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The map label for this gene is era [H]

Identifier: 197294660

GI number: 197294660

Start: 613186

End: 614064

Strand: Reverse

Name: era [H]

Synonym: PAa_0616

Alternate gene names: 197294660

Gene position: 614064-613186 (Counterclockwise)

Preceding gene: 197294661

Following gene: 197294659

Centisome position: 69.78

GC content: 27.99

Gene sequence:

>879_bases
ATGAGTTTTAAATCCGGTTTCATTGCTATTGTCGGCCGTCCTAATGTTGGTAAATCAACTCTTTTAAATGTTTTGACTAA
CCAAAAAATAGCTATTACTAGTGATAAACCCCAAACCACTCGTCATAAAATCGTTGGTATTTGTCATGAATCAGATGCTC
AATATATTTTCGTAGATACTCCAGGAATTAATCAATATAAATATTTATTGAATCAAAAAATGAATCAAATTTCTTTTCGA
AGTATTAGTGATGTTGATGTTATTTTGTTTGTAACAGATTCTTTTTATCATCCCCAAGAAAAAAATTTATTAGATTTTAT
TTTTAAAAAAAAGAAACCACTTTTTTTAGTGATTAATAAAATTGATATTTTAAAAAGTAAAAATAAAATTGATGCCATCA
TTTTAAGCTATTTAAATCATTACCCTTTTATAAATGTGATTCCACTTTCCGCTGTTGAATCCAAAAACATTCCTAAATTA
AAATCCTTTCTTTATCAAAACATGCAAAAAGGAGTCCCTTATTATCCTCAAAATATTATTACTGACCAAAAAAAAGAATT
TTTAATGTCAGAAATTGTTAGAGAAAAGATTCTTTATTATGTCCATGAAGAAGTTCCTCATGCAGCCACAGTTGTTATCG
AAAAGATTAAACCTTTAAACAAAGATTTACTTGAAATCTGGGTTCTTATTTTAGTCGAAAAAAACTCTCAAAAACAAATT
TTGATCGGTGCACAAGGCTCTAAATTAAAAGCAATCGGCTCTCATGCCCGTAAAGATTTAAATGCTTATTTCAACATTAA
AAGTTATTTGCATTTATGGGTCAAAGTTGTTCCTAATTGGCGCAATCAAAAACAATTATTGAGTGGTTTTGGCTTTTAA

Upstream 100 bases:

>100_bases
ACATAATAACGAAGAAGAGTTAGAAAAAATGATTCATTTGCAAGAAAAAATTTTAAAAAAAATTAACTTAGAACGAAAAA
AATAATCAAAGAGGTTTTAT

Downstream 100 bases:

>100_bases
ATAATTTTCAAAAATTTATCAACTACAATCAATTAACGAAACAAAAATAAATTTATTTAAACATTTAAGACTGACTTTTA
AAAATTAAAAACAATCACAA

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MSFKSGFIAIVGRPNVGKSTLLNVLTNQKIAITSDKPQTTRHKIVGICHESDAQYIFVDTPGINQYKYLLNQKMNQISFR
SISDVDVILFVTDSFYHPQEKNLLDFIFKKKKPLFLVINKIDILKSKNKIDAIILSYLNHYPFINVIPLSAVESKNIPKL
KSFLYQNMQKGVPYYPQNIITDQKKEFLMSEIVREKILYYVHEEVPHAATVVIEKIKPLNKDLLEIWVLILVEKNSQKQI
LIGAQGSKLKAIGSHARKDLNAYFNIKSYLHLWVKVVPNWRNQKQLLSGFGF

Sequences:

>Translated_292_residues
MSFKSGFIAIVGRPNVGKSTLLNVLTNQKIAITSDKPQTTRHKIVGICHESDAQYIFVDTPGINQYKYLLNQKMNQISFR
SISDVDVILFVTDSFYHPQEKNLLDFIFKKKKPLFLVINKIDILKSKNKIDAIILSYLNHYPFINVIPLSAVESKNIPKL
KSFLYQNMQKGVPYYPQNIITDQKKEFLMSEIVREKILYYVHEEVPHAATVVIEKIKPLNKDLLEIWVLILVEKNSQKQI
LIGAQGSKLKAIGSHARKDLNAYFNIKSYLHLWVKVVPNWRNQKQLLSGFGF
>Mature_291_residues
SFKSGFIAIVGRPNVGKSTLLNVLTNQKIAITSDKPQTTRHKIVGICHESDAQYIFVDTPGINQYKYLLNQKMNQISFRS
ISDVDVILFVTDSFYHPQEKNLLDFIFKKKKPLFLVINKIDILKSKNKIDAIILSYLNHYPFINVIPLSAVESKNIPKLK
SFLYQNMQKGVPYYPQNIITDQKKEFLMSEIVREKILYYVHEEVPHAATVVIEKIKPLNKDLLEIWVLILVEKNSQKQIL
IGAQGSKLKAIGSHARKDLNAYFNIKSYLHLWVKVVPNWRNQKQLLSGFGF

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism [H]

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=324, Percent_Identity=28.0864197530864, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1788919, Length=290, Percent_Identity=38.9655172413793, Blast_Score=225, Evalue=3e-60,
Organism=Escherichia coli, GI87082120, Length=119, Percent_Identity=36.9747899159664, Blast_Score=85, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24646434, Length=298, Percent_Identity=27.1812080536913, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 33693; Mature: 33562

Theoretical pI: Translated: 10.25; Mature: 10.25

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFKSGFIAIVGRPNVGKSTLLNVLTNQKIAITSDKPQTTRHKIVGICHESDAQYIFVDT
CCCCCCEEEEEECCCCCHHHHHHHHCCCEEEEECCCCCCCHHHEEEEEECCCCCEEEEEC
PGINQYKYLLNQKMNQISFRSISDVDVILFVTDSFYHPQEKNLLDFIFKKKKPLFLVINK
CCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHCCCCEEEEEEH
IDILKSKNKIDAIILSYLNHYPFINVIPLSAVESKNIPKLKSFLYQNMQKGVPYYPQNII
HHHHCCCCHHHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHC
TDQKKEFLMSEIVREKILYYVHEEVPHAATVVIEKIKPLNKDLLEIWVLILVEKNSQKQI
CHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHEECCCCCCEE
LIGAQGSKLKAIGSHARKDLNAYFNIKSYLHLWVKVVPNWRNQKQLLSGFGF
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCC
>Mature Secondary Structure 
SFKSGFIAIVGRPNVGKSTLLNVLTNQKIAITSDKPQTTRHKIVGICHESDAQYIFVDT
CCCCCEEEEEECCCCCHHHHHHHHCCCEEEEECCCCCCCHHHEEEEEECCCCCEEEEEC
PGINQYKYLLNQKMNQISFRSISDVDVILFVTDSFYHPQEKNLLDFIFKKKKPLFLVINK
CCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHCCCCEEEEEEH
IDILKSKNKIDAIILSYLNHYPFINVIPLSAVESKNIPKLKSFLYQNMQKGVPYYPQNII
HHHHCCCCHHHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHC
TDQKKEFLMSEIVREKILYYVHEEVPHAATVVIEKIKPLNKDLLEIWVLILVEKNSQKQI
CHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHEECCCCCCEE
LIGAQGSKLKAIGSHARKDLNAYFNIKSYLHLWVKVVPNWRNQKQLLSGFGF
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA