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The map label for this gene is gcvT [H]

Identifier: 182677726

GI number: 182677726

Start: 822915

End: 824069

Strand: Direct

Name: gcvT [H]

Synonym: Bind_0733

Alternate gene names: 182677726

Gene position: 822915-824069 (Clockwise)

Preceding gene: 182677725

Following gene: 182677727

Centisome position: 19.73

GC content: 63.55

Gene sequence:

>1155_bases
ATGTCGCAAGCTGCCTCTGCCTCCGACACCTCCGGTTCGACGCCGGCGCTTCTGCATACGCCCCTTTACGCGCTGCATTG
CGCGCGCGGCGCCCGCATGGTCCCTTTCGCCTGTTATGCCATGCCGGTGCAATATCCAACCGGCATTCTTGAGGAACATC
TGCATACCCGCGCCAAGGCCGGGCTGTTTGATGTCTCGCATATGGGCCAAGCCCTGCTCGAAGGCCAAGGGGCCGCTGCA
CGCCTTGAAACTCTGGTGCCGGGCGATCTCACGACACTTGCCCCCGGGCGCATGCGCTATACGCAACTGCTGAATCCTGA
AGGTGGCATTCTCGACGACCTGATGGTGACGCGCCTCGCCGATGATGCGGCTGGCGAGCGTTTGTTCCTCGTCGTCAATG
CGGCGACCAAGGCGCAGGATTTCGCCCATATTGGTGCGTCTTTGCCGGATCTGCGGCTGACCCTTCTGGAAGATCGTGCC
CTCCTGGCCTTGCAGGGGCCGAGCGCCGCGACCGTGCTGGCGAAACATTTTCCTGCCGTCGCCACCATGCCCTTCATGAG
CCTGATCGAGACCGAGCGAGAGGGGGCGCTCTGGCGCATTTCGCGCTCGGGTTATACGGGCGAGGACGGTTTCGAAATTG
CCGTGCCGGCTGGCGCCGCTGAGGCCTTCGCCGAAACCTTGCTTGGCGATGAAGAGGTCTGGCCGATTGGCCTTGGCGCC
CGTGATTCGCTGCGGCTCGAAGCCGGCCTCTGCCTTTACGGGCATGATATCGATCCGATCACGACGCCGATCGAGGCCGG
ACTCCTCTGGTCCATTTCCAAGCGCCGGCGTGAGGGGGGCGGTTTTCCCGGCGCGGCGCGCGTCCAGCGCGAGATTGCCG
AAGGACCCGCTCGCCGCCGTGTCGGCTTGAAGATCGAGGGCAAGATCCCAGCCCGCGAGGGAGCAAAAATCGAGACCCTG
GAGGGTGAGGTGATCGGCCTCGTCACTTCGGGTGGTTTTGCGCCGAGCCTCGGCGCGCCGATCGCCATGGGATATGTGGC
GAGCGCCCATGCGGCCAATGGGACTGCCTTACAGGTGATCGTCCGAGGAAAACCACTCGCCGCGACGATTACCTCCATGC
CTTTTGTTCCGAATCATTATTACAGGGGCGCCTGA

Upstream 100 bases:

>100_bases
GAGGGGGCAAGGTATTCGTTGACGCTTCGGGATGGTGTCATTGGCCGTCCTTGCGCACGAATCGCCTTTCCTTAAGGCCT
CTCTCTGGATTTGCCGCGCC

Downstream 100 bases:

>100_bases
TGTCGATCACCCGCTACACCAAGGACCATGAATATATCCGCGTCGAGGGAGAGACCGGCACGGTCGGCATTACCGATTAC
GCCCAGTCGCAATTGGGCGA

Product: glycine cleavage system T protein

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 384; Mature: 383

Protein sequence:

>384_residues
MSQAASASDTSGSTPALLHTPLYALHCARGARMVPFACYAMPVQYPTGILEEHLHTRAKAGLFDVSHMGQALLEGQGAAA
RLETLVPGDLTTLAPGRMRYTQLLNPEGGILDDLMVTRLADDAAGERLFLVVNAATKAQDFAHIGASLPDLRLTLLEDRA
LLALQGPSAATVLAKHFPAVATMPFMSLIETEREGALWRISRSGYTGEDGFEIAVPAGAAEAFAETLLGDEEVWPIGLGA
RDSLRLEAGLCLYGHDIDPITTPIEAGLLWSISKRRREGGGFPGAARVQREIAEGPARRRVGLKIEGKIPAREGAKIETL
EGEVIGLVTSGGFAPSLGAPIAMGYVASAHAANGTALQVIVRGKPLAATITSMPFVPNHYYRGA

Sequences:

>Translated_384_residues
MSQAASASDTSGSTPALLHTPLYALHCARGARMVPFACYAMPVQYPTGILEEHLHTRAKAGLFDVSHMGQALLEGQGAAA
RLETLVPGDLTTLAPGRMRYTQLLNPEGGILDDLMVTRLADDAAGERLFLVVNAATKAQDFAHIGASLPDLRLTLLEDRA
LLALQGPSAATVLAKHFPAVATMPFMSLIETEREGALWRISRSGYTGEDGFEIAVPAGAAEAFAETLLGDEEVWPIGLGA
RDSLRLEAGLCLYGHDIDPITTPIEAGLLWSISKRRREGGGFPGAARVQREIAEGPARRRVGLKIEGKIPAREGAKIETL
EGEVIGLVTSGGFAPSLGAPIAMGYVASAHAANGTALQVIVRGKPLAATITSMPFVPNHYYRGA
>Mature_383_residues
SQAASASDTSGSTPALLHTPLYALHCARGARMVPFACYAMPVQYPTGILEEHLHTRAKAGLFDVSHMGQALLEGQGAAAR
LETLVPGDLTTLAPGRMRYTQLLNPEGGILDDLMVTRLADDAAGERLFLVVNAATKAQDFAHIGASLPDLRLTLLEDRAL
LALQGPSAATVLAKHFPAVATMPFMSLIETEREGALWRISRSGYTGEDGFEIAVPAGAAEAFAETLLGDEEVWPIGLGAR
DSLRLEAGLCLYGHDIDPITTPIEAGLLWSISKRRREGGGFPGAARVQREIAEGPARRRVGLKIEGKIPAREGAKIETLE
GEVIGLVTSGGFAPSLGAPIAMGYVASAHAANGTALQVIVRGKPLAATITSMPFVPNHYYRGA

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=380, Percent_Identity=44.7368421052632, Blast_Score=279, Evalue=4e-75,
Organism=Homo sapiens, GI257796258, Length=358, Percent_Identity=44.4134078212291, Blast_Score=255, Evalue=6e-68,
Organism=Homo sapiens, GI257796254, Length=373, Percent_Identity=42.0911528150134, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI257796256, Length=321, Percent_Identity=43.9252336448598, Blast_Score=221, Evalue=6e-58,
Organism=Homo sapiens, GI197927446, Length=328, Percent_Identity=28.0487804878049, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI21361378, Length=328, Percent_Identity=28.0487804878049, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI24797151, Length=340, Percent_Identity=24.4117647058824, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1789272, Length=374, Percent_Identity=35.8288770053476, Blast_Score=171, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI17560118, Length=379, Percent_Identity=39.3139841688654, Blast_Score=238, Evalue=4e-63,
Organism=Saccharomyces cerevisiae, GI6320222, Length=391, Percent_Identity=41.6879795396419, Blast_Score=256, Evalue=4e-69,
Organism=Drosophila melanogaster, GI20129441, Length=380, Percent_Identity=43.6842105263158, Blast_Score=275, Evalue=3e-74,
Organism=Drosophila melanogaster, GI20130091, Length=332, Percent_Identity=25.9036144578313, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 40519; Mature: 40388

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQAASASDTSGSTPALLHTPLYALHCARGARMVPFACYAMPVQYPTGILEEHLHTRAKA
CCCCCCCCCCCCCCCCHHHCHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHC
GLFDVSHMGQALLEGQGAAARLETLVPGDLTTLAPGRMRYTQLLNPEGGILDDLMVTRLA
CCCCHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCEEHHHHCCCCCCHHHHHHHHHHH
DDAAGERLFLVVNAATKAQDFAHIGASLPDLRLTLLEDRALLALQGPSAATVLAKHFPAV
HCCCCCEEEEEEECCHHHHHHHHHCCCCCCEEEEEECCCEEEEECCCCHHHHHHHHCCHH
ATMPFMSLIETEREGALWRISRSGYTGEDGFEIAVPAGAAEAFAETLLGDEEVWPIGLGA
HHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEECCCHHHHHHHHHCCCCCEEEECCCC
RDSLRLEAGLCLYGHDIDPITTPIEAGLLWSISKRRREGGGFPGAARVQREIAEGPARRR
CCCEEEECCEEEECCCCCCCCCCHHCCEEEEHHHHHHHCCCCCCHHHHHHHHHCCHHHCE
VGLKIEGKIPAREGAKIETLEGEVIGLVTSGGFAPSLGAPIAMGYVASAHAANGTALQVI
ECEEEECCCCCCCCCEEEEECCEEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCEEEEE
VRGKPLAATITSMPFVPNHYYRGA
EECCCCEEHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SQAASASDTSGSTPALLHTPLYALHCARGARMVPFACYAMPVQYPTGILEEHLHTRAKA
CCCCCCCCCCCCCCCHHHCHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHC
GLFDVSHMGQALLEGQGAAARLETLVPGDLTTLAPGRMRYTQLLNPEGGILDDLMVTRLA
CCCCHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCEEHHHHCCCCCCHHHHHHHHHHH
DDAAGERLFLVVNAATKAQDFAHIGASLPDLRLTLLEDRALLALQGPSAATVLAKHFPAV
HCCCCCEEEEEEECCHHHHHHHHHCCCCCCEEEEEECCCEEEEECCCCHHHHHHHHCCHH
ATMPFMSLIETEREGALWRISRSGYTGEDGFEIAVPAGAAEAFAETLLGDEEVWPIGLGA
HHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEECCCHHHHHHHHHCCCCCEEEECCCC
RDSLRLEAGLCLYGHDIDPITTPIEAGLLWSISKRRREGGGFPGAARVQREIAEGPARRR
CCCEEEECCEEEECCCCCCCCCCHHCCEEEEHHHHHHHCCCCCCHHHHHHHHHCCHHHCE
VGLKIEGKIPAREGAKIETLEGEVIGLVTSGGFAPSLGAPIAMGYVASAHAANGTALQVI
ECEEEECCCCCCCCCEEEEECCEEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCEEEEE
VRGKPLAATITSMPFVPNHYYRGA
EECCCCEEHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]