity=29.1028446389497, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI87082354, Length=450, Percent_Identity=29.3333333333333, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI87081717, Length=448, Percent_Identity=29.9107142857143, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1789065, Length=195, Percent_Identity=31.2820512820513, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71983429, Length=440, Percent_Identity=38.4090909090909, Blast_Score=259, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI71983419, Length=440, Percent_Identity=38.4090909090909, Blast_Score=259, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI17557007, Length=479, Percent_Identity=32.776617954071, Blast_Score=238, Evalue=4e-63,
Organism=Caenorhabditis elegans, GI71982272, Length=490, Percent_Identity=32.6530612244898, Blast_Score=212, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI32565766, Length=451, Percent_Identity=28.6031042128603, Blast_Score=162, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6325166, Length=460, Percent_Identity=38.9130434782609, Blast_Score=303, Evalue=5e-83,
Organism=Saccharomyces cerevisiae, GI6321091, Length=484, Percent_Identity=29.3388429752066, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6325240, Length=468, Percent_Identity=28.8461538461538, Blast_Score=136, Evalue=6e-33,
Organism=Drosophila melanogaster, GI17737741, Length=483, Percent_Identity=34.3685300207039, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI24640553, Length=493, Percent_Identity=34.2799188640974, Blast_Score=231, Evalue=7e-61,
Organism=Drosophila melanogaster, GI24640551, Length=493, Percent_Identity=34.2799188640974, Blast_Score=231, Evalue=8e-61,
Organism=Drosophila melanogaster, GI24640549, Length=493, Percent_Identity=34.2799188640974, Blast_Score=231, Evalue=9e-61,
Organism=Drosophila melanogaster, GI21358499, Length=470, Percent_Identity=30.6382978723404, Blast_Score=181, Evalue=8e-46,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006324
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 50250; Mature: 50119

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDYDVDLFVIGAGSGGVRAARIAAGYGARVLIAEEFRVGGTCVIRGCVPKKLMVYASRF
CCCCEEEEEEEECCCCCCEEEEEECCCCEEEEEEECCCCCCEEEEECCCCHHHHHHHHHH
VDHFEDAAGFGWDVPQPSFHWSKLVAAKEKEISRLSAIYRTNLDKAGVTILDSRAEIEDA
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHCCC
HTVLLKADERRVTAGMILVATGGTPVLEPDVPGRDLAITSNEIFDLPEMPKRLLIVGGGY
EEEEEEECCCEEEEEEEEEEECCCCEECCCCCCCCEEEECCCCCCCCCCCCEEEEECCCE
IAVEFASIFARLGSKVTLVQRGDNVLRGFDEDMRNGVRDALIHAGVDVKSGFLPTAIEKR
EEHHHHHHHHHHCCEEEEEECCCHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHCC
GDALHVSLTKGTHIEVDQVLTATGRRPHTLGLGLEKAGVIVDDIGAIKVDAYSKTNVDSI
CCEEEEEECCCCEEEHHHHHHHCCCCCCEECCCCCCCCEEEECCCEEEEECCCCCCCCEE
YAVGDVTNRLALTPVAIREGHAFADTVFGHKSTAVNHTNVATAVFTTPELGTIGLSEMEA
EEECCCCCCEEECEEEEECCCCHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHH
RAIYDCVDVYLASFRPLKATLSGRQEKTVMKILVDGQTDKVLGVHILGEDAGEMAQILGI
HHHHHHHHHHHHCCCCHHHHHCCCCCCEEEEEEECCCCCCEEEEEEECCCHHHHHHHHEE
AITVGATKADFDATMAVHPTSAEELVTMRVRTARYERAPQGLDEAPGAAD
EEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
TDYDVDLFVIGAGSGGVRAARIAAGYGARVLIAEEFRVGGTCVIRGCVPKKLMVYASRF
CCCEEEEEEEECCCCCCEEEEEECCCCEEEEEEECCCCCCEEEEECCCCHHHHHHHHHH
VDHFEDAAGFGWDVPQPSFHWSKLVAAKEKEISRLSAIYRTNLDKAGVTILDSRAEIEDA
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHCCC
HTVLLKADERRVTAGMILVATGGTPVLEPDVPGRDLAITSNEIFDLPEMPKRLLIVGGGY
EEEEEEECCCEEEEEEEEEEECCCCEECCCCCCCCEEEECCCCCCCCCCCCEEEEECCCE
IAVEFASIFARLGSKVTLVQRGDNVLRGFDEDMRNGVRDALIHAGVDVKSGFLPTAIEKR
EEHHHHHHHHHHCCEEEEEECCCHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHCC
GDALHVSLTKGTHIEVDQVLTATGRRPHTLGLGLEKAGVIVDDIGAIKVDAYSKTNVDSI
CCEEEEEECCCCEEEHHHHHHHCCCCCCEECCCCCCCCEEEECCCEEEEECCCCCCCCEE
YAVGDVTNRLALTPVAIREGHAFADTVFGHKSTAVNHTNVATAVFTTPELGTIGLSEMEA
EEECCCCCCEEECEEEEECCCCHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHH
RAIYDCVDVYLASFRPLKATLSGRQEKTVMKILVDGQTDKVLGVHILGEDAGEMAQILGI
HHHHHHHHHHHHCCCCHHHHHCCCCCCEEEEEEECCCCCCEEEEEEECCCHHHHHHHHEE
AITVGATKADFDATMAVHPTSAEELVTMRVRTARYERAPQGLDEAPGAAD
EEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7538273 [H]