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The map label for this gene is gcvPA

Identifier: 182677728

GI number: 182677728

Start: 824480

End: 825823

Strand: Direct

Name: gcvPA

Synonym: Bind_0735

Alternate gene names: 182677728

Gene position: 824480-825823 (Clockwise)

Preceding gene: 182677727

Following gene: 182677729

Centisome position: 19.77

GC content: 59.9

Gene sequence:

>1344_bases
ATGCGCTATCTGCCTTTGACGCCGGAGGATCGGACCGAAATGCTGGCGCGCGTCGGCGTCCCCTCGGTCGATGCTCTCTT
CGAGGATATTCCAGCCGCCAAGCGCCTGGTAGAACTGCCGGACTTGCCGCTCCACAAAGGCGAATTGGAAGTCGAACGCT
GGCTCGGCCGGCTTTCTGCCAAGAATCTCGCGGCTTCCGCCGCGCCTTTCTTTGTCGGCGCTGGCGCATACAAGCACCAT
GTGCCGGCCAGCGTCGATCATCTGATCCAACGCTCGGAATTCATGACGAGCTATACGCCCTATCAGCCGGAAATCGCCCA
GGGCACCCTGCAATATGTGTTTGAGTTCCAGACGCAGGTCGCGGCCTTGACGGGCATGGAGGTCGCTAATGCCTCCATGT
ATGATGGCTCGACCGCGACGGGTGAGGCTGTGCTGATGGCTCATCGCCTGACCAAGCGCGGTAAGGCGATACTTTCAGGG
GGGCTGCATCCCCATTATGCCCAGGTCGTCACGAGTCAGGCGGCTCTGACAGGTCATGACGTCGTGGTCATGCCGCCCGA
CTTGCAAGCCAAGGAAGATCTCGTCGGTCGGCTTGACGCGCAAACCTCCTGCCTCGTCGTGCAATCGCCCGACGTCTTCG
GCAATTTACGCGATCTCGAACCATTGGCCGAAGCCTGCCGCAAACAGGGTGTCTTGCTCATTGCCGTCTTTACTGAAGCC
GTTTCTCTTGGCCTTGTCAAAGCACCGGGTGATATGGGCGCCGACATTGTCGTTGGCGAAGGTCAATCGATTGGCAATGC
GCTGAATTTTGGCGGCCCCTATGTCGGGCTTTTTGCGACGCGCTCGAAATATCTGCGGCAAATGCCAGGACGCCTCTGTG
GCGAAACACTCGACGCGGATGGAAGGCGCGGTTTCGTGCTGACCCTGTCCACCCGCGAGCAGCATATTCGCCGCGATAAG
GCGACCTCGAATATTTGCACGAATTCAGGGCTTTGCTGTCTCGCCTTCACCATCCATCTAACGCTTTTGGGCGAGCAGGG
ATTGCGGCAGTTGGCGACGATCAACCATGCCCATGCGGTCGATCTCGCCGATCGTCTCGCCAAAGTGCCCGGCGTCGAAC
TCCTCAACGAGACGTTCTTCAACGAATTCACGATTCGCCTGCCGGGGCGGGCGGAAGATCATGTCGAAGCCCTGGCGGCG
CAGGGCATTCTCGCCGGTGTCCCGGTCTCGCGTCTACTGCCGGGGCAGGGTTGCGATGATTTGCTGATCATCGCCAGCAC
TGAAGTGAACAGCGACGATGACCGGGCGGCCCTGGTCGATGCGCTCGCCAAGCAAATTGCCTGA

Upstream 100 bases:

>100_bases
TGCCAAGGAACTCGACGGCCTGATGGACGAGGCCGGCTATCAGGATTTCCTGAAAACGCTTTGAGCCGATCAGATGGTTT
CGATCCGATAGGAGAAAGAA

Downstream 100 bases:

>100_bases
ACGCGATATTTGAGGCGCGATATTTGAGGACGGAGTGCGAAGCCATGTTGGATAAGCCGGAGACGGGCCTCGAAGAGGCG
GACGGGGTGCTGGTCGATCG

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MRYLPLTPEDRTEMLARVGVPSVDALFEDIPAAKRLVELPDLPLHKGELEVERWLGRLSAKNLAASAAPFFVGAGAYKHH
VPASVDHLIQRSEFMTSYTPYQPEIAQGTLQYVFEFQTQVAALTGMEVANASMYDGSTATGEAVLMAHRLTKRGKAILSG
GLHPHYAQVVTSQAALTGHDVVVMPPDLQAKEDLVGRLDAQTSCLVVQSPDVFGNLRDLEPLAEACRKQGVLLIAVFTEA
VSLGLVKAPGDMGADIVVGEGQSIGNALNFGGPYVGLFATRSKYLRQMPGRLCGETLDADGRRGFVLTLSTREQHIRRDK
ATSNICTNSGLCCLAFTIHLTLLGEQGLRQLATINHAHAVDLADRLAKVPGVELLNETFFNEFTIRLPGRAEDHVEALAA
QGILAGVPVSRLLPGQGCDDLLIIASTEVNSDDDRAALVDALAKQIA

Sequences:

>Translated_447_residues
MRYLPLTPEDRTEMLARVGVPSVDALFEDIPAAKRLVELPDLPLHKGELEVERWLGRLSAKNLAASAAPFFVGAGAYKHH
VPASVDHLIQRSEFMTSYTPYQPEIAQGTLQYVFEFQTQVAALTGMEVANASMYDGSTATGEAVLMAHRLTKRGKAILSG
GLHPHYAQVVTSQAALTGHDVVVMPPDLQAKEDLVGRLDAQTSCLVVQSPDVFGNLRDLEPLAEACRKQGVLLIAVFTEA
VSLGLVKAPGDMGADIVVGEGQSIGNALNFGGPYVGLFATRSKYLRQMPGRLCGETLDADGRRGFVLTLSTREQHIRRDK
ATSNICTNSGLCCLAFTIHLTLLGEQGLRQLATINHAHAVDLADRLAKVPGVELLNETFFNEFTIRLPGRAEDHVEALAA
QGILAGVPVSRLLPGQGCDDLLIIASTEVNSDDDRAALVDALAKQIA
>Mature_447_residues
MRYLPLTPEDRTEMLARVGVPSVDALFEDIPAAKRLVELPDLPLHKGELEVERWLGRLSAKNLAASAAPFFVGAGAYKHH
VPASVDHLIQRSEFMTSYTPYQPEIAQGTLQYVFEFQTQVAALTGMEVANASMYDGSTATGEAVLMAHRLTKRGKAILSG
GLHPHYAQVVTSQAALTGHDVVVMPPDLQAKEDLVGRLDAQTSCLVVQSPDVFGNLRDLEPLAEACRKQGVLLIAVFTEA
VSLGLVKAPGDMGADIVVGEGQSIGNALNFGGPYVGLFATRSKYLRQMPGRLCGETLDADGRRGFVLTLSTREQHIRRDK
ATSNICTNSGLCCLAFTIHLTLLGEQGLRQLATINHAHAVDLADRLAKVPGVELLNETFFNEFTIRLPGRAEDHVEALAA
QGILAGVPVSRLLPGQGCDDLLIIASTEVNSDDDRAALVDALAKQIA

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=436, Percent_Identity=34.1743119266055, Blast_Score=221, Evalue=2e-57,
Organism=Escherichia coli, GI1789269, Length=390, Percent_Identity=31.025641025641, Blast_Score=164, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17535605, Length=390, Percent_Identity=34.1025641025641, Blast_Score=201, Evalue=6e-52,
Organism=Saccharomyces cerevisiae, GI6323843, Length=400, Percent_Identity=34.5, Blast_Score=194, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24645648, Length=382, Percent_Identity=37.696335078534, Blast_Score=234, Evalue=1e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPA_BEII9 (B2IGK3)

Other databases:

- EMBL:   CP001016
- RefSeq:   YP_001831874.1
- GeneID:   6199453
- GenomeReviews:   CP001016_GR
- KEGG:   bid:Bind_0735
- HOGENOM:   HBG288345
- OMA:   VTEKRTK
- ProtClustDB:   PRK00451
- HAMAP:   MF_00712
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 48032; Mature: 48032

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYLPLTPEDRTEMLARVGVPSVDALFEDIPAAKRLVELPDLPLHKGELEVERWLGRLSA
CCCCCCCCCHHHHHHHHCCCCHHHHHHHHCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
KNLAASAAPFFVGAGAYKHHVPASVDHLIQRSEFMTSYTPYQPEIAQGTLQYVFEFQTQV
HHHHHCCCCCEEECCCHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
AALTGMEVANASMYDGSTATGEAVLMAHRLTKRGKAILSGGLHPHYAQVVTSQAALTGHD
HHHHCHHHHCCCCCCCCCCCCHHHHHHHHHHHHCHHHHCCCCCHHHHHHHHHHHHCCCCC
VVVMPPDLQAKEDLVGRLDAQTSCLVVQSPDVFGNLRDLEPLAEACRKQGVLLIAVFTEA
EEEECCCCCHHHHHHHHCCCCCEEEEEECCHHHCCHHHHHHHHHHHHHCCEEEEEEEHHH
VSLGLVKAPGDMGADIVVGEGQSIGNALNFGGPYVGLFATRSKYLRQMPGRLCGETLDAD
HHHCEEECCCCCCCCEEEECCCCCCCHHCCCCCEEEHHHHHHHHHHHCCHHHHCCCCCCC
GRRGFVLTLSTREQHIRRDKATSNICTNSGLCCLAFTIHLTLLGEQGLRQLATINHAHAV
CCCEEEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHHHCHHHHH
DLADRLAKVPGVELLNETFFNEFTIRLPGRAEDHVEALAAQGILAGVPVSRLLPGQGCDD
HHHHHHHHCCCHHHHHHHHHCCEEEECCCCCHHHHHHHHHCCHHCCCCHHHCCCCCCCCC
LLIIASTEVNSDDDRAALVDALAKQIA
EEEEEECCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MRYLPLTPEDRTEMLARVGVPSVDALFEDIPAAKRLVELPDLPLHKGELEVERWLGRLSA
CCCCCCCCCHHHHHHHHCCCCHHHHHHHHCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
KNLAASAAPFFVGAGAYKHHVPASVDHLIQRSEFMTSYTPYQPEIAQGTLQYVFEFQTQV
HHHHHCCCCCEEECCCHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
AALTGMEVANASMYDGSTATGEAVLMAHRLTKRGKAILSGGLHPHYAQVVTSQAALTGHD
HHHHCHHHHCCCCCCCCCCCCHHHHHHHHHHHHCHHHHCCCCCHHHHHHHHHHHHCCCCC
VVVMPPDLQAKEDLVGRLDAQTSCLVVQSPDVFGNLRDLEPLAEACRKQGVLLIAVFTEA
EEEECCCCCHHHHHHHHCCCCCEEEEEECCHHHCCHHHHHHHHHHHHHCCEEEEEEEHHH
VSLGLVKAPGDMGADIVVGEGQSIGNALNFGGPYVGLFATRSKYLRQMPGRLCGETLDAD
HHHCEEECCCCCCCCEEEECCCCCCCHHCCCCCEEEHHHHHHHHHHHCCHHHHCCCCCCC
GRRGFVLTLSTREQHIRRDKATSNICTNSGLCCLAFTIHLTLLGEQGLRQLATINHAHAV
CCCEEEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHHHCHHHHH
DLADRLAKVPGVELLNETFFNEFTIRLPGRAEDHVEALAAQGILAGVPVSRLLPGQGCDD
HHHHHHHHCCCHHHHHHHHHCCEEEECCCCCHHHHHHHHHCCHHCCCCHHHCCCCCCCCC
LLIIASTEVNSDDDRAALVDALAKQIA
EEEEEECCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA