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The map label for this gene is ftsH1 [H]

Identifier: 197294424

GI number: 197294424

Start: 353151

End: 353678

Strand: Direct

Name: ftsH1 [H]

Synonym: PAa_0339

Alternate gene names: 197294424

Gene position: 353151-353678 (Clockwise)

Preceding gene: 197294423

Following gene: 197294425

Centisome position: 40.13

GC content: 29.73

Gene sequence:

>528_bases
ATGGAAATCAAAAACCAACCTTCCGCCAAACCACTTTTATTAAAAGTAATGGCAATTATCATTTTATTTTTTTTATTTTG
GTTAGCAACTTATATCTGGATTCATCATCAAACTTTAAGCCAAACCGAAGAAGAAATTATTTCTTTAAAAAAAGAAATAA
AATCCCCCCCAACCAAAATGAATAATCTTAACCAAACAGAAACCAAAAAGAAAGAACAAACTTTATTAAATAATAATTAT
TCTTTTACTAACCCAAAACAGAAGACAGAAGAAGGAGTTGTTTCAAAATTTAAAGAACCCCAAAAATTTATCGGTTTTGA
CAAATTAATTGGGTTTAAAGAAGAATTAAAAGCAGTTCAAGGATTTATTGATTATTTAAAAAATCCTGAAAACTACCAAG
GTATTGGACAAGTTGAACCACCCCTAGGAATTTTAATGTATGGGTGTCCTGGAACAGGTAAAACTACCTTAGCACGTGCT
CTTGCCAAAGAAACTAATTTACCATTCTTTGAAGTAAACATTCTTTGA

Upstream 100 bases:

>100_bases
GGTGGCCAAACTATTGAAAACAAAATTAAGCAATTAGCTTAATTAAAAGCAATAAGACTAAGTTTTTTAACTTAGTCTTA
TTTGAGAAAGGAAATAAATT

Downstream 100 bases:

>100_bases
AGTAAATAGTGCCCTTTTTTCCCAAAAGTATAAAGGGGTAGCGCCGAAAATGGTAAAAGATTTATTTGAAGATGCAAGAA
TTGTTGCCGAAGAATGTAAT

Product: Putative ATPase, fragment

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 175; Mature: 175

Protein sequence:

>175_residues
MEIKNQPSAKPLLLKVMAIIILFFLFWLATYIWIHHQTLSQTEEEIISLKKEIKSPPTKMNNLNQTETKKKEQTLLNNNY
SFTNPKQKTEEGVVSKFKEPQKFIGFDKLIGFKEELKAVQGFIDYLKNPENYQGIGQVEPPLGILMYGCPGTGKTTLARA
LAKETNLPFFEVNIL

Sequences:

>Translated_175_residues
MEIKNQPSAKPLLLKVMAIIILFFLFWLATYIWIHHQTLSQTEEEIISLKKEIKSPPTKMNNLNQTETKKKEQTLLNNNY
SFTNPKQKTEEGVVSKFKEPQKFIGFDKLIGFKEELKAVQGFIDYLKNPENYQGIGQVEPPLGILMYGCPGTGKTTLARA
LAKETNLPFFEVNIL
>Mature_175_residues
MEIKNQPSAKPLLLKVMAIIILFFLFWLATYIWIHHQTLSQTEEEIISLKKEIKSPPTKMNNLNQTETKKKEQTLLNNNY
SFTNPKQKTEEGVVSKFKEPQKFIGFDKLIGFKEELKAVQGFIDYLKNPENYQGIGQVEPPLGILMYGCPGTGKTTLARA
LAKETNLPFFEVNIL

Specific function: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins [H]

COG id: COG0465

COG function: function code O; ATP-dependent Zn proteases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein; Cytoplasmic side [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the peptidase M41 family [H]

Homologues:

Organism=Caenorhabditis elegans, GI17531535, Length=91, Percent_Identity=38.4615384615385, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17532375, Length=71, Percent_Identity=43.6619718309859, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320077, Length=71, Percent_Identity=40.8450704225352, Blast_Score=65, Evalue=6e-12,
Organism=Drosophila melanogaster, GI161076486, Length=91, Percent_Identity=39.5604395604396, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17137560, Length=91, Percent_Identity=39.5604395604396, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI161076488, Length=91, Percent_Identity=39.5604395604396, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI45554047, Length=68, Percent_Identity=45.5882352941176, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24639391, Length=68, Percent_Identity=45.5882352941176, Blast_Score=64, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR003960
- InterPro:   IPR005936
- InterPro:   IPR000642 [H]

Pfam domain/function: PF00004 AAA; PF01434 Peptidase_M41 [H]

EC number: 3.4.24.-

Molecular weight: Translated: 20051; Mature: 20051

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIKNQPSAKPLLLKVMAIIILFFLFWLATYIWIHHQTLSQTEEEIISLKKEIKSPPTKM
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
NNLNQTETKKKEQTLLNNNYSFTNPKQKTEEGVVSKFKEPQKFIGFDKLIGFKEELKAVQ
CCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHH
GFIDYLKNPENYQGIGQVEPPLGILMYGCPGTGKTTLARALAKETNLPFFEVNIL
HHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEECC
>Mature Secondary Structure
MEIKNQPSAKPLLLKVMAIIILFFLFWLATYIWIHHQTLSQTEEEIISLKKEIKSPPTKM
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
NNLNQTETKKKEQTLLNNNYSFTNPKQKTEEGVVSKFKEPQKFIGFDKLIGFKEELKAVQ
CCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHH
GFIDYLKNPENYQGIGQVEPPLGILMYGCPGTGKTTLARALAKETNLPFFEVNIL
HHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Metalloendopeptidases [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12835416 [H]