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The map label for this gene is adk

Identifier: 197294610

GI number: 197294610

Start: 573266

End: 573919

Strand: Reverse

Name: adk

Synonym: PAa_0566

Alternate gene names: 197294610

Gene position: 573919-573266 (Counterclockwise)

Preceding gene: 197294611

Following gene: 197294609

Centisome position: 65.22

GC content: 29.2

Gene sequence:

>654_bases
ATGATATTAATATTATTAGGGCCTCCTGGAATTGGCAAAGGCACTCAAGCAGCGGTTTTATCTGATCTTTTAAAACTTCA
ACACGTTGCAACAGGTGATATTTTTCGTAAAAATTTTCAAGAAAACACTCCATTAGGTAAGGAAAGCAAAAAATTTATTA
ATAAAGGTCTTTTAGTTCCTGATGAAATTACTAATCAAATGATTGCTGATTATTTATCTCAAATAGTTCCTCATTCAAAT
TTTTTATTAGATGGTTTTCCTAGAAACGTCTTTCAAGCTCAATTTTTAGAAACTTTTTTTACTAAATCTAATTTACATTT
GAATAAAGTTATTTATTTTAACGCTTTCAAGCAAGATTTAATGAAACGAATTGAGGGACGAAGAATTTGTTCTCATTGCG
GTAAAGTTTATCATCTAGATAACCTACCGCCGAAAATCGAAGGTATTTGTGACAAAGATCAAAAAAAATTAATCCAAAGA
GAAGATGATAAACCTAACACTTTTTTAAAACGTTTGAAAGTTTTTAATCAAGAAACTTTGCATTTAGTCGAGTATTACCG
CTCCAAAAAACAACTTTTTGAAGTTGATGGGATGCAAAACATTCAACAAGTTACTCAAAAAATTTTAAAAGTTTTAGAAA
CGGAGCAAAAATGA

Upstream 100 bases:

>100_bases
TATTGTCAGCGTCGCAATCGAGACTATTCAACGAATTATGGCCACCGCTCAAAAAAAAGAATATGCAAAAATTTTTTAAT
TAGTTAGACTAAATTATATT

Downstream 100 bases:

>100_bases
TTTCTATCAAAACTCCTTATGAAATCTCTTTGATGAGGCAATCCGGGATTATTTTGCAACAAACTCACAAAATGCTCGCT
CCCTTTATTATTCCAGGAAC

Product: Adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MILILLGPPGIGKGTQAAVLSDLLKLQHVATGDIFRKNFQENTPLGKESKKFINKGLLVPDEITNQMIADYLSQIVPHSN
FLLDGFPRNVFQAQFLETFFTKSNLHLNKVIYFNAFKQDLMKRIEGRRICSHCGKVYHLDNLPPKIEGICDKDQKKLIQR
EDDKPNTFLKRLKVFNQETLHLVEYYRSKKQLFEVDGMQNIQQVTQKILKVLETEQK

Sequences:

>Translated_217_residues
MILILLGPPGIGKGTQAAVLSDLLKLQHVATGDIFRKNFQENTPLGKESKKFINKGLLVPDEITNQMIADYLSQIVPHSN
FLLDGFPRNVFQAQFLETFFTKSNLHLNKVIYFNAFKQDLMKRIEGRRICSHCGKVYHLDNLPPKIEGICDKDQKKLIQR
EDDKPNTFLKRLKVFNQETLHLVEYYRSKKQLFEVDGMQNIQQVTQKILKVLETEQK
>Mature_217_residues
MILILLGPPGIGKGTQAAVLSDLLKLQHVATGDIFRKNFQENTPLGKESKKFINKGLLVPDEITNQMIADYLSQIVPHSN
FLLDGFPRNVFQAQFLETFFTKSNLHLNKVIYFNAFKQDLMKRIEGRRICSHCGKVYHLDNLPPKIEGICDKDQKKLIQR
EDDKPNTFLKRLKVFNQETLHLVEYYRSKKQLFEVDGMQNIQQVTQKILKVLETEQK

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=208, Percent_Identity=37.5, Blast_Score=134, Evalue=7e-32,
Organism=Homo sapiens, GI19923437, Length=197, Percent_Identity=35.5329949238579, Blast_Score=134, Evalue=8e-32,
Organism=Homo sapiens, GI4502013, Length=208, Percent_Identity=37.5, Blast_Score=134, Evalue=9e-32,
Organism=Homo sapiens, GI310110345, Length=198, Percent_Identity=35.3535353535354, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI53832003, Length=198, Percent_Identity=35.3535353535354, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI8051579, Length=198, Percent_Identity=35.3535353535354, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI53832001, Length=198, Percent_Identity=35.3535353535354, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI22749187, Length=191, Percent_Identity=28.2722513089005, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI4502011, Length=208, Percent_Identity=24.0384615384615, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI7706497, Length=221, Percent_Identity=23.0769230769231, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI28144899, Length=205, Percent_Identity=26.3414634146341, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI28144897, Length=205, Percent_Identity=26.3414634146341, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1786680, Length=217, Percent_Identity=33.6405529953917, Blast_Score=135, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17552384, Length=209, Percent_Identity=35.8851674641148, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17537943, Length=213, Percent_Identity=27.6995305164319, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17567503, Length=205, Percent_Identity=26.3414634146341, Blast_Score=87, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6320432, Length=211, Percent_Identity=36.9668246445498, Blast_Score=132, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6321018, Length=195, Percent_Identity=32.8205128205128, Blast_Score=121, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6322828, Length=210, Percent_Identity=24.2857142857143, Blast_Score=69, Evalue=4e-13,
Organism=Drosophila melanogaster, GI22026816, Length=213, Percent_Identity=37.5586854460094, Blast_Score=140, Evalue=6e-34,
Organism=Drosophila melanogaster, GI17737899, Length=210, Percent_Identity=32.3809523809524, Blast_Score=124, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24645822, Length=210, Percent_Identity=32.3809523809524, Blast_Score=124, Evalue=5e-29,
Organism=Drosophila melanogaster, GI221459597, Length=217, Percent_Identity=23.5023041474654, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21356893, Length=217, Percent_Identity=23.5023041474654, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17647141, Length=189, Percent_Identity=25.9259259259259, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24663208, Length=189, Percent_Identity=25.9259259259259, Blast_Score=74, Evalue=8e-14,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_PHYAS (B1VAC7)

Other databases:

- EMBL:   AM422018
- RefSeq:   YP_001799151.1
- ProteinModelPortal:   B1VAC7
- SMR:   B1VAC7
- GeneID:   6799366
- GenomeReviews:   AM422018_GR
- HOGENOM:   HBG630208
- OMA:   CGEGYHD
- ProtClustDB:   CLSK343680
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 25131; Mature: 25131

Theoretical pI: Translated: 9.84; Mature: 9.84

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILILLGPPGIGKGTQAAVLSDLLKLQHVATGDIFRKNFQENTPLGKESKKFINKGLLVP
CEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCC
DEITNQMIADYLSQIVPHSNFLLDGFPRNVFQAQFLETFFTKSNLHLNKVIYFNAFKQDL
HHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHH
MKRIEGRRICSHCGKVYHLDNLPPKIEGICDKDQKKLIQREDDKPNTFLKRLKVFNQETL
HHHHHHHHHHHHCCCEEECCCCCCHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
HLVEYYRSKKQLFEVDGMQNIQQVTQKILKVLETEQK
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MILILLGPPGIGKGTQAAVLSDLLKLQHVATGDIFRKNFQENTPLGKESKKFINKGLLVP
CEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCC
DEITNQMIADYLSQIVPHSNFLLDGFPRNVFQAQFLETFFTKSNLHLNKVIYFNAFKQDL
HHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHH
MKRIEGRRICSHCGKVYHLDNLPPKIEGICDKDQKKLIQREDDKPNTFLKRLKVFNQETL
HHHHHHHHHHHHCCCEEECCCCCCHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
HLVEYYRSKKQLFEVDGMQNIQQVTQKILKVLETEQK
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA