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The map label for this gene is hslU

Identifier: 182681293

GI number: 182681293

Start: 867968

End: 869347

Strand: Direct

Name: hslU

Synonym: XfasM23_0738

Alternate gene names: 182681293

Gene position: 867968-869347 (Clockwise)

Preceding gene: 182681292

Following gene: 182681294

Centisome position: 34.23

GC content: 51.67

Gene sequence:

>1380_bases
ATGCCTTCTAAGACTGATTTCACTTCCTCAACCATGACGCCACGCGAGATTGTGCAGGAGCTTGATCGCCATATTGTTGG
TCAGCAGGCCGCGAAGCGGTCTGTGGCAATTGCGTTGCGTAATCGTTGGCGCCGTATGCAGTTGCCTGAGGAGTTGCGTA
ATGAGGTGATGCCTAAGAACATTTTGATGATCGGTCCGACGGGCGTAGGTAAGACGGAGATTGCACGCCGTTTGGCAACT
TTGGCTAATGCACCGTTTGTCAAAGTCGAGGCGACGCGTTTCACTGAGGTGGGCTACGTTGGCAAGGATGTGGAACAAAT
CGGGCGTGATTTGGTTGATACCGCAGTCAAAATGTATCGTGAGCAAGCTAAGGTGCGTGTACGCACTCAGGCTGAGGAGT
ACGCTGAGGAGCGCATTCTTGACGCGTTATTGCCGCGTCGTAGCGTTGGTATCGGTTTTGATGCTGATGCCGATGCTATA
CGTCAAGAACCCTCTGCGCATGAGAGTGAGACTAGGGCGAAGTTCCGTCGTATGTTGCGCAGCGGTGAGTTAGAAGAGCG
CGAGATTGAGTTGGACGTTGCTGTCAACGTGAGTATGGACATTATGACTCCTCCTGGTATGGAGGAAATGGGTCAGCAGT
TGCGTCAGATGTTCTCCAATATTGGGGGAGGCAAGTCTCAGAAGCGTAAGCTGGCGATCAAGGCGGCACGCCCGTTATTA
ATCGAAGAAGAGGCGGCTAAGCTGGTCAACGAAGACGAAATCCGTGCTGCAGCGATCGAAGCTTGCGAACAGAATGGGAT
CGTCTTTATTGATGAGATCGATAAGGTCGTTAAACGTGGTGATACTGTTGGCGGCGGTGATGTGAGTCGCGAAGGTGTGC
AGCGCGATTTGCTGCCATTGGTAGAGGGGTCGAATGTGTCTACCAAGTACGGCACGATCAGGACCAACCACATTTTGTTC
ATTGCTTCCGGTGCCTTTCACCTCACCAAGCCAAGCGATTTAATTCCGGAGTTGCAAGGCCGTTTCCCGATTCGGGTGGA
GTTGGATGCGCTGAGTAAAGCGGATTTTATCCGTATCCTGACAGAGCCGAAGGCGGCGCTCACTAAGCAGTATCAGGAAT
TGTTGAAAACGGAAGGTGTGTCGCTTGATTTTACAGAGGATGCGATTGACCGTATTGCCGAGATTGCTTATTTGGTCAAC
GAGCGTCAGGAGAATATCGGTGCGCGGCGTTTGCACACGGTGTTGGAGCGATTGTTGGAAACGCTGAGTTATGAGTCTCC
GGATCGTGATGGCGAGTCCGTGACGGTCGATGCCGATTATGTCAATGCGCATTTGGGGGAATTAGTGAAGGATCCAGATC
TGAGTCGTTACATTTTGTAA

Upstream 100 bases:

>100_bases
ACGAATCGTAATGTGGTGGTTGACGAGTTATAAGTACGGGATGCTTGGCTCTTCTACTTTGTTATTCAGCATGGCTGCGG
CCGCAATCTAGAGTTTATGT

Downstream 100 bases:

>100_bases
TGTGTAAGGCATCGTGCGATCTTCATTGTTTGCCAGCGAGGCGTATCGTTATTCTACGGTGTTCTCTATCTGGTAGAGGA
CGATGCTGTTAACCATTGTC

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MPSKTDFTSSTMTPREIVQELDRHIVGQQAAKRSVAIALRNRWRRMQLPEELRNEVMPKNILMIGPTGVGKTEIARRLAT
LANAPFVKVEATRFTEVGYVGKDVEQIGRDLVDTAVKMYREQAKVRVRTQAEEYAEERILDALLPRRSVGIGFDADADAI
RQEPSAHESETRAKFRRMLRSGELEEREIELDVAVNVSMDIMTPPGMEEMGQQLRQMFSNIGGGKSQKRKLAIKAARPLL
IEEEAAKLVNEDEIRAAAIEACEQNGIVFIDEIDKVVKRGDTVGGGDVSREGVQRDLLPLVEGSNVSTKYGTIRTNHILF
IASGAFHLTKPSDLIPELQGRFPIRVELDALSKADFIRILTEPKAALTKQYQELLKTEGVSLDFTEDAIDRIAEIAYLVN
ERQENIGARRLHTVLERLLETLSYESPDRDGESVTVDADYVNAHLGELVKDPDLSRYIL

Sequences:

>Translated_459_residues
MPSKTDFTSSTMTPREIVQELDRHIVGQQAAKRSVAIALRNRWRRMQLPEELRNEVMPKNILMIGPTGVGKTEIARRLAT
LANAPFVKVEATRFTEVGYVGKDVEQIGRDLVDTAVKMYREQAKVRVRTQAEEYAEERILDALLPRRSVGIGFDADADAI
RQEPSAHESETRAKFRRMLRSGELEEREIELDVAVNVSMDIMTPPGMEEMGQQLRQMFSNIGGGKSQKRKLAIKAARPLL
IEEEAAKLVNEDEIRAAAIEACEQNGIVFIDEIDKVVKRGDTVGGGDVSREGVQRDLLPLVEGSNVSTKYGTIRTNHILF
IASGAFHLTKPSDLIPELQGRFPIRVELDALSKADFIRILTEPKAALTKQYQELLKTEGVSLDFTEDAIDRIAEIAYLVN
ERQENIGARRLHTVLERLLETLSYESPDRDGESVTVDADYVNAHLGELVKDPDLSRYIL
>Mature_458_residues
PSKTDFTSSTMTPREIVQELDRHIVGQQAAKRSVAIALRNRWRRMQLPEELRNEVMPKNILMIGPTGVGKTEIARRLATL
ANAPFVKVEATRFTEVGYVGKDVEQIGRDLVDTAVKMYREQAKVRVRTQAEEYAEERILDALLPRRSVGIGFDADADAIR
QEPSAHESETRAKFRRMLRSGELEEREIELDVAVNVSMDIMTPPGMEEMGQQLRQMFSNIGGGKSQKRKLAIKAARPLLI
EEEAAKLVNEDEIRAAAIEACEQNGIVFIDEIDKVVKRGDTVGGGDVSREGVQRDLLPLVEGSNVSTKYGTIRTNHILFI
ASGAFHLTKPSDLIPELQGRFPIRVELDALSKADFIRILTEPKAALTKQYQELLKTEGVSLDFTEDAIDRIAEIAYLVNE
RQENIGARRLHTVLERLLETLSYESPDRDGESVTVDADYVNAHLGELVKDPDLSRYIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily

Homologues:

Organism=Homo sapiens, GI7242140, Length=108, Percent_Identity=39.8148148148148, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1790366, Length=451, Percent_Identity=66.0753880266075, Blast_Score=585, Evalue=1e-168,
Organism=Escherichia coli, GI1786642, Length=235, Percent_Identity=33.6170212765957, Blast_Score=102, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI71982905, Length=246, Percent_Identity=30.8943089430894, Blast_Score=95, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI71982908, Length=246, Percent_Identity=30.8943089430894, Blast_Score=95, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI71988663, Length=253, Percent_Identity=31.6205533596838, Blast_Score=86, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6319704, Length=124, Percent_Identity=38.7096774193548, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24648291, Length=108, Percent_Identity=41.6666666666667, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24648289, Length=108, Percent_Identity=41.6666666666667, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HSLU_XYLF2 (B2IA20)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001829453.1
- GeneID:   6202096
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_0738
- HOGENOM:   HBG745965
- OMA:   EASKFTE
- ProtClustDB:   PRK05201
- HAMAP:   MF_00249
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491
- PANTHER:   PTHR11262:SF3
- SMART:   SM00382
- TIGRFAMs:   TIGR00390

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small

EC number: NA

Molecular weight: Translated: 51489; Mature: 51358

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: BINDING 26-26 BINDING 271-271 BINDING 337-337 BINDING 409-409

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSKTDFTSSTMTPREIVQELDRHIVGQQAAKRSVAIALRNRWRRMQLPEELRNEVMPKN
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCC
ILMIGPTGVGKTEIARRLATLANAPFVKVEATRFTEVGYVGKDVEQIGRDLVDTAVKMYR
EEEECCCCCCHHHHHHHHHHHHCCCEEEEEHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EQAKVRVRTQAEEYAEERILDALLPRRSVGIGFDADADAIRQEPSAHESETRAKFRRMLR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHH
SGELEEREIELDVAVNVSMDIMTPPGMEEMGQQLRQMFSNIGGGKSQKRKLAIKAARPLL
CCCCCCCEEEEEEEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCE
IEEEAAKLVNEDEIRAAAIEACEQNGIVFIDEIDKVVKRGDTVGGGDVSREGVQRDLLPL
EHHHHHHHCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
VEGSNVSTKYGTIRTNHILFIASGAFHLTKPSDLIPELQGRFPIRVELDALSKADFIRIL
HCCCCCCCCCCEEEECEEEEEECCCEEECCCHHHHHHHCCCCCEEEEHHHCCCCHHHHHH
TEPKAALTKQYQELLKTEGVSLDFTEDAIDRIAEIAYLVNERQENIGARRLHTVLERLLE
CCCHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLSYESPDRDGESVTVDADYVNAHLGELVKDPDLSRYIL
HHCCCCCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
PSKTDFTSSTMTPREIVQELDRHIVGQQAAKRSVAIALRNRWRRMQLPEELRNEVMPKN
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCC
ILMIGPTGVGKTEIARRLATLANAPFVKVEATRFTEVGYVGKDVEQIGRDLVDTAVKMYR
EEEECCCCCCHHHHHHHHHHHHCCCEEEEEHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EQAKVRVRTQAEEYAEERILDALLPRRSVGIGFDADADAIRQEPSAHESETRAKFRRMLR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHH
SGELEEREIELDVAVNVSMDIMTPPGMEEMGQQLRQMFSNIGGGKSQKRKLAIKAARPLL
CCCCCCCEEEEEEEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCE
IEEEAAKLVNEDEIRAAAIEACEQNGIVFIDEIDKVVKRGDTVGGGDVSREGVQRDLLPL
EHHHHHHHCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
VEGSNVSTKYGTIRTNHILFIASGAFHLTKPSDLIPELQGRFPIRVELDALSKADFIRIL
HCCCCCCCCCCEEEECEEEEEECCCEEECCCHHHHHHHCCCCCEEEEHHHCCCCHHHHHH
TEPKAALTKQYQELLKTEGVSLDFTEDAIDRIAEIAYLVNERQENIGARRLHTVLERLLE
CCCHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLSYESPDRDGESVTVDADYVNAHLGELVKDPDLSRYIL
HHCCCCCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA