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The map label for this gene is cobC

Identifier: 170755309

GI number: 170755309

Start: 931024

End: 931638

Strand: Direct

Name: cobC

Synonym: CLD_3753

Alternate gene names: 170755309

Gene position: 931024-931638 (Clockwise)

Preceding gene: 170755784

Following gene: 170754284

Centisome position: 23.52

GC content: 26.5

Gene sequence:

>615_bases
ATGAATATATACTTAATAAGGCATGGAGAAACGGAACAAAACAAAAGGAAAAATTTTTATGGTAAATTAGATGTAGGATT
AAATGAAAAGGGAAAGGAGCAAAGCTATAAAGTAGGAGAACTTTTAAAAGATGTAAAGTTCAATAAAATTTATATAAGTG
ATAGAAAAAGAACTAGAGAAACTTCAGAAAGAATCTTAGAGAGAAACAGATTTTATGAAAAAGAAAAAAATATTATTTAT
AAAGATGAGAAAATAAATGAATTAGACTTCGGAATTTTTGAAGGTAAATCTTATGAGGAAATAGGTTCTTTATATCCAAA
GGAACAAGAGAAATGGGAAAAGGATTGGAAAAACTTTGTCCCGCCTAAAGGTGAAAGTGCAGTGGTATTTTATAATAGAG
TAGAAAATTTTATGAAACATATACAAAAAGAAGAGGATGGGAACTATTTAATAGTTACCCATGGAGGAGTAATAAGAATG
ATATATAGTTATATACTTCAGAATAATATGGATTTTTACTGGAATTTTGCTTCAAGAAATGGAGATATAACATTAATCAA
ATATGAGTATGAAAACTTATTTATAGATTACATATTACCTACAAAGTTAATTTGA

Upstream 100 bases:

>100_bases
ACTAGGTATTTAATAATGTGTAAGTATAAAATATTTGTATGCAAATAAATTAAAGTATTTACAGGGAATTTTATATTAAA
ACTTAGATTAGGAGAGAAAC

Downstream 100 bases:

>100_bases
GATTAGTACTATCATAGTTACCTAAATTTCGTACAAATATAGAAATCATATTTTCATGATATACAGAATATTTTACTTTT
TTCATCTTAAGCTTAAAGCT

Product: alpha-ribazole phosphatase

Products: NA

Alternate protein names: Alpha-ribazole-5'-phosphate phosphatase [H]

Number of amino acids: Translated: 204; Mature: 204

Protein sequence:

>204_residues
MNIYLIRHGETEQNKRKNFYGKLDVGLNEKGKEQSYKVGELLKDVKFNKIYISDRKRTRETSERILERNRFYEKEKNIIY
KDEKINELDFGIFEGKSYEEIGSLYPKEQEKWEKDWKNFVPPKGESAVVFYNRVENFMKHIQKEEDGNYLIVTHGGVIRM
IYSYILQNNMDFYWNFASRNGDITLIKYEYENLFIDYILPTKLI

Sequences:

>Translated_204_residues
MNIYLIRHGETEQNKRKNFYGKLDVGLNEKGKEQSYKVGELLKDVKFNKIYISDRKRTRETSERILERNRFYEKEKNIIY
KDEKINELDFGIFEGKSYEEIGSLYPKEQEKWEKDWKNFVPPKGESAVVFYNRVENFMKHIQKEEDGNYLIVTHGGVIRM
IYSYILQNNMDFYWNFASRNGDITLIKYEYENLFIDYILPTKLI
>Mature_204_residues
MNIYLIRHGETEQNKRKNFYGKLDVGLNEKGKEQSYKVGELLKDVKFNKIYISDRKRTRETSERILERNRFYEKEKNIIY
KDEKINELDFGIFEGKSYEEIGSLYPKEQEKWEKDWKNFVPPKGESAVVFYNRVENFMKHIQKEEDGNYLIVTHGGVIRM
IYSYILQNNMDFYWNFASRNGDITLIKYEYENLFIDYILPTKLI

Specific function: Converts N1-(5-phospho-alpha-D-ribosyl)-5,6- dimethylbenzimidazole into N1-alpha-D-ribosyl-5,6- dimethylbenzimidazole; involved in the assembly of the nucleotide loop of cobalamin [H]

COG id: COG0406

COG function: function code G; Fructose-2,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family [H]

Homologues:

Organism=Homo sapiens, GI118582286, Length=172, Percent_Identity=32.5581395348837, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI4758902, Length=168, Percent_Identity=32.1428571428571, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI9966849, Length=125, Percent_Identity=35.2, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI4758900, Length=172, Percent_Identity=30.2325581395349, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI224282149, Length=172, Percent_Identity=30.2325581395349, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI64762445, Length=175, Percent_Identity=30.2857142857143, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI64762406, Length=175, Percent_Identity=30.2857142857143, Blast_Score=70, Evalue=9e-13,
Organism=Escherichia coli, GI1786857, Length=187, Percent_Identity=26.7379679144385, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1790856, Length=200, Percent_Identity=28, Blast_Score=80, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71993390, Length=173, Percent_Identity=30.0578034682081, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25145314, Length=165, Percent_Identity=27.8787878787879, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17510917, Length=173, Percent_Identity=30.0578034682081, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324857, Length=191, Percent_Identity=27.7486910994764, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322306, Length=167, Percent_Identity=31.1377245508982, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR017578 [H]

Pfam domain/function: PF00300 PGAM [H]

EC number: =3.1.3.73 [H]

Molecular weight: Translated: 24682; Mature: 24682

Theoretical pI: Translated: 8.54; Mature: 8.54

Prosite motif: PS00175 PG_MUTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIYLIRHGETEQNKRKNFYGKLDVGLNEKGKEQSYKVGELLKDVKFNKIYISDRKRTRE
CEEEEEECCCCCCHHHHCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEECCCHHHHH
TSERILERNRFYEKEKNIIYKDEKINELDFGIFEGKSYEEIGSLYPKEQEKWEKDWKNFV
HHHHHHHHHHHHHHHCCEEECCCCCCCCCCEEECCCCHHHHHCCCCCHHHHHHHHHHHCC
PPKGESAVVFYNRVENFMKHIQKEEDGNYLIVTHGGVIRMIYSYILQNNMDFYWNFASRN
CCCCCCEEEEHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEEECCC
GDITLIKYEYENLFIDYILPTKLI
CCEEEEEEECCEEEEEEECCCCCC
>Mature Secondary Structure
MNIYLIRHGETEQNKRKNFYGKLDVGLNEKGKEQSYKVGELLKDVKFNKIYISDRKRTRE
CEEEEEECCCCCCHHHHCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEECCCHHHHH
TSERILERNRFYEKEKNIIYKDEKINELDFGIFEGKSYEEIGSLYPKEQEKWEKDWKNFV
HHHHHHHHHHHHHHHCCEEECCCCCCCCCCEEECCCCHHHHHCCCCCHHHHHHHHHHHCC
PPKGESAVVFYNRVENFMKHIQKEEDGNYLIVTHGGVIRMIYSYILQNNMDFYWNFASRN
CCCCCCEEEEHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEEECCC
GDITLIKYEYENLFIDYILPTKLI
CCEEEEEEECCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]