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The map label for this gene is pkn1 [H]

Identifier: 182682521

GI number: 182682521

Start: 2248227

End: 2249876

Strand: Reverse

Name: pkn1 [H]

Synonym: XfasM23_2008

Alternate gene names: 182682521

Gene position: 2249876-2248227 (Counterclockwise)

Preceding gene: 182682524

Following gene: 182682520

Centisome position: 88.73

GC content: 58.85

Gene sequence:

>1650_bases
ATGACTTCCGTGCAGGTCAGGCGGCGTGCTGCGCAGGCATTGGCTGAAGATCGACTGTACCGCAGCCCTGACGATGCGAT
TCCGCTGTATTTGGCATTGCGTGCCCGCAGTGACGGCCGTGACCGTGTGGCTGAAGAAGGGCTGCGCCGTGCCTTGCTGC
GTTTGCTGGTCCTGGCGGATGGCTTATTGCTGCAACCGCAGGCACAGGAAGAAGCATTGGAACAAGCGGGCGATGTCACC
ATGGTGGCCTTGTCGCTGGCACCGCAGGATCCGCGAGTGCATCGTTTGCAAAGTCGCGTTGAGACTGCACAACGTGTACT
GGCCTTCAATCTTGCTGGTGAGGACGATTTGCGTGCTGGAACGTTAGGCGAGAGTAGTCGCAGTGCATTGGATCACTTCC
GCGATGCATTGGGCTTGGATCCGGACAATGCGCGTGCCCGTCAAGGCTTGGCGGCAGTGGAGAGCGCGATGATCCGCTAC
GCAGAACAAGCGGCTGAGACCACTCATTTCGACAGTGCCACATACTGGCTTGATGTTGCATCCACGGTGCGCGAACAAGC
ACCTACGGTGATCGACGCGCGTAGGCGCATCGCTATCTTGCGTATAGAAAAAATTGCCGCATTGCGGGATGCCGTATTGC
GTGCAATTTCTGACCCAAAGAAATTAAAGAGCGCGCATGCCCTCTTTACGGAGATTGTCCGTATTGCTGCTCCTGGTGAT
GCGGTGATTAGCGAGTTGCGGGAGCGCATCAATCGCGCAACCCATTATGGGAGCTTCCGCCGAGGACAAGTGTTTACCGA
TGCGATGCAAGACGGTACTCGAGGTCCCCAGATGCTGGTGGTCCCCCACGGCAGCTTTCAGATGGGCGCAACCGATACCG
AAGTAGGTGCCTCAGCGGCGGAACGACCGCAACACCATGTCCGTTTTGAACGCGGTTTTGCGATGTCGATTACTGAAGTC
ACCGTCGCTCAGTTCCGGCGCTTTGTTGAGCAGACAGGTTACCGACCGCGAGCAACCCGGCGAGGGCATTCACTGGTGTA
TGACGAACGCAGTGGGAACTTTGTGCGGCGCAGCGGCGTAGATTGGCAGTCTGGTTACGATGGCCGCGCGGCTGCTCCCA
ACGATCCAGTGATGCATGTCAGCGTGCGCGATGCAGAGGCGTATGCGGCATGGATGTCGCGTCAAACCGGGCGTTATTAC
CGCCTCCCAAGTGAAGCTGAGTTTGAGTACGCCCTGCGTGCCGGCCGACAAGGCTACTACCCTTGGGGCAACGCCGCCGT
CCCAGTGACCGGAAACTATACTGGCGGCAACGATGTCTCTCCGAGTGGACGGCGTTGGGCCAATGCCTTTATCGGTTATG
GGGATCGCTACTGGGCTGTGGCCCCTGTAGCTAGTTTCCGCGCCAATGCCTGGGGCCTTCACGACATGGGCGGCAACTTG
AGTGAATGGGTAGCCGATTGCTGGCACTCCAGTTATCGGCGTGCCCCAGCCGATGGTGTCGCCTGGTACAACCCAGGCTG
CCGTCAGCGTTTGGTACGTGGCGGCAGCTGGGCCAACTCACCACAGCAGACCCGTGCAGCGTGGCGTGGATCACAGGATT
CAGAGATGACCAGCGCCAGGATTGGTTTCCGTCTCGTTCGTGGCATATAA

Upstream 100 bases:

>100_bases
CGTTGCTGCACCGCCAGCAACACCGCATGTTGCGATTAGCACCAAAAAATCCGCCCCGACACGCGCGCTTTGGCAATCCC
CACCGGTTGTATTAGGTGAC

Downstream 100 bases:

>100_bases
CGTGCAGCTCTTTAGGGTAGAGGATCGTCACGGCGGGTGCTTGTCATGACGTCTTCCTCATAACATTCGGCGAAGACTGT
TTCGGCGAGGACTGTATGAA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 549; Mature: 548

Protein sequence:

>549_residues
MTSVQVRRRAAQALAEDRLYRSPDDAIPLYLALRARSDGRDRVAEEGLRRALLRLLVLADGLLLQPQAQEEALEQAGDVT
MVALSLAPQDPRVHRLQSRVETAQRVLAFNLAGEDDLRAGTLGESSRSALDHFRDALGLDPDNARARQGLAAVESAMIRY
AEQAAETTHFDSATYWLDVASTVREQAPTVIDARRRIAILRIEKIAALRDAVLRAISDPKKLKSAHALFTEIVRIAAPGD
AVISELRERINRATHYGSFRRGQVFTDAMQDGTRGPQMLVVPHGSFQMGATDTEVGASAAERPQHHVRFERGFAMSITEV
TVAQFRRFVEQTGYRPRATRRGHSLVYDERSGNFVRRSGVDWQSGYDGRAAAPNDPVMHVSVRDAEAYAAWMSRQTGRYY
RLPSEAEFEYALRAGRQGYYPWGNAAVPVTGNYTGGNDVSPSGRRWANAFIGYGDRYWAVAPVASFRANAWGLHDMGGNL
SEWVADCWHSSYRRAPADGVAWYNPGCRQRLVRGGSWANSPQQTRAAWRGSQDSEMTSARIGFRLVRGI

Sequences:

>Translated_549_residues
MTSVQVRRRAAQALAEDRLYRSPDDAIPLYLALRARSDGRDRVAEEGLRRALLRLLVLADGLLLQPQAQEEALEQAGDVT
MVALSLAPQDPRVHRLQSRVETAQRVLAFNLAGEDDLRAGTLGESSRSALDHFRDALGLDPDNARARQGLAAVESAMIRY
AEQAAETTHFDSATYWLDVASTVREQAPTVIDARRRIAILRIEKIAALRDAVLRAISDPKKLKSAHALFTEIVRIAAPGD
AVISELRERINRATHYGSFRRGQVFTDAMQDGTRGPQMLVVPHGSFQMGATDTEVGASAAERPQHHVRFERGFAMSITEV
TVAQFRRFVEQTGYRPRATRRGHSLVYDERSGNFVRRSGVDWQSGYDGRAAAPNDPVMHVSVRDAEAYAAWMSRQTGRYY
RLPSEAEFEYALRAGRQGYYPWGNAAVPVTGNYTGGNDVSPSGRRWANAFIGYGDRYWAVAPVASFRANAWGLHDMGGNL
SEWVADCWHSSYRRAPADGVAWYNPGCRQRLVRGGSWANSPQQTRAAWRGSQDSEMTSARIGFRLVRGI
>Mature_548_residues
TSVQVRRRAAQALAEDRLYRSPDDAIPLYLALRARSDGRDRVAEEGLRRALLRLLVLADGLLLQPQAQEEALEQAGDVTM
VALSLAPQDPRVHRLQSRVETAQRVLAFNLAGEDDLRAGTLGESSRSALDHFRDALGLDPDNARARQGLAAVESAMIRYA
EQAAETTHFDSATYWLDVASTVREQAPTVIDARRRIAILRIEKIAALRDAVLRAISDPKKLKSAHALFTEIVRIAAPGDA
VISELRERINRATHYGSFRRGQVFTDAMQDGTRGPQMLVVPHGSFQMGATDTEVGASAAERPQHHVRFERGFAMSITEVT
VAQFRRFVEQTGYRPRATRRGHSLVYDERSGNFVRRSGVDWQSGYDGRAAAPNDPVMHVSVRDAEAYAAWMSRQTGRYYR
LPSEAEFEYALRAGRQGYYPWGNAAVPVTGNYTGGNDVSPSGRRWANAFIGYGDRYWAVAPVASFRANAWGLHDMGGNLS
EWVADCWHSSYRRAPADGVAWYNPGCRQRLVRGGSWANSPQQTRAAWRGSQDSEMTSARIGFRLVRGI

Specific function: Together with the serine/threonine kinase pknD, may play a role in the specific interactions with host proteins during intracellular growth [H]

COG id: COG1262

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI38202250, Length=301, Percent_Identity=28.9036544850498, Blast_Score=104, Evalue=3e-22,
Organism=Homo sapiens, GI257470977, Length=238, Percent_Identity=30.672268907563, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI257470975, Length=286, Percent_Identity=29.020979020979, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI194248087, Length=283, Percent_Identity=31.095406360424, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI194248088, Length=293, Percent_Identity=30.7167235494881, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI226437577, Length=177, Percent_Identity=35.0282485875706, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI194248090, Length=175, Percent_Identity=33.7142857142857, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI20130397, Length=301, Percent_Identity=29.2358803986711, Blast_Score=92, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016187
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR017442
- InterPro:   IPR005532 [H]

Pfam domain/function: PF03781 DUF323; PF00069 Pkinase [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 61002; Mature: 60871

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSVQVRRRAAQALAEDRLYRSPDDAIPLYLALRARSDGRDRVAEEGLRRALLRLLVLAD
CCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHC
GLLLQPQAQEEALEQAGDVTMVALSLAPQDPRVHRLQSRVETAQRVLAFNLAGEDDLRAG
CCEECCCHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
TLGESSRSALDHFRDALGLDPDNARARQGLAAVESAMIRYAEQAAETTHFDSATYWLDVA
CCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
STVREQAPTVIDARRRIAILRIEKIAALRDAVLRAISDPKKLKSAHALFTEIVRIAAPGD
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCH
AVISELRERINRATHYGSFRRGQVFTDAMQDGTRGPQMLVVPHGSFQMGATDTEVGASAA
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCEEEEEECCCEECCCCCHHHCCHHH
ERPQHHVRFERGFAMSITEVTVAQFRRFVEQTGYRPRATRRGHSLVYDERSGNFVRRSGV
HCCHHHHHHHCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCEEEECCC
DWQSGYDGRAAAPNDPVMHVSVRDAEAYAAWMSRQTGRYYRLPSEAEFEYALRAGRQGYY
CCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHCCCCEEECCCCCHHHHHHHCCCCCCC
PWGNAAVPVTGNYTGGNDVSPSGRRWANAFIGYGDRYWAVAPVASFRANAWGLHDMGGNL
CCCCEEEEEECCCCCCCCCCCCCHHHHHHHHCCCCCEEEECCHHHHCCCCCCCHHCCCCH
SEWVADCWHSSYRRAPADGVAWYNPGCRQRLVRGGSWANSPQQTRAAWRGSQDSEMTSAR
HHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHH
IGFRLVRGI
HHHHHHCCC
>Mature Secondary Structure 
TSVQVRRRAAQALAEDRLYRSPDDAIPLYLALRARSDGRDRVAEEGLRRALLRLLVLAD
CCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHC
GLLLQPQAQEEALEQAGDVTMVALSLAPQDPRVHRLQSRVETAQRVLAFNLAGEDDLRAG
CCEECCCHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
TLGESSRSALDHFRDALGLDPDNARARQGLAAVESAMIRYAEQAAETTHFDSATYWLDVA
CCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
STVREQAPTVIDARRRIAILRIEKIAALRDAVLRAISDPKKLKSAHALFTEIVRIAAPGD
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCH
AVISELRERINRATHYGSFRRGQVFTDAMQDGTRGPQMLVVPHGSFQMGATDTEVGASAA
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCEEEEEECCCEECCCCCHHHCCHHH
ERPQHHVRFERGFAMSITEVTVAQFRRFVEQTGYRPRATRRGHSLVYDERSGNFVRRSGV
HCCHHHHHHHCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCEEEECCC
DWQSGYDGRAAAPNDPVMHVSVRDAEAYAAWMSRQTGRYYRLPSEAEFEYALRAGRQGYY
CCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHCCCCEEECCCCCHHHHHHHCCCCCCC
PWGNAAVPVTGNYTGGNDVSPSGRRWANAFIGYGDRYWAVAPVASFRANAWGLHDMGGNL
CCCCEEEEEECCCCCCCCCCCCCHHHHHHHHCCCCCEEEECCHHHHCCCCCCCHHCCCCH
SEWVADCWHSSYRRAPADGVAWYNPGCRQRLVRGGSWANSPQQTRAAWRGSQDSEMTSAR
HHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHH
IGFRLVRGI
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]