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The map label for this gene is fhs

Identifier: 170755010

GI number: 170755010

Start: 3836674

End: 3838347

Strand: Reverse

Name: fhs

Synonym: CLD_0967

Alternate gene names: 170755010

Gene position: 3838347-3836674 (Counterclockwise)

Preceding gene: 170755847

Following gene: 170755838

Centisome position: 96.97

GC content: 31.36

Gene sequence:

>1674_bases
ATGTTTAAATCCGATATAGAAATAGCACAAGAATCTAAAATGAAAAATATAAAAAATATAGCTGAGAAGATAGGGTTAAC
AGAAGAAGATATAGATTTATATGGAAAATATAAATGTAAAATTTCATTAGATGTTTTAGAGAGCAATAAAGATAAAAAAG
ATGGAAAACTAATTTTAGTTACAGCTATAAATCCTACTCCAGCAGGAGAAGGAAAATCCACAGTTACAGTAGGTTTAGGG
CAAGCCTTATGGAAGAAAAATAAAAAAGCGGTTATAGCATTAAGAGAACCTTCTTTGGGGCCTGTATTTGGTATAAAAGG
AGGTGCAGCTGGAGGAGGATACTCTCAAGTTGTACCTATGGAAGATATAAATCTTCATTTTACAGGTGATATGCATGCTA
TTACTTCAGCTAATAATTTATTAGCTGCTGCTATAGATAACCATATTCATCAAGGGAATATTTTGAAGATTGATCAAAGA
AGAATTCTCTTTAAAAGAGTTATGGATATGAATGATAGAGCTTTAAGAAATGTAATTGTAGCCTTAGGTGGAAAAATAAA
TGGGTTTCCAAGAGAAGATGGATTTATGATAACTGTAGCTTCAGAGATTATGGCTATATTATGTTTAGCAGAAGATCTTA
TGGATCTTAAGAATAAAATGGGAGAAATATTAGTAGCTTATAGTACAGAGGGGAAACCTATATACTGCAAAGATTTAGAG
GTTCAAGGAGCTATGGCATTATTAATGAAAGATGCTATAAAACCTAATTTAGTTCAAACTTTAGAAAATACTCCGGCTAT
TATACACGGTGGACCTTTCGCTAATATAGCTCATGGATGTAATAGTATATTGGGAACAAAGATGGCCTTAAAATTAGGAG
ATTATGTAATAACAGAGGCAGGTTTTGGAGCAGATCTAGGAGCAGAAAAGTTTTTTGATATTAAGTGTAGAAAAGCTAAT
TTAAAACCAAATTGTGTAGTTATAGTAGCTACAGTAAGAGCTTTAAAATATAATGGTGGGATTCCTAAGGAAAATCTAAA
GGAACAAAATATGGAAGCCCTATCAAAGGGTATAAAAAATCTAGGAAAACATATAGAGAATGTTAATAAGTTTGGTGTAC
CAGCAGTAGTTGCTATAAATAAATTTATATCAGATACAGAAGAAGAAATAGAATTTATAAAAAAATATTGTAAAGAATTA
GGTGCAGAAGTGTCTATCGCAGAGGTATGGGAAAAAGGTGGAAATGGTGGCTTAGAATTAGCTGATAAAGTTTTAGATAC
CATAGAAAATAAAGAAAGTAAATTTAATCCTATATACGAGGAAACTCTTAATATAAAACAAAAAATAGAAACAATTGCCC
AGGAAATATATGGAGCAGAAGGGGTAGATTATTCTAAAGAGGCAGAAAAGCAAATATCTGAAATAGAAAAATTAGATTTA
GATAAAAAGCCTGTATGTATGGCAAAAACTCAGTATTCTTTATCAGATGATGCTAAACTATTAGGAAGACCATGTGGATT
TAGAATTAATGTCAAAGAAGTTAGAATATCCAATGGAGCTGGATTTATAGTTGTGCTAACAGGAAATGTTATGACTATGC
CAGGTTTACCTAAGAAACCTGCAGCTAACAATATGGATGTATTATCAGATGGCAATATAGTTGGACTATTCTAA

Upstream 100 bases:

>100_bases
AGAGTAGAATTAAAAAATTATTAAACAACGAATAAATAATTATTCAATTACACAAAAATAATTAATAGGGTCCGTATTAT
AACTAAGGGGGAATATATAA

Downstream 100 bases:

>100_bases
CATTAATATAACAGAAGTATTAACTTGACAAAATAATTGGAACTGATAAAATAAAATTATTAAATTGACATTAAATCAAG
CATAAAGGGCAGCGGCAAGG

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS [H]

Number of amino acids: Translated: 557; Mature: 557

Protein sequence:

>557_residues
MFKSDIEIAQESKMKNIKNIAEKIGLTEEDIDLYGKYKCKISLDVLESNKDKKDGKLILVTAINPTPAGEGKSTVTVGLG
QALWKKNKKAVIALREPSLGPVFGIKGGAAGGGYSQVVPMEDINLHFTGDMHAITSANNLLAAAIDNHIHQGNILKIDQR
RILFKRVMDMNDRALRNVIVALGGKINGFPREDGFMITVASEIMAILCLAEDLMDLKNKMGEILVAYSTEGKPIYCKDLE
VQGAMALLMKDAIKPNLVQTLENTPAIIHGGPFANIAHGCNSILGTKMALKLGDYVITEAGFGADLGAEKFFDIKCRKAN
LKPNCVVIVATVRALKYNGGIPKENLKEQNMEALSKGIKNLGKHIENVNKFGVPAVVAINKFISDTEEEIEFIKKYCKEL
GAEVSIAEVWEKGGNGGLELADKVLDTIENKESKFNPIYEETLNIKQKIETIAQEIYGAEGVDYSKEAEKQISEIEKLDL
DKKPVCMAKTQYSLSDDAKLLGRPCGFRINVKEVRISNGAGFIVVLTGNVMTMPGLPKKPAANNMDVLSDGNIVGLF

Sequences:

>Translated_557_residues
MFKSDIEIAQESKMKNIKNIAEKIGLTEEDIDLYGKYKCKISLDVLESNKDKKDGKLILVTAINPTPAGEGKSTVTVGLG
QALWKKNKKAVIALREPSLGPVFGIKGGAAGGGYSQVVPMEDINLHFTGDMHAITSANNLLAAAIDNHIHQGNILKIDQR
RILFKRVMDMNDRALRNVIVALGGKINGFPREDGFMITVASEIMAILCLAEDLMDLKNKMGEILVAYSTEGKPIYCKDLE
VQGAMALLMKDAIKPNLVQTLENTPAIIHGGPFANIAHGCNSILGTKMALKLGDYVITEAGFGADLGAEKFFDIKCRKAN
LKPNCVVIVATVRALKYNGGIPKENLKEQNMEALSKGIKNLGKHIENVNKFGVPAVVAINKFISDTEEEIEFIKKYCKEL
GAEVSIAEVWEKGGNGGLELADKVLDTIENKESKFNPIYEETLNIKQKIETIAQEIYGAEGVDYSKEAEKQISEIEKLDL
DKKPVCMAKTQYSLSDDAKLLGRPCGFRINVKEVRISNGAGFIVVLTGNVMTMPGLPKKPAANNMDVLSDGNIVGLF
>Mature_557_residues
MFKSDIEIAQESKMKNIKNIAEKIGLTEEDIDLYGKYKCKISLDVLESNKDKKDGKLILVTAINPTPAGEGKSTVTVGLG
QALWKKNKKAVIALREPSLGPVFGIKGGAAGGGYSQVVPMEDINLHFTGDMHAITSANNLLAAAIDNHIHQGNILKIDQR
RILFKRVMDMNDRALRNVIVALGGKINGFPREDGFMITVASEIMAILCLAEDLMDLKNKMGEILVAYSTEGKPIYCKDLE
VQGAMALLMKDAIKPNLVQTLENTPAIIHGGPFANIAHGCNSILGTKMALKLGDYVITEAGFGADLGAEKFFDIKCRKAN
LKPNCVVIVATVRALKYNGGIPKENLKEQNMEALSKGIKNLGKHIENVNKFGVPAVVAINKFISDTEEEIEFIKKYCKEL
GAEVSIAEVWEKGGNGGLELADKVLDTIENKESKFNPIYEETLNIKQKIETIAQEIYGAEGVDYSKEAEKQISEIEKLDL
DKKPVCMAKTQYSLSDDAKLLGRPCGFRINVKEVRISNGAGFIVVLTGNVMTMPGLPKKPAANNMDVLSDGNIVGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family [H]

Homologues:

Organism=Homo sapiens, GI222136639, Length=620, Percent_Identity=44.1935483870968, Blast_Score=468, Evalue=1e-132,
Organism=Homo sapiens, GI36796743, Length=619, Percent_Identity=45.0726978998384, Blast_Score=461, Evalue=1e-129,
Organism=Homo sapiens, GI310124614, Length=86, Percent_Identity=41.8604651162791, Blast_Score=66, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17568737, Length=622, Percent_Identity=44.0514469453376, Blast_Score=468, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI17568739, Length=622, Percent_Identity=44.0514469453376, Blast_Score=468, Evalue=1e-132,
Organism=Saccharomyces cerevisiae, GI6321643, Length=626, Percent_Identity=42.6517571884984, Blast_Score=452, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6319558, Length=633, Percent_Identity=42.3380726698262, Blast_Score=450, Evalue=1e-127,
Organism=Drosophila melanogaster, GI62472483, Length=619, Percent_Identity=43.1340872374798, Blast_Score=464, Evalue=1e-131,
Organism=Drosophila melanogaster, GI45551871, Length=619, Percent_Identity=43.1340872374798, Blast_Score=464, Evalue=1e-131,
Organism=Drosophila melanogaster, GI24645718, Length=619, Percent_Identity=43.1340872374798, Blast_Score=463, Evalue=1e-130,
Organism=Drosophila melanogaster, GI17137370, Length=619, Percent_Identity=43.1340872374798, Blast_Score=463, Evalue=1e-130,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000559
- InterPro:   IPR020628 [H]

Pfam domain/function: PF01268 FTHFS [H]

EC number: =6.3.4.3 [H]

Molecular weight: Translated: 60701; Mature: 60701

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS00721 FTHFS_1 ; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKSDIEIAQESKMKNIKNIAEKIGLTEEDIDLYGKYKCKISLDVLESNKDKKDGKLILV
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEEEEECCCCCCCCCCEEEE
TAINPTPAGEGKSTVTVGLGQALWKKNKKAVIALREPSLGPVFGIKGGAAGGGYSQVVPM
EEECCCCCCCCCCEEEEECCHHHHCCCCCEEEEEECCCCCCEEECCCCCCCCCCCEECCC
EDINLHFTGDMHAITSANNLLAAAIDNHIHQGNILKIDQRRILFKRVMDMNDRALRNVIV
CCCEEEECCCCCEECCCCCCHHHHHHCCCCCCCEEEEHHHHHHHHHHHCCCHHHHHHHHH
ALGGKINGFPREDGFMITVASEIMAILCLAEDLMDLKNKMGEILVAYSTEGKPIYCKDLE
HHCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEECCC
VQGAMALLMKDAIKPNLVQTLENTPAIIHGGPFANIAHGCNSILGTKMALKLGDYVITEA
HHHHHHHHHHHHCCCHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCEEEECC
GFGADLGAEKFFDIKCRKANLKPNCVVIVATVRALKYNGGIPKENLKEQNMEALSKGIKN
CCCCCCCCCCEEEEEEEECCCCCCEEEEEEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LGKHIENVNKFGVPAVVAINKFISDTEEEIEFIKKYCKELGAEVSIAEVWEKGGNGGLEL
HHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHH
ADKVLDTIENKESKFNPIYEETLNIKQKIETIAQEIYGAEGVDYSKEAEKQISEIEKLDL
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCC
DKKPVCMAKTQYSLSDDAKLLGRPCGFRINVKEVRISNGAGFIVVLTGNVMTMPGLPKKP
CCCCEEEEECCCCCCCCHHHHCCCCCCEEEEEEEEEECCCCEEEEEECCEEECCCCCCCC
AANNMDVLSDGNIVGLF
CCCCCCEECCCCEEEEC
>Mature Secondary Structure
MFKSDIEIAQESKMKNIKNIAEKIGLTEEDIDLYGKYKCKISLDVLESNKDKKDGKLILV
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEEEEECCCCCCCCCCEEEE
TAINPTPAGEGKSTVTVGLGQALWKKNKKAVIALREPSLGPVFGIKGGAAGGGYSQVVPM
EEECCCCCCCCCCEEEEECCHHHHCCCCCEEEEEECCCCCCEEECCCCCCCCCCCEECCC
EDINLHFTGDMHAITSANNLLAAAIDNHIHQGNILKIDQRRILFKRVMDMNDRALRNVIV
CCCEEEECCCCCEECCCCCCHHHHHHCCCCCCCEEEEHHHHHHHHHHHCCCHHHHHHHHH
ALGGKINGFPREDGFMITVASEIMAILCLAEDLMDLKNKMGEILVAYSTEGKPIYCKDLE
HHCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEECCC
VQGAMALLMKDAIKPNLVQTLENTPAIIHGGPFANIAHGCNSILGTKMALKLGDYVITEA
HHHHHHHHHHHHCCCHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCEEEECC
GFGADLGAEKFFDIKCRKANLKPNCVVIVATVRALKYNGGIPKENLKEQNMEALSKGIKN
CCCCCCCCCCEEEEEEEECCCCCCEEEEEEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LGKHIENVNKFGVPAVVAINKFISDTEEEIEFIKKYCKELGAEVSIAEVWEKGGNGGLEL
HHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHH
ADKVLDTIENKESKFNPIYEETLNIKQKIETIAQEIYGAEGVDYSKEAEKQISEIEKLDL
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCC
DKKPVCMAKTQYSLSDDAKLLGRPCGFRINVKEVRISNGAGFIVVLTGNVMTMPGLPKKP
CCCCEEEEECCCCCCCCHHHHCCCCCCEEEEEEEEEECCCCEEEEEECCEEECCCCCCCC
AANNMDVLSDGNIVGLF
CCCCCCEECCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA