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The map label for this gene is adk

Identifier: 170755733

GI number: 170755733

Start: 3767380

End: 3768030

Strand: Reverse

Name: adk

Synonym: CLD_1045

Alternate gene names: 170755733

Gene position: 3768030-3767380 (Counterclockwise)

Preceding gene: 170754866

Following gene: 170757409

Centisome position: 95.19

GC content: 30.88

Gene sequence:

>651_bases
ATGCGTATAATTTTGTTAGGTCCTCCAGGAGCAGGTAAAGGAACTCAAGCAAAATTAATAAGTGAAAAATTTTCTATTCC
TCATATATCAACAGGTGATATATTTAGGGCAAACATAAAGGAGAAAACTCCTTTAGGAATAGAAGCAAAAAGATATATAG
ATAATGGTCAATTAGTACCAGATGAGGTAACTATAGGAATAGTTAAAGATAGATTAACAAAAGATGATTGTGATAATGGT
TTCCTTTTAGATGGTTTTCCAAGAACAGTTGCTCAAGCAGAAGCTTTAGATGAATTTCTAAAGGGTATAAATAAGGAGCT
AGATGTAGCACTATTAATTAAAGTGCCTGAAGGATTTATCTTGGAAAGAATGACTGGTAGAAGAGTTTGCACATCTTGTG
GTGCAAGTTATCACATAAGATTTAATCCTCCTAAAATAGAAGGAAAATGTGATATATGTGATAATGAATTAATTCAAAGA
AAAGATGATACAGAAGCAACAGTAAAAGAAAGATTAGAAGTTTACAGCAAACAAACTTATCCGCTTATAAATTATTATAA
AGACAATGGTATAATCTCAGAGGTTAATGGGACTGAATCAATTAATGAGGTATTTGGAAATATTTCGAATATCTTAGGGA
GAGATAAATAA

Upstream 100 bases:

>100_bases
TTGGATTTGCATTGGATACTATAAGACAAATAGAATCTCAATTAGTTATGCGTCACTATCAAGGTTTCTTAAAATAAAAA
TGTTTTGGAGATGATTATGG

Downstream 100 bases:

>100_bases
TGATAACAATAAAAACCGATTCTGAAATAGAATACATGGTAAAAGCAGGAAAAGTTGTTGCTGAAGCCTTAGACACTTTA
GAAAAACATGTAAAGCCAGG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MRIILLGPPGAGKGTQAKLISEKFSIPHISTGDIFRANIKEKTPLGIEAKRYIDNGQLVPDEVTIGIVKDRLTKDDCDNG
FLLDGFPRTVAQAEALDEFLKGINKELDVALLIKVPEGFILERMTGRRVCTSCGASYHIRFNPPKIEGKCDICDNELIQR
KDDTEATVKERLEVYSKQTYPLINYYKDNGIISEVNGTESINEVFGNISNILGRDK

Sequences:

>Translated_216_residues
MRIILLGPPGAGKGTQAKLISEKFSIPHISTGDIFRANIKEKTPLGIEAKRYIDNGQLVPDEVTIGIVKDRLTKDDCDNG
FLLDGFPRTVAQAEALDEFLKGINKELDVALLIKVPEGFILERMTGRRVCTSCGASYHIRFNPPKIEGKCDICDNELIQR
KDDTEATVKERLEVYSKQTYPLINYYKDNGIISEVNGTESINEVFGNISNILGRDK
>Mature_216_residues
MRIILLGPPGAGKGTQAKLISEKFSIPHISTGDIFRANIKEKTPLGIEAKRYIDNGQLVPDEVTIGIVKDRLTKDDCDNG
FLLDGFPRTVAQAEALDEFLKGINKELDVALLIKVPEGFILERMTGRRVCTSCGASYHIRFNPPKIEGKCDICDNELIQR
KDDTEATVKERLEVYSKQTYPLINYYKDNGIISEVNGTESINEVFGNISNILGRDK

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=208, Percent_Identity=44.2307692307692, Blast_Score=191, Evalue=3e-49,
Organism=Homo sapiens, GI4502013, Length=208, Percent_Identity=44.2307692307692, Blast_Score=191, Evalue=4e-49,
Organism=Homo sapiens, GI19923437, Length=212, Percent_Identity=38.6792452830189, Blast_Score=160, Evalue=7e-40,
Organism=Homo sapiens, GI310110345, Length=213, Percent_Identity=35.2112676056338, Blast_Score=147, Evalue=9e-36,
Organism=Homo sapiens, GI53832003, Length=213, Percent_Identity=35.2112676056338, Blast_Score=147, Evalue=9e-36,
Organism=Homo sapiens, GI8051579, Length=213, Percent_Identity=35.2112676056338, Blast_Score=147, Evalue=9e-36,
Organism=Homo sapiens, GI53832001, Length=213, Percent_Identity=35.2112676056338, Blast_Score=147, Evalue=9e-36,
Organism=Homo sapiens, GI4502011, Length=211, Percent_Identity=33.6492890995261, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI22749187, Length=213, Percent_Identity=27.6995305164319, Blast_Score=98, Evalue=6e-21,
Organism=Homo sapiens, GI7706497, Length=219, Percent_Identity=28.7671232876712, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI28144899, Length=210, Percent_Identity=29.0476190476191, Blast_Score=88, Evalue=5e-18,
Organism=Homo sapiens, GI28144897, Length=210, Percent_Identity=29.0476190476191, Blast_Score=88, Evalue=5e-18,
Organism=Escherichia coli, GI1786680, Length=218, Percent_Identity=51.3761467889908, Blast_Score=219, Evalue=8e-59,
Organism=Caenorhabditis elegans, GI17552384, Length=214, Percent_Identity=39.2523364485981, Blast_Score=180, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI17537943, Length=217, Percent_Identity=30.4147465437788, Blast_Score=116, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17533833, Length=211, Percent_Identity=30.3317535545024, Blast_Score=107, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17567503, Length=208, Percent_Identity=27.8846153846154, Blast_Score=103, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17550688, Length=212, Percent_Identity=29.2452830188679, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI25147457, Length=216, Percent_Identity=23.6111111111111, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6320432, Length=216, Percent_Identity=44.4444444444444, Blast_Score=203, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6321018, Length=205, Percent_Identity=42.9268292682927, Blast_Score=157, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6322828, Length=213, Percent_Identity=27.2300469483568, Blast_Score=85, Evalue=1e-17,
Organism=Drosophila melanogaster, GI22026816, Length=213, Percent_Identity=44.131455399061, Blast_Score=192, Evalue=2e-49,
Organism=Drosophila melanogaster, GI17737899, Length=200, Percent_Identity=38, Blast_Score=149, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24645822, Length=200, Percent_Identity=38, Blast_Score=149, Evalue=1e-36,
Organism=Drosophila melanogaster, GI221459597, Length=211, Percent_Identity=28.9099526066351, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21356893, Length=211, Percent_Identity=28.9099526066351, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24663208, Length=204, Percent_Identity=25.4901960784314, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17647141, Length=204, Percent_Identity=25.4901960784314, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 24061; Mature: 24061

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIILLGPPGAGKGTQAKLISEKFSIPHISTGDIFRANIKEKTPLGIEAKRYIDNGQLVP
CEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCHHEECCCCCCCC
DEVTIGIVKDRLTKDDCDNGFLLDGFPRTVAQAEALDEFLKGINKELDVALLIKVPEGFI
CCEEEEEHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHH
LERMTGRRVCTSCGASYHIRFNPPKIEGKCDICDNELIQRKDDTEATVKERLEVYSKQTY
HHHHCCHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCC
PLINYYKDNGIISEVNGTESINEVFGNISNILGRDK
CEEEEEECCCEEEECCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRIILLGPPGAGKGTQAKLISEKFSIPHISTGDIFRANIKEKTPLGIEAKRYIDNGQLVP
CEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCHHEECCCCCCCC
DEVTIGIVKDRLTKDDCDNGFLLDGFPRTVAQAEALDEFLKGINKELDVALLIKVPEGFI
CCEEEEEHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHH
LERMTGRRVCTSCGASYHIRFNPPKIEGKCDICDNELIQRKDDTEATVKERLEVYSKQTY
HHHHCCHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCC
PLINYYKDNGIISEVNGTESINEVFGNISNILGRDK
CEEEEEECCCEEEECCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA