Click here to switch to the map view.

The map label for this gene is GRS1 [H]

Identifier: 197294659

GI number: 197294659

Start: 611510

End: 612868

Strand: Reverse

Name: GRS1 [H]

Synonym: PAa_0615

Alternate gene names: 197294659

Gene position: 612868-611510 (Counterclockwise)

Preceding gene: 197294660

Following gene: 197294658

Centisome position: 69.65

GC content: 30.54

Gene sequence:

>1359_bases
ATGGAATCTTTTGAAAAAATTATTAATTTAGCTAAACAAACTGGTTTTGTTTTTTCTGGTAGTGAAATTTATGGCGGTCT
TGCAAATAGTTGGGATTATGGACCCTTAGGCAGTTTATTAAAAAACAATCTTAAAAAAGCGTGGTTGCAAAAGTTTTTTC
AAGAACAAAGCCAAAATATTTTATTAGATGGATCTATTTTACTTAATTCTTCTGTTTGGCGTTCATCCGGTCATCTAGAT
TCTTTTTCTGATCCACTTACAGAAAATAAAGATAACAATAAAAGATTTCGAGCTGATAAATTGATTGAAGAACACCAACC
AGGCCTAGACATTAGTTGTTGGACTTATGAACAAATGCATCAATATTTAGTTGAAAATAAAGTTTTGGGGACAAGCAATT
GGACACCCATCCAACCATTTAATATGCTTTTTCAAACTCATCAAGGAGTTGTTTTGGAAAAATCCAAACCCCTTTATTTA
AGACCCGAAACAGCCCAAGGTATTTTTATCCAATTTAAAAATATTTTAAAGACAACTCGCAAAAAAATTCCTTTTGGCGT
TTGTCAAGTTGGCAAAGTTTTTCGCAATGAAATCACTCCCGGTAATTTCATTTTTCGTAGTTGTGAATTTGAACAAATGG
AATTAGAGTTTTTTTGCGAACCGAACACGCAAAATGAATGGTTTGAATATTGGAAAAATTTTATGTATCAATTTTTAATT
ACTTTAGGGATGAAAAAAGAAAATTTATCTTTCAAGAATCATCAAAAAGAAGAGTTAAGTCATTATTCTGAAAAAACCAC
TGATATTTTATTTAAATTTCCTTGGGGCATGGATGAACTTTGGGGAATCGCTTCAAGAACTGATTTTGATTTAAAAAACC
ACCAAAATCATTCAAAAAAAGACCTTACTTATTTTGATCCAAATACCCAAAAAAGATATTTTCCTTATGTTATTGAACCT
TCTTTGGGAGTTGAAAGGTTGTTTTTAGCTCTTTTAATCAATAATTATCATGAAGATTCAGTTAACCAAACGCCCAGACA
AGTTTTAACTTTTCACCCTTTTTTGGCACCTTATAAAGTGGCAGTTTTGCCTTTAATTAAAAAAGAACATGCTTCTAAGG
CCAAAGAAATCGAAAATTATTTGATGAAATATTTAGATGTTTGTTATGATGATACTCAAAGTATTGGAAAAAGGTATCGC
AGACAAGATATGATAGGTACCCCTTTTTGTTTAACAGTTGATCATGAAACTCTGGAAAAAAATACAGTCACTTTAAGAAA
TCGCGACACTTTAAAACAAGAAACAATGACTTTAGAAGAAGTTAAAAATTATGTTTTATCGCAGGTGACATTAAAATAA

Upstream 100 bases:

>100_bases
TTTTAAATACTTAACAAATTATTTAATCTTTTTTTGTTTAGTTTTTGTGTCTCAATTCGTAAGGATTATGAAATTTAAAA
AAATAAAAGGATATTTGGAG

Downstream 100 bases:

>100_bases
AGTTATGCAAAAACAATTAATTCAAGAAATTAATGAAAAAACATCCATTGTTGAATTAGCTCAAGAGTTTGTTCAACTAA
AAAAATCTGGAAAGAATTAT

Product: glycyl-tRNA synthetase

Products: NA

Alternate protein names: Glycine--tRNA ligase; GlyRS [H]

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MESFEKIINLAKQTGFVFSGSEIYGGLANSWDYGPLGSLLKNNLKKAWLQKFFQEQSQNILLDGSILLNSSVWRSSGHLD
SFSDPLTENKDNNKRFRADKLIEEHQPGLDISCWTYEQMHQYLVENKVLGTSNWTPIQPFNMLFQTHQGVVLEKSKPLYL
RPETAQGIFIQFKNILKTTRKKIPFGVCQVGKVFRNEITPGNFIFRSCEFEQMELEFFCEPNTQNEWFEYWKNFMYQFLI
TLGMKKENLSFKNHQKEELSHYSEKTTDILFKFPWGMDELWGIASRTDFDLKNHQNHSKKDLTYFDPNTQKRYFPYVIEP
SLGVERLFLALLINNYHEDSVNQTPRQVLTFHPFLAPYKVAVLPLIKKEHASKAKEIENYLMKYLDVCYDDTQSIGKRYR
RQDMIGTPFCLTVDHETLEKNTVTLRNRDTLKQETMTLEEVKNYVLSQVTLK

Sequences:

>Translated_452_residues
MESFEKIINLAKQTGFVFSGSEIYGGLANSWDYGPLGSLLKNNLKKAWLQKFFQEQSQNILLDGSILLNSSVWRSSGHLD
SFSDPLTENKDNNKRFRADKLIEEHQPGLDISCWTYEQMHQYLVENKVLGTSNWTPIQPFNMLFQTHQGVVLEKSKPLYL
RPETAQGIFIQFKNILKTTRKKIPFGVCQVGKVFRNEITPGNFIFRSCEFEQMELEFFCEPNTQNEWFEYWKNFMYQFLI
TLGMKKENLSFKNHQKEELSHYSEKTTDILFKFPWGMDELWGIASRTDFDLKNHQNHSKKDLTYFDPNTQKRYFPYVIEP
SLGVERLFLALLINNYHEDSVNQTPRQVLTFHPFLAPYKVAVLPLIKKEHASKAKEIENYLMKYLDVCYDDTQSIGKRYR
RQDMIGTPFCLTVDHETLEKNTVTLRNRDTLKQETMTLEEVKNYVLSQVTLK
>Mature_452_residues
MESFEKIINLAKQTGFVFSGSEIYGGLANSWDYGPLGSLLKNNLKKAWLQKFFQEQSQNILLDGSILLNSSVWRSSGHLD
SFSDPLTENKDNNKRFRADKLIEEHQPGLDISCWTYEQMHQYLVENKVLGTSNWTPIQPFNMLFQTHQGVVLEKSKPLYL
RPETAQGIFIQFKNILKTTRKKIPFGVCQVGKVFRNEITPGNFIFRSCEFEQMELEFFCEPNTQNEWFEYWKNFMYQFLI
TLGMKKENLSFKNHQKEELSHYSEKTTDILFKFPWGMDELWGIASRTDFDLKNHQNHSKKDLTYFDPNTQKRYFPYVIEP
SLGVERLFLALLINNYHEDSVNQTPRQVLTFHPFLAPYKVAVLPLIKKEHASKAKEIENYLMKYLDVCYDDTQSIGKRYR
RQDMIGTPFCLTVDHETLEKNTVTLRNRDTLKQETMTLEEVKNYVLSQVTLK

Specific function: Catalyzes the attachment of glycine to tRNA(Gly) [H]

COG id: COG0423

COG function: function code J; Glycyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI116805340, Length=368, Percent_Identity=29.8913043478261, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI70887790, Length=309, Percent_Identity=24.9190938511327, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI32564541, Length=411, Percent_Identity=27.007299270073, Blast_Score=146, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17554996, Length=411, Percent_Identity=27.007299270073, Blast_Score=145, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6325338, Length=348, Percent_Identity=28.1609195402299, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6319597, Length=230, Percent_Identity=29.5652173913043, Blast_Score=103, Evalue=6e-23,
Organism=Drosophila melanogaster, GI21357965, Length=355, Percent_Identity=29.5774647887324, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24664462, Length=355, Percent_Identity=29.5774647887324, Blast_Score=159, Evalue=5e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR022961
- InterPro:   IPR002315 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.14 [H]

Molecular weight: Translated: 53181; Mature: 53181

Theoretical pI: Translated: 7.61; Mature: 7.61

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESFEKIINLAKQTGFVFSGSEIYGGLANSWDYGPLGSLLKNNLKKAWLQKFFQEQSQNI
CCHHHHHHHHHHHCCCEEECHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCE
LLDGSILLNSSVWRSSGHLDSFSDPLTENKDNNKRFRADKLIEEHQPGLDISCWTYEQMH
EEECEEEECCHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEHHHHH
QYLVENKVLGTSNWTPIQPFNMLFQTHQGVVLEKSKPLYLRPETAQGIFIQFKNILKTTR
HHHHHCCEECCCCCCCCCHHHHHHHHCCCEEEECCCCEEECCCCCCHHHHHHHHHHHHHH
KKIPFGVCQVGKVFRNEITPGNFIFRSCEFEQMELEFFCEPNTQNEWFEYWKNFMYQFLI
HHCCHHHHHHHHHHHHCCCCCCCEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHH
TLGMKKENLSFKNHQKEELSHYSEKTTDILFKFPWGMDELWGIASRTDFDLKNHQNHSKK
HHCCCCCCCCCCCCCHHHHHHHHHHCCEEEEECCCCHHHHHCCCCCCCCCCCCCCCCCCC
DLTYFDPNTQKRYFPYVIEPSLGVERLFLALLINNYHEDSVNQTPRQVLTFHPFLAPYKV
CCEEECCCCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCHHHHHH
AVLPLIKKEHASKAKEIENYLMKYLDVCYDDTQSIGKRYRRQDMIGTPFCLTVDHETLEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEECHHHHCC
NTVTLRNRDTLKQETMTLEEVKNYVLSQVTLK
CCEEECCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MESFEKIINLAKQTGFVFSGSEIYGGLANSWDYGPLGSLLKNNLKKAWLQKFFQEQSQNI
CCHHHHHHHHHHHCCCEEECHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCE
LLDGSILLNSSVWRSSGHLDSFSDPLTENKDNNKRFRADKLIEEHQPGLDISCWTYEQMH
EEECEEEECCHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEHHHHH
QYLVENKVLGTSNWTPIQPFNMLFQTHQGVVLEKSKPLYLRPETAQGIFIQFKNILKTTR
HHHHHCCEECCCCCCCCCHHHHHHHHCCCEEEECCCCEEECCCCCCHHHHHHHHHHHHHH
KKIPFGVCQVGKVFRNEITPGNFIFRSCEFEQMELEFFCEPNTQNEWFEYWKNFMYQFLI
HHCCHHHHHHHHHHHHCCCCCCCEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHH
TLGMKKENLSFKNHQKEELSHYSEKTTDILFKFPWGMDELWGIASRTDFDLKNHQNHSKK
HHCCCCCCCCCCCCCHHHHHHHHHHCCEEEEECCCCHHHHHCCCCCCCCCCCCCCCCCCC
DLTYFDPNTQKRYFPYVIEPSLGVERLFLALLINNYHEDSVNQTPRQVLTFHPFLAPYKV
CCEEECCCCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCHHHHHH
AVLPLIKKEHASKAKEIENYLMKYLDVCYDDTQSIGKRYRRQDMIGTPFCLTVDHETLEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEECHHHHCC
NTVTLRNRDTLKQETMTLEEVKNYVLSQVTLK
CCEEECCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA