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The map label for this gene is nox [H]

Identifier: 197294850

GI number: 197294850

Start: 875623

End: 876963

Strand: Reverse

Name: nox [H]

Synonym: PAa_0837

Alternate gene names: 197294850

Gene position: 876963-875623 (Counterclockwise)

Preceding gene: 197294851

Following gene: 197294849

Centisome position: 99.66

GC content: 31.39

Gene sequence:

>1341_bases
ATGAAAGTTATAATCATTGGTTGCACTCACGCAGGAACTGCAGCGGCCAAAACTATTAAAAAAACATCACCCCAAACTGA
TATTGTAGTTTATGAGAGAAATGATAATATTTCCTTCCTTTCTTGTGGACTTGCATTATATGTTGGCGGAGTTGTTAAAG
ATAGTCGTGGACTTTTTTATTCCAACCCTGAAGAATTAATCCACATGGGAATAAATACCAAATTACAACATGACGTTTTA
AAAATAGATTTTGAAAAAAAAGAAGTTTTGGTTTGCAACCTAGAAACCAAACAAGAGTTTAAAGATAATTACGATAAATT
AGTTATTGCGGCAGGATCATGGCCGGTTGTTCCTCCAATTGAAGGAATTCATAGCAAAAACGTTTTATTATCTAAAAACT
TTAATCAAGCTAAAGAAATTATTTCTTATAGTCAAAAAGTTAATAAAATAACAGTGGTTGGAGCCGGTTATATTGGAGTT
GAATTAGCAGAAGCTTTTGCTTTGCGAAAAAAAGAAGTGGTTTTAATTGATGCCGAAACTCGTATTATGCCTAAATATTT
AGATGAAGAATTTACTGATGTAGCTCAAAAAGAATTAACCGATCATGGAGTTAAATTAGCTTTAGGACAAAGAATAGTCG
GTTTTGAAACAAAAGATGGATTAGTTACTAAAGTTAAAACCGACAAGGACACTTTTGAAACTGAAATGGTTATTATGTGT
ATCGGATTCAAACCTAACACTAAATTATTTAATCAAGCTTTAAAAACCTTACCTAATGGTGCTTTAATAGTTAATGAATA
TATGCAAACATCAAACCCTGATGTTTATGCTTGTGGGGATTGTGTTAATGTTTATTCCAACCCTAAAAAAATCACCCAAT
ATATTCCTTTAGCAACTAATGCTGTTAGAATGGGAACACTTGTTGGTCTAAATTTAATGAAAAACCAAGTTAAATATTTA
GGAACCCAAGGAACAAGCGGTATCAAAATCATTGATTTAAATATTTCTTCTACTGGTTTAACAGAAACAGTTGCCAAAGA
ATTAGGAAAAAACTATGACACTGTTACCATTAAAGACGCTAACCGACCTGAATTTATGCCTGATTTTGAAACAGTTACTT
TAAAATTAGTTTTTGACAAAGATTCTCGTAAAATTTTAGGTGGTCAAATCGTTTCTCGAATGGATTTAACTGAAAAAATA
AACACTTTAAGTGTTTGTATTCAAAACGAAATGACAGTTGAACAATTAGCTTTTGTAGACTTTTTCTTCCAACCTCATTT
TAATAAACCTTGGAGCCTTCTTAATTTGGCAGGACTCAAAGCTTTAGAAAAAAAGATTTAA

Upstream 100 bases:

>100_bases
TATTTGTTTTGTCAACTTAGTTATTTTTTTATTGTATAATTAAAAGTGTATAGTTTAAGAGAAACTTGAAAGCAAAATAA
AATTTTAAAAGGAGTTTATT

Downstream 100 bases:

>100_bases
AACCATTTATTTTTCTTGAAAAAACAAAAAGGAGTTTTTTAAAATGCAATTTAGTTTGCCGCCTTTAAATTTTAAATATG
ACGCTTTGGAACCATTTTTA

Product: Putative NADH oxidase H2O2-forming

Products: NA

Alternate protein names: NOXase [H]

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MKVIIIGCTHAGTAAAKTIKKTSPQTDIVVYERNDNISFLSCGLALYVGGVVKDSRGLFYSNPEELIHMGINTKLQHDVL
KIDFEKKEVLVCNLETKQEFKDNYDKLVIAAGSWPVVPPIEGIHSKNVLLSKNFNQAKEIISYSQKVNKITVVGAGYIGV
ELAEAFALRKKEVVLIDAETRIMPKYLDEEFTDVAQKELTDHGVKLALGQRIVGFETKDGLVTKVKTDKDTFETEMVIMC
IGFKPNTKLFNQALKTLPNGALIVNEYMQTSNPDVYACGDCVNVYSNPKKITQYIPLATNAVRMGTLVGLNLMKNQVKYL
GTQGTSGIKIIDLNISSTGLTETVAKELGKNYDTVTIKDANRPEFMPDFETVTLKLVFDKDSRKILGGQIVSRMDLTEKI
NTLSVCIQNEMTVEQLAFVDFFFQPHFNKPWSLLNLAGLKALEKKI

Sequences:

>Translated_446_residues
MKVIIIGCTHAGTAAAKTIKKTSPQTDIVVYERNDNISFLSCGLALYVGGVVKDSRGLFYSNPEELIHMGINTKLQHDVL
KIDFEKKEVLVCNLETKQEFKDNYDKLVIAAGSWPVVPPIEGIHSKNVLLSKNFNQAKEIISYSQKVNKITVVGAGYIGV
ELAEAFALRKKEVVLIDAETRIMPKYLDEEFTDVAQKELTDHGVKLALGQRIVGFETKDGLVTKVKTDKDTFETEMVIMC
IGFKPNTKLFNQALKTLPNGALIVNEYMQTSNPDVYACGDCVNVYSNPKKITQYIPLATNAVRMGTLVGLNLMKNQVKYL
GTQGTSGIKIIDLNISSTGLTETVAKELGKNYDTVTIKDANRPEFMPDFETVTLKLVFDKDSRKILGGQIVSRMDLTEKI
NTLSVCIQNEMTVEQLAFVDFFFQPHFNKPWSLLNLAGLKALEKKI
>Mature_446_residues
MKVIIIGCTHAGTAAAKTIKKTSPQTDIVVYERNDNISFLSCGLALYVGGVVKDSRGLFYSNPEELIHMGINTKLQHDVL
KIDFEKKEVLVCNLETKQEFKDNYDKLVIAAGSWPVVPPIEGIHSKNVLLSKNFNQAKEIISYSQKVNKITVVGAGYIGV
ELAEAFALRKKEVVLIDAETRIMPKYLDEEFTDVAQKELTDHGVKLALGQRIVGFETKDGLVTKVKTDKDTFETEMVIMC
IGFKPNTKLFNQALKTLPNGALIVNEYMQTSNPDVYACGDCVNVYSNPKKITQYIPLATNAVRMGTLVGLNLMKNQVKYL
GTQGTSGIKIIDLNISSTGLTETVAKELGKNYDTVTIKDANRPEFMPDFETVTLKLVFDKDSRKILGGQIVSRMDLTEKI
NTLSVCIQNEMTVEQLAFVDFFFQPHFNKPWSLLNLAGLKALEKKI

Specific function: Catalyzes the four-electron reduction of molecular oxygen to water [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI21389617, Length=332, Percent_Identity=24.3975903614458, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI65787454, Length=332, Percent_Identity=24.3975903614458, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI226437568, Length=332, Percent_Identity=24.3975903614458, Blast_Score=79, Evalue=7e-15,
Organism=Escherichia coli, GI1789065, Length=198, Percent_Identity=32.8282828282828, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI87082354, Length=408, Percent_Identity=25.7352941176471, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786307, Length=324, Percent_Identity=24.3827160493827, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1789765, Length=292, Percent_Identity=21.9178082191781, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1787352, Length=271, Percent_Identity=28.4132841328413, Blast_Score=65, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24585130, Length=187, Percent_Identity=29.4117647058824, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24639257, Length=292, Percent_Identity=23.2876712328767, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281359715, Length=292, Percent_Identity=23.2876712328767, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281359713, Length=292, Percent_Identity=23.2876712328767, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24639250, Length=292, Percent_Identity=23.2876712328767, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI18543267, Length=292, Percent_Identity=23.2876712328767, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24639252, Length=292, Percent_Identity=23.2876712328767, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.99.3 [H]

Molecular weight: Translated: 49637; Mature: 49637

Theoretical pI: Translated: 8.03; Mature: 8.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVIIIGCTHAGTAAAKTIKKTSPQTDIVVYERNDNISFLSCGLALYVGGVVKDSRGLFY
CEEEEEEECCCCHHHHHHHHCCCCCCEEEEEEECCCEEEEEHHHHHHCCCEEECCCCCEE
SNPEELIHMGINTKLQHDVLKIDFEKKEVLVCNLETKQEFKDNYDKLVIAAGSWPVVPPI
CCHHHHEEECCCCCCCCCEEEEEECCCEEEEEECCHHHHHHCCCCEEEEEECCCCCCCCC
EGIHSKNVLLSKNFNQAKEIISYSQKVNKITVVGAGYIGVELAEAFALRKKEVVLIDAET
CCCCCCCEEEECCHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHCCCCCEEEEECCC
RIMPKYLDEEFTDVAQKELTDHGVKLALGQRIVGFETKDGLVTKVKTDKDTFETEMVIMC
CCCHHHHHHHHHHHHHHHHHHCCEEEEECCEEEEEECCCCEEEEEECCCCCCCCEEEEEE
IGFKPNTKLFNQALKTLPNGALIVNEYMQTSNPDVYACGDCVNVYSNPKKITQYIPLATN
ECCCCCHHHHHHHHHHCCCCEEEEEHHHHCCCCCEEEECCHHHHCCCHHHHHHHCCCCCC
AVRMGTLVGLNLMKNQVKYLGTQGTSGIKIIDLNISSTGLTETVAKELGKNYDTVTIKDA
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCEEEEECC
NRPEFMPDFETVTLKLVFDKDSRKILGGQIVSRMDLTEKINTLSVCIQNEMTVEQLAFVD
CCCCCCCCCCEEEEEEEEECCCCEEHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHH
FFFQPHFNKPWSLLNLAGLKALEKKI
HEECCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKVIIIGCTHAGTAAAKTIKKTSPQTDIVVYERNDNISFLSCGLALYVGGVVKDSRGLFY
CEEEEEEECCCCHHHHHHHHCCCCCCEEEEEEECCCEEEEEHHHHHHCCCEEECCCCCEE
SNPEELIHMGINTKLQHDVLKIDFEKKEVLVCNLETKQEFKDNYDKLVIAAGSWPVVPPI
CCHHHHEEECCCCCCCCCEEEEEECCCEEEEEECCHHHHHHCCCCEEEEEECCCCCCCCC
EGIHSKNVLLSKNFNQAKEIISYSQKVNKITVVGAGYIGVELAEAFALRKKEVVLIDAET
CCCCCCCEEEECCHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHCCCCCEEEEECCC
RIMPKYLDEEFTDVAQKELTDHGVKLALGQRIVGFETKDGLVTKVKTDKDTFETEMVIMC
CCCHHHHHHHHHHHHHHHHHHCCEEEEECCEEEEEECCCCEEEEEECCCCCCCCEEEEEE
IGFKPNTKLFNQALKTLPNGALIVNEYMQTSNPDVYACGDCVNVYSNPKKITQYIPLATN
ECCCCCHHHHHHHHHHCCCCEEEEEHHHHCCCCCEEEECCHHHHCCCHHHHHHHCCCCCC
AVRMGTLVGLNLMKNQVKYLGTQGTSGIKIIDLNISSTGLTETVAKELGKNYDTVTIKDA
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCEEEEECC
NRPEFMPDFETVTLKLVFDKDSRKILGGQIVSRMDLTEKINTLSVCIQNEMTVEQLAFVD
CCCCCCCCCCEEEEEEEEECCCCEEHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHH
FFFQPHFNKPWSLLNLAGLKALEKKI
HEECCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1404382; 12663927; 2511195; 8262333 [H]