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The map label for this gene is yfhQ [H]

Identifier: 182677741

GI number: 182677741

Start: 838732

End: 839883

Strand: Direct

Name: yfhQ [H]

Synonym: Bind_0748

Alternate gene names: 182677741

Gene position: 838732-839883 (Clockwise)

Preceding gene: 182677729

Following gene: 182677742

Centisome position: 20.11

GC content: 61.98

Gene sequence:

>1152_bases
ATGGAGCCGCCCTTGACGGGCTATTCCCTGTCGGAGCCATCCGTTTCGCGGGCCTTGCTCGCCTGGTATGACGCGCATCG
CCGTGATCTGCCCTGGCGCGCCAAACCGGGCGAACAGGCTGATCCCTATGCCGTTTGGCTCTCCGAGATCATGTTGCAGC
AGACTACGGTCACGGCAGTCAAACCTTATTATGCGACTTTTCTTGGCCAATGGCCGCGTCTCGAAGATTTGGCCGCCGCC
CCGCTCGACGCGGTTTTGCGGCAATGGGCTGGGCTCGGTTATTATTCGCGGGCGCGTAACCTTCATGCTTGCGCCATTAT
GGTCATGCAGCGCCATGGCGGTGTTTTTCCCGCCGAGGAATCTCTTCTCAGGGCTTTGCCAGGGATCGGCGCCTATACCG
CGGCGGCTATTGCCGCCATCGCCCATGGCCGCCGCGCCGTGGTTGTTGACGGTAATGTCGAGCGGGTCATCAGCCGGCTC
TTCGCGATAGAGAGTCCTTTGCCGGAAGCAAAGGCGGTGATTCGCGCCGAAACGGATCGGTTGACACCCAACGAGCGGGC
TGGTGATTTCGCCCAGGCGATGATGGATCTCGGCTCGATGATCTGCACACCCCGGCAGCCGCAATGCCTGCTGTGTCCAT
TGGCGGCGTTCTGTGTCGCGAAAGCAGAAGGCCGCGCGGGTGAATTTCCTATCAAGGCGCCGAAGCGGGAAAAACCCATC
CGCCATGGCGTGGCCTTTTTTCTGCGGCGCGGCGATGGCGCCGTTCTTCTCACCCGGCGCCCGGCGCGTGGTCTTCTTGG
CGGCATGATGGAAATTCCAGGCGGTGCATGGAACGAAACGCCCGACCTAGAACCCTTGCGCCTGGCACCCGTCGCGGCCG
ATTGGCAAAGGCTGGAGGGTGAAGTGACGCATGTCTTCACCCATTTCGCATTGCGGCTGAGTGTCTATGCGGCGAAAGCG
CCATCCACCCTCAAAGTCCCCGATGGGTGCCGCTTCGTCGCCGAAGAAGATCTCGACGCCGAGGCGCTGCCGAGCCTGAT
GCGCAAAGCGGTTGCAGCCGGGCGGGCCTTTTTCGCAGACAAACAGGAACGAGCAGGCGAGAGGAAGAAGCGATGGCCAA
ACGGCGAGGCCCGGAACTCAAGGTCGAACTGA

Upstream 100 bases:

>100_bases
AGACTGCAACCGGGAGGCCCCCGTGAGGCTCCCATTGTGTCTCTTGGCGTAAGGCGGCGAATGGGCAAGGGAGCATGCGA
GGGAGCATGACGGAGTGAAA

Downstream 100 bases:

>100_bases
CGGAAGGTGCCGTCAGGATCATCAAGGGAGAAAAAATCCTGACCCTGGTGCGGGCGGATTGCCCACCCGGGGAAGAAGAT
CCCGCCGATTTCATCATCTT

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MEPPLTGYSLSEPSVSRALLAWYDAHRRDLPWRAKPGEQADPYAVWLSEIMLQQTTVTAVKPYYATFLGQWPRLEDLAAA
PLDAVLRQWAGLGYYSRARNLHACAIMVMQRHGGVFPAEESLLRALPGIGAYTAAAIAAIAHGRRAVVVDGNVERVISRL
FAIESPLPEAKAVIRAETDRLTPNERAGDFAQAMMDLGSMICTPRQPQCLLCPLAAFCVAKAEGRAGEFPIKAPKREKPI
RHGVAFFLRRGDGAVLLTRRPARGLLGGMMEIPGGAWNETPDLEPLRLAPVAADWQRLEGEVTHVFTHFALRLSVYAAKA
PSTLKVPDGCRFVAEEDLDAEALPSLMRKAVAAGRAFFADKQERAGERKKRWPNGEARNSRSN

Sequences:

>Translated_383_residues
MEPPLTGYSLSEPSVSRALLAWYDAHRRDLPWRAKPGEQADPYAVWLSEIMLQQTTVTAVKPYYATFLGQWPRLEDLAAA
PLDAVLRQWAGLGYYSRARNLHACAIMVMQRHGGVFPAEESLLRALPGIGAYTAAAIAAIAHGRRAVVVDGNVERVISRL
FAIESPLPEAKAVIRAETDRLTPNERAGDFAQAMMDLGSMICTPRQPQCLLCPLAAFCVAKAEGRAGEFPIKAPKREKPI
RHGVAFFLRRGDGAVLLTRRPARGLLGGMMEIPGGAWNETPDLEPLRLAPVAADWQRLEGEVTHVFTHFALRLSVYAAKA
PSTLKVPDGCRFVAEEDLDAEALPSLMRKAVAAGRAFFADKQERAGERKKRWPNGEARNSRSN
>Mature_383_residues
MEPPLTGYSLSEPSVSRALLAWYDAHRRDLPWRAKPGEQADPYAVWLSEIMLQQTTVTAVKPYYATFLGQWPRLEDLAAA
PLDAVLRQWAGLGYYSRARNLHACAIMVMQRHGGVFPAEESLLRALPGIGAYTAAAIAAIAHGRRAVVVDGNVERVISRL
FAIESPLPEAKAVIRAETDRLTPNERAGDFAQAMMDLGSMICTPRQPQCLLCPLAAFCVAKAEGRAGEFPIKAPKREKPI
RHGVAFFLRRGDGAVLLTRRPARGLLGGMMEIPGGAWNETPDLEPLRLAPVAADWQRLEGEVTHVFTHFALRLSVYAAKA
PSTLKVPDGCRFVAEEDLDAEALPSLMRKAVAAGRAFFADKQERAGERKKRWPNGEARNSRSN

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI115298648, Length=397, Percent_Identity=36.5239294710327, Blast_Score=216, Evalue=4e-56,
Organism=Homo sapiens, GI115298650, Length=397, Percent_Identity=36.5239294710327, Blast_Score=216, Evalue=4e-56,
Organism=Homo sapiens, GI6912520, Length=397, Percent_Identity=36.5239294710327, Blast_Score=215, Evalue=4e-56,
Organism=Homo sapiens, GI190358497, Length=397, Percent_Identity=36.5239294710327, Blast_Score=215, Evalue=5e-56,
Organism=Homo sapiens, GI115298654, Length=397, Percent_Identity=36.5239294710327, Blast_Score=215, Evalue=5e-56,
Organism=Homo sapiens, GI115298652, Length=397, Percent_Identity=36.5239294710327, Blast_Score=215, Evalue=5e-56,
Organism=Escherichia coli, GI1789331, Length=302, Percent_Identity=43.046357615894, Blast_Score=223, Evalue=2e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 42084; Mature: 42084

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPPLTGYSLSEPSVSRALLAWYDAHRRDLPWRAKPGEQADPYAVWLSEIMLQQTTVTAV
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
KPYYATFLGQWPRLEDLAAAPLDAVLRQWAGLGYYSRARNLHACAIMVMQRHGGVFPAEE
HHHHHHHHCCCCCHHHHHCCCHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHCCCCCCHHH
SLLRALPGIGAYTAAAIAAIAHGRRAVVVDGNVERVISRLFAIESPLPEAKAVIRAETDR
HHHHHCCCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHCCC
LTPNERAGDFAQAMMDLGSMICTPRQPQCLLCPLAAFCVAKAEGRAGEFPIKAPKREKPI
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHH
RHGVAFFLRRGDGAVLLTRRPARGLLGGMMEIPGGAWNETPDLEPLRLAPVAADWQRLEG
HHHHHHHEECCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCEEECCCHHHHHHHCC
EVTHVFTHFALRLSVYAAKAPSTLKVPDGCRFVAEEDLDAEALPSLMRKAVAAGRAFFAD
HHHHHHHHHHHHHHHHHCCCCCEEECCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCC
KQERAGERKKRWPNGEARNSRSN
CHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MEPPLTGYSLSEPSVSRALLAWYDAHRRDLPWRAKPGEQADPYAVWLSEIMLQQTTVTAV
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
KPYYATFLGQWPRLEDLAAAPLDAVLRQWAGLGYYSRARNLHACAIMVMQRHGGVFPAEE
HHHHHHHHCCCCCHHHHHCCCHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHCCCCCCHHH
SLLRALPGIGAYTAAAIAAIAHGRRAVVVDGNVERVISRLFAIESPLPEAKAVIRAETDR
HHHHHCCCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHCCC
LTPNERAGDFAQAMMDLGSMICTPRQPQCLLCPLAAFCVAKAEGRAGEFPIKAPKREKPI
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHH
RHGVAFFLRRGDGAVLLTRRPARGLLGGMMEIPGGAWNETPDLEPLRLAPVAADWQRLEG
HHHHHHHEECCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCEEECCCHHHHHHHCC
EVTHVFTHFALRLSVYAAKAPSTLKVPDGCRFVAEEDLDAEALPSLMRKAVAAGRAFFAD
HHHHHHHHHHHHHHHHHCCCCCEEECCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCC
KQERAGERKKRWPNGEARNSRSN
CHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]