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The map label for this gene is (tetP [H]

Identifier: 170756709

GI number: 170756709

Start: 2237513

End: 2239468

Strand: Reverse

Name: (tetP [H]

Synonym: CLD_2537

Alternate gene names: 170756709

Gene position: 2239468-2237513 (Counterclockwise)

Preceding gene: 170756226

Following gene: 170754466

Centisome position: 56.58

GC content: 29.4

Gene sequence:

>1956_bases
ATGAATAAGACAATAGGAATATTAGCACATGTGGATGCAGGAAAAACCACATTTGCAGAACAAATATTGTATCATACAAA
AAGTATTAGAAGTAGAGGGAGAGTGGATCATAAAAACTCTTTTTTAGATAATCATAAAATTGAAAAGGAAAGAGGAATAA
CAGTATTTTCAGAACAAGGGACCTTTCAGTATAGAGATTCTACATGCTACCTTATAGATACTCCAGGACATATGGATTTT
TCATCTGAAATGGAAAGAGCTATTCAGGTTATGGACTATGCTGTAATTATAATAAGTGGGGTTGAAGGAATACAAGGACA
TACAGAAACAGTATGGAATCTTTTAAGAAAGCACAATATTCCTGTTCTTTTTTTCATAAATAAAATAGATAGAGTAGGAG
CTAATGCTGAAAATGTAATTGAAGAAATAAAACTTAATTTTACTAAAAAGGCTTTTCTTATTGATAAATCATTAAGTAAT
GAAGATCTTTCATCTGAGCTTATAGAATTTATTGCAGATCAAGATGAATGTCTTTTAGAGAAATATTTAGAAGATAATTA
TGATAAAGAGTTATGGCTGAATTTTATGAAGAAACTTATTAAAACAAGTAAAATTTTTCCTTGTTTTTCAGGCTCTGCAT
TACAGGATATAGGCATAGAAGACTTTTTAGAAAACCTACATATTTTAACCTATACAGAATACAATGAAGAAGAAAAATTT
AGTGGAAGAGTATATAAAATACGTCACGATGAACAAAGCAATAGATTAACCTATATAAAAGCATTAAGTGGCAGCTTAAA
GGTGAAAGATGAAATAGCTTTACCTAATATTGAAAATGATTTTTGTGAGAAGGTTAATGAAATAAGAATATATAATGGTG
ATAAATATACAAATGTAGATAAAGCTGAAGCGGGACAAATTTTTGCAGTGGCAGGTTTGAATTCTGCTAACGTAGGTGAT
GGAATTGGAACTTTGAAAGATAAAGCTACATATAATATGGTTCCAACTTTAAAATCGAAAGTTATATTTGATGAAACATT
AAATGTAAAGGATGTTTTAAGGTATTTTAAAATTTTAGAATCAGAAGATCCTTCCCTAAATATAATTTGGAATGAAAGAT
TTCAAGAAATTCAAGTTTACATTATGGGGATTATCCAATTAGAAGTTTTAAAGAATTTGATGGAAGAAAGATTTCATATA
TTGATAGATTTTGGCCCTTGCGAAATATTGTATAAGGAAACTATTTTAGATACACTAATAGGCTATGGTCATTTTGAACC
TTTAGGGCACTACTCAGAAGTTCATCTTAAATTAGAGCCAGGAGAGCGAAATAGTGGTATTACATTTGAAAATTTATGCC
ATACAGATGATTTAACCATAGGTAATCAAAATTTAGTAAAGACTCATATTTTTGAAAGAGATCACCATGGTATTTTAACA
GGATCTCCTATAACAGATATAAAGATAACGCTTTTAACTGGAAGAGCACATAATAAACATACTAGTGGAGGAGATTTTAG
AGAATCTACCTTTAGAGCTTTAAGACAAGGATTAGAAAAGGCTAAAAATGTTTTGCTGGAACCTTATTATTCTTTTAAAA
TGGAAGCACCATTAGATTGTATGGGAAGAATTTTATCAGATATACAAAAGTTAAAGGGCTCTTTTAATCCTCCAGAAACA
ATTGGCAATAAAGCTATTATAAAAGGAAGAGGTCCAGTTGCAACATTTATGAATTATAGTGTGGAGTTTATTTCTTTTAC
TAAAGGAAAGGGTAAATTTAATTTCCTATTTGATGGATACGATATTTGCCATAATGAGAAAGAGATTATAGAAAATATAG
CCTATGATAAAAATGTAGACATTGAATATACTTCAACTTCAATCTTCTGTTCTAAAGGACAAGCATTTCTAGTTAAGTAT
GATGAAGCAGAAGGATATATGCATTGTTTGAAATAG

Upstream 100 bases:

>100_bases
TATATTAGATTATTATAGAGTTATGTTTCTGGCTTAAATAGCTTATTCTGTGGTAATATAATAGTGTCATTAGAATCAAA
ATTACAATGGGAGATAGATT

Downstream 100 bases:

>100_bases
ATTTTAGTTTGTAGCAGGGCACTTGAAAGAGTACTAGTTTATAATTTTAGCAAATGGCTCAAATCTATGGGAAAAATGCA
GAACATGTCTAAACATATGA

Product: putative tetracycline resistance protein

Products: NA

Alternate protein names: TetB(P) [H]

Number of amino acids: Translated: 651; Mature: 651

Protein sequence:

>651_residues
MNKTIGILAHVDAGKTTFAEQILYHTKSIRSRGRVDHKNSFLDNHKIEKERGITVFSEQGTFQYRDSTCYLIDTPGHMDF
SSEMERAIQVMDYAVIIISGVEGIQGHTETVWNLLRKHNIPVLFFINKIDRVGANAENVIEEIKLNFTKKAFLIDKSLSN
EDLSSELIEFIADQDECLLEKYLEDNYDKELWLNFMKKLIKTSKIFPCFSGSALQDIGIEDFLENLHILTYTEYNEEEKF
SGRVYKIRHDEQSNRLTYIKALSGSLKVKDEIALPNIENDFCEKVNEIRIYNGDKYTNVDKAEAGQIFAVAGLNSANVGD
GIGTLKDKATYNMVPTLKSKVIFDETLNVKDVLRYFKILESEDPSLNIIWNERFQEIQVYIMGIIQLEVLKNLMEERFHI
LIDFGPCEILYKETILDTLIGYGHFEPLGHYSEVHLKLEPGERNSGITFENLCHTDDLTIGNQNLVKTHIFERDHHGILT
GSPITDIKITLLTGRAHNKHTSGGDFRESTFRALRQGLEKAKNVLLEPYYSFKMEAPLDCMGRILSDIQKLKGSFNPPET
IGNKAIIKGRGPVATFMNYSVEFISFTKGKGKFNFLFDGYDICHNEKEIIENIAYDKNVDIEYTSTSIFCSKGQAFLVKY
DEAEGYMHCLK

Sequences:

>Translated_651_residues
MNKTIGILAHVDAGKTTFAEQILYHTKSIRSRGRVDHKNSFLDNHKIEKERGITVFSEQGTFQYRDSTCYLIDTPGHMDF
SSEMERAIQVMDYAVIIISGVEGIQGHTETVWNLLRKHNIPVLFFINKIDRVGANAENVIEEIKLNFTKKAFLIDKSLSN
EDLSSELIEFIADQDECLLEKYLEDNYDKELWLNFMKKLIKTSKIFPCFSGSALQDIGIEDFLENLHILTYTEYNEEEKF
SGRVYKIRHDEQSNRLTYIKALSGSLKVKDEIALPNIENDFCEKVNEIRIYNGDKYTNVDKAEAGQIFAVAGLNSANVGD
GIGTLKDKATYNMVPTLKSKVIFDETLNVKDVLRYFKILESEDPSLNIIWNERFQEIQVYIMGIIQLEVLKNLMEERFHI
LIDFGPCEILYKETILDTLIGYGHFEPLGHYSEVHLKLEPGERNSGITFENLCHTDDLTIGNQNLVKTHIFERDHHGILT
GSPITDIKITLLTGRAHNKHTSGGDFRESTFRALRQGLEKAKNVLLEPYYSFKMEAPLDCMGRILSDIQKLKGSFNPPET
IGNKAIIKGRGPVATFMNYSVEFISFTKGKGKFNFLFDGYDICHNEKEIIENIAYDKNVDIEYTSTSIFCSKGQAFLVKY
DEAEGYMHCLK
>Mature_651_residues
MNKTIGILAHVDAGKTTFAEQILYHTKSIRSRGRVDHKNSFLDNHKIEKERGITVFSEQGTFQYRDSTCYLIDTPGHMDF
SSEMERAIQVMDYAVIIISGVEGIQGHTETVWNLLRKHNIPVLFFINKIDRVGANAENVIEEIKLNFTKKAFLIDKSLSN
EDLSSELIEFIADQDECLLEKYLEDNYDKELWLNFMKKLIKTSKIFPCFSGSALQDIGIEDFLENLHILTYTEYNEEEKF
SGRVYKIRHDEQSNRLTYIKALSGSLKVKDEIALPNIENDFCEKVNEIRIYNGDKYTNVDKAEAGQIFAVAGLNSANVGD
GIGTLKDKATYNMVPTLKSKVIFDETLNVKDVLRYFKILESEDPSLNIIWNERFQEIQVYIMGIIQLEVLKNLMEERFHI
LIDFGPCEILYKETILDTLIGYGHFEPLGHYSEVHLKLEPGERNSGITFENLCHTDDLTIGNQNLVKTHIFERDHHGILT
GSPITDIKITLLTGRAHNKHTSGGDFRESTFRALRQGLEKAKNVLLEPYYSFKMEAPLDCMGRILSDIQKLKGSFNPPET
IGNKAIIKGRGPVATFMNYSVEFISFTKGKGKFNFLFDGYDICHNEKEIIENIAYDKNVDIEYTSTSIFCSKGQAFLVKY
DEAEGYMHCLK

Specific function: Abolishes the inhibitory effect of tetracyclin on protein synthesis by a non-covalent modification of the ribosomes [H]

COG id: COG0480

COG function: function code J; Translation elongation factors (GTPases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TetM/tetO subfamily [H]

Homologues:

Organism=Homo sapiens, GI19923640, Length=693, Percent_Identity=25.8297258297258, Blast_Score=217, Evalue=3e-56,
Organism=Homo sapiens, GI18390331, Length=687, Percent_Identity=24.8908296943231, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI25306287, Length=656, Percent_Identity=26.0670731707317, Blast_Score=192, Evalue=9e-49,
Organism=Homo sapiens, GI25306283, Length=379, Percent_Identity=29.5514511873351, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI94966754, Length=134, Percent_Identity=37.3134328358209, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI157426893, Length=149, Percent_Identity=34.2281879194631, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI4503483, Length=146, Percent_Identity=32.1917808219178, Blast_Score=73, Evalue=8e-13,
Organism=Homo sapiens, GI310132016, Length=106, Percent_Identity=36.7924528301887, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI310110807, Length=106, Percent_Identity=36.7924528301887, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI310123363, Length=106, Percent_Identity=36.7924528301887, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1789738, Length=691, Percent_Identity=27.3516642547033, Blast_Score=213, Evalue=3e-56,
Organism=Escherichia coli, GI1790835, Length=457, Percent_Identity=23.6323851203501, Blast_Score=131, Evalue=2e-31,
Organism=Escherichia coli, GI48994988, Length=141, Percent_Identity=31.2056737588652, Blast_Score=97, Evalue=4e-21,
Organism=Escherichia coli, GI1788922, Length=147, Percent_Identity=31.2925170068027, Blast_Score=84, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17533571, Length=686, Percent_Identity=25.0728862973761, Blast_Score=188, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17556745, Length=677, Percent_Identity=25.1107828655835, Blast_Score=163, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17557151, Length=142, Percent_Identity=35.2112676056338, Blast_Score=99, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71988819, Length=130, Percent_Identity=34.6153846153846, Blast_Score=82, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI71988811, Length=130, Percent_Identity=34.6153846153846, Blast_Score=82, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17506493, Length=158, Percent_Identity=29.1139240506329, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17552882, Length=135, Percent_Identity=32.5925925925926, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323098, Length=703, Percent_Identity=27.027027027027, Blast_Score=211, Evalue=4e-55,
Organism=Saccharomyces cerevisiae, GI6322359, Length=517, Percent_Identity=26.4990328820116, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6323320, Length=151, Percent_Identity=31.7880794701987, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324707, Length=146, Percent_Identity=32.1917808219178, Blast_Score=77, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6320593, Length=146, Percent_Identity=32.1917808219178, Blast_Score=77, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6324166, Length=205, Percent_Identity=31.219512195122, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24582462, Length=684, Percent_Identity=24.5614035087719, Blast_Score=198, Evalue=1e-50,
Organism=Drosophila melanogaster, GI221458488, Length=697, Percent_Identity=24.8206599713056, Blast_Score=190, Evalue=3e-48,
Organism=Drosophila melanogaster, GI78706572, Length=149, Percent_Identity=36.241610738255, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24585711, Length=167, Percent_Identity=29.940119760479, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24585713, Length=167, Percent_Identity=29.940119760479, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24585709, Length=167, Percent_Identity=29.940119760479, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28574573, Length=139, Percent_Identity=35.2517985611511, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2520 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 20 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 7984 Molecules/Cell In: Growth Phase, Gl

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR005225
- InterPro:   IPR002127
- InterPro:   IPR000640
- InterPro:   IPR005517
- InterPro:   IPR004161
- InterPro:   IPR009000 [H]

Pfam domain/function: PF00679 EFG_C; PF03764 EFG_IV; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 74512; Mature: 74512

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKTIGILAHVDAGKTTFAEQILYHTKSIRSRGRVDHKNSFLDNHKIEKERGITVFSEQG
CCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCEEEECCC
TFQYRDSTCYLIDTPGHMDFSSEMERAIQVMDYAVIIISGVEGIQGHTETVWNLLRKHNI
CEEEECCEEEEEECCCCCCHHHHHHHHHHHHHEEEEEEECCCCCCCCHHHHHHHHHHCCC
PVLFFINKIDRVGANAENVIEEIKLNFTKKAFLIDKSLSNEDLSSELIEFIADQDECLLE
CEEEEEECHHHCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHCCCHHHHHH
KYLEDNYDKELWLNFMKKLIKTSKIFPCFSGSALQDIGIEDFLENLHILTYTEYNEEEKF
HHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCHHHHHCCCEEEEEECCCCCCCC
SGRVYKIRHDEQSNRLTYIKALSGSLKVKDEIALPNIENDFCEKVNEIRIYNGDKYTNVD
CCCEEEEECCCCCCCEEEEEECCCCEEEECCCCCCCCCHHHHHCCCCEEEECCCCCCCCC
KAEAGQIFAVAGLNSANVGDGIGTLKDKATYNMVPTLKSKVIFDETLNVKDVLRYFKILE
CCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHCEEECCCCCHHHHHHHHHHHC
SEDPSLNIIWNERFQEIQVYIMGIIQLEVLKNLMEERFHILIDFGPCEILYKETILDTLI
CCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHH
GYGHFEPLGHYSEVHLKLEPGERNSGITFENLCHTDDLTIGNQNLVKTHIFERDHHGILT
CCCCCCCCCCCEEEEEEECCCCCCCCCCHHHCCCCCCCEECCCCCEEEEEEECCCCCEEE
GSPITDIKITLLTGRAHNKHTSGGDFRESTFRALRQGLEKAKNVLLEPYYSFKMEAPLDC
CCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCEECCCCHHH
MGRILSDIQKLKGSFNPPETIGNKAIIKGRGPVATFMNYSVEFISFTKGKGKFNFLFDGY
HHHHHHHHHHHCCCCCCCHHCCCCEEEECCCCHHHHHCCEEEEEEEECCCCEEEEEECCH
DICHNEKEIIENIAYDKNVDIEYTSTSIFCSKGQAFLVKYDEAEGYMHCLK
HHHCCHHHHHHHHCCCCCCCEEEECCEEEEECCCEEEEEEECCCCHHHHCC
>Mature Secondary Structure
MNKTIGILAHVDAGKTTFAEQILYHTKSIRSRGRVDHKNSFLDNHKIEKERGITVFSEQG
CCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCEEEECCC
TFQYRDSTCYLIDTPGHMDFSSEMERAIQVMDYAVIIISGVEGIQGHTETVWNLLRKHNI
CEEEECCEEEEEECCCCCCHHHHHHHHHHHHHEEEEEEECCCCCCCCHHHHHHHHHHCCC
PVLFFINKIDRVGANAENVIEEIKLNFTKKAFLIDKSLSNEDLSSELIEFIADQDECLLE
CEEEEEECHHHCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHCCCHHHHHH
KYLEDNYDKELWLNFMKKLIKTSKIFPCFSGSALQDIGIEDFLENLHILTYTEYNEEEKF
HHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCHHHHHCCCEEEEEECCCCCCCC
SGRVYKIRHDEQSNRLTYIKALSGSLKVKDEIALPNIENDFCEKVNEIRIYNGDKYTNVD
CCCEEEEECCCCCCCEEEEEECCCCEEEECCCCCCCCCHHHHHCCCCEEEECCCCCCCCC
KAEAGQIFAVAGLNSANVGDGIGTLKDKATYNMVPTLKSKVIFDETLNVKDVLRYFKILE
CCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHCEEECCCCCHHHHHHHHHHHC
SEDPSLNIIWNERFQEIQVYIMGIIQLEVLKNLMEERFHILIDFGPCEILYKETILDTLI
CCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHH
GYGHFEPLGHYSEVHLKLEPGERNSGITFENLCHTDDLTIGNQNLVKTHIFERDHHGILT
CCCCCCCCCCCEEEEEEECCCCCCCCCCHHHCCCCCCCEECCCCCEEEEEEECCCCCEEE
GSPITDIKITLLTGRAHNKHTSGGDFRESTFRALRQGLEKAKNVLLEPYYSFKMEAPLDC
CCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCEECCCCHHH
MGRILSDIQKLKGSFNPPETIGNKAIIKGRGPVATFMNYSVEFISFTKGKGKFNFLFDGY
HHHHHHHHHHHCCCCCCCHHCCCCEEEECCCCHHHHHCCEEEEEEEECCCCEEEEEECCH
DICHNEKEIIENIAYDKNVDIEYTSTSIFCSKGQAFLVKYDEAEGYMHCLK
HHHCCHHHHHHHHCCCCCCCEEEECCEEEEECCCEEEEEEECCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8170402 [H]