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The map label for this gene is gcvPB [H]

Identifier: 182677729

GI number: 182677729

Start: 825868

End: 827424

Strand: Direct

Name: gcvPB [H]

Synonym: Bind_0736

Alternate gene names: 182677729

Gene position: 825868-827424 (Clockwise)

Preceding gene: 182677728

Following gene: 182677741

Centisome position: 19.8

GC content: 61.08

Gene sequence:

>1557_bases
ATGTTGGATAAGCCGGAGACGGGCCTCGAAGAGGCGGACGGGGTGCTGGTCGATCGTGCGACTTTTACCGGCAATCGGGG
GCTGGCGATCGAGGAGGGCCTGATCTTTGAGCTTGGCCGGCCGGAAGCTTCGGGCGTTGATCTGCCAGAACCCGCGCCGT
TCCAGAGCCGCCTCGGCGGGCTTGAACGCAAGACGCCGATCGGTCTGCCGGGTCTCAGCGAACCTGAGACGGTGCGCCAT
TATGTGCGCCTCAGCCAGAAGAATTATTCCATCGATACGGGCATTTTCCCTCTCGGCTCCTGTACGATGAAGCATAATCC
GAGGCTCAATGAACGCATGGCGCGTTTGCCGGGTTTTGGCGATATCCATCCGCTGCAGCCGCAATCGAGTGTTCAGGGCG
CGCTCGAATTGATGAAAGAGATCAGCCATTGGCTCTTGACGCTGACGGGCATGCAGGCGGTCGCGCTTTCGCCGCGGGCC
GGTGCGCATGGCGAGGCCTGCGGCATGATGGCGATCAAACAAGCTTTGATCGCCAGGGGCGAGGCTGAACAGCGTAAGGT
GGTTTTGGTCCCAGATTCAGCGCATGGCACCAATCCGGCGACGGCGACACTGGTCGGTTTCGAGGTGCGTTCGGTGCCGG
CGCGCGAAGACGGCATTGTCGATGTGGAAGCGGTGCGCCAGGCGCTGGGACCGGACGTCGCCGCTATCATGCTGACCAAT
CCGAACACCTGTGGATTGTTTGAAAAGAACATTGTCGAAATCGCCGAGGCCATGCATGAGGCCGGCGCTTATTTCTATTG
CGATGGCGCCAATTTCAACGCGATCGTCGGGCGCGCCCGGCCAGGCGATCTTGGCGTCGATGCCATGCATATCAATCTGC
ACAAAACTTTTTCGACGCCGCATGGCGGTGGCGGGCCGGGCGCGGGGCCGGTCGTGCTCTCGAGCCGGCTTGCGCCTCAT
GCGCCGCTGCCTTTCCTTGTCCAAGAAAAAGCGGGTCTGAGGCTTGTCGAGGACAAGGCCGAGGCTCCCGGCACATTTGG
CCGTATTGGCGCCTTCCATGGCCAGATGGGTATGTACGTGCGGGCATTGACCTATATGCTCTCGCATGGCGCCGATGGTT
TGCGTCAAGCGTCGGAAGATGCCGTCCTTAATGCCAATTATGTGCGGGTGGGTCTTGCCGATCTGATGTCACTGCCCTTT
GGCAACCGCCCCTGTATGCATGAGGCTCTCTTCGACGATGCGTGGTTGAAGGGGACGGGCCTGAGCGTGCTCGATTTCGC
CAAGGCGATGATCGACGAAGGTTTCCATCCGATGACGGTCTATTTCCCGCTCGTCGTACATGGAGCCATGCTGATCGAGC
CGACCGAATCGGAATCCAAGGCGACGCTCGACCTGTTCGTCGCGGCCCTGCGCGATCTGGCCATGGCTGTACAGCGGGGC
GATAAAGAGCGTTTCCTTGGCGCCCCGCATTATGCGCCGCGCCGCAGGCTCGATGAAACGCGGGCGGCGAGAACGCCCGT
GCTCAAATGGACGAAGCCGGCGCCGATCGAGAATTGA

Upstream 100 bases:

>100_bases
ACAGCGACGATGACCGGGCGGCCCTGGTCGATGCGCTCGCCAAGCAAATTGCCTGAACGCGATATTTGAGGCGCGATATT
TGAGGACGGAGTGCGAAGCC

Downstream 100 bases:

>100_bases
AAACAGGCTGACGTAGCGTGCCCTGTGAGGGAGTGCCCATTCGATTTATCGGATGGGCACGTTTTCTGTTTTTGTGGCCG
CAGAGGATGCGGTGACGCGC

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 518; Mature: 518

Protein sequence:

>518_residues
MLDKPETGLEEADGVLVDRATFTGNRGLAIEEGLIFELGRPEASGVDLPEPAPFQSRLGGLERKTPIGLPGLSEPETVRH
YVRLSQKNYSIDTGIFPLGSCTMKHNPRLNERMARLPGFGDIHPLQPQSSVQGALELMKEISHWLLTLTGMQAVALSPRA
GAHGEACGMMAIKQALIARGEAEQRKVVLVPDSAHGTNPATATLVGFEVRSVPAREDGIVDVEAVRQALGPDVAAIMLTN
PNTCGLFEKNIVEIAEAMHEAGAYFYCDGANFNAIVGRARPGDLGVDAMHINLHKTFSTPHGGGGPGAGPVVLSSRLAPH
APLPFLVQEKAGLRLVEDKAEAPGTFGRIGAFHGQMGMYVRALTYMLSHGADGLRQASEDAVLNANYVRVGLADLMSLPF
GNRPCMHEALFDDAWLKGTGLSVLDFAKAMIDEGFHPMTVYFPLVVHGAMLIEPTESESKATLDLFVAALRDLAMAVQRG
DKERFLGAPHYAPRRRLDETRAARTPVLKWTKPAPIEN

Sequences:

>Translated_518_residues
MLDKPETGLEEADGVLVDRATFTGNRGLAIEEGLIFELGRPEASGVDLPEPAPFQSRLGGLERKTPIGLPGLSEPETVRH
YVRLSQKNYSIDTGIFPLGSCTMKHNPRLNERMARLPGFGDIHPLQPQSSVQGALELMKEISHWLLTLTGMQAVALSPRA
GAHGEACGMMAIKQALIARGEAEQRKVVLVPDSAHGTNPATATLVGFEVRSVPAREDGIVDVEAVRQALGPDVAAIMLTN
PNTCGLFEKNIVEIAEAMHEAGAYFYCDGANFNAIVGRARPGDLGVDAMHINLHKTFSTPHGGGGPGAGPVVLSSRLAPH
APLPFLVQEKAGLRLVEDKAEAPGTFGRIGAFHGQMGMYVRALTYMLSHGADGLRQASEDAVLNANYVRVGLADLMSLPF
GNRPCMHEALFDDAWLKGTGLSVLDFAKAMIDEGFHPMTVYFPLVVHGAMLIEPTESESKATLDLFVAALRDLAMAVQRG
DKERFLGAPHYAPRRRLDETRAARTPVLKWTKPAPIEN
>Mature_518_residues
MLDKPETGLEEADGVLVDRATFTGNRGLAIEEGLIFELGRPEASGVDLPEPAPFQSRLGGLERKTPIGLPGLSEPETVRH
YVRLSQKNYSIDTGIFPLGSCTMKHNPRLNERMARLPGFGDIHPLQPQSSVQGALELMKEISHWLLTLTGMQAVALSPRA
GAHGEACGMMAIKQALIARGEAEQRKVVLVPDSAHGTNPATATLVGFEVRSVPAREDGIVDVEAVRQALGPDVAAIMLTN
PNTCGLFEKNIVEIAEAMHEAGAYFYCDGANFNAIVGRARPGDLGVDAMHINLHKTFSTPHGGGGPGAGPVVLSSRLAPH
APLPFLVQEKAGLRLVEDKAEAPGTFGRIGAFHGQMGMYVRALTYMLSHGADGLRQASEDAVLNANYVRVGLADLMSLPF
GNRPCMHEALFDDAWLKGTGLSVLDFAKAMIDEGFHPMTVYFPLVVHGAMLIEPTESESKATLDLFVAALRDLAMAVQRG
DKERFLGAPHYAPRRRLDETRAARTPVLKWTKPAPIEN

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=404, Percent_Identity=39.3564356435644, Blast_Score=230, Evalue=2e-60,
Organism=Escherichia coli, GI1789269, Length=404, Percent_Identity=39.8514851485149, Blast_Score=253, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI17535605, Length=429, Percent_Identity=38.6946386946387, Blast_Score=246, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI32564013, Length=386, Percent_Identity=38.860103626943, Blast_Score=221, Evalue=9e-58,
Organism=Saccharomyces cerevisiae, GI6323843, Length=409, Percent_Identity=38.6308068459658, Blast_Score=255, Evalue=2e-68,
Organism=Drosophila melanogaster, GI24645648, Length=459, Percent_Identity=34.4226579520697, Blast_Score=228, Evalue=8e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 55760; Mature: 55760

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDKPETGLEEADGVLVDRATFTGNRGLAIEEGLIFELGRPEASGVDLPEPAPFQSRLGG
CCCCCCCCCHHHCCEEEEEEEECCCCCCEECCCEEEEECCCCCCCCCCCCCCCHHHHHCC
LERKTPIGLPGLSEPETVRHYVRLSQKNYSIDTGIFPLGSCTMKHNPRLNERMARLPGFG
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCC
DIHPLQPQSSVQGALELMKEISHWLLTLTGMQAVALSPRAGAHGEACGMMAIKQALIARG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHHCC
EAEQRKVVLVPDSAHGTNPATATLVGFEVRSVPAREDGIVDVEAVRQALGPDVAAIMLTN
CCCCCEEEEEECCCCCCCCCEEEEEEEEEECCCCCCCCCEEHHHHHHHHCCCEEEEEEEC
PNTCGLFEKNIVEIAEAMHEAGAYFYCDGANFNAIVGRARPGDLGVDAMHINLHKTFSTP
CCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCEEEEECCCCCCCCCEEEEEEEEEEECCC
HGGGGPGAGPVVLSSRLAPHAPLPFLVQEKAGLRLVEDKAEAPGTFGRIGAFHGQMGMYV
CCCCCCCCCHHHHHCCCCCCCCCCCEEECCCCCEEEECCCCCCCCHHHHHHHHHHHHHHH
RALTYMLSHGADGLRQASEDAVLNANYVRVGLADLMSLPFGNRPCMHEALFDDAWLKGTG
HHHHHHHHCCCHHHHHCCCCCEECCCEEEEEHHHHHHCCCCCCCHHHHHHHCCCCCCCCC
LSVLDFAKAMIDEGFHPMTVYFPLVVHGAMLIEPTESESKATLDLFVAALRDLAMAVQRG
CHHHHHHHHHHHCCCCCHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCC
DKERFLGAPHYAPRRRLDETRAARTPVLKWTKPAPIEN
CHHHCCCCCCCCHHHHHHHHHHHCCCCEECCCCCCCCC
>Mature Secondary Structure
MLDKPETGLEEADGVLVDRATFTGNRGLAIEEGLIFELGRPEASGVDLPEPAPFQSRLGG
CCCCCCCCCHHHCCEEEEEEEECCCCCCEECCCEEEEECCCCCCCCCCCCCCCHHHHHCC
LERKTPIGLPGLSEPETVRHYVRLSQKNYSIDTGIFPLGSCTMKHNPRLNERMARLPGFG
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCC
DIHPLQPQSSVQGALELMKEISHWLLTLTGMQAVALSPRAGAHGEACGMMAIKQALIARG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHHCC
EAEQRKVVLVPDSAHGTNPATATLVGFEVRSVPAREDGIVDVEAVRQALGPDVAAIMLTN
CCCCCEEEEEECCCCCCCCCEEEEEEEEEECCCCCCCCCEEHHHHHHHHCCCEEEEEEEC
PNTCGLFEKNIVEIAEAMHEAGAYFYCDGANFNAIVGRARPGDLGVDAMHINLHKTFSTP
CCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCEEEEECCCCCCCCCEEEEEEEEEEECCC
HGGGGPGAGPVVLSSRLAPHAPLPFLVQEKAGLRLVEDKAEAPGTFGRIGAFHGQMGMYV
CCCCCCCCCHHHHHCCCCCCCCCCCEEECCCCCEEEECCCCCCCCHHHHHHHHHHHHHHH
RALTYMLSHGADGLRQASEDAVLNANYVRVGLADLMSLPFGNRPCMHEALFDDAWLKGTG
HHHHHHHHCCCHHHHHCCCCCEECCCEEEEEHHHHHHCCCCCCCHHHHHHHCCCCCCCCC
LSVLDFAKAMIDEGFHPMTVYFPLVVHGAMLIEPTESESKATLDLFVAALRDLAMAVQRG
CHHHHHHHHHHHCCCCCHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCC
DKERFLGAPHYAPRRRLDETRAARTPVLKWTKPAPIEN
CHHHCCCCCCCCHHHHHHHHHHHCCCCEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]