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The map label for this gene is gcvPA

Identifier: 170757782

GI number: 170757782

Start: 819330

End: 820670

Strand: Direct

Name: gcvPA

Synonym: CLD_0068

Alternate gene names: 170757782

Gene position: 819330-820670 (Clockwise)

Preceding gene: 170754700

Following gene: 170757826

Centisome position: 20.7

GC content: 30.95

Gene sequence:

>1341_bases
ATGTTTCCATATATTCCAAACACAGAAAAAGAAACAAAAGAAATTTTAGATTTTCTTTCAATAAAATCTGTAGATGAATT
ATTCAGTGATATACCAGATAATCTGAAGTTAAATAGGGAGTTAAACCTAGAAAGTTCTTTATCAGAACTAGAGGTTGAAA
AAAGATTAAAAGCCTTAGCTTTAAAAAATAAATCTATGGAAGATATGACATGTTTCTTAGGGGCTGGAATTTATGATCAT
TATATACCTTCTGTAATTAAACATATAACAGGAAGATCAGAATTTTATACAGCATATACACCTTACCAACCAGAGGTAAG
TCAAGGAACACTCCAAGCTATCTTTGAATATCAAAGTATGATTTGTGCTTTAACAGGCATGGAAGTTTCAAACTCTTCTA
TGTATGATGGAGCAACAGCAACAGCTGAGGCAGCTATACTTTCTATTGTTAGTACTAAAAGAAATACTATTATAGTTTCT
AAATCAGTAAATCTTGATACAAGAAAAGTGCTTAAAACTTACTTAAAGTACAGAGGATACAATATGGTAGAGGTTGATTT
AGAAGATGGTACTGCAGATGTAGATAAAGTTATTAATAGCTTAGATAAAAATGTAGCTGCAGTTATAATTCAAAGTCCAA
ACTTCCTTGGCTTAGTTGAAGATGTAGAAAATATGGTAGATGCTATTCATAAAAATAAGTCACTATTAATAATGAATGTA
GACCCAATATCATTAGGTGTATTAAAAAGTCCAGGAGAATTAGGTGCAGATATTGTTGTTGGTGATGGGCAATGTTTAGG
TGCCAACATGAGTTATGGTGGTCCAGGTTTTGGATTTATGAATACTACAAAAAAACTTATGAGAAAAATGCCAGGCAGGA
TAGTTGGTGAAACTAAAGATGTTGAAGGAAAAAGAGGCTTTGTCTTAACACTTCAAGCTAGAGAACAACATATAAGAAGA
GAAAAAGCAACTTCTAATATTTGTTCAGACCAGACAGCAGTGGCTATAGGTGCAGCTGTTTATATGGCTACTTTAGGAAA
AGAAGGAATAAAGGAAGTAGCAAAACAATGTGCAGCTAAATCACACTATGCATATAATGAGTTAATTAAATCTGGAAAAT
ATAAGCCTGTGTTCAATAAACCATTCTTTAAGGAATTTGTAGTAAAAGGAGAAATTTCACCTTGTGAAATTAATGATAAA
TTATTAGAAAATAATATTTTAGGTGGATATGATTTAGGAAAAGTTTACTCAGAGTATAAAAATTCTATGTTACTTTGTGT
TACAGAAAAAAGAACAAGGGAAGATATAGATAATTTAGTGAAAATGATGGAGGAGATATAA

Upstream 100 bases:

>100_bases
TTGCTGCAATAGAGATGTCAGATAAAAATGAATTAGAAGAATTAATAAAACCAGAAGTTTATGAGAAAATATGTGAAGAG
TTAGACAAGGAGGCATAATT

Downstream 100 bases:

>100_bases
TGAAAGATTATAATAAAGTTATATTTGAGCTGTCATCAGAAGGTAGAAAAGGCTATAGACTTCCTAATTTAGATGTACCA
GAAGTAGAACTTTCAAAATT

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1 [H]

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MFPYIPNTEKETKEILDFLSIKSVDELFSDIPDNLKLNRELNLESSLSELEVEKRLKALALKNKSMEDMTCFLGAGIYDH
YIPSVIKHITGRSEFYTAYTPYQPEVSQGTLQAIFEYQSMICALTGMEVSNSSMYDGATATAEAAILSIVSTKRNTIIVS
KSVNLDTRKVLKTYLKYRGYNMVEVDLEDGTADVDKVINSLDKNVAAVIIQSPNFLGLVEDVENMVDAIHKNKSLLIMNV
DPISLGVLKSPGELGADIVVGDGQCLGANMSYGGPGFGFMNTTKKLMRKMPGRIVGETKDVEGKRGFVLTLQAREQHIRR
EKATSNICSDQTAVAIGAAVYMATLGKEGIKEVAKQCAAKSHYAYNELIKSGKYKPVFNKPFFKEFVVKGEISPCEINDK
LLENNILGGYDLGKVYSEYKNSMLLCVTEKRTREDIDNLVKMMEEI

Sequences:

>Translated_446_residues
MFPYIPNTEKETKEILDFLSIKSVDELFSDIPDNLKLNRELNLESSLSELEVEKRLKALALKNKSMEDMTCFLGAGIYDH
YIPSVIKHITGRSEFYTAYTPYQPEVSQGTLQAIFEYQSMICALTGMEVSNSSMYDGATATAEAAILSIVSTKRNTIIVS
KSVNLDTRKVLKTYLKYRGYNMVEVDLEDGTADVDKVINSLDKNVAAVIIQSPNFLGLVEDVENMVDAIHKNKSLLIMNV
DPISLGVLKSPGELGADIVVGDGQCLGANMSYGGPGFGFMNTTKKLMRKMPGRIVGETKDVEGKRGFVLTLQAREQHIRR
EKATSNICSDQTAVAIGAAVYMATLGKEGIKEVAKQCAAKSHYAYNELIKSGKYKPVFNKPFFKEFVVKGEISPCEINDK
LLENNILGGYDLGKVYSEYKNSMLLCVTEKRTREDIDNLVKMMEEI
>Mature_446_residues
MFPYIPNTEKETKEILDFLSIKSVDELFSDIPDNLKLNRELNLESSLSELEVEKRLKALALKNKSMEDMTCFLGAGIYDH
YIPSVIKHITGRSEFYTAYTPYQPEVSQGTLQAIFEYQSMICALTGMEVSNSSMYDGATATAEAAILSIVSTKRNTIIVS
KSVNLDTRKVLKTYLKYRGYNMVEVDLEDGTADVDKVINSLDKNVAAVIIQSPNFLGLVEDVENMVDAIHKNKSLLIMNV
DPISLGVLKSPGELGADIVVGDGQCLGANMSYGGPGFGFMNTTKKLMRKMPGRIVGETKDVEGKRGFVLTLQAREQHIRR
EKATSNICSDQTAVAIGAAVYMATLGKEGIKEVAKQCAAKSHYAYNELIKSGKYKPVFNKPFFKEFVVKGEISPCEINDK
LLENNILGGYDLGKVYSEYKNSMLLCVTEKRTREDIDNLVKMMEEI

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=416, Percent_Identity=34.375, Blast_Score=244, Evalue=1e-64,
Organism=Escherichia coli, GI1789269, Length=351, Percent_Identity=34.1880341880342, Blast_Score=184, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17535605, Length=386, Percent_Identity=37.8238341968912, Blast_Score=249, Evalue=3e-66,
Organism=Saccharomyces cerevisiae, GI6323843, Length=426, Percent_Identity=34.9765258215962, Blast_Score=235, Evalue=9e-63,
Organism=Drosophila melanogaster, GI24645648, Length=392, Percent_Identity=35.2040816326531, Blast_Score=242, Evalue=4e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 49551; Mature: 49551

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPYIPNTEKETKEILDFLSIKSVDELFSDIPDNLKLNRELNLESSLSELEVEKRLKALA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHH
LKNKSMEDMTCFLGAGIYDHYIPSVIKHITGRSEFYTAYTPYQPEVSQGTLQAIFEYQSM
HCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHH
ICALTGMEVSNSSMYDGATATAEAAILSIVSTKRNTIIVSKSVNLDTRKVLKTYLKYRGY
HHHHHCCEECCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCC
NMVEVDLEDGTADVDKVINSLDKNVAAVIIQSPNFLGLVEDVENMVDAIHKNKSLLIMNV
CEEEEECCCCCCHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEC
DPISLGVLKSPGELGADIVVGDGQCLGANMSYGGPGFGFMNTTKKLMRKMPGRIVGETKD
CCCEEEEECCCCCCCCEEEEECCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCEECCCCC
VEGKRGFVLTLQAREQHIRREKATSNICSDQTAVAIGAAVYMATLGKEGIKEVAKQCAAK
CCCCCCEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
SHYAYNELIKSGKYKPVFNKPFFKEFVVKGEISPCEINDKLLENNILGGYDLGKVYSEYK
CHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHC
NSMLLCVTEKRTREDIDNLVKMMEEI
CCEEEEEECHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MFPYIPNTEKETKEILDFLSIKSVDELFSDIPDNLKLNRELNLESSLSELEVEKRLKALA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHH
LKNKSMEDMTCFLGAGIYDHYIPSVIKHITGRSEFYTAYTPYQPEVSQGTLQAIFEYQSM
HCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHH
ICALTGMEVSNSSMYDGATATAEAAILSIVSTKRNTIIVSKSVNLDTRKVLKTYLKYRGY
HHHHHCCEECCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCC
NMVEVDLEDGTADVDKVINSLDKNVAAVIIQSPNFLGLVEDVENMVDAIHKNKSLLIMNV
CEEEEECCCCCCHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEC
DPISLGVLKSPGELGADIVVGDGQCLGANMSYGGPGFGFMNTTKKLMRKMPGRIVGETKD
CCCEEEEECCCCCCCCEEEEECCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCEECCCCC
VEGKRGFVLTLQAREQHIRREKATSNICSDQTAVAIGAAVYMATLGKEGIKEVAKQCAAK
CCCCCCEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
SHYAYNELIKSGKYKPVFNKPFFKEFVVKGEISPCEINDKLLENNILGGYDLGKVYSEYK
CHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHC
NSMLLCVTEKRTREDIDNLVKMMEEI
CCEEEEEECHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]