Click here to switch to the map view.

The map label for this gene is gcvPB

Identifier: 170757826

GI number: 170757826

Start: 820670

End: 822124

Strand: Direct

Name: gcvPB

Synonym: CLD_0067

Alternate gene names: 170757826

Gene position: 820670-822124 (Clockwise)

Preceding gene: 170757782

Following gene: 170756245

Centisome position: 20.73

GC content: 31.68

Gene sequence:

>1455_bases
ATGAAAGATTATAATAAAGTTATATTTGAGCTGTCATCAGAAGGTAGAAAAGGCTATAGACTTCCTAATTTAGATGTACC
AGAAGTAGAACTTTCAAAATTACTACCTAAAAACTTATTAAGAGAAGATGAAATAGATCTTCCAGAAGTAAGTGAAGTTG
ATGTTGTAAGGCACTATACAGCTCTTTCAAATAAAAATTATACTGTTGATAACGGATTTTATCCATTAGGATCATGCACT
ATGAAATATAATCCTAAAATAAATGAAGATATAGCTGCATTGAGCGGATTTTCAAAAATACATCCACTTCAAGATGAAAA
TATTTCACAAGGTGCATTGGAATTAATGTATGATTTAAAGACTAGATTATGTGAAATTACAGGACTCTATGATTTTACTC
TTCAACCAGCAGCAGGTGCACATGGTGAGTATACTGGACTTTTAATTATAAAAGCTTACCATGAAAAAAGAGGAGATACA
AAACGAACAAAAATTATAGTTCCTGATTCAGCACATGGTACAAATCCTGCTAGTGCATCAGTGGCCGGATTTGATATTGT
AGAAATAAAATCTGGTGAAGATGGTAGGGTTTCTATTGAAGAACTTAAAAAAGTTTTAAATGATGAAATAGCAGGATTAA
TGCTTACAAATCCAAGTACCTTAGGATTATTTGAAAAAGATATAAAACTTATAAGTGAGTTAGTTCATGAAGCTGGTGGA
TTATTATATTATGATGGAGCTAACCTAAATGCAATAATGGGAATTGCAAGACCAGGGGATATGGGATTTGATGTATGTCA
TTTAAATATGCATAAAACATTCTCAACTCCACATGGTGGTGGCGGACCAGGATCAGGACCTGTAGGAGTTAAAAAGCATT
TAGCTAAATTCCTTCCAGTACCAACAGTTGAAAAAGAAAATGATAAATTTATATTAGATTATAATAGAGAAGATTCACTT
GGAAAAATTAGAAGTTTATATGGAAACTTTGGTGTTATGGTTAAAGCATACACTTATATTTTAACAATGGGTAAGGAAGG
ATTAAAAGCAGCTTCCCACAATGCTGTTTTAAATGCAAATTATATAAAAGAATCTTTAAGAGATTATTATAATATCGGAA
AAGATGATATTTGTAAACATGAGGTGATTTTAAGTACCCTTAAGGAAAATCCACATCATATAGCTACATTAGATATTGCA
AAGAGATTAATAGATTATGGCGTACATCCACCTACAGTTTATTTCCCATTAATAATTGAAGAGGCCCTTATGATAGAGCC
TACTGAAAGTGAAAGTAAAGAGACCGTTGATGAATTTATAGATGCTATGAAAAAAATAGCTGTAGAAGCTAAAGAAAATC
CAGAACTTTTACATGAGGCACCAGTAAAAGCACCGGTAAGAAGATTAGACCAAGTAAAAGCAGCTAGAAAACCTATATTA
AAGTGGCAAAAATAA

Upstream 100 bases:

>100_bases
AAGTTTACTCAGAGTATAAAAATTCTATGTTACTTTGTGTTACAGAAAAAAGAACAAGGGAAGATATAGATAATTTAGTG
AAAATGATGGAGGAGATATA

Downstream 100 bases:

>100_bases
GTAAGGATATGTCTATGCAATCCAATATCACATAGTTTAGTGTATAAAATATAGATATAAACAGAGTTCTTGGCTTCAGA
GGGAGTTTTTACTCCCACTA

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 484; Mature: 484

Protein sequence:

>484_residues
MKDYNKVIFELSSEGRKGYRLPNLDVPEVELSKLLPKNLLREDEIDLPEVSEVDVVRHYTALSNKNYTVDNGFYPLGSCT
MKYNPKINEDIAALSGFSKIHPLQDENISQGALELMYDLKTRLCEITGLYDFTLQPAAGAHGEYTGLLIIKAYHEKRGDT
KRTKIIVPDSAHGTNPASASVAGFDIVEIKSGEDGRVSIEELKKVLNDEIAGLMLTNPSTLGLFEKDIKLISELVHEAGG
LLYYDGANLNAIMGIARPGDMGFDVCHLNMHKTFSTPHGGGGPGSGPVGVKKHLAKFLPVPTVEKENDKFILDYNREDSL
GKIRSLYGNFGVMVKAYTYILTMGKEGLKAASHNAVLNANYIKESLRDYYNIGKDDICKHEVILSTLKENPHHIATLDIA
KRLIDYGVHPPTVYFPLIIEEALMIEPTESESKETVDEFIDAMKKIAVEAKENPELLHEAPVKAPVRRLDQVKAARKPIL
KWQK

Sequences:

>Translated_484_residues
MKDYNKVIFELSSEGRKGYRLPNLDVPEVELSKLLPKNLLREDEIDLPEVSEVDVVRHYTALSNKNYTVDNGFYPLGSCT
MKYNPKINEDIAALSGFSKIHPLQDENISQGALELMYDLKTRLCEITGLYDFTLQPAAGAHGEYTGLLIIKAYHEKRGDT
KRTKIIVPDSAHGTNPASASVAGFDIVEIKSGEDGRVSIEELKKVLNDEIAGLMLTNPSTLGLFEKDIKLISELVHEAGG
LLYYDGANLNAIMGIARPGDMGFDVCHLNMHKTFSTPHGGGGPGSGPVGVKKHLAKFLPVPTVEKENDKFILDYNREDSL
GKIRSLYGNFGVMVKAYTYILTMGKEGLKAASHNAVLNANYIKESLRDYYNIGKDDICKHEVILSTLKENPHHIATLDIA
KRLIDYGVHPPTVYFPLIIEEALMIEPTESESKETVDEFIDAMKKIAVEAKENPELLHEAPVKAPVRRLDQVKAARKPIL
KWQK
>Mature_484_residues
MKDYNKVIFELSSEGRKGYRLPNLDVPEVELSKLLPKNLLREDEIDLPEVSEVDVVRHYTALSNKNYTVDNGFYPLGSCT
MKYNPKINEDIAALSGFSKIHPLQDENISQGALELMYDLKTRLCEITGLYDFTLQPAAGAHGEYTGLLIIKAYHEKRGDT
KRTKIIVPDSAHGTNPASASVAGFDIVEIKSGEDGRVSIEELKKVLNDEIAGLMLTNPSTLGLFEKDIKLISELVHEAGG
LLYYDGANLNAIMGIARPGDMGFDVCHLNMHKTFSTPHGGGGPGSGPVGVKKHLAKFLPVPTVEKENDKFILDYNREDSL
GKIRSLYGNFGVMVKAYTYILTMGKEGLKAASHNAVLNANYIKESLRDYYNIGKDDICKHEVILSTLKENPHHIATLDIA
KRLIDYGVHPPTVYFPLIIEEALMIEPTESESKETVDEFIDAMKKIAVEAKENPELLHEAPVKAPVRRLDQVKAARKPIL
KWQK

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=409, Percent_Identity=43.0317848410758, Blast_Score=289, Evalue=4e-78,
Organism=Escherichia coli, GI1789269, Length=475, Percent_Identity=39.7894736842105, Blast_Score=291, Evalue=8e-80,
Organism=Caenorhabditis elegans, GI17535605, Length=434, Percent_Identity=41.705069124424, Blast_Score=286, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI32564013, Length=388, Percent_Identity=42.5257731958763, Blast_Score=261, Evalue=7e-70,
Organism=Saccharomyces cerevisiae, GI6323843, Length=435, Percent_Identity=42.5287356321839, Blast_Score=310, Evalue=2e-85,
Organism=Drosophila melanogaster, GI24645648, Length=465, Percent_Identity=39.7849462365591, Blast_Score=286, Evalue=2e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 53803; Mature: 53803

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDYNKVIFELSSEGRKGYRLPNLDVPEVELSKLLPKNLLREDEIDLPEVSEVDVVRHYT
CCCHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
ALSNKNYTVDNGFYPLGSCTMKYNPKINEDIAALSGFSKIHPLQDENISQGALELMYDLK
HHCCCCEEECCCCEECCCEEEEECCCCCHHHHHHCCHHHCCCCCCCCCCHHHHHHHHHHH
TRLCEITGLYDFTLQPAAGAHGEYTGLLIIKAYHEKRGDTKRTKIIVPDSAHGTNPASAS
HHHHHHHCCEEEEECCCCCCCCCEEEEEEEEEEHHCCCCCCCEEEEECCCCCCCCCCCCC
VAGFDIVEIKSGEDGRVSIEELKKVLNDEIAGLMLTNPSTLGLFEKDIKLISELVHEAGG
CCCEEEEEEECCCCCCEEHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHHHHCC
LLYYDGANLNAIMGIARPGDMGFDVCHLNMHKTFSTPHGGGGPGSGPVGVKKHLAKFLPV
EEEECCCCCEEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCC
PTVEKENDKFILDYNREDSLGKIRSLYGNFGVMVKAYTYILTMGKEGLKAASHNAVLNAN
CCCCCCCCCEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHCCCCCEEEHH
YIKESLRDYYNIGKDDICKHEVILSTLKENPHHIATLDIAKRLIDYGVHPPTVYFPLIIE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCCCCEEHHHHHH
EALMIEPTESESKETVDEFIDAMKKIAVEAKENPELLHEAPVKAPVRRLDQVKAARKPIL
HHHEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHC
KWQK
CCCC
>Mature Secondary Structure
MKDYNKVIFELSSEGRKGYRLPNLDVPEVELSKLLPKNLLREDEIDLPEVSEVDVVRHYT
CCCHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
ALSNKNYTVDNGFYPLGSCTMKYNPKINEDIAALSGFSKIHPLQDENISQGALELMYDLK
HHCCCCEEECCCCEECCCEEEEECCCCCHHHHHHCCHHHCCCCCCCCCCHHHHHHHHHHH
TRLCEITGLYDFTLQPAAGAHGEYTGLLIIKAYHEKRGDTKRTKIIVPDSAHGTNPASAS
HHHHHHHCCEEEEECCCCCCCCCEEEEEEEEEEHHCCCCCCCEEEEECCCCCCCCCCCCC
VAGFDIVEIKSGEDGRVSIEELKKVLNDEIAGLMLTNPSTLGLFEKDIKLISELVHEAGG
CCCEEEEEEECCCCCCEEHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHHHHCC
LLYYDGANLNAIMGIARPGDMGFDVCHLNMHKTFSTPHGGGGPGSGPVGVKKHLAKFLPV
EEEECCCCCEEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCC
PTVEKENDKFILDYNREDSLGKIRSLYGNFGVMVKAYTYILTMGKEGLKAASHNAVLNAN
CCCCCCCCCEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHCCCCCEEEHH
YIKESLRDYYNIGKDDICKHEVILSTLKENPHHIATLDIAKRLIDYGVHPPTVYFPLIIE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCCCCEEHHHHHH
EALMIEPTESESKETVDEFIDAMKKIAVEAKENPELLHEAPVKAPVRRLDQVKAARKPIL
HHHEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHC
KWQK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]