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The map label for this gene is uvrD [H]

Identifier: 197294727

GI number: 197294727

Start: 703690

End: 705831

Strand: Reverse

Name: uvrD [H]

Synonym: PAa_0693

Alternate gene names: 197294727

Gene position: 705831-703690 (Counterclockwise)

Preceding gene: 197294728

Following gene: 197294726

Centisome position: 80.21

GC content: 26.24

Gene sequence:

>2142_bases
ATGTCATCTAAAATAGATAGTTGGTTAAAAAAATTAAATAAAAATCAAGTAGAAGCGGCTACCTCCAAATCTTTGGCTAC
TTATTTATTGGCTGGTGCAGGAACTGGCAAAACGACTACTTTAACTACTAAAATTGCTTATTTAATTGAAAAACAAAATT
TTTTGAGCAAAAACATTTTAGCACTTACTTTCACTAACAAAGCTGCTGACCAAATGAAAAACAAAATCTTGGAAATGATT
GGAGAAAAAAGCAAAGGAGTCAATATTTTGACTTTTCATGCTTTAGGGAACCGTATTTTAAGGCAATTTATTAATATTTT
GCCTTTTAACTATAACAGAAATTTCATTATTTTAAATGATAAAGAATGCAACCAAATCCTTAAGATAGTTGCCAAAGAGG
TCAATTTTGATATCCAGAAGGTAGAAAATATCGATAATTTGAGGAAAGAAGTTTTTAGACTTAAAAAAAAGACTAACGAA
TTTTTGCAACATCAACAAACCTCAACTCAAAACAACAATCCTTTAATTGTAAAAATTAAGAATCAATATCAAAAATATCT
TCAAAAAAATAATTTAGTTGATTTTAATGATTTAATTTTATATACTTATCAATTATTAAAAGAATATCCAGAAATAAAAC
AATTTTGGCAAAAAAAATTCCAATATATTTTAGTGGATGAATTTCAAGATACCGATTTTTATCAATATCAAATTTTAACT
TTTTTAACTGAAAAAAATCCTTGTATTTTTGTTGTGGGCGATCCTGATCAAAATATTTATTCTTTTAGAGGTGCTTGTTT
TGGAAATAGTCAATTATTTTTAAATAAATTTAATCCTCAAATATATGTCCTTAAACAAAATTATCGTTCTTCTGAAAATA
TTTTAGAAAAAGCGAATCTCTTAATTAGTTATAATAAAGATCATCCTTTTAAAAAAAAGTTAAATAGCGTCAAAGGTAAA
GGAACTAAAGTTAACGCTCATTTTTTTGTAGATAGCAGAATTGAGGCACAATATATAGTTCAAAAAATAAAACATTTAGT
CCAAATTTATCATTATAATTATCGAGATTTTGCTATTTTATACCGCGTTAATTCTTTGGGACATTTTTTGGAAAAATACC
TTATTAGTGCAGGCATCCCTTATATGTTTTTAGGAAACTTATCTTTTTATCAAAAAAAAGTAGTCAAGGATTTCCTAGCT
TATTTACATTTAGCTGTCAACCCTTTGCAAGATTTTTATTTAAGACGAGTTATTAACGTTCCCAAAAGACAAATTGGAAA
AATTACTATAACATGTTTAGAAAAAATAGTTCAAGAAAAAGAACGTTCCTTTTTTGAAATTTTAAAAGATTACAAAGATA
TTCCTGTTAGCGACAAAACTCAAAAACAACTTTATCAATTTTATTGTTTGATTGAAGAGTTGAATAATAAAATAATAAAC
AATGAATTTGAGAAATTGAGCGATATAATTACTTATGTTGATCAAAAAACTCAATATTCTTATCAAATATCTCTTGAAAC
TCAAAAAAACCCTCAAAAAGCTAACGAAGAGCAATCATCGTTAGTTGCTATAGAAGAATTAAAATCCATTTTAAATCAAA
TAGATGAAAGTTTTCAAGGCAGTAATTTACAAAAAATAAATAATTTTTTAGAAGAAGTATCTTTGAATAATGAAACTAAA
ATCAACAATTCTTCTGGTAATAAAGCCAACAATCGTGTTAAATTAGCAACTATTCATAAAGTTAAAGGTTTAGAGTTTAA
AGTTGTTTTTCTGGCGGGATTAGAAAAAGAATTTTTCGATGATTTAGATGATATACAAGAATCAAGGCGACTTACTTATG
TTGCCGTCACAAGAGCACAAGAAAAATTATTTTTAACGGGCGTTTCTCAAAGAATGTTATTTGGAAAAAATTTTTCGCAT
GAACCATCAGTATTTTTTAAAGAAATGGGCTTTGGGTCAAGAAAAAATTATTTTCTTTCGCAAACGCAAAAACCATTTCA
AAAAGGCGATCAGGTAAGACATAACCTTTTTGGTTTGGGAATAGTTTTAGAATTGGAAAGAAACAATATAATTGTTGAAT
TTGTAAATCCCAAAAAAACTAAAATGTTTGAAAATTCGTTCAAATATCTTCAAAAAATATAA

Upstream 100 bases:

>100_bases
ACAAGGTTTTTTTGTTTTAGAAAAAAAAGCAGATAAAAAATTACATTTTAATAAAATAGTAAGTTTAAAAGTAAGTAATT
TGAAATAAAAAGGTTCAATA

Downstream 100 bases:

>100_bases
TTAAATTTAATAAATGAAAGGAAAAGTAATTATGGATTTTTATAATGATGTTGTCAATAATAGAGCTATTTGGACTTTCG
TTTCTGTTTTAATTATTTTA

Product: ATP-dependent DNA helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 713; Mature: 712

Protein sequence:

>713_residues
MSSKIDSWLKKLNKNQVEAATSKSLATYLLAGAGTGKTTTLTTKIAYLIEKQNFLSKNILALTFTNKAADQMKNKILEMI
GEKSKGVNILTFHALGNRILRQFINILPFNYNRNFIILNDKECNQILKIVAKEVNFDIQKVENIDNLRKEVFRLKKKTNE
FLQHQQTSTQNNNPLIVKIKNQYQKYLQKNNLVDFNDLILYTYQLLKEYPEIKQFWQKKFQYILVDEFQDTDFYQYQILT
FLTEKNPCIFVVGDPDQNIYSFRGACFGNSQLFLNKFNPQIYVLKQNYRSSENILEKANLLISYNKDHPFKKKLNSVKGK
GTKVNAHFFVDSRIEAQYIVQKIKHLVQIYHYNYRDFAILYRVNSLGHFLEKYLISAGIPYMFLGNLSFYQKKVVKDFLA
YLHLAVNPLQDFYLRRVINVPKRQIGKITITCLEKIVQEKERSFFEILKDYKDIPVSDKTQKQLYQFYCLIEELNNKIIN
NEFEKLSDIITYVDQKTQYSYQISLETQKNPQKANEEQSSLVAIEELKSILNQIDESFQGSNLQKINNFLEEVSLNNETK
INNSSGNKANNRVKLATIHKVKGLEFKVVFLAGLEKEFFDDLDDIQESRRLTYVAVTRAQEKLFLTGVSQRMLFGKNFSH
EPSVFFKEMGFGSRKNYFLSQTQKPFQKGDQVRHNLFGLGIVLELERNNIIVEFVNPKKTKMFENSFKYLQKI

Sequences:

>Translated_713_residues
MSSKIDSWLKKLNKNQVEAATSKSLATYLLAGAGTGKTTTLTTKIAYLIEKQNFLSKNILALTFTNKAADQMKNKILEMI
GEKSKGVNILTFHALGNRILRQFINILPFNYNRNFIILNDKECNQILKIVAKEVNFDIQKVENIDNLRKEVFRLKKKTNE
FLQHQQTSTQNNNPLIVKIKNQYQKYLQKNNLVDFNDLILYTYQLLKEYPEIKQFWQKKFQYILVDEFQDTDFYQYQILT
FLTEKNPCIFVVGDPDQNIYSFRGACFGNSQLFLNKFNPQIYVLKQNYRSSENILEKANLLISYNKDHPFKKKLNSVKGK
GTKVNAHFFVDSRIEAQYIVQKIKHLVQIYHYNYRDFAILYRVNSLGHFLEKYLISAGIPYMFLGNLSFYQKKVVKDFLA
YLHLAVNPLQDFYLRRVINVPKRQIGKITITCLEKIVQEKERSFFEILKDYKDIPVSDKTQKQLYQFYCLIEELNNKIIN
NEFEKLSDIITYVDQKTQYSYQISLETQKNPQKANEEQSSLVAIEELKSILNQIDESFQGSNLQKINNFLEEVSLNNETK
INNSSGNKANNRVKLATIHKVKGLEFKVVFLAGLEKEFFDDLDDIQESRRLTYVAVTRAQEKLFLTGVSQRMLFGKNFSH
EPSVFFKEMGFGSRKNYFLSQTQKPFQKGDQVRHNLFGLGIVLELERNNIIVEFVNPKKTKMFENSFKYLQKI
>Mature_712_residues
SSKIDSWLKKLNKNQVEAATSKSLATYLLAGAGTGKTTTLTTKIAYLIEKQNFLSKNILALTFTNKAADQMKNKILEMIG
EKSKGVNILTFHALGNRILRQFINILPFNYNRNFIILNDKECNQILKIVAKEVNFDIQKVENIDNLRKEVFRLKKKTNEF
LQHQQTSTQNNNPLIVKIKNQYQKYLQKNNLVDFNDLILYTYQLLKEYPEIKQFWQKKFQYILVDEFQDTDFYQYQILTF
LTEKNPCIFVVGDPDQNIYSFRGACFGNSQLFLNKFNPQIYVLKQNYRSSENILEKANLLISYNKDHPFKKKLNSVKGKG
TKVNAHFFVDSRIEAQYIVQKIKHLVQIYHYNYRDFAILYRVNSLGHFLEKYLISAGIPYMFLGNLSFYQKKVVKDFLAY
LHLAVNPLQDFYLRRVINVPKRQIGKITITCLEKIVQEKERSFFEILKDYKDIPVSDKTQKQLYQFYCLIEELNNKIINN
EFEKLSDIITYVDQKTQYSYQISLETQKNPQKANEEQSSLVAIEELKSILNQIDESFQGSNLQKINNFLEEVSLNNETKI
NNSSGNKANNRVKLATIHKVKGLEFKVVFLAGLEKEFFDDLDDIQESRRLTYVAVTRAQEKLFLTGVSQRMLFGKNFSHE
PSVFFKEMGFGSRKNYFLSQTQKPFQKGDQVRHNLFGLGIVLELERNNIIVEFVNPKKTKMFENSFKYLQKI

Specific function: Essential helicase [H]

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=706, Percent_Identity=30.8781869688385, Blast_Score=324, Evalue=1e-89,
Organism=Escherichia coli, GI48994965, Length=659, Percent_Identity=31.866464339909, Blast_Score=290, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6322369, Length=755, Percent_Identity=26.6225165562914, Blast_Score=178, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6324477, Length=697, Percent_Identity=24.390243902439, Blast_Score=105, Evalue=3e-23,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 83637; Mature: 83505

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSKIDSWLKKLNKNQVEAATSKSLATYLLAGAGTGKTTTLTTKIAYLIEKQNFLSKNIL
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHCCCEE
ALTFTNKAADQMKNKILEMIGEKSKGVNILTFHALGNRILRQFINILPFNYNRNFIILND
EEEECCHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCEEEECC
KECNQILKIVAKEVNFDIQKVENIDNLRKEVFRLKKKTNEFLQHQQTSTQNNNPLIVKIK
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEH
NQYQKYLQKNNLVDFNDLILYTYQLLKEYPEIKQFWQKKFQYILVDEFQDTDFYQYQILT
HHHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHCCEEEEECCCCCCCHHEEEEE
FLTEKNPCIFVVGDPDQNIYSFRGACFGNSQLFLNKFNPQIYVLKQNYRSSENILEKANL
EEECCCCEEEEECCCCCCHHHHCCEEECCCEEEEEECCCEEEEEECCCCCHHHHHHHCCE
LISYNKDHPFKKKLNSVKGKGTKVNAHFFVDSRIEAQYIVQKIKHLVQIYHYNYRDFAIL
EEEECCCCCHHHHHHHCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEE
YRVNSLGHFLEKYLISAGIPYMFLGNLSFYQKKVVKDFLAYLHLAVNPLQDFYLRRVINV
EEHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PKRQIGKITITCLEKIVQEKERSFFEILKDYKDIPVSDKTQKQLYQFYCLIEELNNKIIN
CHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
NEFEKLSDIITYVDQKTQYSYQISLETQKNPQKANEEQSSLVAIEELKSILNQIDESFQG
HHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
SNLQKINNFLEEVSLNNETKINNSSGNKANNRVKLATIHKVKGLEFKVVFLAGLEKEFFD
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCEEEEEEEECCCHHHHH
DLDDIQESRRLTYVAVTRAQEKLFLTGVSQRMLFGKNFSHEPSVFFKEMGFGSRKNYFLS
HHHHHHHHCCEEEEEEEHHHHHHEECCHHHHHHHCCCCCCCCHHHHHHCCCCCCCCHHHH
QTQKPFQKGDQVRHNLFGLGIVLELERNNIIVEFVNPKKTKMFENSFKYLQKI
HCCCHHHHHHHHHHHHEEEEEEEEEECCCEEEEECCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SSKIDSWLKKLNKNQVEAATSKSLATYLLAGAGTGKTTTLTTKIAYLIEKQNFLSKNIL
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHCCCEE
ALTFTNKAADQMKNKILEMIGEKSKGVNILTFHALGNRILRQFINILPFNYNRNFIILND
EEEECCHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCEEEECC
KECNQILKIVAKEVNFDIQKVENIDNLRKEVFRLKKKTNEFLQHQQTSTQNNNPLIVKIK
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEH
NQYQKYLQKNNLVDFNDLILYTYQLLKEYPEIKQFWQKKFQYILVDEFQDTDFYQYQILT
HHHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHCCEEEEECCCCCCCHHEEEEE
FLTEKNPCIFVVGDPDQNIYSFRGACFGNSQLFLNKFNPQIYVLKQNYRSSENILEKANL
EEECCCCEEEEECCCCCCHHHHCCEEECCCEEEEEECCCEEEEEECCCCCHHHHHHHCCE
LISYNKDHPFKKKLNSVKGKGTKVNAHFFVDSRIEAQYIVQKIKHLVQIYHYNYRDFAIL
EEEECCCCCHHHHHHHCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEE
YRVNSLGHFLEKYLISAGIPYMFLGNLSFYQKKVVKDFLAYLHLAVNPLQDFYLRRVINV
EEHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PKRQIGKITITCLEKIVQEKERSFFEILKDYKDIPVSDKTQKQLYQFYCLIEELNNKIIN
CHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
NEFEKLSDIITYVDQKTQYSYQISLETQKNPQKANEEQSSLVAIEELKSILNQIDESFQG
HHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
SNLQKINNFLEEVSLNNETKINNSSGNKANNRVKLATIHKVKGLEFKVVFLAGLEKEFFD
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCEEEEEEEECCCHHHHH
DLDDIQESRRLTYVAVTRAQEKLFLTGVSQRMLFGKNFSHEPSVFFKEMGFGSRKNYFLS
HHHHHHHHCCEEEEEEEHHHHHHEECCHHHHHHHCCCCCCCCHHHHHHCCCCCCCCHHHH
QTQKPFQKGDQVRHNLFGLGIVLELERNNIIVEFVNPKKTKMFENSFKYLQKI
HCCCHHHHHHHHHHHHEEEEEEEEEECCCEEEEECCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA