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The map label for this gene is cobD [H]

Identifier: 170756649

GI number: 170756649

Start: 1036319

End: 1037407

Strand: Direct

Name: cobD [H]

Synonym: CLD_3644

Alternate gene names: 170756649

Gene position: 1036319-1037407 (Clockwise)

Preceding gene: 170755827

Following gene: 170757453

Centisome position: 26.18

GC content: 25.8

Gene sequence:

>1089_bases
ATGCATGGTGGAGATATTTATACAGAGGGAATTTTAAAAGGAAAAGAACTCATAGATTTTAGTTCTAATATAAACCCTTT
AGGGTTGCCAGATAGTTTTAAAGATAATTTGGAGGAGGCTCTAAGTTGGGTACAAGTCTATCCTGATATTCAATACAGAA
ATTTAAAAAGAAACTTAATAGACTATTTAAGTTTTTCTCTAGGCTATTTTTATAAAGAAAAAGTAGAGAACCCTAATATA
AAGGAAGAAAATTTGGTTCTAGGTAATGGAGCAATAGAAATAATTGATTTAGCCATAAGCAATTTAAAGAGTATATCTAT
TTTAGTACCTTCCTTTGTGGAATATGAATTATGTGCTAAAAAATGGAATGTACAAATAGATTATTGCAATTTAAATGAGG
ATATGACATATAACTATGAAAATATAAAAAAATCCTTAGAAAAAACAGAAGGAATAATATTGGGAAATCCTAATAATCCT
AATGGATCAGTAATAGATAAGGAAGAGTTTATATACATATTAGATTACTGCGAAAAAAATAATAAGATTGTAATTTTAGA
TGAAGCTTTTATAGAATTTACAGGAAAGAATTCTTTTAGTTTTTTAAACTTATGTGAAAGATACAAGTGTATTTTTATAA
TAAGAGCTTTAACTAAGTTCTTTTCTATGCCAGGTATAAGGTTTGGCTATGGAATAAGTTTTAATAATGAATTTTTAAAT
AAAATAAGAGAAAAACAAAACCCTTGGAATATAAATTGTTTTGCAGAAATTGCAGTTAAATATGTTTTGAAAGATGAGGA
GTTTATAGAAAAATCCATAAATTACATAGAGAAAGAAAGAACATTTATGTATGAAAATCTAAAAAGATGTCATTTGTTTC
ATGATGTATATAGTACCTATAGTAATTTTATACTTTGTAAGCTAAAGAGAATTACAGGGGAAGAGCTTAAAGAAAAGCTT
TTAGATAAAGGATTCGTTTTAAGAGTTTGCAAGGATTTCAAAGCTTTAAATAATGATTATGTAAGATTGGCAATAAAAAC
TAGAGAATTGAATGAAAATTTAATCCATGTTTTGAAAGAAATAAATTAG

Upstream 100 bases:

>100_bases
AAGTTTTTTCATTTAATAAAAAACTATATCCTCAATTGATTATTAATAATTGTCAACTGATCATTGTTAATTGACAATTG
CTAAATAAGGTGGTGTTTAT

Downstream 100 bases:

>100_bases
AATTAAATTTTATTTTAATCTAAGAATCCTTTAATGAAATGGGGAAATATTTATAAAACTAAATAATTTATTTTATATAA
CGAAGGGATGACAGCAATGA

Product: aminotransferase family protein

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MHGGDIYTEGILKGKELIDFSSNINPLGLPDSFKDNLEEALSWVQVYPDIQYRNLKRNLIDYLSFSLGYFYKEKVENPNI
KEENLVLGNGAIEIIDLAISNLKSISILVPSFVEYELCAKKWNVQIDYCNLNEDMTYNYENIKKSLEKTEGIILGNPNNP
NGSVIDKEEFIYILDYCEKNNKIVILDEAFIEFTGKNSFSFLNLCERYKCIFIIRALTKFFSMPGIRFGYGISFNNEFLN
KIREKQNPWNINCFAEIAVKYVLKDEEFIEKSINYIEKERTFMYENLKRCHLFHDVYSTYSNFILCKLKRITGEELKEKL
LDKGFVLRVCKDFKALNNDYVRLAIKTRELNENLIHVLKEIN

Sequences:

>Translated_362_residues
MHGGDIYTEGILKGKELIDFSSNINPLGLPDSFKDNLEEALSWVQVYPDIQYRNLKRNLIDYLSFSLGYFYKEKVENPNI
KEENLVLGNGAIEIIDLAISNLKSISILVPSFVEYELCAKKWNVQIDYCNLNEDMTYNYENIKKSLEKTEGIILGNPNNP
NGSVIDKEEFIYILDYCEKNNKIVILDEAFIEFTGKNSFSFLNLCERYKCIFIIRALTKFFSMPGIRFGYGISFNNEFLN
KIREKQNPWNINCFAEIAVKYVLKDEEFIEKSINYIEKERTFMYENLKRCHLFHDVYSTYSNFILCKLKRITGEELKEKL
LDKGFVLRVCKDFKALNNDYVRLAIKTRELNENLIHVLKEIN
>Mature_362_residues
MHGGDIYTEGILKGKELIDFSSNINPLGLPDSFKDNLEEALSWVQVYPDIQYRNLKRNLIDYLSFSLGYFYKEKVENPNI
KEENLVLGNGAIEIIDLAISNLKSISILVPSFVEYELCAKKWNVQIDYCNLNEDMTYNYENIKKSLEKTEGIILGNPNNP
NGSVIDKEEFIYILDYCEKNNKIVILDEAFIEFTGKNSFSFLNLCERYKCIFIIRALTKFFSMPGIRFGYGISFNNEFLN
KIREKQNPWNINCFAEIAVKYVLKDEEFIEKSINYIEKERTFMYENLKRCHLFHDVYSTYSNFILCKLKRITGEELKEKL
LDKGFVLRVCKDFKALNNDYVRLAIKTRELNENLIHVLKEIN

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=289, Percent_Identity=24.5674740484429, Blast_Score=94, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6322075, Length=379, Percent_Identity=24.802110817942, Blast_Score=76, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 42458; Mature: 42458

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHGGDIYTEGILKGKELIDFSSNINPLGLPDSFKDNLEEALSWVQVYPDIQYRNLKRNLI
CCCCCEEHHHHHCCHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
DYLSFSLGYFYKEKVENPNIKEENLVLGNGAIEIIDLAISNLKSISILVPSFVEYELCAK
HHHHHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHCCCCEEEECCHHHHHHHHHH
KWNVQIDYCNLNEDMTYNYENIKKSLEKTEGIILGNPNNPNGSVIDKEEFIYILDYCEKN
HCCEEEEEEECCCCCEECHHHHHHHHHHHCCEEEECCCCCCCCEECCCCEEEEEEEECCC
NKIVILDEAFIEFTGKNSFSFLNLCERYKCIFIIRALTKFFSMPGIRFGYGISFNNEFLN
CCEEEEEHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHH
KIREKQNPWNINCFAEIAVKYVLKDEEFIEKSINYIEKERTFMYENLKRCHLFHDVYSTY
HHHHCCCCCCEEHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SNFILCKLKRITGEELKEKLLDKGFVLRVCKDFKALNNDYVRLAIKTRELNENLIHVLKE
HCEEEEEEHHCCHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEEECHHHHHHHHHHHH
IN
CC
>Mature Secondary Structure
MHGGDIYTEGILKGKELIDFSSNINPLGLPDSFKDNLEEALSWVQVYPDIQYRNLKRNLI
CCCCCEEHHHHHCCHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
DYLSFSLGYFYKEKVENPNIKEENLVLGNGAIEIIDLAISNLKSISILVPSFVEYELCAK
HHHHHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHCCCCEEEECCHHHHHHHHHH
KWNVQIDYCNLNEDMTYNYENIKKSLEKTEGIILGNPNNPNGSVIDKEEFIYILDYCEKN
HCCEEEEEEECCCCCEECHHHHHHHHHHHCCEEEECCCCCCCCEECCCCEEEEEEEECCC
NKIVILDEAFIEFTGKNSFSFLNLCERYKCIFIIRALTKFFSMPGIRFGYGISFNNEFLN
CCEEEEEHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHH
KIREKQNPWNINCFAEIAVKYVLKDEEFIEKSINYIEKERTFMYENLKRCHLFHDVYSTY
HHHHCCCCCCEEHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SNFILCKLKRITGEELKEKLLDKGFVLRVCKDFKALNNDYVRLAIKTRELNENLIHVLKE
HCEEEEEEHHCCHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEEECHHHHHHHHHHHH
IN
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]